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Original Articles

Large Volume Injection of Biological Samples Dissolved in a Non-Eluting Solvent: A Way to Increase Sensitivity and a Means of Automating Drug Determination Using Hplc

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Pages 2039-2061 | Published online: 05 Dec 2006

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M.R. Silver, T.D. Trosper, M.R. Gould, J.E. Dickinson & G.A. Desotelle. (1984) The Use of Large Volume Injections for the Isocratic Separation of Phenylthiohydantoin Amino Acids by Microbore Liquid Chromatography. Journal of Liquid Chromatography 7:3, pages 559-568.
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Articles from other publishers (37)

Kevin C. Honeychurch. (2024) Development of an On-Column Trace Enrichment Method for the Determination of Sub-μg/L Bisphenol A in Bottled Water by RP-HPLC with Fluorescent Detection. International Journal of Analytical Chemistry 2024, pages 1-8.
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Koudi Zhu, Matthias Pursch, Bram Huygens, Sebastiaan Eeltink & Gert Desmet. (2023) Minimize Precolumn Band Broadening with Immiscible Solvent Sandwich Injection. Analytical Chemistry 95:41, pages 15311-15317.
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Larry Miller & Shawn J. Ayube. (2020) In-column dilution: Improving volume loadability in reverse phase gradient chromatography through the use of a silica pre-column. Journal of Chromatography A 1618, pages 460897.
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Jialiang Pan, Yuling Hu, Tingan Liang & Gongke Li. (2012) Preparation of solid-phase microextraction fibers by in-mold coating strategy for derivatization analysis of 24-epibrassinolide in pollen samples. Journal of Chromatography A 1262, pages 49-55.
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A. Carl Sanchez, Jason A. Anspach & Tivadar Farkas. (2012) Performance optimizing injection sequence for minimizing injection band broadening contributions in high efficiency liquid chromatographic separations. Journal of Chromatography A 1228, pages 338-348.
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J. D. Mozo, J. Carbajo, J. C. Sturm, L. J. Núñez‐Vergara, P. Salgado & J. A. Squella. (2012) Determination of Nifuroxazide by Flow Injection Linear Adsorptive Stripping Voltammetry on a Screen‐Printed Carbon Nanofiber Modified Electrode. Electroanalysis 24:3, pages 676-682.
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Milan Hutta, Mária Chalányová, Radoslav Halko, Róbert Góra, Svetlana Dokupilová & Ivan Rybár. (2009) Reversed phase liquid chromatography trace analysis of pesticides in soil by on‐column sample pumping large volume injection and UV detection. Journal of Separation Science 32:12, pages 2034-2042.
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Qing Chang, Lisheng Kang, Keri Varner, Joyce Bridges, Norman Sesi & Margo Palmieri. 2009. Formulation and Analytical Development for Low‐Dose Oral Drug Products. Formulation and Analytical Development for Low‐Dose Oral Drug Products 327 343 .
Aurea C. Chiaia, Caleb Banta-Green & Jennifer Field. (2008) Eliminating Solid Phase Extraction with Large-Volume Injection LC/MS/MS: Analysis of Illicit and Legal Drugs and Human Urine Indicators in US Wastewaters. Environmental Science & Technology 42:23, pages 8841-8848.
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Tarek Saied Belal. (2008) A Simple and Sensitive Spectrofluorimetric Method for Analysis of Some Nitrofuran Drugs in Pharmaceutical Preparations. Journal of Fluorescence 18:5, pages 771-780.
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Milan Hutta, Mária Chalányová, Radoslav Halko, Róbert Góra, Ivan Rybár, Marek Pajchl & Svetlana Dokupilová. (2006) New approach to large‐volume injection in reversed‐phase high performance liquid chromatography: Determination of atrazine and hydroxyatrazine in soil samples. Journal of Separation Science 29:13, pages 1977-1987.
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Magda Mohammed Ayad, Nadia Fayek Youssef, Hisham Ezzat Abdellatif & Suzan Mahmod Soliman. (2006) A Comparative Study on Various Spectrometries with Thin Layer Chromatography for Simultaneous Analysis of Drotaverine and Nifuroxazide in Capsules. Chemical and Pharmaceutical Bulletin 54:6, pages 807-813.
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Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow & A. Kluge. 1999. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 235 340 .
Achille Cappiello, Giorgio Famiglini & Arnaldo Berloni. (1997) Large volume injection of acidic pesticides by reversed-phase micro high-performance liquid chromatography. Journal of Chromatography A 768:2, pages 215-222.
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Stephen R. Bakalyar, Corey Phipps, Barbara Spruce & Kristine Olsen. (1997) Choosing sample volume to achieve maximum detection sensitivity and resolution with high-performance liquid chromatography columns of 1.0, 2.1 and 4.6 mm I.D.. Journal of Chromatography A 762:1-2, pages 167-185.
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Zuoxiang Yu & Douglas Westerlund. (1996) Ion-pair chromatography of methotrexate in a column-switching system using an alkyl-diol silica precolumn for direct injection of plasma. Journal of Chromatography A 742:1-2, pages 113-120.
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Mehdi Attaran Rezai, Giorgio Famiglini & Achille Cappiello. (1996) Enhanced detection sensitivity by large volume injection in reversed-phase micro-high-performance liquid chromatography. Journal of Chromatography A 742:1-2, pages 69-78.
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Bart N. Zegers, Jody F.C. de Brouwer, Aldi Poppema, Henk Lingeman & Udo A.Th. Brinkman. (1995) Electron-capture detection in reversed-phase liquid chromatography using packed-capillary columns. Analytica Chimica Acta 304:1, pages 47-56.
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Charles E. Kientz, Albert Verweij, Gerhardus J. De Jong & Udo A. Th. Brinkman. (2005) Verification of nonproduction of chemical warfare agents: II. Large volume injections in microcolumn liquid chromatography using flame photometric detection. Journal of Microcolumn Separations 4:6, pages 477-483.
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B. Delhotal Landes, G. Miscoria & B. Flouvat. (1992) Determination of lansoprazole and its metabolites in plasma by high-performance liquid chromatography using a loop column. Journal of Chromatography B: Biomedical Sciences and Applications 577:1, pages 117-122.
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Paul Guinebault, Deirdre McAnena‐Morice, Colette Colafranceschi & Alain Rouchouse. (2004) Plasma determination of the enantiomers of SL 84.0418, a new antihyperglycaemic drug, by HPLC on a chiral α 1 ‐agp column . Chirality 4:2, pages 116-121.
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R.B. Taylor, R.G. Reid & I.M. Gould. (1991) Determination of teicoplanin in plasma using microbore high-performance liquid chromatography and injection-generated gradients. Journal of Chromatography B: Biomedical Sciences and Applications 563:2, pages 451-457.
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René B. Geerdink. (1991) Direct determination of metamitron in surface water by large sample by volume injection. Journal of Chromatography A 543, pages 244-249.
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David N. Mallett & Brian Law. (1991) Demonstration of the compatibility of narrow-bore packed column high-performance liquid chromatography with conventional detection systems. Journal of Pharmaceutical and Biomedical Analysis 9:1, pages 53-57.
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M.C. Rouan, J. Campestrini, J.B. Lecaillon, J.P. Dubois, M. Lamontagne & B. Pichon. (1988) Fully automated analytical system using liquid—solid extraction and liquid chromatography for the determination of CGP 6140 in plasma. Journal of Chromatography A 456, pages 45-51.
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R.B. Taylor, K.E. Kendle, R.G. Reid & C.T. Hung. (1987) Chromatography of progesterone and its major metabolites in rat plasma using microbore high-performance liquid chromatography columns with conventional injection and detection systems. Journal of Chromatography A 385, pages 383-392.
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K. Šlais, M. Krejčí, J. Chmelíková & D. Kouřilová. (1987) Trace analysis using a competing modifier added to the sample for retention and focusing control in microbore column high-performance liquid chromatography. Journal of Chromatography A 388, pages 179-187.
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Harold McNair & Jeff Bowermaster. (2005) Microbore HPLC column performance and temperature programming capabilities. Journal of High Resolution Chromatography 10:1, pages 27-31.
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P. Guinebault, M. Broquaire, C. Colafranceschi & J.P. Thénot. (1986) High-performance liquid chromatographic determination of alfuzosin in biological fluids with fluorimetric detection and large-volume injection. Journal of Chromatography A 353, pages 361-369.
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M. Krejči, K. Šlais, D. Kouřilová & M. Vespalcová. (1984) Enrichment techniques and trace analysis with microbore columns in liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 2:2, pages 197-205.
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