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Journal of Liquid Chromatography Volume 11, 1988 - Issue 6
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Original Articles

The Determination of a New Trifluorinated Quinolone, Fleroxacin, Its N-Demethyl, and N-Oxide Metabolites in Plasma and Urine by High Performance Liquid Chromatography with Fluorescence Detection

Dennis Dell Biological Pharmaceutical Research Department F. Hoffmann-La Roche & Co. Ltd., CH-4002, Basel, Switzerland
,
Charles Partos Biological Pharmaceutical Research Department F. Hoffmann-La Roche & Co. Ltd., CH-4002, Basel, Switzerland
&
Renée Portmann Biological Pharmaceutical Research Department F. Hoffmann-La Roche & Co. Ltd., CH-4002, Basel, Switzerland
Pages 1299-1312 | Published online: 06 Dec 2006

Citations (18)

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D. Kowalczuk, H. Hopkała & A. Gumieniczek. (2003) Application of Solid‐Phase Extraction of Fluoroquinolone Derivatives from a Biological Matrix to Their Biodetermination by Liquid Chromatography. Journal of Liquid Chromatography & Related Technologies 26:11, pages 1731-1741.
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Articles from other publishers (17)

Huan Yu, Yanfei Tao, Dongmei Chen, Yuanhu Pan, Zhenli Liu, Yulian Wang, Lingli Huang, Menghong Dai, Dapeng Peng, Xu Wang & Zonghui Yuan. (2012) Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction. Journal of Chromatography B 885-886, pages 150-159.
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V. Kapetanović, Lj. Milovanović, M. Aleksić & Lj. Ignjatović. (2000) Voltammetric methods for analytical determination of fleroxacin in Quinodis® tablets. Journal of Pharmaceutical and Biomedical Analysis 22:6, pages 925-932.
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P.G Gigosos, P.R Revesado, O Cadahı́a, C.A Fente, B.I Vazquez, C.M Franco & A Cepeda. (2000) Determination of quinolones in animal tissues and eggs by high-performance liquid chromatography with photodiode-array detection. Journal of Chromatography A 871:1-2, pages 31-36.
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F. Belal, A.A. Al-Majed & A.M. Al-Obaid. (1999) Methods of analysis of 4-quinolone antibacterials. Talanta 50:4, pages 765-786.
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Milena Jelikic-Stankov, Jadranka Odovic, Dejan Stankov & Predrag Djurdjevic. (1998) Determination of fleroxacin in human serum and in dosage forms by derivative UV spectrophotometry. Journal of Pharmaceutical and Biomedical Analysis 18:1-2, pages 145-150.
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Giuseppe Carlucci. (1998) Analysis of fluoroquinolones in biological fluids by high-performance liquid chromatography. Journal of Chromatography A 812:1-2, pages 343-367.
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B G ReignerH A Welker. (1996) Factors influencing elimination and distribution of fleroxacin: metaanalysis of individual data from 10 pharmacokinetic studies. Antimicrobial Agents and Chemotherapy 40:3, pages 575-580.
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J SchrenzelF CerrutiM HerrmannT LeemannE WeidekammR PortmannB HirschelD P Lew. (1994) Single-dose pharmacokinetics of oral fleroxacin in bacteremic patients. Antimicrobial Agents and Chemotherapy 38:6, pages 1219-1224.
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J SchrenzelP DayerT LeemannE WeidekammR PortmannD P Lew. (1993) Influence of rifampin on fleroxacin pharmacokinetics. Antimicrobial Agents and Chemotherapy 37:10, pages 2132-2138.
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Erhard Weidekamm & R. Portmann. (1993) Penetration of Fleroxacin into Body Tissues and Fluids. The American Journal of Medicine 94:3, pages 75S-80S.
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Erhard Weidekamm. (1993) Pharmacokinetics of Fleroxacin in Renal Impairment. The American Journal of Medicine 94:3, pages 70S-74S.
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M DanE WeidekammR SagivR PortmannH Zakut. (1993) Penetration of fleroxacin into breast milk and pharmacokinetics in lactating women. Antimicrobial Agents and Chemotherapy 37:2, pages 293-296.
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Wolfgang Cullmann, Alasdair M. Geddes, Erhard Weidekamm, Heinrich Urwyler & Alfred Braunsteiner. (1993) Fleroxacin: a review of its chemistry, microbiology, toxicology, pharmacokinetics, clinical efficacy and safety. International Journal of Antimicrobial Agents 2:4, pages 203-230.
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F. Lombardi, R. Ardemagni, V. Colzani & M. Visconti. (1992) High-performance liquid chromatographic determination of rufloxacin and its main active metabolite in biological fluids. Journal of Chromatography B: Biomedical Sciences and Applications 576:1, pages 129-134.
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W L HaytonV VlahovN BacrachevaI ViachkiR PortmannG MuirheadK StoeckelE Weidekamm. (1990) Pharmacokinetics and biliary concentrations of fleroxacin in cholecystectomized patients. Antimicrobial Agents and Chemotherapy 34:12, pages 2375-2380.
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P. Heizmann, D. Dell, H. Eggers & R. Gora. (1990) Determination of the new fluoroquinolone fleroxacin and its N-demethyl and N-oxide metabolites in plasma and urine by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications 527, pages 91-101.
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A E StuckF J FreyP HeizmannR BrandtE Weidekamm. (1989) Pharmacokinetics and metabolism of intravenous and oral fleroxacin in subjects with normal and impaired renal function and in patients on continuous ambulatory peritoneal dialysis. Antimicrobial Agents and Chemotherapy 33:3, pages 373-381.
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