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Journal of Liquid Chromatography Volume 14, 1991 - Issue 12
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Original Articles

A Coupled HPLC/Radioimmunoassay for Analysis of Zidovudine Metabolites in Mononuclear Cells

B. N. Stretcher Department of Laboratory, Medicine University of Cincinnati Hospital 234 Goodman Street Cincinnati, Ohio, 45267-0714
,
A. J. Pesce Department of Laboratory, Medicine University of Cincinnati Hospital 234 Goodman Street Cincinnati, Ohio, 45267-0714
,
B. A. Geisler Department of Laboratory, Medicine University of Cincinnati Hospital 234 Goodman Street Cincinnati, Ohio, 45267-0714
&
W. H. Vine Department of Laboratory, Medicine University of Cincinnati Hospital 234 Goodman Street Cincinnati, Ohio, 45267-0714
Pages 2261-2272 | Published online: 23 Oct 2006

Citations (16)

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Silvina A. Teijeiro, Mónica A. Raviolo, Marisa I. Motura & Margarita C. Briñón. (2003) 3′-Azido-3′-deoxy-5′-O-isonicotinoylthymidine: A Novel Antiretroviral Analog of Zidovudine. II. Stability in Aqueous Media and Experimental and Theoretical Ionization Constants. Nucleosides, Nucleotides & Nucleic Acids 22:9, pages 1789-1803.
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Raluca-Ioana Stefan & Rahel Girmai Bokretsion. (2003) Diamond Paste Based Immunosensor for the Determination of Azidothymidine. Journal of Immunoassay and Immunochemistry 24:3, pages 319-324.
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Brian Stretcher & B. Conway. (1994) Management of Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection. Critical Reviews in Clinical Laboratory Sciences 31:2, pages 169-196.
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Articles from other publishers (13)

H. Kalász, M. Y. Hasan, E. Adeghate, K. Tekes & A. Adem. (2010) Chromatographic separation of antiviral/anticancer nucleoside reverse transcriptase inhibitor drugs. Analytical and Bioanalytical Chemistry 398:1, pages 295-312.
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D. V. Moiseev, S. I. Marchenko, A. M. Moiseeva, T. V. Trukhacheva, P. T. Petrov & A. I. Zhebentyaev. (2007) HPLC in biopharmaceutical investigations of drugs representing pyrimidine derivatives (A review). Pharmaceutical Chemistry Journal 41:1, pages 25-33.
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Stephen Kewn, Laurene H. Wang, Patrick G. Hoggard, Franck Rousseau, Robert Hart, John P. MacNeela, Saye H. Khoo & David J. Back. (2003) Enzymatic Assay for Measurement of Intracellular DXG Triphosphate Concentrations in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus Type 1-Infected Patients. Antimicrobial Agents and Chemotherapy 47:1, pages 255-261.
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Stephen Kewn, Patrick G. Hoggard, Sean D. Sales, Kevin Jones, Bridget Maher, Saye H. Khoo & David J. Back. (2002) Development of Enzymatic Assays for Quantification of Intracellular Lamivudine and Carbovir Triphosphate Levels in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Patients. Antimicrobial Agents and Chemotherapy 46:1, pages 135-143.
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Lourdes N Thevanayagam, Anura L Jayewardene & John G Gambertoglio. (2000) The stability of intracellular zidovudine and its anabolites in extracts of peripheral blood mononuclear cells (PBMCs). Journal of Pharmaceutical and Biomedical Analysis 22:3, pages 597-603.
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Thierry Brossette, Alain Valleix, Laure Goujon, Christophe Cre´minon, Jacques Grassi, Charles Mioskowski & Luc Lebeau. (1999) Synthesis of a non-hydrolyzable AZT-triphosphate analogue designed for the production of anti-AZT-TP antibodies. Tetrahedron Letters 40:17, pages 3391-3394.
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Laure Goujon, Thierry Brossette, Nathalie Dereudre-Bosquet, Christophe Creminon, Pascal Clayette, Dominique Dormont, Charles Mioskowski, Luc Lebeau & Jacques Grassi. (1998) Monitoring of intracellular levels of 5′-monophosphate-AZT using an enzyme immunoassay. Journal of Immunological Methods 218:1-2, pages 19-30.
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Mary DeRemer, Robin D'Ambrosio, Linda Bartos, Stephen Cousins & Gene D. Morse. (1997) Radioimmunoassay of Zidovudine. Therapeutic Drug Monitoring 19:2, pages 195-200.
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Katrin Peter, Jacob P. Lalezari & John G. Gambertoglio. (1996) Quantification of zidovudine and individual zidovudine phosphates in peripheral blood mononuclear cells by a combined isocratic high performance liquid chromatography radioimmunoassay method. Journal of Pharmaceutical and Biomedical Analysis 14:4, pages 491-499.
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A M O'Donnell, D J Letting, M F DeRemer & G D Morse. (1994) Evidence of alkaline phosphatase interference in a zidovudine radioimmunoassay.. Antimicrobial Agents and Chemotherapy 38:12, pages 2689-2694.
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B N StretcherA J PesceP T FrameD S Stein. (1994) Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus. Antimicrobial Agents and Chemotherapy 38:7, pages 1541-1547.
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G. D. Nordblom & C. M. Barksdale. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 23 39 .
J T SlusherS K KuwaharaF M HamzehL D LewisD M KornhauserP S Lietman. (1992) Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure. Antimicrobial Agents and Chemotherapy 36:11, pages 2473-2477.
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