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Archives of Andrology
Journal of Reproductive Systems
Volume 50, 2004 - Issue 1
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Research Article

EFFECT OF CHRONIC LOW DOSE OF METHOTREXATE ON CELLULAR PROLIFERATION DURING SPERMATOGENESIS IN RATS

A. K. Saxena Department of Anatomy, B.P. Koirala Institute of Health Sciences, Dharan-NepalCorrespondence[email protected]
,
S. DHUNGEL Department of Anatomy, B.P. Koirala Institute of Health Sciences, Dharan-Nepal
,
S. BHATTACHARYA Department of Anatomy, B.P. Koirala Institute of Health Sciences, Dharan-Nepal
,
C. B. JHA Department of Anatomy, B.P. Koirala Institute of Health Sciences, Dharan-Nepal
&
A. K. SRIVASTAVA Department of Anatomy, B.P. Koirala Institute of Health Sciences, Dharan-Nepal
Pages 33-35 | Published online: 09 Jul 2009

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F Koc, Z Erısgın, Y Tekelıoglu & S Takır. (2018) The effect of beta glucan on MTX induced testicular damage in rats. Biotechnic & Histochemistry 93:1, pages 70-75.
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Jennifer Christine Gutierrez & Kathleen Hwang. (2017) The toxicity of methotrexate in male fertility and paternal teratogenicity. Expert Opinion on Drug Metabolism & Toxicology 13:1, pages 51-58.
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Articles from other publishers (31)

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Paloma da Cunha de Medeiros, Cinthia C. Nascimento & Juliana E. Perobelli. (2023) Antineoplastic drugs in environmentally relevant concentrations cause endocrine disruption and testicular dysfunction in experimental conditions. Environmental Toxicology and Pharmacology 100, pages 104122.
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Emad H.M. Hassanein, Wafaa R. Mohamed, Rasha M. Hussein & El-Shaimaa A. Arafa. (2023) Edaravone alleviates methotrexate-induced testicular injury in rats: Implications on inflammation, steroidogenesis, and Akt/p53 signaling. International Immunopharmacology 117, pages 109969.
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Leyla Kilinc & Yesim Hulya Uz. (2021) Protective effects of curcumin against methotrexate-induced testicular damage in rats by suppression of the p38-MAPK and nuclear factor-kappa B pathways. Clinical and Experimental Reproductive Medicine 48:3, pages 211-220.
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Nicolai B. Jensen, Signe D. Justesen, Agnete Larsen, Erik Ernst & Lars H. Pedersen. (2021) A systematic overview of the spermatotoxic and genotoxic effects of methotrexate, ganciclovir and mycophenolate mofetil. Acta Obstetricia et Gynecologica Scandinavica 100:9, pages 1557-1580.
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Antara Banerjee, Marco Scarpa, Surajit Pathak, Patrizia Burra, Giacomo C. Sturniolo, Francesco P. Russo, Ram Murugesan & Renata D'Incá. (2019) Inflammatory Bowel Disease Therapies Adversely Affect Fertility in Men- A Systematic Review and Meta-analysis. Endocrine, Metabolic & Immune Disorders - Drug Targets 19:7, pages 959-974.
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Mehmet Güvenç & Mesut Aksakal. (2018) Ameliorating effect of kisspeptin-10 on methotrexate-induced sperm damages and testicular oxidative stress in rats. Andrologia 50:8, pages e13057.
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Rongrong Xie, Linqi Chen, Haiying Wu, Ting Chen, Fengyun Wang, Xiuli Chen, Hui Sun & Xiaozhong Li. (2018) GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats. International Journal of Endocrinology 2018, pages 1-7.
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Turan Yaman, Ahmet Uyar, Mehmet Salih Kaya, Ömer Faruk Keles, Baris Atalay Uslu & Zabit Yener. (2018) Protective effects of silymarin on methotrexate-induced damages in rat testes. Brazilian Journal of Pharmaceutical Sciences 54:1.
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Mariangela Allocca, Daniela Gilardi, Gionata Fiorino, Federica Furfaro, Laurent Peyrin-Biroulet & Silvio Danese. (2018) Sexual and reproductive issues and inflammatory bowel disease: a neglected topic in men. European Journal of Gastroenterology & Hepatology 30:3, pages 316-322.
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Anne Grosen, Jens Kelsen, Christian Lodberg Hvas, Emanuelle Bellaguarda & Stephen B. Hanauer. (2017) The Influence of Methotrexate Treatment on Male Fertility and Pregnancy Outcome After Paternal Exposure. Inflammatory Bowel Diseases 23:4, pages 561-569.
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Ayano Hirako, Yuki Takeoka, Satoshi Furukawa & Akihiko Sugiyama. (2017) Effects of methotrexate exposure on medaka (<i>Oryzias latipes</i>) testes. Journal of Toxicologic Pathology 30:4, pages 283-289.
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Erma Z. Drobnis & Ajay K. NangiaErma Z. Drobnis & Ajay K. Nangia. 2017. Impacts of Medications on Male Fertility. Impacts of Medications on Male Fertility 179 210 .
John Koo & Mio NakamuraJohn Koo & Mio Nakamura. 2017. Clinical Cases in Phototherapy. Clinical Cases in Phototherapy 119 121 .
Takeshi Shin & Hiroshi Okada. (2016) Infertility in men with inflammatory bowel disease. World Journal of Gastrointestinal Pharmacology and Therapeutics 7:3, pages 361.
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K. Sands, R. Jansen, S. Zaslau & D. Greenwald. (2015) Review article: the safety of therapeutic drugs in male inflammatory bowel disease patients wishing to conceive. Alimentary Pharmacology & Therapeutics 41:9, pages 821-834.
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Hayder Gaeed Oufi & Nada Naji Al-Shawi. (2014) The effects of different doses of silibinin in combination with methotrexate on testicular tissue of mice. European Journal of Pharmacology 730, pages 36-40.
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Maria Moscandrew & Sunanda Kane. (2009) Inflammatory bowel diseases and management considerations: Fertility and pregnancy. Current Gastroenterology Reports 11:5, pages 395-399.
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Alan Menter, Neil J. Korman, Craig A. Elmets, Steven R. Feldman, Joel M. Gelfand, Kenneth B. Gordon, Alice B. Gottlieb, John Y.M. Koo, Mark Lebwohl, Henry W. Lim, Abby S. Van Voorhees, Karl R. Beutner & Reva Bhushan. (2009) Guidelines of care for the management of psoriasis and psoriatic arthritis. Journal of the American Academy of Dermatology 61:3, pages 451-485.
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Robert E. Kalb, Bruce Strober, Gerald Weinstein & Mark Lebwohl. (2009) Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. Journal of the American Academy of Dermatology 60:5, pages 824-837.
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H. Serati Nouri, Y. Azarmi & M. Movahedin. (2009) Effect of growth hormone on testicular dysfunction induced by methotrexate in rats. Andrologia 41:2, pages 105-110.
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Linda A. Feagins & Sunanda V. Kane. (2009) Sexual and Reproductive Issues for Men With Inflammatory Bowel Disease. American Journal of Gastroenterology 104:3, pages 768-773.
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Linda A Feagins & Sunanda V Kane. (2009) Sexual and Reproductive Issues for Men With Inflammatory Bowel Disease. The American Journal of Gastroenterology 104:3, pages 768-773.
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S. Padmanabhan, D.N. Tripathi, A. Vikram, P. Ramarao & G.B. Jena. (2008) Cytotoxic and genotoxic effects of methotrexate in germ cells of male Swiss mice. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 655:1-2, pages 59-67.
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L. Tauchmanovà, C. Alviggi, C. Foresta, I. Strina, A. Garolla, A. Colao, G. Lombardi, G. De Placido, B. Rotoli & C. Selleri. (2007) Cryptozoospermia with normal testicular function after allogeneic stem cell transplantation: A Case Report. Human Reproduction 22:2, pages 495-499.
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