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Catalysis Reviews
Science and Engineering
Volume 57, 2015 - Issue 3
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Original Articles

Distant C-H Activation/Functionalization: A New Horizon of Selectivity Beyond Proximity

Ritika SharmaNatural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, IndiaView further author information
,
Kavita ThakurNatural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, IndiaView further author information
,
Rakesh KumarNatural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India;Academy of Scientific and Innovative Research, CSIR-Institute of Himalayan Bioresource Technology, Palampur, IndiaView further author information
,
Inder KumarNatural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, IndiaView further author information
&
Upendra SharmaNatural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India;Academy of Scientific and Innovative Research, CSIR-Institute of Himalayan Bioresource Technology, Palampur, IndiaCorrespondence[email protected]
View further author information
Pages 345-405 | Received 26 Dec 2014, Accepted 14 Apr 2015, Published online: 30 Jun 2015

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Pavneet Kaur, Vinod Kumar & Rakesh Kumar. (2020) Recent advances in decarboxylative C-C bond formation using direct or in situ generated alkenyl acids. Catalysis Reviews 62:1, pages 118-161.
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Ritika Sharma & Upendra Sharma. (2018) Remote C-H bond activation/transformations: A continuous growing synthetic tool; Part II. Catalysis Reviews 60:4, pages 497-565.
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Articles from other publishers (59)

Wen-Jie Liu, Zhi-Chao Hu, Yu-Xi Wu, Shi-Hao Deng, Zhi-Lin Ren & Zhi-Bing Dong. (2024) Selective Construction of C–S/S–N Bonds from N -Substituted O -Thiocarbamates and Indoles under Transition-Metal-Free Conditions . The Journal of Organic Chemistry 89:6, pages 4098-4112.
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Paulo J. Costa, Frederico F. Martins, Chao Pi, Xiuling Cui & Maria José Calhorda. (2023) C–H functionalization of quinoline N-oxides catalyzed by Pd( ii ) complexes: a computational study . Physical Chemistry Chemical Physics 25:34, pages 22755-22767.
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Yueting Huang & Dong Zou. (2023) Recent progress in remote &gamma;-C(sp<sup>3</sup>)&ndash;H functionalization of carboxylic acid derivatives. SCIENTIA SINICA Chimica 53:6, pages 932-957.
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Ming-Zhu Lu, Jeffrey Goh, Manikantha Maraswami, Zhenhua Jia, Jie-Sheng Tian & Teck-Peng Loh. (2022) Recent Advances in Alkenyl sp 2 C–H and C–F Bond Functionalizations: Scope, Mechanism, and Applications . Chemical Reviews 122:24, pages 17479-17646.
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Wajid Ali, Gaurav Prakash, Shaeel A. Al‐Thabaiti, Mohamed Mokhtar & Debabrata Maiti. 2022. Handbook of CH-Functionalization. Handbook of CH-Functionalization 1 27 .
Ankit K. Dhiman & Upendra Sharma. 2022. Handbook of CH-Functionalization. Handbook of CH-Functionalization 1 25 .
Zhong Jin. 2022. Handbook of CH-Functionalization. Handbook of CH-Functionalization 1 109 .
Diksha Parmar, Ankit Kumar Dhiman, Rohit Kumar, Akhilesh K. Sharma & Upendra Sharma. (2022) Cp*Co(III)-Catalyzed Selective C8-Olefination and Oxyarylation of Quinoline N -Oxides with Terminal Alkynes . The Journal of Organic Chemistry 87:14, pages 9069-9087.
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M. Shahid, Vijay Basavaraj Banakar, Pothapragada S. K. Prabhakar Ganesh & Purushothaman Gopinath. (2022) Transition‐Metal‐Catalyzed Remote C(sp 3 )−H Functionalization Of Carboxylic Acid And Its Derivatives . Asian Journal of Organic Chemistry 11:7.
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Ankita Thakur, Manisha, Inder Kumar & Upendra Sharma. (2022) Visible Light‐induced Functionalization of C−H Bonds: Opening of New Avenues in Organic Synthesis. Asian Journal of Organic Chemistry 11:6.
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Perla Ramesh, Chinnabattigalla Sreenivasulu, Dakoju Ravi Kishore, Dasari Srinivas, Koteswara Rao Gorantla, Bhabani S. Mallik & Gedu Satyanarayana. (2022) Recyclable Aliphatic Nitrile-Template Enabled Remote meta -C–H Functionalization at Room Temperature . The Journal of Organic Chemistry 87:5, pages 2204-2221.
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Shiv Shankar Gupta, Manisha, Rakesh Kumar, Ankit Kumar Dhiman & Upendra Sharma. (2021) Predictable site-selective functionalization: Promoter group assisted para -halogenation of N -substituted ( hetero ) aromatics under metal-free condition . Organic & Biomolecular Chemistry 19:44, pages 9675-9687.
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Dasari Srinivas & Gedu Satyanarayana. (2021) Palladium-Catalyzed Distal m -C–H Functionalization of Arylacetic Acid Derivatives . Organic Letters 23:19, pages 7353-7358.
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Alessandra Corio, Christine Gravier-Pelletier & Patricia Busca. (2021) Regioselective Functionalization of Quinolines through C-H Activation: A Comprehensive Review. Molecules 26:18, pages 5467.
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Perla Ramesh, Chinnabattigalla Sreenivasulu, Koteswara Rao Gorantla, Bhabani S. Mallik & Gedu Satyanarayana. (2021) A simple removable aliphatic nitrile template 2-cyano-2,2-di-isobutyl acetic acid for remote meta -selective C–H functionalization . Organic Chemistry Frontiers 8:9, pages 1959-1969.
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Uttam Dutta & Debabrata Maiti. 2021. Remote CH Bond Functionalizations. Remote CH Bond Functionalizations 221 251 .
Bingxian Liu, Lingyun Yang, Pengfei Li, Fen Wang & Xingwei Li. (2021) Recent advances in transition metal-catalyzed olefinic C–H functionalization. Organic Chemistry Frontiers 8:5, pages 1085-1101.
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Uttam Dutta & Debabrata Maiti. 2001. Encyclopedia of Reagents for Organic Synthesis. Encyclopedia of Reagents for Organic Synthesis 1 5 .
Arun Kumar Sinha & Rakesh Kumar. 2021. Green Synthetic Approaches for Biologically Relevant Heterocycles. Green Synthetic Approaches for Biologically Relevant Heterocycles 207 248 .
Mu‐Wang Chen, Minhao Lou, Zhihong Deng, Qin Yang & Yiyuan Peng. (2020) Rhodium(III)‐Catalyzed Alkylation of 2‐Arylquinazolin‐4(3H)‐ones with Cyclopropanols by Directing C‐H Activation and Ring Opening at Ambient Temperature. Asian Journal of Organic Chemistry 10:1, pages 192-195.
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Ankit K. Dhiman, Ankita Thakur, Rakesh Kumar & Upendra Sharma. (2020) Rhodium‐Catalyzed Selective C−H Bond Functionalization of Quinolines. Asian Journal of Organic Chemistry 9:10, pages 1502-1518.
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Diksha Parmar, Rohit Kumar, Rakesh Kumar & Upendra Sharma. (2020) Ru(II)-Catalyzed Chemoselective C(sp 3 )–H Monoarylation of 8-Methyl Quinolines with Arylboronic Acids . The Journal of Organic Chemistry 85:18, pages 11844-11855.
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Rohit Kumar, Rakesh Kumar, Diksha Parmar, Shiv Shankar Gupta & Upendra Sharma. (2019) Ru(II)/Rh(III)-Catalyzed C(sp 3 )–C(sp 3 ) Bond Formation through C(sp 3 )–H Activation: Selective Linear Alkylation of 8-Methylquinolines and Ketoximes with Olefins . The Journal of Organic Chemistry 85:2, pages 1181-1192.
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Shiv Shankar Gupta, Rakesh Kumar & Upendra Sharma. (2019) Regioselective Arylation of Quinoline N -Oxides (C8), Indolines (C7) and N - tert -Butylbenzamide with Arylboronic Acids . ACS Omega 5:1, pages 904-913.
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Dong Zhang, Di Gao, Jinlin Cai, Xiaoyu Wu, Hong Qin, Kai Qiao, Chengkou Liu, Zheng Fang & Kai Guo. (2019) The ruthenium-catalyzed meta -selective C–H nitration of various azole ring-substituted arenes . Organic & Biomolecular Chemistry 17:40, pages 9065-9069.
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Rakesh Kumar, Ritika Sharma, Inder Kumar, Pooja Upadhyay, Ankit Kumar Dhiman, Rohit Kumar, Rakesh Kumar, Rituraj Purohit, Dinkar Sahal & Upendra Sharma. (2019) Evaluation of Antiplasmodial Potential of C2 and C8 Modified Quinolines: in vitro and in silico Study. Medicinal Chemistry 15:7, pages 790-800.
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Pravin Kumar & Manmohan Kapur. (2019) Catalyst Control in Positional-Selective C–H Alkenylation of Isoxazoles and a Ruthenium-Mediated Assembly of Trisubstituted Pyrroles. Organic Letters 21:7, pages 2134-2138.
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Ritika Sharma, Rakesh Kumar & Upendra Sharma. (2019) Rh/O 2 -Catalyzed C8 Olefination of Quinoline N -Oxides with Activated and Unactivated Olefins . The Journal of Organic Chemistry 84:5, pages 2786-2797.
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Minoo Dabiri, Seyed Iman Alavioon & Siyavash Kazemi Movahed. (2019) Decarboxylative Arylation of Pyridine 1‐Oxides and Anilides with Benzoic Acid via Palladium‐Catalyzed C–H Functionalization. European Journal of Organic Chemistry 2019:7, pages 1479-1487.
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Soumya Kumar Sinha, Trisha Bhattacharya & Debabrata Maiti. (2019) Role of hexafluoroisopropanol in C–H activation. Reaction Chemistry & Engineering 4:2, pages 244-253.
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Virendra Kumar Tiwari & Manmohan Kapur. (2019) Catalyst-controlled positional-selectivity in C–H functionalizations. Organic & Biomolecular Chemistry 17:5, pages 1007-1026.
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Guang-Hui Li, Dao-Qing Dong, Xian-Yong Yu & Zu-Li Wang. (2019) Direct synthesis of 8-acylated quinoline N-oxides via palladium-catalyzed selective C–H activation and C(sp 2 )–C(sp 2 ) cleavage . New Journal of Chemistry 43:4, pages 1667-1670.
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Ritika Sharma, Rakesh Kumar, Rohit Kumar, Pooja Upadhyay, Dinkar Sahal & Upendra Sharma. (2018) Rh(III)-Catalyzed C(8)–H Functionalization of Quinolines via Simultaneous C–C and C–O Bond Formation: Direct Synthesis of Quinoline Derivatives with Antiplasmodial Potential. The Journal of Organic Chemistry 83:20, pages 12702-12710.
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Bhuttu Khan, Himangsu Sekhar Dutta & Dipankar Koley. (2018) Remote C−H Functionalization of 8‐Aminoquinolinamides. Asian Journal of Organic Chemistry 7:7, pages 1270-1297.
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Zhoulong Fan, Heng Lu & Ao Zhang. (2018) PMes 3 -Promoted Ruthenium-Catalyzed Meta C–H Nitration of 6-Arylpurines . The Journal of Organic Chemistry 83:6, pages 3245-3251.
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Zhoulong Fan, Heng Lu, Zhen Cheng & Ao Zhang. (2018) Ligand-promoted ruthenium-catalyzed meta C–H chlorination of arenes using N -chloro-2,10-camphorsultam . Chemical Communications 54:47, pages 6008-6011.
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Gang Li, Biao Zhu, Xingxing Ma, Chunqi Jia, Xulu Lv, Junjie Wang, Feng Zhao, Yunhe Lv & Suling Yang. (2017) Ruthenium-Catalyzed ortho / meta -Selective Dual C–H Bonds Functionalizations of Arenes . Organic Letters 19:19, pages 5166-5169.
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Ritika Sharma, Inder Kumar, Rakesh Kumar & Upendra Sharma. (2017) Rhodium‐Catalyzed Remote C‐8 Alkylation of Quinolines with Activated and Unactivated Olefins: Mechanistic Study and Total Synthesis of EP4 Agonist. Advanced Synthesis & Catalysis 359:17, pages 3022-3028.
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Hyung Yoon, Martin Rölz, Felicitas Landau & Mark Lautens. (2017) Palladium‐Catalyzed Spirocyclization through C−H Activation and Regioselective Alkyne Insertion. Angewandte Chemie 129:36, pages 11060-11063.
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Zhoulong Fan, Jie Li, Heng Lu, Dong-Yu Wang, Chao Wang, Masanobu Uchiyama & Ao Zhang. (2017) Monomeric Octahedral Ruthenium(II) Complex Enabled meta -C–H Nitration of Arenes with Removable Auxiliaries . Organic Letters 19:12, pages 3199-3202.
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Jun-Ming Li, Yong-Heng Wang, Yang Yu, Rui-Bo Wu, Jiang Weng & Gui Lu. (2017) Copper-Catalyzed Remote C–H Functionalizations of Naphthylamides through a Coordinating Activation Strategy and Single-Electron-Transfer (SET) Mechanism. ACS Catalysis 7:4, pages 2661-2667.
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Yilu Xu, Shengwen Yang, Lijuan Du & Juan Li. (2017) A Computational Mechanistic Study of Metal‐Catalyzed Remote C–H Functionalizations – Insights into the Origin of Regioselectivity and the Role of Acid. European Journal of Organic Chemistry 2017:2, pages 381-388.
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Rakesh Kumar, Inder Kumar, Ritika Sharma & Upendra Sharma. (2016) Catalyst and solvent-free alkylation of quinoline N-oxides with olefins: A direct access to quinoline-substituted α-hydroxy carboxylic derivatives. Organic & Biomolecular Chemistry 14:9, pages 2613-2617.
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Ritika Sharma, Rakesh Kumar, Inder Kumar & Upendra Sharma. (2015) Rh III ‐Catalyzed Dehydrogenative Coupling of Quinoline N ‐Oxides with Alkenes: N ‐Oxide as Traceless Directing Group for Remote C–H Activation . European Journal of Organic Chemistry 2015:34, pages 7519-7528.
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Ritika Sharma, Kavita Thakur, Rakesh Kumar, Inder Kumar & Upendra Sharma. (2015) ChemInform Abstract: Distant C—H Activation/Functionalization: A New Horizon of Selectivity Beyond Proximity. ChemInform 46:51.
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