Advanced search
Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 40, 2018 - Issue 8
Submit an article Journal homepage
471
Views
11
CrossRef citations to date
0
Altmetric
Original Research Paper

Sildenafil protective effects on high glucose-induced neurotoxicity in PC12 cells: the role of oxidative stress, apoptosis, and inflammation pathways in an in vitro cellular model for diabetic neuropathy

Saeedeh Saberi FirouziFaculty of Medicine, Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
,
Nazanin Namazi SarvestaniDepartment of Animal Biology, School of Biology, Department of Science, University of Tehran, Tehran, Iran
,
Azam BakhtiarianFaculty of Medicine, Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
,
Mahmoud Ghazi KhansariFaculty of Medicine, Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
,
Mohammad Yahya KarimiRazi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
,
Akram RanjbarDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
,
Majid SafaFaculty of Allied Medicine, Cellular and Molecular Research Center and Department of Hematology and blood banking, Iran University of Medical Sciences, Tehran, Iran
&
Asieh HosseiniRazi Drug Research Center, Iran University of Medical Sciences, Tehran, IranCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2712-2799
ORCID Icon show all
Pages 624-636 | Received 21 Jan 2018, Accepted 08 Mar 2018, Published online: 06 Apr 2018

Citations (11)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Miguel Angel Garcia-Gonzalez, Veronica Vallejo-Ruiz, Fausto Atonal-Flores, Jorge Flores-Hernandez, Oswaldo Torres-Ramírez, Alfonso Diaz-Fonsecae, Francisco Perez Vizcaino & Jose Gustavo Lopez-Lopez. (2022) Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes. Clinical and Experimental Hypertension 44:4, pages 355-365.
Read now
Mohammad Reza Hooshangi Shayesteh, Hamed Haghi-Aminjan, Maryam Baeeri, Mahban Rahimifard, Shokoufeh Hassani, Mehdi Gholami, Saeideh Momtaz, Seyed Alireza Salami, Maryam Armandeh, Behnaz Bameri, Mahedeh Samadi, Taraneh Mousavi, Seyed Nasser Ostad & Mohammad Abdollahi. (2022) Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiol. Toxicology Mechanisms and Methods 32:4, pages 288-301.
Read now
Gabriela Elisa Hirsch & Thiago Gomes Heck. (2022) Inflammation, oxidative stress and altered heat shock response in type 2 diabetes: the basis for new pharmacological and non-pharmacological interventions. Archives of Physiology and Biochemistry 128:2, pages 411-425.
Read now

Articles from other publishers (8)

Mona Dastgheib, Reza Falak, Maryam Vakilian Moghaddam, Gholamreza Hassanzadeh, Majid Safa & Asieh Hosseini. (2023) Rolipram and pentoxifylline combination ameliorates the morphological abnormalities of dorsal root ganglion neurons in experimental diabetic neuropathy by reducing mitochondrial dysfunction and apoptosis. Journal of Biochemical and Molecular Toxicology 37:11.
Crossref
Deer Li, Jiaxing Guo, Xiyu Ni, Guanwen Sun & Huhe Bao. (2022) The progress and challenges of circRNA for diabetic foot ulcers: A mini-review. Frontiers in Endocrinology 13.
Crossref
Mona Dastgheib, Seyed Vahid Shetab-Boushehri, Maryam Baeeri, Mahdi Gholami, Mohammad Yahya Karimi & Asieh Hosseini. (2022) Rolipram and pentoxifylline combination ameliorates experimental diabetic neuropathy through inhibition of oxidative stress and inflammatory pathways in the dorsal root ganglion neurons. Metabolic Brain Disease 37:7, pages 2615-2627.
Crossref
Asieh Hosseini, Mahedeh Samadi, Maryam Baeeri, Mahban Rahimifard & Hamed Haghi-Aminjan. (2022) The neuroprotective effects of melatonin against diabetic neuropathy: A systematic review of non-clinical studies. Frontiers in Pharmacology 13.
Crossref
Mallesh Kurakula, Raghavendra Naveen N.Bhaumik Patel, Ravi Manne & Devang B. Patel. (2021) Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells. Gels 7:3, pages 96.
Crossref
Adel G. Bakr, Ali H. El-Bahrawy, Hesham H. Taha & Fares E.M. Ali. (2020) Diosmin enhances the anti-angiogenic activity of sildenafil and pentoxifylline against hepatopulmonary syndrome via regulation of TNF-α/VEGF, IGF-1/PI3K/AKT, and FGF-1/ANG-2 signaling pathways. European Journal of Pharmacology 873, pages 173008.
Crossref
Zhong-Jie Liu, Wei Zhao, Hong-Yi Lei, Hua-Li Xu, Lu-Ying Lai, Rui Xu & Shi-Yuan Xu. (2019) High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity 2019, pages 1-11.
Crossref
Seddigheh Niknia, Ayat Kaeidi, Mohammad Reza Hajizadeh, Mohammad Reza Mirzaei, Alireza Khoshdel, Zahra Hajializadeh, Mohammad Ali Fahmidehkar & Mehdi Mahmoodi. (2019) Neuroprotective and antihyperalgesic effects of orexin-A in rats with painful diabetic neuropathy. Neuropeptides 73, pages 34-40.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.