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Nutrition and Cancer Volume 59, 2007 - Issue 2
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Quercetin Selectively Inhibits Bioreduction and Enhances Apoptosis in Melanoma Cells That Overexpress Tyrosinase

Thilakavathy Thangasamy Department of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721
,
Sivanandane Sittadjody Department of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721
,
Susan Lanza-Jacoby Department of Surgery, Thomas Jefferson University, Philadelphia, PA, 19107
,
Phyllis R. Wachsberger Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107
,
Kirsten H. Limesand Department of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721
&
Randy Burd Department of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721
Pages 258-268 | Received 06 Apr 2007, Accepted 29 May 2007, Published online: 05 Dec 2007

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Mariana Teixeira Santos Figueiredo Salgado, Estela Fernandes e Silva, Mariana Amaral do Nascimento, Alessandra Costa Lopes, Luciana Souza de Paiva & Ana Paula de Souza Votto. (2023) Potential Therapeutic Targets of Quercetin in the Cutaneous Melanoma Model and Its Cellular Regulation Pathways: A Systematic Review. Nutrition and Cancer 75:9, pages 1687-1709.
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Yuh-Fang Chang, Yi-Chiung Hsu, Hui-Fang Hung, Hui-Ju Lee, Wing-Yiu Lui, Chin-Wen Chi & Jane-Jen Wang. (2009) Quercetin Induces Oxidative Stress and Potentiates the Apoptotic Action of 2-Methoxyestradiol in Human Hepatoma Cells. Nutrition and Cancer 61:5, pages 735-745.
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Articles from other publishers (27)

Ellen Schanknecht, Ava Bachari, Nazim Nassar, Terrence Piva & Nitin Mantri. (2023) Phytochemical Constituents and Derivatives of Cannabis sativa; Bridging the Gap in Melanoma Treatment. International Journal of Molecular Sciences 24:1, pages 859.
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Fengguang Zhai, Jie Wang, Weili Yang, Meng Ye & Xiaofeng Jin. (2022) The E3 Ligases in Cervical Cancer and Endometrial Cancer. Cancers 14:21, pages 5354.
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Catarina Cunha, Ana L. Daniel-da-Silva & Helena Oliveira. (2022) Drug Delivery Systems and Flavonoids: Current Knowledge in Melanoma Treatment and Future Perspectives. Micromachines 13:11, pages 1838.
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Elif Ozyilmaz, Pembegul Uyar Arpaci, Serkan Sayin, Ayse Yildirim, Sebahat Ascioglu & Emine Gok. (2022) Inclusion complexes of water-soluble calix[n]arenes with quercetin: preparation, characterization, water solubility, and antioxidant features. Monatshefte für Chemie - Chemical Monthly 153:2, pages 201-209.
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Gabriel Zazeri, Ana Paula Ribeiro Povinelli, Nathalia M. Pavan, Daniella Romano de Carvalho, Carmen Lúcia Cardoso & Valdecir Farias Ximenes. (2021) Experimental studies and computational modeling on cytochrome c reduction by quercetin: The role of oxidability and binding affinity. Journal of Molecular Structure 1244, pages 130995.
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Teodora Daria Pop & Zorita Diaconeasa. (2021) Recent Advances in Phenolic Metabolites and Skin Cancer. International Journal of Molecular Sciences 22:18, pages 9707.
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Elizabeth L. Thompson, Jiayi J. Hu & Laura J. Niedernhofer. (2021) The Role of Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma. Cancers 13:9, pages 2241.
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Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi, Amit Kumar Verma, Abdulaziz Aloliqi, Khaled S. Allemailem, Amjad Ali Khan & Arshad Husain Rahmani. (2021) Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways. Molecules 26:5, pages 1315.
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Harald Hundsberger, Anna Stierschneider, Victoria Sarne, Doris Ripper, Jasmin Schimon, Hans Peter Weitzenböck, Dominik Schild, Nico Jacobi, Andreas Eger, Josef Atzler, Christian T. Klein & Christoph Wiesner. (2021) Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules 26:3, pages 717.
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Fabrizio Fontana, Michela Raimondi, Alessandro Di Domizio, Roberta M. Moretti, Marina Montagnani Marelli & Patrizia Limonta. (2019) Unraveling the molecular mechanisms and the potential chemopreventive/therapeutic properties of natural compounds in melanoma. Seminars in Cancer Biology 59, pages 266-282.
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Gayathri Heenatigala Palliyage, Somnath Singh, Charles R. AshbyJrJr, Amit K. Tiwari & Harsh Chauhan. (2019) Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma. AAPS PharmSciTech 20:6.
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Aldo Clemente‑Soto, Enrique Salas‑Vidal, Cesar Milan‑Pacheco, Jessica S�nchez‑Carranza, Oscar Peralta‑Zaragoza & Leticia Gonz�lez‑Maya. (2019) Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer‑derived cells. Molecular Medicine Reports.
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Adrian Sturza, Ioana Pavel, Sebastian Ancușa, Corina Danciu, Cristina Dehelean, Oana Duicu & Danina Muntean. (2018) Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. Molecular and Cellular Biochemistry 447:1-2, pages 103-109.
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Zoey Harris, Micah G. Donovan, Gisele Morais Branco, Kirsten H. Limesand & Randy Burd. (2016) Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy. Frontiers in Nutrition 3.
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Feng Liu‐Smith & Frank L. Meyskens. (2016) Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma. Molecular Nutrition & Food Research 60:6, pages 1264-1274.
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Zekun Liu, Junpeng Zhao, Weichen Li, Xinkun Wang, Jingxuan Xu, Jin Xie, Ke Tao, Li Shen & Ran Zhang. (2015) Molecular Docking of Potential Inhibitors for Influenza H7N9. Computational and Mathematical Methods in Medicine 2015, pages 1-8.
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Diana Ionescu, Denisa Margină, Mihaela Ilie, Adrian Iftime & Constanţa Ganea. (2013) Quercetin and epigallocatechin-3-gallate effect on the anisotropy of model membranes with cholesterol. Food and Chemical Toxicology 61, pages 94-100.
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Shu-Ting Chan, Nae-Cherng Yang, Chin-Shiu Huang, Jiunn-Wang Liao & Shu-Lan Yeh. (2013) Quercetin Enhances the Antitumor Activity of Trichostatin A through Upregulation of p53 Protein Expression In Vitro and In Vivo. PLoS ONE 8:1, pages e54255.
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Lang Bai, Xiuling Xu, Qiong Wang, Shanling Xu, Wei Ju, Xia Wang, Wenshu Chen, Weiyang He, Hong Tang & Yong Lin. (2012) A Superoxide-Mediated Mitogen-Activated Protein Kinase Phosphatase-1 Degradation and c-Jun NH 2 -Terminal Kinase Activation Pathway for Luteolin-Induced Lung Cancer Cytotoxicity . Molecular Pharmacology 81:4, pages 549-555.
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Diana Ionescu & Constanţa Ganea. (2012) A study of quercetin effects on phospholipid membranes containing cholesterol using Laurdan fluorescence. European Biophysics Journal 41:3, pages 307-318.
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Ashley J. Vargas, Sivanandane Sittadjody, Thilakavathy Thangasamy, Erin E. Mendoza, Kirsten H. Limesand & Randy Burd. (2017) Exploiting Tyrosinase Expression and Activity in Melanocytic Tumors. Integrative Cancer Therapies 10:4, pages 328-340.
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Shashi K. Kudugunti, Helen Thorsheim, Mohammad S. Yousef, Lan Guan & Majid Y. Moridani. (2011) The metabolic bioactivation of caffeic acid phenethyl ester (CAPE) mediated by tyrosinase selectively inhibits glutathione S-transferase. Chemico-Biological Interactions 192:3, pages 243-256.
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Florastina Payton, Rumu Bose, William L. Alworth, Addanki P. Kumar & Rita Ghosh. (2011) 4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells. Biochemical Pharmacology 81:10, pages 1211-1218.
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Thilakavathy Thangasamy, Sivanandane Sittadjody, Geoffrey C Mitchell, Erin E Mendoza, Vijayababu M Radhakrishnan, Kirsten H Limesand & Randy Burd. (2010) Quercetin abrogates chemoresistance in melanoma cells by modulating ΔNp73. BMC Cancer 10:1.
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Gabriella Leonarduzzi, Barbara Sottero & Giuseppe Poli. (2010) Targeting tissue oxidative damage by means of cell signaling modulators: The antioxidant concept revisited. Pharmacology & Therapeutics 128:2, pages 336-374.
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Ashley J Vargas & Randy Burd. (2010) Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Nutrition Reviews 68:7, pages 418-428.
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Thilakavathy Thangasamy, Sivanandane Sittadjody & Randy Burd. 2009. Complementary and Alternative Therapies and the Aging Population. Complementary and Alternative Therapies and the Aging Population 563 584 .

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