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Nutrition and Cancer Volume 60, 2007 - Issue 1
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Original Articles

Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial

Xavier Durando Centre Jean Perrin, Unité de Recherche Clinique, Université Clermont 1, UFR Médecine; Inserm UMR 484; and Centre d'Investigation Clinique, Clermont-Ferrand, France
,
Emilie Thivat Centre Jean Perrin, Unité de Recherche Clinique, Université Clermont 1, UFR Médecine; Inserm UMR 484; and Centre d'Investigation Clinique, Clermont-Ferrand, France
,
Marie-Chantal Farges Université Clermont 1, UFR Pharmacie, Laboratoire de Biochimie et Nutrition, Clermont-Ferrand, France
,
Eric Cellarier Centre Jean Perrin, Unité de Recherche Clinique, Université Clermont 1, UFR Médecine; Inserm UMR 484; and Centre d'Investigation Clinique, Clermont-Ferrand, France
,
Michel D'Incan CHU Clermont-Ferrand, Hotel-Dieu/Polyclinique, Service de Dermatologie and the Université Clermont 1, UFR Médecine, Clermont-Ferrand, France
,
Aïcha Demidem Inserm UMR 484 and the Université Clermont 1, UFR Médecine, Clermont-Ferrand, France
,
Marie-Paule Vasson Université Clermont 1, UFR Pharmacie, EA2416, Laboratoire de Biochimie et Nutrition, Clermont-Ferrand, France
,
Chantal Barthomeuf Inserm UMR 484 and the Université Clermont 1, UFR Médecine, Clermont-Ferrand, France
&
Philippe Chollet Centre Jean Perrin, Unité de Recherche Clinique, Université Clermont 1, UFR Médecine; Inserm UMR 484; and Centre d'Investigation Clinique, Clermont-Ferrand, France
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Pages 23-30 | Received 23 Mar 2007, Accepted 12 Jun 2007, Published online: 02 Jan 2008

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Robert M Hoffman. (2015) Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey. Expert Opinion on Biological Therapy 15:1, pages 21-31.
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Vaidehi Agrawal, Sarah EJ Alpini, Everett M Stone, Eugene P Frenkel & Arthur E Frankel. (2012) Targeting methionine auxotrophy in cancer: discovery & exploration. Expert Opinion on Biological Therapy 12:1, pages 53-61.
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AthanassiosP. Kyritsis, MelissaL. Bondy & VictorA. Levin. (2011) Modulation of Glioma Risk and Progression by Dietary Nutrients and Antiinflammatory Agents. Nutrition and Cancer 63:2, pages 174-184.
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Malcolm D. Mattes, Igor Koturbash, Calvin N. Leung, Sijin Wen & Geraldine M. Jacobson. A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy. Nutrition and Cancer 0:0, pages 1-6.
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Articles from other publishers (34)

Ming Ji, Qing Xu & Xiaoling Li. (2024) Dietary methionine restriction in cancer development and antitumor immunity. Trends in Endocrinology & Metabolism.
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Yutaro Kubota, Yusuke Aoki, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Qinghong Han, Michael Bouvet, Takuya Tsunoda & Robert M. Hoffman. (2024) Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: A potential curable approach to a clinically-incurable disease. Biochemical and Biophysical Research Communications 695, pages 149418.
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Guangyuan Zhang, Zhenshan Zhang, Yulei Pei, Wei Hu, Yushan Xue, Renli Ning, Xiaomao Guo, Yun Sun & Qing Zhang. (2023) Biological and clinical significance of radiomics features obtained from magnetic resonance imaging preceding pre-carbon ion radiotherapy in prostate cancer based on radiometabolomics. Frontiers in Endocrinology 14.
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Navyateja Korimerla & Daniel R. Wahl. (2022) Interactions between Radiation and One-Carbon Metabolism. International Journal of Molecular Sciences 23:3, pages 1919.
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Kexin Fan, Zhan Liu, Min Gao, Kangsheng Tu, Qiuran Xu & Yilei Zhang. (2022) Targeting Nutrient Dependency in Cancer Treatment. Frontiers in Oncology 12.
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Carly S. Wilder, Zhao Chen & John DiGiovanni. (2021) Pharmacologic approaches to amino acid depletion for cancer therapy. Molecular Carcinogenesis 61:2, pages 127-152.
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Lucie Safrhansova, Katerina Hlozkova & Julia Starkova. 2022. Nutrition and Cancer. Nutrition and Cancer 37 79 .
Dmitry Malin, Yoonkyu Lee, Olga Chepikova, Elena Strekalova, Alexis Carlson & Vincent L. Cryns. (2021) Methionine restriction exposes a targetable redox vulnerability of triple-negative breast cancer cells by inducing thioredoxin reductase. Breast Cancer Research and Treatment 190:3, pages 373-387.
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Vanesa Cepas, Friederike Manig, Juan C. Mayo, Michael Hellwig, Debora Collotta, Valentina Sanmartino, Rebeca Carrocera-Pumarino, Massimo Collino, Thomas Henle & Rosa M. Sainz. (2021) In Vitro Evaluation of the Toxicological Profile and Oxidative Stress of Relevant Diet-Related Advanced Glycation End Products and Related 1,2-Dicarbonyls. Oxidative Medicine and Cellular Longevity 2021, pages 1-20.
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Mark Sorin, David Watkins, Brian M. Gilfix & David S. Rosenblatt. (2021) Methionine dependence in tumor cells: The potential role of cobalamin and MMACHC. Molecular Genetics and Metabolism 132:3, pages 155-161.
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Munehiro Kitada, Yoshio Ogura, Itaru Monno, Jing Xu & Daisuke Koya. (2021) Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress. Biomedicines 9:2, pages 130.
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Nisreen Wahwah, Debanjan Dhar, Hui Chen, Shunhui Zhuang, Adriano Chan, Darren E. Casteel, Hema Kalyanaraman, Renate B. Pilz & Gerry R. Boss. (2020) Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Scientific Reports 10:1.
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Wei-Cheng LuAchinto SahaWupeng YanKendra GarrisonCandice LambRenu PandeySeema IraniAlessia LodiXiyuan LuStefano TizianiYan Jessie Zhang, George Georgiou, John DiGiovanni & Everett Stone. (2020) Enzyme-mediated depletion of serum l -Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity . Proceedings of the National Academy of Sciences 117:23, pages 13000-13011.
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Jean-Louis Guéant, Abderrahim Oussalah, Racha Zgheib, Youssef Siblini, Shyuefang Battaglia Hsu & Fares Namour. (2020) Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles. Biochimie 173, pages 123-128.
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Ellie Shingler, Rachel Perry, Alexandra Mitchell, Clare England, Claire Perks, Georgia Herbert, Andy Ness & Charlotte Atkinson. (2019) Dietary restriction during the treatment of cancer: results of a systematic scoping review. BMC Cancer 19:1.
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Sydney M. Sanderson, Xia Gao, Ziwei Dai & Jason W. Locasale. (2019) Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nature Reviews Cancer 19:11, pages 625-637.
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Xia Gao, Sydney M. Sanderson, Ziwei Dai, Michael A. Reid, Daniel E. Cooper, Min Lu, John P. RichieJrJr, Amy Ciccarella, Ana Calcagnotto, Peter G. Mikhael, Samantha J. Mentch, Juan Liu, Gene Ables, David G. Kirsch, David S. Hsu, Sailendra N. Nichenametla & Jason W. Locasale. (2019) Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature 572:7769, pages 397-401.
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Dušan Mladenović, Tatjana Radosavljević, Dragan Hrnčić, Aleksandra Rasic-Markovic & Olivera Stanojlović. (2019) The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain – implications for longevity. Reviews in the Neurosciences 30:6, pages 581-593.
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Robert M. Hoffman. 2019. Methionine Dependence of Cancer and Aging. Methionine Dependence of Cancer and Aging 95 105 .
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Igor Koturbash. (2018) 2017 Michael Fry Award Lecture When DNA is Actually Not a Target: Radiation Epigenetics as a Tool to Understand and Control Cellular Response to Ionizing Radiation. Radiation Research 190:1, pages 5-11.
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Deyang Yu, Shany E. Yang, Blake R. Miller, Jaclyn A. Wisinski, Dawn S. Sherman, Jacqueline A. Brinkman, Jay L. Tomasiewicz, Nicole E. Cummings, Michelle E. Kimple, Vincent L. Cryns & Dudley W. Lamming. (2018) Short‐term methionine deprivation improves metabolic health via sexually dimorphic, mTORCI‐independent mechanisms . The FASEB Journal 32:6, pages 3471-3482.
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Zhen Dong, Raghu Sinha & John P. RichieJr.Jr.. (2018) Disease prevention and delayed aging by dietary sulfur amino acid restriction: translational implications. Annals of the New York Academy of Sciences 1418:1, pages 44-55.
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Evan C. Lien, Laura Ghisolfi, Renee C. Geck, John M. AsaraAlex Toker. (2017) Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT. Science Signaling 10:510.
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Elena Strekalova, Dmitry Malin, David M. Good & Vincent L. Cryns. (2015) Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression. Clinical Cancer Research 21:12, pages 2780-2791.
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