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Original Articles

Induction of Apoptosis by Lupeol and Mango Extract in Mouse Prostate and LNCaP Cells

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Pages 120-130 | Received 27 Jan 2007, Accepted 19 Apr 2007, Published online: 02 Jan 2008

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Bilal Mirza, Courtney R. Croley, Maha Ahmad, Joshua Pumarol, Niranjan Das, Gautam Sethi & Anupam Bishayee. (2021) Mango (Mangifera indica L.): a magnificent plant with cancer preventive and anticancer therapeutic potential. Critical Reviews in Food Science and Nutrition 61:13, pages 2125-2151.
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Articles from other publishers (34)

Kamilia Mustikasari, Mardi Santoso, Mohd Fadzelly Abu Bakar & Sri Fatmawati. (2024) Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/MS analysis. Arabian Journal of Chemistry 17:1, pages 105391.
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Rizwan Ahmad, Aljawharah Alqathama, Mohammed Aldholmi, Muhammad Riaz, Ashraf N. Abdalla, Fatema Aljishi, Ebtihal Althomali, Mohd Amir, Omeima Abdullah, Muntathir Ali Alamer, Deema Alaswad, Wala Alsulais & Ahad Alsulays. (2023) Antidiabetic and Anticancer Potentials of Mangifera indica L. from Different Geographical Origins. Pharmaceuticals 16:3, pages 350.
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Pankaj Prabhakar, Giriyapura Srikantachar Pavankumar, Shamprasad Varija Raghu, Suresh Rao, Krishna Prasad, Thomas George & Manjeshwar Shrinath Baliga. (2022) Utility of Indian Fruits in Cancer Prevention and Treatment: Time to Undertake Translational and Bedside Studies. Current Pharmaceutical Design 28:19, pages 1543-1560.
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Franklyn O. Ohiagu, Paul C. Chikezie, Chinwendu M. Chikezie & Christian E. Enyoh. (2021) Anticancer activity of Nigerian medicinal plants: a review. Future Journal of Pharmaceutical Sciences 7:1.
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Kayode Ezekiel Adewole & Ahmed Adebayo Ishola. (2021) A Computational Approach to Investigate the HDAC6 and HDAC10 Binding Propensity of Psidium guajava-derived Compounds as Potential Anticancer Agents. Current Drug Discovery Technologies 18:3, pages 423-436.
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Kai Liu, Xumin Zhang, Long Xie, Mao Deng, Huijuan Chen, Jiawen Song, Jiaying Long, Xiaofang Li & Jia Luo. (2021) Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy. Pharmacological Research 164, pages 105373.
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Oluwasesan Micheal Bello, Abiodun Busuyi Ogbesejana, Oluwasogo A. Dada, Oluwatoyin E. Bello & Mojeed O. Bello. 2021. Bioactive Compounds in Underutilized Vegetables and Legumes. Bioactive Compounds in Underutilized Vegetables and Legumes 211 224 .
Mital Bhatt, Mitesh Patel, Mohd Adnan & Mandadi N. Reddy. (2020) Anti-Metastatic Effects of Lupeol via the Inhibition of MAPK/ERK Pathway in Lung Cancer. Anti-Cancer Agents in Medicinal Chemistry 21:2, pages 201-206.
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Kayode Ezekiel Adewole. (2020) Nigerian antimalarial plants and their anticancer potential: A review. Journal of Integrative Medicine 18:2, pages 92-113.
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Oluwasesan Micheal Bello, Abiodun Busuyi Ogbesejana, Oluwasogo A. Dada, Oluwatoyin E. Bello & Mojeed O. Bello. 2020. Bioactive Compounds in Underutilized Vegetables and Legumes. Bioactive Compounds in Underutilized Vegetables and Legumes 1 14 .
Marianna Lauricella, Valentina Lo Galbo, Cesare Cernigliaro, Antonella Maggio, Antonio Palumbo Piccionello, Giuseppe Calvaruso, Daniela Carlisi, Sonia Emanuele, Michela Giuliano & Antonella D’Anneo. (2019) The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells. Antioxidants 8:10, pages 422.
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Mahavir H. Ghante & Prasad G. Jamkhande. (2019) Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms. Journal of Pharmacopuncture 22:2, pages 55-67.
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Shirley H. Arbizu-Berrocal, Hyemee Kim, Chuo Fang, Kimberly A. Krenek, Stephen T. Talcott & Susanne U. Mertens-Talcott. (2019) Polyphenols from mango (Mangifera indica L.) modulate PI3K/AKT/mTOR-associated micro-RNAs and reduce inflammation in non-cancer and induce cell death in breast cancer cells. Journal of Functional Foods 55, pages 9-16.
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Ming-Bo Guo, De-Chun Wang, Hai-Fei Liu, Long-Wei Chen, Jian-Wei Wei, Yong Lin & Hui Xue. (2018) Lupeol against high-glucose-induced apoptosis via enhancing the anti-oxidative stress in rabbit nucleus pulposus cells. European Spine Journal 27:10, pages 2609-2620.
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Yao Yuan, Jiewei Wu, Bailin Li, Jia Niu, Haibo Tan & Shengxiang Qiu. (2018) Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. Scientific Reports 8:1.
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Manjeshwar Shrinath Baliga, Suresh Rao, Pratima Rao, Krishnaprasad, Sanath Kumar Hegde, Kandel Codi Jalaluddin Akbar, Soniya Abraham, Thomas George & Princy Louis Palatty. 2018. Anticancer plants: Properties and Application. Anticancer plants: Properties and Application 57 76 .
Szu-Ping Huang, Tzu-Ming Ho, Chih-Wen Yang, Ya-Ju Chang, Jie-Fu Chen, Ning-Sing Shaw, Jia-Cherng Horng, Shih-Lan Hsu, Ming-Yuan Liao, Li-Chen Wu & Ja-an Ho. (2017) Chemopreventive Potential of Ethanolic Extracts of Luobuma Leaves (Apocynum venetum L.) in Androgen Insensitive Prostate Cancer. Nutrients 9:9, pages 948.
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Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon & Sameera Ranganath Samarakoon. (2017) A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango) . Evidence-Based Complementary and Alternative Medicine 2017, pages 1-24.
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Hyemee Kim, Nivedita Banerjee, Ryan C. Barnes, Catherine M. Pfent, Stephen T. Talcott, Roderick H. Dashwood & Susanne U. Mertens-Talcott. (2017) Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo. Molecular Carcinogenesis 56:1, pages 197-207.
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Muthu K. Shanmugam, Frank Arfuso, Alan Prem Kumar & Gautam Sethi. 2016. Complementary and Alternative Medicines in Prostate Cancer. Complementary and Alternative Medicines in Prostate Cancer 93 110 .
M. Cuccioloni, L. Bonfili, M. Mozzicafreddo, V. Cecarini, S. Scuri, M. Cocchioni, M. Nabissi, G. Santoni, A. M. Eleuteri & M. Angeletti. (2016) Mangiferin blocks proliferation and induces apoptosis of breast cancer cells via suppression of the mevalonate pathway and by proteasome inhibition. Food & Function 7:10, pages 4299-4309.
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Nivedita Banerjee, Hyemee Kim, Kimberly Krenek, Stephen T. Talcott & Susanne U. Mertens-Talcott. (2015) Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: role of the PI3K/AKT pathway and associated microRNAs. Nutrition Research 35:8, pages 744-751.
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B.R. Vijay Avin, T. Prabhu, C.K. Ramesh, V. Vigneshwaran, Mahmood Riaz, K. Jayashree & B.T. Prabhakar. (2014) New role of lupeol in reticence of angiogenesis, the cellular parameter of neoplastic progression in tumorigenesis models through altered gene expression. Biochemical and Biophysical Research Communications 448:2, pages 139-144.
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Rohinton S. Tarapore, Imtiaz A. Siddiqui, Vaqar M. Adhami, Vladimir S. Spiegelman & Hasan Mukhtar. (2013) The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling. Molecular Nutrition & Food Research 57:11, pages 1950-1958.
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Joydeb Kumar Kundu & Young-Joon Surh. 2013. Dried Fruits. Dried Fruits 19 51 .
Archana Kumari & Poonam Kakkar. (2012) Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade. Life Sciences 90:15-16, pages 561-570.
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Jean T. Pierson, Ralf G. Dietzgen, Paul N. Shaw, Sarah J. Roberts‐Thomson, Gregory R. Monteith & Michael J. Gidley. (2011) Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities. Molecular Nutrition & Food Research 56:3, pages 357-387.
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Lim T. K.T. K. Lim. 2012. Edible Medicinal and Non-Medicinal Plants. Edible Medicinal and Non-Medicinal Plants 87 120 .
Vivek R. Yadav, Sahdeo Prasad, Bokyung Sung, Ramaswamy Kannappan & Bharat B. Aggarwal. (2010) Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer. Toxins 2:10, pages 2428-2466.
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Giuliana D. Noratto, Michele C. Bertoldi, Kimberley Krenek, Stephen T. Talcott, Paulo C. Stringheta & Susanne U. Mertens-Talcott. (2010) Anticarcinogenic Effects of Polyphenolics from Mango (Mangifera indica) Varieties. Journal of Agricultural and Food Chemistry 58:7, pages 4104-4112.
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Sônia Machado Rocha Ribeiro & Andreas Schieber. 2010. Bioactive Foods in Promoting Health. Bioactive Foods in Promoting Health 507 523 .
F. Marotta, H. Yadav, S. Pathak, E. Minelli, P. Signorelli, A. Lorenzetti & P. Marandola. (2009) Inhibition of Human Breast Cancer Cell Growth and Enzymatic Activity by a Fermented Nutraceutical. Annals of the New York Academy of Sciences 1155:1, pages 273-277.
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Reen-Yen Kuo, Keduo Qian, Susan L. Morris-Natschke & Kuo-Hsiung Lee. (2009) Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents. Natural Product Reports 26:10, pages 1321.
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Sahdeo Prasad, Vinay Kumar Yadav, Smita Srivastava & Yogeshwer Shukla. (2008) Protective effects of lupeol against benzo[a]pyrene induced clastogenicity in mouse bone marrow cells. Molecular Nutrition & Food Research 52:10, pages 1117-1120.
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