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Nutrition and Cancer Volume 60, 2008 - Issue 2
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In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing MiceFootnote*

Nariman K. Badr El-Din Department of Zoology, Faculty of Science, University of Mansoura, Mansoura, Egypt
,
Eman Noaman Department of Radiation Biology, National Center for Radiation and Technology, Cairo, Egypt
&
Mamdooh Ghoneum Department of Otolaryngology, Drew University of Medicine and Science, 1621 E. 120th Street, Los Angeles, California, USA
Pages 235-244 | Received 29 Jan 2007, Accepted 07 May 2007, Published online: 25 Mar 2008

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Nariman K. Badr El-Din, Doaa A. Ali, Mai Alaa El-Dein & Mamdooh Ghoneum. (2016) Enhancing the Apoptotic Effect of a Low Dose of Paclitaxel on Tumor Cells in Mice by Arabinoxylan Rice Bran (MGN-3/Biobran). Nutrition and Cancer 68:6, pages 1010-1020.
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Shuangyue Zhang, W. Li, C. J. Smith & H. Musa. (2015) Cereal-Derived Arabinoxylans as Biological Response Modifiers: Extraction, Molecular Features, and Immune-Stimulating Properties. Critical Reviews in Food Science and Nutrition 55:8, pages 1035-1052.
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Bart G.J. Moerings, Suzanne Abbring, Monic M.M. Tomassen, Henk A. Schols, Renger F. Witkamp, Klaske van Norren, Coen Govers, Jeroen van Bergenhenegouwen & Jurriaan J. Mes. (2024) Rice-derived arabinoxylan fibers are particle size-dependent inducers of trained immunity in a human macrophage-intestinal epithelial cell co-culture model. Current Research in Food Science 8, pages 100666.
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Morvarid Noormohammadi, Zeinab Ghorbani, Hossein Shahinfar & Farzad Shidfar. (2023) Is there any hepatic impact associated with rice bran arabinoxylan compound supplementation? A systematic review and dose–response meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN 57, pages 665-675.
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Soo Liang Ooi, Peter S. Micalos & Sok Cheon Pak. (2023) Modified rice bran arabinoxylan as a nutraceutical in health and disease—A scoping review with bibliometric analysis. PLOS ONE 18:8, pages e0290314.
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Soo Liang Ooi, Peter S. Micalos & Sok Cheon Pak. (2023) Modified Rice Bran Arabinoxylan by Lentinus edodes Mycelial Enzyme as an Immunoceutical for Health and Aging—A Comprehensive Literature Review. Molecules 28:17, pages 6313.
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Heba M. Abdou, Fatma A. Hamaad, Ghada M. Abd Elmageed & Mamdooh H. Ghoneum. (2023) Efficiency of Biobran/MGN-3, an Arabinoxylan Rice Bran, in Attenuating Diabetes-Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF-κB in Rats. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-10.
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Bee Tan, Mohd Norhaizan & Lee Chan. (2023) Rice Bran: From Waste to Nutritious Food Ingredients. Nutrients 15:11, pages 2503.
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Mamdooh Ghoneum, Shaymaa Abdulmalek & Hewida H. Fadel. (2023) Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study. Nutrients 15:2, pages 453.
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Mamdooh Ghoneum, Mai Alaa El-Dein & Nariman K. Badr El-Din. (2023) Anticancer potential of Marina Crystal Minerals (MCM) against the growth of murine mammary adenocarcinoma cells in vivo. Biomedicine & Pharmacotherapy 157, pages 113975.
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Tibor Hajto. 2023. Modified Rice Bran Arabinoxylan. Modified Rice Bran Arabinoxylan 67 79 .
Soo Liang Ooi, Sok Cheon Pak & Peter S. Micalos. 2023. Modified Rice Bran Arabinoxylan. Modified Rice Bran Arabinoxylan 27 39 .
Mamdooh H. Ghoneum. 2023. Modified Rice Bran Arabinoxylan. Modified Rice Bran Arabinoxylan 15 25 .
Wamidh H. Talib, Asma Ismail Mahmod, Dima Awajan, Reem Ali Hamed & Intisar Hadi Al-Yasari. (2022) Immunomodulatory, Anticancer, and Antimicrobial Effects of Rice Bran Grown in Iraq: An In Vitro and In Vivo Study. Pharmaceuticals 15:12, pages 1502.
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Bart G.J. Moerings, Jeroen van Bergenhenegouwen, Matthew Furber, Suzanne Abbring, Henk A. Schols, Renger F. Witkamp, Coen Govers & Jurriaan J. Mes. (2022) Dectin-1b activation by arabinoxylans induces trained immunity in human monocyte-derived macrophages. International Journal of Biological Macromolecules 209, pages 942-950.
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Nariman K. Badr El-Din, Azza I. Othman, Maggie E. Amer & Mamdooh Ghoneum. (2022) Thymax, a gross thymic extract, exerts cell cycle arrest and apoptosis in Ehrlich ascites carcinoma in vivo. Heliyon 8:3, pages e09047.
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Wei Han, Hongjuan Chen, Lin Zhou, Haijie Zou, Xiaohong Luo, Bo Sun & Xuhui Zhuang. (2021) Polysaccharides from Ganoderma Sinense - rice bran fermentation products and their anti-tumor activities on non-small-cell lung cancer. BMC Complementary Medicine and Therapies 21:1.
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Soo Liang Ooi, Sok Cheon Pak, Peter S. Micalos, Emily Schupfer, Catherine Lockley, Mi Houn Park & Sung-Joo Hwang. (2021) The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme—A Narrative Review. Molecules 26:9, pages 2539.
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Nariman K. Badr El-Din, Doaa A. Ali, Reem Othman, Samuel W. French & Mamdooh Ghoneum. (2020) Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats. Biomedicine & Pharmacotherapy 126, pages 110064.
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Zhenguo Zhao, Wei Cheng, Wei Qu & Kai Wang. (2020) Arabinoxylan rice bran (MGN-3/Biobran) alleviates radiation-induced intestinal barrier dysfunction of mice in a mitochondrion-dependent manner. Biomedicine & Pharmacotherapy 124, pages 109855.
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A. F. Elsaid, R. M. Fahmi, M. Shaheen & M. Ghoneum. (2019) The enhancing effects of Biobran/MGN-3, an arabinoxylan rice bran, on healthy old adults’ health-related quality of life: a randomized, double-blind, placebo-controlled clinical trial. Quality of Life Research 29:2, pages 357-367.
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Nariman K Badr El-Din, Said K Areida, Kvan O Ahmed & Mamdooh Ghoneum. (2019) Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma†. Journal of Radiation Research 60:6, pages 747-758.
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Yonghui Yu, Jingjie Zhang, Jing Wang & Baogao Sun. (2019) The anti-cancer activity and potential clinical application of rice bran extracts and fermentation products. RSC Advances 9:31, pages 18060-18069.
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Nariman K. Badr El-Din, Doaa A. Ali & Rania F. Abou-El-Magd. (2019) Grape seeds and skin induce tumor growth inhibition via G1-phase arrest and apoptosis in mice inoculated with Ehrlich ascites carcinoma. Nutrition 58, pages 100-109.
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Huijuan Zhang. 2019. Bioactive Factors and Processing Technology for Cereal Foods. Bioactive Factors and Processing Technology for Cereal Foods 65 76 .
Tibor Hajto. (2018) Urgent Necessity for Standardized and Evidence Based Plant Immunomodulators (Such As Rice Bran Arabinoxylan Concentrate/MGN-3) for the Tumor Research. International Journal of Complementary & Alternative Medicine 9:2.
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Mayra Alejandra Mendez-Encinas, Elizabeth Carvajal-Millan, Agustín Rascon-Chu, Humberto Francisco Astiazaran-Garcia & Dora Edith Valencia-Rivera. (2018) Ferulated Arabinoxylans and Their Gels: Functional Properties and Potential Application as Antioxidant and Anticancer Agent. Oxidative Medicine and Cellular Longevity 2018, pages 1-22.
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Soo Liang Ooi, Debbie McMullen, Terry Golombick, Dipl Nut & Sok Cheon Pak. (2017) Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment. Integrative Cancer Therapies 17:2, pages 165-178.
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Abdulmannan Fadel, Ayman M. Mahmoud, Jason J. Ashworth, Weili Li, Yu Lam Ng & Andrew Plunkett. (2018) Health-related effects and improving extractability of cereal arabinoxylans. International Journal of Biological Macromolecules 109, pages 819-831.
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Abdulmannan Fadel, Andrew Plunkett, Weili Li, Yazan Ranneh, Vivian Elewosi Tessu Gyamfi, Yasser Salmon, Rosemarie Roma Nyaranga & Jason Ashworth. (2018) Arabinoxylans from rice bran and wheat immunomodulatory potentials: a review article. Nutrition & Food Science 48:1, pages 97-110.
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Ahmed Elsaid, Magda Shaheen & Mamdooh Ghoneum. (2018) Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double‑blind, placebo-controlled clinical trial. Experimental and Therapeutic Medicine.
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Xia ZHU, Aya OKUBO, Naoki IGARI, Kentaro NINOMIYA & Yukari EGASHIRA. (2017) Modified rice bran hemicellulose inhibits vascular endothelial growth factor-induced angiogenesis <i>in vitro</i> via VEGFR2 and its downstream signaling pathways. Bioscience of Microbiota, Food and Health 36:2, pages 45-53.
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Bee Ling Tan & Mohd Esa Norhaizan. (2017) Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on Carcinogenesis In Vitro and In Vivo . BioMed Research International 2017, pages 1-18.
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Nariman K. Badr El-Din, Salma M. Abdel Fattah, Deyu Pan, Lucilene Tolentino & Mamdooh Ghoneum. (2016) Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integrative Cancer Therapies 15:4, pages NP26-NP34.
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Antonio P?rez-Mart?nez, Jaime Valent?n, Luc?a Fern?ndez, Enrique Hern?ndez-Jim?nez, Eduardo L?pez-Collazo, Petra Zerbes, Ellen Schw?rer, Fernando Nu??z, Inmaculada G?nesis Mart?n, Hannah Sallis, Miguel ?ngel D?az, Rupert Handgretinger & Matthias Manuel Pfeiffer. (2015) Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell?mediated cytotoxicity against neuroblastoma in?vitro and in?vivo. Cytotherapy 17:5, pages 601-612.
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Ji-young Choi, Doo-Jin Paik, Dae Young Kwon & Yongsoon Park. (2014) Dietary supplementation with rice bran fermented with Lentinus edodesincreases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. Nutrition Journal 13:1.
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Bruno Burlando & Laura Cornara. (2014) Therapeutic properties of rice constituents and derivatives (Oryza sativa L.): A review update. Trends in Food Science & Technology 40:1, pages 82-98.
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M. GhoneumS. Agrawal. (2014) MGN-3/Biobran Enhances Generation of Cytotoxic CD8+ T Cells VIA Upregulation of DEC-205 Expression on Dendritic Cells. International Journal of Immunopathology and Pharmacology 27:4, pages 523-530.
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Mamdooh Helal Ghoneum. 2014. Wheat and Rice in Disease Prevention and Health. Wheat and Rice in Disease Prevention and Health 401 408 .
Chun-Hung Chiu, Chiung-Chi Peng, Yaw-Bee Ker, Chin-Chu Chen, Arwen Lee, Wan-Lin Chang, Charng-Cherng Chyau & Robert Peng. (2013) Physicochemical Characteristics and Anti-Inflammatory Activities of Antrodan, a Novel Glycoprotein Isolated from Antrodia cinnamomea Mycelia. Molecules 19:1, pages 22-40.
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Mendel Friedman. (2013) Rice Brans, Rice Bran Oils, and Rice Hulls: Composition, Food and Industrial Uses, and Bioactivities in Humans, Animals, and Cells. Journal of Agricultural and Food Chemistry 61:45, pages 10626-10641.
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M. Ghoneum, N. K. Badr El-Din, S. M. Abdel Fattah & L. Tolentino. (2013) Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body  -irradiation in mice via restoration of hematopoietic tissues. Journal of Radiation Research 54:3, pages 419-429.
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E. Revilla, C. Santa-María, E. Miramontes, M. Candiracci, B. Rodríguez-Morgado, M. Carballo, J. Bautista, A. Castaño & J. Parrado. (2013) Antiproliferative and immunoactivatory ability of an enzymatic extract from rice bran. Food Chemistry 136:2, pages 526-531.
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Angela J. Henderson, Cadie A. Ollila, Ajay Kumar, Erica C. Borresen, Komal Raina, Rajesh Agarwal & Elizabeth P. Ryan. (2012) Chemopreventive Properties of Dietary Rice Bran: Current Status and Future Prospects. Advances in Nutrition 3:5, pages 643-653.
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Jerry T. Thornthwaite, Hare Shah, Pashupati Shah & Henry Respess. (2012) The Natural Killer Cell: A Historical Perspective and the Use of Supplements to Enhance NKC Activity. Journal of Immune Based Therapies, Vaccines and Antimicrobials 01:03, pages 21-51.
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Kan Sato, Kazuaki Takahashi, Michiru Aoki, Toshihiko Kamada & Satohiro Yagyu. (2012) Dietary Supplementation with Modified Arabinoxylan Rice Bran (MGN-3) Modulates Inflammatory Responses in Broiler Chickens. The Journal of Poultry Science 49:2, pages 86-93.
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M. Ghoneum & S. Agrawal. (2011) Activation of Human Monocyte-Derived Dendritic Cells in Vitro by the Biological Response Modifier Arabinoxylan Rice Bran (MGN-3/BIOBRAN) . International Journal of Immunopathology and Pharmacology 24:4, pages 941-948.
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Pushpak Bhattacharjee, Biplab Giri & Antony Gomes. (2011) Apoptogenic activity and toxicity studies of a cytotoxic protein (BMP1) from the aqueous extract of common Indian toad (Bufo melanostictus Schneider) skin. Toxicon 57:2, pages 225-236.
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Sumei Zhou, Xiuzhen Liu, Yan Guo, Qiang Wang, Daiyin Peng & Li Cao. (2010) Comparison of the immunological activities of arabinoxylans from wheat bran with alkali and xylanase-aided extraction. Carbohydrate Polymers 81:4, pages 784-789.
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Eman Noaman, Nariman K. Badr El-Din, Mona A. Bibars, Ahlam A. Abou Mossallam & Mamdooh Ghoneum. (2008) Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Letters 268:2, pages 348-359.
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