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Original Article

Allicin Inhibits Blood Vessel Growth and Downregulates Akt Phosphorylation and Actin Polymerization

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Pages 412-420 | Received 03 Jan 2007, Accepted 13 May 2007, Published online: 28 Apr 2008

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Jackie Yan-Yan Chan, Hei-Tung Tsui, Ivan Ying-Ming Chung, Robbie Yat-Kan Chan, Yiu-Wa Kwan & Shun-Wan Chan. (2014) Allicin protects rat cardiomyoblasts (H9c2 cells) from hydrogen peroxide-induced oxidative injury through inhibiting the generation of intracellular reactive oxygen species. International Journal of Food Sciences and Nutrition 65:7, pages 868-873.
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Anisur Rahman Khuda-Bukhsh, Sreemanti Das & Santu Kumar Saha. (2014) Molecular Approaches Toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and Other Signal Pathways. Nutrition and Cancer 66:2, pages 194-205.
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Articles from other publishers (14)

Wamidh H. Talib, Media Mohammed Baban, Aya O. Azzam, Jenan J. Issa, Alaa Y. Ali, Alia Kh. AlSuwais, Sana Allala & Lina T. AL Kury. (2024) Allicin and Cancer Hallmarks. Molecules 29:6, pages 1320.
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Susmita Bose, Samuel F. Robertson & Ashley A. Vu. (2023) Garlic extract enhances bioceramic bone scaffolds through upregulating ALP & BGLAP expression in hMSC-monocyte co-culture. Biomaterials Advances 154, pages 213622.
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Burhan CEYLAN & Gizem TİRİS. (2023) Development of a New HPLC Method for the Identification of Allicin and S-allyl Cysteine in Garlic (<i>Allium sativum L.</i>) Extracts. Bezmialem Science 11:2, pages 195-199.
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Min Li, Wingyan Yun, Guibin Wang, Anqi Li, Jing Gao & Qingyong He. (2022) Roles and mechanisms of garlic and its extracts on atherosclerosis: A review. Frontiers in Pharmacology 13.
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Elena Catanzaro, Donatella Canistro, Valentina Pellicioni, Fabio Vivarelli & Carmela Fimognari. (2022) Anticancer potential of allicin: A review. Pharmacological Research 177, pages 106118.
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Hui-Hui Sun, Xin-Min Feng, Jing-Cheng Wang & Jun Cai. (2020) Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway. Molecular and Cellular Biochemistry 476:1, pages 435-441.
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Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa Mousa, Kavitha Godugu, Murat Yalcin & Shaker Mousa. (2017) Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 22:12, pages 2081.
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Wamidh H. Talib. (2017) Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation. Nutrition 43-44, pages 89-97.
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Lukas Schwingshackl, Benjamin Missbach & Georg Hoffmann. (2016) An umbrella review of garlic intake and risk of cardiovascular disease. Phytomedicine 23:11, pages 1127-1133.
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Weicang Wang, Zheyuan Du, Yoshiki Nimiya, Elvira Sukamtoh, Daeyoung Kim & Guodong Zhang. (2016) Allicin inhibits lymphangiogenesis through suppressing activation of vascular endothelial growth factor (VEGF) receptor. The Journal of Nutritional Biochemistry 29, pages 83-89.
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Shu-Guang Liu, Peng-Yu Ren, Guo-Yu Wang, Shu-Xin Yao & Xi-Jing He. (2015) Allicin protects spinal cord neurons from glutamate-induced oxidative stress through regulating the heat shock protein 70/inducible nitric oxide synthase pathway. Food & Function 6:1, pages 320-329.
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Youra Lee, Ji‐Yeon Lee & Myoung Hee Kim. (2014) PI 3K/Akt pathway regulates retinoic acid‐induced Hox gene expression in F9 cells . Development, Growth & Differentiation 56:7, pages 518-525.
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Md Soriful Islam, Most Mauluda Akhtar, Andrea Ciavattini, Stefano Raffaele Giannubilo, Olga Protic, Milijana Janjusevic, Antonio Domenico Procopio, James H. Segars, Mario Castellucci & Pasquapina Ciarmela. (2014) Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: Promising options for prevention and treatment of uterine fibroids?. Molecular Nutrition & Food Research 58:8, pages 1667-1684.
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Jackie Yan‐Yan Chan, Ailsa Chui‐Ying Yuen, Robbie Yat‐Kan Chan & Shun‐Wan Chan. (2012) A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin. Phytotherapy Research 27:5, pages 637-646.
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