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Nutrition and Cancer Volume 60, 2008 - Issue 3
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Original Article

Ursodeoxycholic Acid Suppresses Cox-2 Expression in Colon Cancer: Roles of Ras, p38, and CCAAT/Enhancer-Binding Protein

Sharad Khare Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA
,
Reba Mustafi Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Sonia Cerda Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Weihua Yuan Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Sujatha Jagadeeswaran Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Urszula Dougherty Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Maria Tretiakova Department of Pathology, University of Chicago, Chicago, Illinois, USA
,
Allen Samarel Cardiovascular Institute, Loyola University Medical Center, Maywood, Illinois, USA
,
Greg Cohen Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Julia Wang Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Christopher Moore Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Ramesh Wali Department of Medicine, University of Chicago, Chicago, Illinois, USA
,
Cory Holgren Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA
,
Loren Joseph Department of Pathology, University of Chicago, Chicago, Illinois, USA
,
Alessandro Fichera Department of Surgery, University of Chicago, Chicago, Illinois, USA
,
Yan Chun Li Department of Medicine, University of Chicago, Chicago, Illinois, USA
&
Marc Bissonnette Department of Medicine, University of Chicago, Chicago, Illinois, USA
 show all
Pages 389-400 | Received 26 Mar 2007, Accepted 23 Sep 2007, Published online: 28 Apr 2008

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Yongkun Fang, Cheng Yan, Qi Zhao, Jiaming Xu, Zhuangzhuang Liu, Jin Gao, Hanjian Zhu, Zhujiang Dai, Daorong Wang & Dong Tang. (2021) The roles of microbial products in the development of colorectal cancer: a review. Bioengineered 12:1, pages 720-735.
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Seung Rim Hwang, In Jae Kim & Jin Woo Park. (2015) Formulations of deoxycholic for therapy: a patent review (2011 – 2014). Expert Opinion on Therapeutic Patents 25:12, pages 1423-1440.
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Tohru Saeki, Satoko Yui, Tadashi Hirai, Takami Fujii, Sawami Okada & Ryuhei Kanamoto. (2012) Ursodeoxycholic Acid Protects Colon Cancer HCT116 Cells From Deoxycholic Acid-Induced Apoptosis by Inhibiting Apoptosome Formation. Nutrition and Cancer 64:4, pages 617-626.
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Zhenyu Dong, Ruixian Shi, Pengda Li, Xiaobiao Song, Fan Dong, Jianmin Zhu, Riga Wu, Zhi Liang, Mingyue Du, Jijun Wang & Zhigang Yang. (2023) Does postcholecystectomy increase the risk of colorectal cancer?. Frontiers in Microbiology 14.
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Qiqing Yang, Bin Wang, Qinghui Zheng, Heyu Li, Xuli Meng, Fangfang Zhou & Long Zhang. (2023) A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy. Advanced Science 10:15.
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Himani Pandey, Daryl W. T. Tang, Sunny H. Wong & Devi Lal. (2023) Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities. Cancers 15:3, pages 866.
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Linkang Chen, Chengji Li, Xiaoting Zhong, Chengze Lai, Bin Zhang, Yu Luo, Honghui Guo, Keqing Liang, Jingwen Fang, Xuan Zhu, Jingjing Zhang & Lianxian Guo. (2023) The gut microbiome promotes arsenic metabolism and alleviates the metabolic disorder for their mammal host under arsenic exposure. Environment International 171, pages 107660.
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Jin Lee, Eun Hong, Jung Kim, Jung Kim, Jang Jung, Se Park & Dong Koh. (2022) Ursodeoxycholic acid inhibits epithelial‑mesenchymal transition, suppressing invasiveness of bile duct cancer cells: An in vitro study . Oncology Letters 24:6.
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Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Jiang, Jun Gao, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian & Haifeng Chen. (2022) Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway. Pharmaceuticals 15:1, pages 107.
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Jin Lee, Eun Mi Hong, Jung Han Kim, Jung Hee Kim, Jang Han Jung, Se Woo Park, Dong Hee Koh & Hyun Joo Jang. (2021) Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition. Molecular Biology Reports 48:9, pages 6231-6240.
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Dimitrios Papakonstantinou, Anna Paspala, Emmanouil Pikoulis, Despoina N Perrea, Anastasios Machairas, Georgios Agrogiannis, Nikolaos Machairas, Paulos Patapis & Nikolaos J Zavras. (2021) The Modulating Effect of Ursodeoxycholic Acid on Liver Tissue Cyclooxygenase-2 Expression Following Extended Hepatectomy. Cureus.
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Lulu Sun, Jie Cai & Frank J. Gonzalez. (2021) The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. Nature Reviews Gastroenterology & Hepatology 18:5, pages 335-347.
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Wei Zhu, Yan Si, Jun Xu, Yu Lin, Jing‐Zi Wang, Mengda Cao, Shanwen Sun, Qiang Ding, Lingjun Zhu & Ji‐Fu Wei. (2020) Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A‐dependent manner. Journal of Cellular and Molecular Medicine 24:6, pages 3521-3533.
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R. G. Lopes, S. B. R. do Prado & J. P. Fabi. 2019. Nutrition and Cancer Prevention. Nutrition and Cancer Prevention 261 293 .
Jean-François Goossens & Christian Bailly. (2019) Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy. Pharmacology & Therapeutics 203, pages 107396.
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Tanja Šarenac & Momir Mikov. (2019) Cervical Cancer, Different Treatments and Importance of Bile Acids as Therapeutic Agents in This Disease. Frontiers in Pharmacology 10.
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Tingting Yang, Ghulam Jilany Khan, Ziteng Wu, Xue Wang, Luyong Zhang & Zhenzhou Jiang. (2019) Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases. Drug Discovery Today 24:1, pages 112-128.
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Thi Thinh Nguyen, Trong Thuan Ung, Nam Ho Kim & Young Do Jung. (2018) Role of bile acids in colon carcinogenesis. World Journal of Clinical Cases 6:13, pages 577-588.
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Jamie M. Golden, Oswaldo H. Escobar, Michelle V. L. Nguyen, Michael U. Mallicote, Patil Kavarian, Mark R. Frey & Christopher P. Gayer. (2018) Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms. American Journal of Physiology-Gastrointestinal and Liver Physiology 315:2, pages G259-G271.
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Shaomin Zou, Lekun Fang & Mong-Hong Lee. (2018) Dysbiosis of gut microbiota in promoting the development of colorectal cancer. Gastroenterology Report 6:1, pages 1-12.
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Takahiro Nakazawa. 2017. Bile Acids in Gastroenterology. Bile Acids in Gastroenterology 121 134 .
Qiong Zhang, Katherine Shim, Kevin Wright, Alexander Jurkevich & Sharad Khare. (2015) Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer. Molecular Carcinogenesis 55:9, pages 1355-1368.
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Elizabeth C. Goode & Simon M. Rushbrook. (2015) A review of the medical treatment of primary sclerosing cholangitis in the 21st century. Therapeutic Advances in Chronic Disease 7:1, pages 68-85.
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Jason M. Ridlon & Jasmohan S. Bajaj. (2015) The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics. Acta Pharmaceutica Sinica B 5:2, pages 99-105.
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Yang Xu, Qiang Luo, Ting Lin, Zhiping Zeng, Guanghui Wang, Dequan Zeng, Rong Ding, Cuiling Sun, Xiao-kun Zhang & Haifeng Chen. (2014) U12, a UDCA Derivative, Acts as an Anti-Hepatoma Drug Lead and Inhibits the mTOR/S6K1 and Cyclin/CDK Complex Pathways. PLoS ONE 9:12, pages e113479.
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Lei Zhu, Lu Juan Shan, Yue Jian Liu, Dan Chen, Xiao Guang Xiao & Yan Li. (2014) Ursodeoxycholic acid induces apoptosis of hepatocellular carcinoma cells in vitro . Journal of Digestive Diseases 15:12, pages 684-693.
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Sara M. Centuori & Jesse D. Martinez. (2014) Differential Regulation of EGFR–MAPK Signaling by Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in Colon Cancer. Digestive Diseases and Sciences 59:10, pages 2367-2380.
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Bjorn WH van Heumen, Hennie MJ Roelofs, M Vink-Börger, Evelien Dekker, Elisabeth MH Mathus-Vliegen, Jan Dees, Jan J Koornstra, Alexandra MJ Langers, Iris D Nagtegaal, Ellen Kampman, Wilbert HM Peters & Fokko M Nagengast,. (2013) Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial. Orphanet Journal of Rare Diseases 8:1, pages 118.
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Shailendra Kapoor. (2012) Ursodeoxycholic acid and its emerging role in attenuation of tumor growth in gastrointestinal malignancies. Journal of Cachexia, Sarcopenia and Muscle 3:4, pages 277-278.
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Elizabeth J. Carey & Keith D. Lindor. (2012) Chemoprevention of colorectal cancer with ursodeoxycholic acid: Cons. Clinics and Research in Hepatology and Gastroenterology 36, pages S61-S64.
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Magd A. Kotb. (2012) Molecular Mechanisms of Ursodeoxycholic Acid Toxicity & Side Effects: Ursodeoxycholic Acid Freezes Regeneration & Induces Hibernation Mode. International Journal of Molecular Sciences 13:7, pages 8882-8914.
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Bjorn W.H. van Heumen, Hennie M.J. Roelofs, René H.M. te Morsche, Brigitte Marian, Fokko M. Nagengast & Wilbert H.M. Peters. (2012) Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells. Experimental Cell Research 318:7, pages 819-827.
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John E Eaton, Marina G Silveira, Darrell S Pardi, Emmanouil Sinakos, Kris V Kowdley, Velimir A C Luketic, Edwyn M Harrison, Timothy McCashland, Alex S Befeler, Denise Harnois, Roberta Jorgensen, Jan Petz & Keith D Lindor. (2011) High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis. American Journal of Gastroenterology 106:9, pages 1638-1645.
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Riccardo Solimando, Franco Bazzoli & Luigi Ricciardiello. (2011) Chemoprevention of colorectal cancer: A role for ursodeoxycholic acid, folate and hormone replacement treatment?. Best Practice & Research Clinical Gastroenterology 25:4-5, pages 555-568.
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L. Serfaty, M. Bissonnette & R. Poupon. (2010) Ursodeoxycholic acid and chemoprevention of colorectal cancer. Gastroentérologie Clinique et Biologique 34:10, pages 516-522.
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C Holgren, U Dougherty, F Edwin, D Cerasi, I Taylor, A Fichera, L Joseph, M Bissonnette & S Khare. (2010) Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas. Oncogene 29:38, pages 5241-5253.
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Sung‐Chul Lim, Jeong Eun Choi, Ho Sung Kang & Han SI. (2010) Ursodeoxycholic acid switches oxaliplatin‐induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53‐caspase 8 pathway in HepG2 hepatocellular carcinoma. International Journal of Cancer 126:7, pages 1582-1595.
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S. Viennot, A. Deleporte, D. Moussata, S. Nancey, B. Flourié & J.-M. Reimund. (2009) Colon cancer in inflammatory bowel disease: recent trends, questions and answers. Gastroentérologie Clinique et Biologique 33, pages S190-S201.
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Shrikant Anant & Courtney W. Houchen. (2009) HuR and TTP: Two RNA Binding Proteins That Deliver Message From the 3′ End. Gastroenterology 136:5, pages 1495-1498.
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Raffaele Palmirotta, Patrizia Ferroni, Mario Roselli & Fiorella Guadagni. 2009. Intestinal Polyps and Polyposis. Intestinal Polyps and Polyposis 77 93 .

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