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Orignal Articles

Immunological Effect of Active Hexose Correlated Compound (AHCC) in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial

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Pages 643-651 | Received 31 May 2007, Accepted 17 Jan 2008, Published online: 12 Sep 2008

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Read on this site (4)

Priscilla de Graaff, Coen Govers, Harry J. Wichers & Reno Debets. (2018) Consumption of β-glucans to spice up T cell treatment of tumors: a review. Expert Opinion on Biological Therapy 18:10, pages 1023-1040.
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Hiroaki Yanagimoto, Sohei Satoi, Tomohisa Yamamoto, Satoshi Hirooka, So Yamaki, Masaya Kotsuka, Hironori Ryota, Taku Michiura, Kentaro Inoue, Yoichi Matsui, Koji Tsuta & Masanori Kon. (2016) Alleviating Effect of Active Hexose Correlated Compound (AHCC) on Chemotherapy-Related Adverse Events in Patients with Unresectable Pancreatic Ductal Adenocarcinoma. Nutrition and Cancer 68:2, pages 234-240.
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Catherine Ulbricht, Ashley Brigham, J. Kathryn Bryan, Marisa Catapang, Divya Chowdary, Dawn Costa, Samantha Culwell, Denise D'Auria, Nicole Giese, Ramon Iovin, Richard Isaac, Vijaya Juturu, Angela Liu, Meredith Mintzer, Erica Rusie, Michael Shaffer & Regina C. Windsor. (2013) An Evidence-Based Systematic Review of Active Hexose Correlated Compound (AHCC) by the Natural Standard Research Collaboration. Journal of Dietary Supplements 10:3, pages 264-308.
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Articles from other publishers (30)

Zehra KEÇECİ, Cansu BÖLÜKBAŞ & Hazal EKEN. (2024) İNSAN PAPİLLOMA VİRÜSÜ (HPV) TEDAVİSİNDE YENİ YAKLAŞIMLAR: AKTİF HEKSOZ İLİŞKİLİ BİLEŞİK (AHCC®)NEW APPROACHES IN HUMAN PAPILLOMAVIRUS (HPV) TREATMENT: ACTIVE HEXOSE-RELATED COMPOUND (AHCC®). Ankara Universitesi Eczacilik Fakultesi Dergisi 48:2, pages 6-6.
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Giovanna Merchand-Reyes, Ramasamy Santhanam, Maria L. Valencia-Pena, Krishan Kumar, Xiaokui Mo, Tesfaye Belay, Jennifer A. Woyach, Bethany Mundy-Bosse, Susheela Tridandapani & Jonathan P. Butchar. (2023) Active Hexose-Correlated Compound Shows Direct and Indirect Effects against Chronic Lymphocytic Leukemia. Nutrients 15:24, pages 5138.
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Mamdooh H. Ghoneum. 2023. Modified Rice Bran Arabinoxylan. Modified Rice Bran Arabinoxylan 15 25 .
Daisuke Hashimoto, Sohei Satoi, Hideki Ishikawa, Yasuhiro Kodera, Keiko Kamei, Satoshi Hirano, Tsutomu Fujii, Kenichiro Uemura, Akihiko Tsuchida, Suguru Yamada, Tomohisa Yamamoto, Kiichi Hirota & Mitsugu Sekimoto. (2022) Efficacy of active hexose correlated compound on survival of patients with resectable/borderline resectable pancreatic cancer: a study protocol for a double-blind randomized phase II study. Trials 23:1.
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Beatriz López-Cauce, Andrés Urquía, Luis Menchén, Kohei Homma, Francisco Bolás-Fernández, Juan J. García-Rodriguez & Marta Puerto. (2022) Lentinula edodes extract increases goblet cell number and Muc2 expression in an intestinal inflammatory model of Trichinella spiralis infection. Biomedicine & Pharmacotherapy 150, pages 112937.
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Hong-Jai Park, Sunjin Boo, Inkeun Park, Min Sun Shin, Tsukasa Takahashi, Jun Takanari, Kohei Homma & Insoo Kang. (2022) AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer. Frontiers in Immunology 13.
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Francesca Paganelli, Francesca Chiarini, Annalisa Palmieri, Marcella Martinelli, Paola Sena, Jessika Bertacchini, Luca Roncucci, Alessandra Cappellini, Alberto M. Martelli, Massimo Bonucci, Carla Fiorentini & Ivano Hammarberg Ferri. (2021) The Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells: A Novel Potential Approach for Integrative Medicine. Pharmaceuticals 14:12, pages 1325.
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Daisuke Hashimoto, Sohei Satoi, Tomohisa Yamamoto, So Yamaki, Mitsuaki Ishida, Hironori Ryota, Tatsuma Sakaguchi, Satoshi Hirooka, Kentaro Inoue & Mitsugu Sekimoto. (2021) Nutritional impact of active hexose-correlated compound for patients with resectable or borderline-resectable pancreatic cancer treated with neoadjuvant therapy. Surgery Today 51:11, pages 1872-1876.
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Tesfaye Belay, Rajnish Sahu, Elisha Martin, Kristin Brown, Courtney Rolen, Shomonique Hankins, Brianna Punturi, Maya Patterson, Chase Chambers, Brandon Kirby & Jonathan Butchar. (2021) Active Hexose-Correlated Compound Restores Gene Expression and Protein Secretion of Protective Cytokines of Immune Cells in a Murine Stress Model during Chlamydia muridarum Genital Infection. Infection and Immunity 89:5.
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Min Sun Shin, Hong-Jai Park, Takahiro Maeda, Hiroshi Nishioka, Hajime Fujii & Insoo Kang. (2019) The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies . Journal of Immunology Research 2019, pages 1-7.
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Yen-Nien Hou, Gary Deng & Jun J. Mao. (2019) Practical Application of “About Herbs” Website. The Cancer Journal 25:5, pages 357-366.
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Jun Takanari, Atsuya Sato, Hideaki Waki, Shogo Miyazaki, Kazuo Uebaba & Tatsuya Hisajima. (2018) Effects of AHCC® on Immune and Stress Responses in Healthy Individuals. Journal of Evidence-Based Integrative Medicine 23, pages 215658721875651.
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Courtney J. Berg, David J. Habibian, Aaron E. Katz, Kaitlin E. Kosinski, Anthony T. Corcoran & Andrew S. Fontes. (2016) Active Holistic Surveillance: The Nutritional Aspect of Delayed Intervention in Prostate Cancer. Journal of Nutrition and Metabolism 2016, pages 1-7.
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Jun Takanari, Yosuke Hirayama, Kohei Homma, Takehito Miura, Hiroshi Nishioka & Takahiro Maeda. (2014) Effects of Active Hexose Correlated Compound on the Seasonal Variations of Immune Competence in Healthy Subjects. Journal of Evidence-Based Complementary & Alternative Medicine 20:1, pages 28-34.
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Yoshito Tanaka, Satomi Ohashi, Aya Ohtsuki, Tamami Kiyono, Eun Young Park, Yasushi Nakamura, Kenji Sato, Masaharu Oishi, Hirokazu Miki, Katsuji Tokuhara, Kosuke Matsui, Masaki Kaibori, Mikio Nishizawa, Tadayoshi Okumura & A-Hon Kwon. (2014) Adenosine, a hepato-protective component in active hexose correlated compound: Its identification and iNOS suppression mechanism. Nitric Oxide 40, pages 75-86.
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Sho HangaiSatoru IwaseTakashi KawaguchiYasunori KogureTempei MiyajiTadaharu MatsunagaYoshinori NagumoTakuhiro Yamaguchi. (2013) Effect of Active Hexose-Correlated Compound in Women Receiving Adjuvant Chemotherapy for Breast Cancer: A Retrospective Study. The Journal of Alternative and Complementary Medicine 19:11, pages 905-910.
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Zdeněk Zloch & Pavel Sedláček. (2013) The Significance and Use of Natural Substances in Cancer Therapy. Hygiena 58:2, pages 86-89.
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Katie M. Love, Rebecca E. Barnett, Ian Holbrook, Gerald Sonnenfeld, Hajime Fujii, Buxiang Sun, James C. Peyton & William G. Cheadle. (2013) A natural immune modulator attenuates stress hormone and catecholamine concentrations in polymicrobial peritonitis. Journal of Trauma and Acute Care Surgery 74:6, pages 1411-1418.
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Brooke E. Roman, Eleni Beli, David M. Duriancik & Elizabeth M. Gardner. (2013) Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutrition Research 33:1, pages 12-17.
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. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 183 350 .
Philippa J. Cheetham & Aaron E. Katz. 2013. Prostate Cancer: A Comprehensive Perspective. Prostate Cancer: A Comprehensive Perspective 355 367 .
Daisuke Nakamoto, Kota Shigama, Hiroshi Nishioka & Hajime Fujii. (2012) Active Hexose Correlated Compound (AHCC) Alleviates Gemcitabine-Induced Hematological Toxicity in Non-Tumor-Bearing Mice. International Journal of Clinical Medicine 03:05, pages 361-367.
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Won-Woo Lee, Naeun Lee, Hajime Fujii & Insoo Kang. (2012) Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans. Cellular Immunology 275:1-2, pages 19-23.
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Shinil K. Shah, Peter A. Walker, Stacey D. Moore‐Olufemi, Alamelu Sundaresan, Anil D. Kulkarni & Richard J. Andrassy. (2011) An Evidence‐Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient . Journal of Parenteral and Enteral Nutrition 35:4, pages 449-458.
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H. Fujii, N. Nishioka, R.R. Simon, R. Kaur, B. Lynch & A. Roberts. (2011) Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC). Regulatory Toxicology and Pharmacology 59:2, pages 237-250.
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Dillip Kumar Parida, Koji Wakame & Taisei Nomura. (2011) Integrating Complimentary and Alternative Medicine in Form of Active Hexose Co-Related Compound (AHCC) in the Management of Head & Neck Cancer Patients. International Journal of Clinical Medicine 02:05, pages 588-592.
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Zhinan Yin, Hajime Fujii & Thomas Walshe. (2010) Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor–α in healthy adults. Human Immunology 71:12, pages 1187-1190.
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Takehito Miura, Kentaro Kitadate, Hiroshi Nishioka & Koji Wakame. 2010. Biotechnology in Functional Foods and Nutraceuticals. Biotechnology in Functional Foods and Nutraceuticals 51 60 .
Shuhui Wang, Thomas Welte, Hao Fang, Gwong-Jen J. Chang, Willi K. Born, Rebecca L. O’Brien, Buxiang Sun, Hajime Fujii, Ken-Ichi Kosuna & Tian Wang. (2009) Oral Administration of Active Hexose Correlated Compound Enhances Host Resistance to West Nile Encephalitis in Mice. The Journal of Nutrition 139:3, pages 598-602.
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Takehito MIURA, Kentaro KITADATE & Hiroshi NISHIOKA. (2009) Basic and Clinical Studies on AHCC -Recent Topics-AHCC の基礎と臨床  ‐最近の話題‐. Japanese Journal of Complementary and Alternative Medicine 6:1, pages 1-7.
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