Advanced search
Publication Cover
Nutrition and Cancer Volume 61, 2009 - Issue 3
Submit an article Journal homepage
290
Views
59
CrossRef citations to date
0
Altmetric
Original Articles

Flavonoid-Induced Morphological Modifications of Endothelial Cells Through Microtubule Stabilization

Yasmine S. Touil Inserm, Paris, France; Université Paris Descartes, Paris, France; Ecole Nationale Supérieure de Chimie de Paris, Paris, France
,
Arlette Fellous MAPREG Laboratory, Centre Hospitalier Universitaire de Biĉetre, Bicêtre, France
,
Daniel Scherman Inserm, Paris, France; Université Paris Descartes, Paris, France; Ecole Nationale Supérieure de Chimie de Paris, Paris, France
&
Guy G. Chabot Inserm, Paris, France; Université Paris Descartes, Paris, France; Ecole Nationale Supérieure de Chimie de Paris, Paris, France
Pages 310-321 | Received 01 Aug 2008, Accepted 29 Sep 2008, Published online: 16 Apr 2009

Citations (59)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Mariana Teixeira Santos Figueiredo Salgado, Estela Fernandes e Silva, Mariana Amaral do Nascimento, Alessandra Costa Lopes, Luciana Souza de Paiva & Ana Paula de Souza Votto. (2023) Potential Therapeutic Targets of Quercetin in the Cutaneous Melanoma Model and Its Cellular Regulation Pathways: A Systematic Review. Nutrition and Cancer 75:9, pages 1687-1709.
Read now
Anass Elouaddari, Abdelaziz Elamrani, Mouna Moutia, Nadia Oubrim, Noureddine Habti & Jamal JamalEddine. (2019) Chemical Composition and Evaluation of Antioxidant, Antimicrobial and Cytotoxic Activities of Moroccan Cladanthus mixtus Essential Oil and Extracts. Journal of Essential Oil Bearing Plants 22:6, pages 1450-1466.
Read now
Mangat Singh, Shanti Devi, Virendra S. Rana, Bhuwan B. Mishra, Jitendra Kumar & Vivek Ahluwalia. (2019) Delivery of phytochemicals by liposome cargos: recent progress, challenges and opportunities. Journal of Microencapsulation 36:3, pages 215-235.
Read now
Katrin Sak. (2014) Site-Specific Anticancer Effects of Dietary Flavonoid Quercetin. Nutrition and Cancer 66:2, pages 177-193.
Read now
Lanan Wassy Soromou, Lanxiang Jiang, Miaomiao Wei, Na Chen, Meixia Huo, Xiao Chu, Weiting Zhong, Qianchao Wu, Abdourahmane Baldé, Xuming Deng & Haihua Feng. (2014) Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion. Journal of Immunotoxicology 11:1, pages 56-61.
Read now
Chellampillai Bothiraja, Bhagwat D Yojana, Atmaram P Pawar, Karimunnisa S Shaikh & Uday H Thorat. (2014) Fisetin-loaded nanocochleates: formulation, characterisation, in vitro anticancer testing, bioavailability and biodistribution study. Expert Opinion on Drug Delivery 11:1, pages 17-29.
Read now

Articles from other publishers (53)

Natalia Rosiak, Ewa Tykarska & Judyta Cielecka-Piontek. (2024) Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity. International Journal of Molecular Sciences 25:7, pages 3648.
Crossref
Morgane Renault-Mahieux, Johanne Seguin, Victoire Vieillard, Dang–Tri Le, Philippe Espeau, René Lai–Kuen, Cyrille Richard, Nathalie Mignet, Muriel Paul & Karine Andrieux. (2024) Co-encapsulation of fisetin and cisplatin into liposomes: Stability considerations and in vivo efficacy on lung cancer animal model. International Journal of Pharmaceutics 651, pages 123744.
Crossref
Panpan Ma, Johanne Seguin, Nhu Ky Ly, Luis Castillo Henríquez, Eva Plansart, Karim Hammad, Rabah Gahoual, Hélène Dhôtel, Charlotte Izabelle, Bruno Saubamea, Cyrille Richard, Virginie Escriou, Nathalie Mignet & Yohann Corvis. (2022) Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy. International Journal of Pharmaceutics: X 4, pages 100138.
Crossref
Saheed O. Anifowose, Wejdan S. N. Alqahtani, Badr A. Al-Dahmash, Florenz Sasse, Maroua Jalouli, Mourad A. M. Aboul-Soud, Ahmed Y. Badjah-Hadj-Ahmed & Yasser A. Elnakady. (2022) Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade. Molecules 27:23, pages 8307.
Crossref
Morgane Renault–Mahieux, Nathalie Mignet, Johanne Seguin, Khair Alhareth, Muriel Paul & Karine Andrieux. (2022) Co–encapsulation of flavonoids with anti–cancer drugs: A challenge ahead. International Journal of Pharmaceutics 623, pages 121942.
Crossref
Aleksandra M. Juszczak, Ute Wöelfle, Marijana Zovko Končić & Michał Tomczyk. (2022) Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics. Medicinal Research Reviews 42:4, pages 1423-1462.
Crossref
Bao-Yue ZHANG, Yi-Fu ZHENG, Jun ZHAO, De KANG, Zhe WANG, Lv-Jie XU, Ai-Lin LIU & Guan-Hua DU. (2022) Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation. Chinese Journal of Natural Medicines 20:5, pages 332-351.
Crossref
Salvatore Chirumbolo. (2021) Antioxidants associated with NSAIDs might even exacerbate the progress of SARS‐CoV2 disease. Journal of Medical Virology 94:4, pages 1264-1266.
Crossref
Ruting Zhong, Mohamed A. Farag, Meiwan Chen, Chengwei He & Jianbo Xiao. (2022) Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin. eFood 3:1-2.
Crossref
Lukasz Szoka, Jolanta Nazaruk, Marcin Stocki & Valery Isidorov. (2021) Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells . Journal of Cellular and Molecular Medicine 25:24, pages 11085-11096.
Crossref
Sarah C. Kammerud, Brandon J. Metge, Amr R. Elhamamsy, Shannon E. Weeks, Heba A. Alsheikh, Alexa L. Mattheyses, Lalita A. Shevde & Rajeev S. Samant. (2021) Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis. Laboratory Investigation 101:11, pages 1439-1448.
Crossref
Morgane Renault-Mahieux, Victoire Vieillard, Johanne Seguin, Philippe Espeau, Dang Tri Le, René Lai-Kuen, Nathalie Mignet, Muriel Paul & Karine Andrieux. (2021) Co-Encapsulation of Fisetin and Cisplatin into Liposomes for Glioma Therapy: From Formulation to Cell Evaluation. Pharmaceutics 13:7, pages 970.
Crossref
QingLing Jia, Hui Cao, DingZhu Shen, Li Yan, Chuan Chen & Sanli Xing. (2019) Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells. European Journal of Pharmacology 865, pages 172748.
Crossref
Beatriz Martínez-Poveda, José Antonio Torres-Vargas, María del Carmen Ocaña, Melissa García-Caballero, Miguel Ángel Medina & Ana R. Quesada. (2019) The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer. Nutrients 11:9, pages 2036.
Crossref
Ruchi Badoni Semwal, Deepak Kumar Semwal, Sandra Combrinck, Jeanne Trill, Simon Gibbons & Alvaro Viljoen. (2019) Acacetin—A simple flavone exhibiting diverse pharmacological activities. Phytochemistry Letters 32, pages 56-65.
Crossref
Lara Bieler, Michael Vogl, Michael Kirchinger, Corinna Urmann, Herbert Riepl, Christine Bandtlow, Lars Klimaschewski, Ludwig Aigner & Sebastien Couillard-Despres. (2019) The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons. Frontiers in Cellular Neuroscience 13.
Crossref
Zhihui Jiang, Chunyan Peng, Wenping Huang, Bei Wu, Dan Zhang, Hui Ouyang, Yulin Feng & Shilin Yang. (2019) A High Throughput Three-step Ultra-performance Liquid Chromatography Tandem Mass Spectrometry Method to Study Metabolites of Atractylenolide-III. Journal of Chromatographic Science 57:2, pages 163-176.
Crossref
JULIANA M. SOARES, BRUNA M. DE FARIA, LUCAS M. ASCARI, SONIZA V. ALVES-LEON, JORGE M. DE SOUZA, ANTONIO G. SOARES, YRAIMA CORDEIRO & LUCIANA F. ROMÃO. (2019) Diosmin induces caspase-dependent apoptosis in human glioblastoma cells. Anais da Academia Brasileira de Ciências 91:4.
Crossref
Piyush Mehta, Atmaram Pawar, Kakasaheb Mahadik & C. Bothiraja. (2018) Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. Biomedicine & Pharmacotherapy 106, pages 1282-1291.
Crossref
Jarosław Popłoński, Eliza Turlej, Sandra Sordon, Tomasz Tronina, Agnieszka Bartmańska, Joanna Wietrzyk & Ewa Huszcza. (2018) Synthesis and Antiproliferative Activity of Minor Hops Prenylflavonoids and New Insights on Prenyl Group Cyclization. Molecules 23:4, pages 776.
Crossref
Anna Klimaszewska-Wiśniewska, Marta Hałas-Wiśniewska, Alina Grzanka & Dariusz Grzanka. (2018) Evaluation of Anti-Metastatic Potential of the Combination of Fisetin with Paclitaxel on A549 Non-Small Cell Lung Cancer Cells. International Journal of Molecular Sciences 19:3, pages 661.
Crossref
Bee Ling Tan & Mohd Esa Norhaizan. 2018. Anticancer plants: Properties and Application. Anticancer plants: Properties and Application 91 127 .
Xia Zhang, Jintuo Yin, Caijuan Liang, Yupeng Sun & Lantong Zhang. (2017) UHPLC-Q-TOF-MS/MS Method Based on Four-Step Strategy for Metabolism Study of Fisetin in Vitro and in Vivo . Journal of Agricultural and Food Chemistry 65:50, pages 10959-10972.
Crossref
Anna Palko-Labuz, Kamila Sroda-Pomianek, Anna Uryga, Edyta Kostrzewa-Suslow & Krystyna Michalak. (2017) Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells. Biomedicine & Pharmacotherapy 88, pages 232-241.
Crossref
Xin GUAN, Si TAN, Günther Buchholz, Nick Peter & Zhi-qin ZHOU. (2017) A method to evaluate the bioactive function of fruit extracts of Chinese wild Citrus with microtubular activity. Journal of Integrative Agriculture 16:4, pages 867-873.
Crossref
Lijuan Lv, Yuan Xia, Dezhi Zou, Huarui Han, Yingli Wang, Huiyong Fang & Minhui Li. (2017) <i>Fagopyrum tataricum</i> (L.) Gaertn.: A Review on its Traditional Uses, Phytochemical and Pharmacology. Food Science and Technology Research 23:1, pages 1-7.
Crossref
Anna Klimaszewska-Wisniewska, Marta Halas-Wisniewska, Tadeusz Tadrowski, Maciej Gagat, Dariusz Grzanka & Alina Grzanka. (2016) Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells. Cancer Cell International 16:1.
Crossref
Jun Hyeon Jo, Jung Jae Jo, Jae-Mok Lee & Sangkyu Lee. (2016) Identification of absolute conversion to geraldol from fisetin and pharmacokinetics in mouse. Journal of Chromatography B 1038, pages 95-100.
Crossref
Deeba N. Syed, Vaqar Mustafa Adhami, Naghma Khan, Mohammad Imran Khan & Hasan Mukhtar. (2016) Exploring the molecular targets of dietary flavonoid fisetin in cancer. Seminars in Cancer Biology 40-41, pages 130-140.
Crossref
Verónica Bolaños, Alfredo Díaz-Martínez, Jacqueline Soto, Laurence A. Marchat, Virginia Sanchez-Monroy & Esther Ramírez-Moreno. (2015) Kaempferol inhibits Entamoeba histolytica growth by altering cytoskeletal functions. Molecular and Biochemical Parasitology 204:1, pages 16-25.
Crossref
Fatemeh Razzaghi, Johanne Seguin, Abdelilah Amar, Sophie Griveau & Fethi Bedioui. (2015) Biological cell morphology studies by scanning electrochemical microscopy imagery at constant height: Contrast enhancement using biocompatible conductive substrates. Electrochimica Acta 157, pages 95-100.
Crossref
W.L. PEREIRA, T.T. OLIVEIRA, M. KANASHIRO & M.R. COSTA. (2015) Ação antiproliferativado flavonoide morina e do extrato da folha de oliveira (Oleaeuropaea L.) contra a linhagem de célula H460. Revista Brasileira de Plantas Medicinais 17:4 suppl 1, pages 798-806.
Crossref
Mohamed Saeed, Onat Kadioglu, Hassan Khalid, Yoshikazu Sugimoto & Thomas Efferth. (2015) Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. The Journal of Nutritional Biochemistry 26:1, pages 44-56.
Crossref
Azhar Rasul, Bin-Ji Zhao, Jun Liu, Bao Liu, Jia-Xin Sun, Jiang Li & Xiao-Meng Li. (2014) Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions. Asian Pacific Journal of Cancer Prevention 15:21, pages 9049-9058.
Crossref
Hiroko Isoda, Hideko Motojima, Shoko Onaga, Imen Samet, Myra O. Villareal & Junkyu Han. (2014) Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells. Chemico-Biological Interactions 220, pages 269-277.
Crossref
M. Elizabeth Meredith, Zhi-Chao Qu & James M. May. (2014) Ascorbate reverses high glucose- and RAGE-induced leak of the endothelial permeability barrier. Biochemical and Biophysical Research Communications 445:1, pages 30-35.
Crossref
Constant Pieme, Guru Santosh, Emmanuel Tekwu, Tülin Askun, Hatice Aydeniz, Jeanne Ngogang, Shashi Bhushan & Ajit Saxena. (2014) Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells. Biological Research 47:1, pages 54.
Crossref
Sylvie Crauste-Manciet, Eric Larquet, Karel Khawand, Michel Bessodes, Guy G. Chabot, Denis Brossard & Nathalie Mignet. (2013) Lipidic spherulites: Formulation optimisation by paired optical and cryoelectron microscopy. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 1088-1094.
Crossref
Juan Li, Hua Sun, Lu Jin, Wei Cao, Jin Zhang, Chong-Yi Guo, Ke Ding, Cheng Luo, Wen-Cai Ye & Ren-Wang Jiang. (2013) Alleviation of Podophyllotoxin Toxicity Using Coexisting Flavonoids from Dysosma versipellis. PLoS ONE 8:8, pages e72099.
Crossref
Valentina Uivarosi, Mihaela Badea, Rodica Olar, Constantin Drǎghici & Ştefania Bǎrbuceanu. (2013) Synthesis and Characterization of Some New Complexes of Magnesium (II) and Zinc (II) with the Natural Flavonoid Primuletin. Molecules 18:7, pages 7631-7645.
Crossref
L.W. Soromou, Y. Zhang, Y. Cui, M. Wei, N. Chen, X. Yang, M. Huo, A. Baldé, S. Guan, X. Deng & D. Wang. (2013) Subinhibitory concentrations of pinocembrin exert anti- Staphylococcus aureus activity by reducing α -toxin expression . Journal of Applied Microbiology 115:1, pages 41-49.
Crossref
Johanne Seguin, Laura Brullé, Renaud Boyer, Yen Mei Lu, Miriam Ramos Romano, Yasmine S. Touil, Daniel Scherman, Michel Bessodes, Nathalie Mignet & Guy G. Chabot. (2013) Liposomal encapsulation of the natural flavonoid fisetin improves bioavailability and antitumor efficacy. International Journal of Pharmaceutics 444:1-2, pages 146-154.
Crossref
Azhar Rasul, Faya Martin Millimouno, Wafa Ali Eltayb, Muhammad Ali, Jiang Li & Xiaomeng Li. (2013) Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities. BioMed Research International 2013, pages 1-9.
Crossref
Ali Ghasemzadeh, Hawa Jaafar & Ehsan Karimi. (2012) Involvement of Salicylic Acid on Antioxidant and Anticancer Properties, Anthocyanin Production and Chalcone Synthase Activity in Ginger (Zingiber officinale Roscoe) Varieties. International Journal of Molecular Sciences 13:12, pages 14828-14844.
Crossref
Vaqar Mustafa Adhami, Deeba Nadeem Syed, Naghma Khan & Hasan Mukhtar. (2012) Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochemical Pharmacology 84:10, pages 1277-1281.
Crossref
Héloïse Ragelle, Sylvie Crauste-Manciet, Johanne Seguin, Denis Brossard, Daniel Scherman, Philippe Arnaud & Guy G. Chabot. (2012) Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice. International Journal of Pharmaceutics 427:2, pages 452-459.
Crossref
Nathalie Mignet, Johanne Seguin, Miriam Ramos Romano, Laura Brullé, Yasmine S. Touil, Daniel Scherman, Michel Bessodes & Guy G. Chabot. (2012) Development of a liposomal formulation of the natural flavonoid fisetin. International Journal of Pharmaceutics 423:1, pages 69-76.
Crossref
D.K. Patel, K. Patel, M. Gadewar & V. Tahilyani. (2012) Pharmacological and bioanalytical aspects of galangin-a concise report. Asian Pacific Journal of Tropical Biomedicine 2:1, pages S449-S455.
Crossref
Yasmine S. Touil, Nicolas Auzeil, François Boulinguez, Hanane Saighi, Anne Regazzetti, Daniel Scherman & Guy G. Chabot. (2011) Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. Biochemical Pharmacology 82:11, pages 1731-1739.
Crossref
Jean-Philippe Monserrat, Rasha I. Al-Safi, Keshri Nath Tiwari, Lionel Quentin, Guy G. Chabot, Anne Vessières, Gérard Jaouen, Nouri Neamati & Elizabeth A. Hillard. (2011) Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells. Bioorganic & Medicinal Chemistry Letters 21:20, pages 6195-6197.
Crossref
Yasmine S. Touil, Johanne Seguin, Daniel Scherman & Guy G. Chabot. (2010) Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice. Cancer Chemotherapy and Pharmacology 68:2, pages 445-455.
Crossref
Jean-Philippe Monserrat, Guy G. Chabot, Louis Hamon, Lionel Quentin, Daniel Scherman, Gérard Jaouen & Elizabeth A. Hillard. (2010) Synthesis of cytotoxic ferrocenyl flavones via a ferricenium-mediated 1,6-oxidative cyclization. Chemical Communications 46:28, pages 5145.
Crossref
Guy G. Chabot, Yasmine S. Touil, Minh Hien Pham & Daniel Dauzonne. 2010. Alternative and Complementary Therapies for Cancer. Alternative and Complementary Therapies for Cancer 583 612 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.