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Original Articles

Synergistic Role of Curcumin With Current Therapeutics in Colorectal Cancer: Minireview

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Pages 842-846 | Received 01 May 2009, Accepted 24 Aug 2009, Published online: 10 Nov 2009

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S. Uday Kumar, I. Matai, P. Dubey, B. Bhushan, A. Sachdev & P. Gopinath. (2014) Differentially cross-linkable core–shell nanofibers for tunable delivery of anticancer drugs: synthesis, characterization and their anticancer efficacy. RSC Adv. 4:72, pages 38263-38272.
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Sivapriya Ponnurangam, David Standing, Parthasarathy Rangarajan & Dharmalingam Subramaniam. (2013) Tandutinib Inhibits the Akt/mTOR Signaling Pathway to Inhibit Colon Cancer Growth. Molecular Cancer Therapeutics 12:5, pages 598-609.
Crossref
X.Z. Cai, W.Y. Huang, Y. Qiao, S.Y. Du, Y. Chen, D. Chen, S. Yu, R.C. Che, N. Liu & Y. Jiang. (2013) Inhibitory effects of curcumin on gastric cancer cells: A proteomic study of molecular targets. Phytomedicine 20:6, pages 495-505.
Crossref
B S Vinod, J Antony, H H Nair, V T Puliyappadamba, M Saikia, S Shyam Narayanan, A Bevin & R John Anto. (2013) Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil. Cell Death & Disease 4:2, pages e505-e505.
Crossref
Yuanrui Huang, Rui Tian, Wenjing Hu, Yuntao Jia, Jingqing Zhang, Huiming Jiang & Liangke Zhang. (2013) A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS. Carbohydrate Polymers 92:2, pages 2218-2223.
Crossref
Min‐Bin Chen, Xiao‐Yang Wu, Guo‐Qing Tao, Chao‐Ying Liu, Jian Chen, Li‐Qiang Wang & Pei‐Hua Lu. (2012) Perifosine sensitizes curcumin‐induced anti‐colorectal cancer effects by targeting multiple signaling pathways both in vivo and in vitro . International Journal of Cancer 131:11, pages 2487-2498.
Crossref
N Rocks, S Bekaert, I Coia, G Paulissen, M Gueders, B Evrard, J-C Van Heugen, P Chiap, J-M Foidart, A Noel & D Cataldo. (2012) Curcumin–cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer. British Journal of Cancer 107:7, pages 1083-1092.
Crossref
Yonggang Li, Jingru Zhang, Daoxin Ma, Lei Zhang, Meng Si, Han Yin & Jianmin Li. (2012) Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch‐1 signaling. The FEBS Journal 279:12, pages 2247-2259.
Crossref
Dennis Ma, Phillip Tremblay, Kevinjeet Mahngar, Jonathan Collins, Tomas Hudlicky & Siyaram Pandey. (2011) Selective Cytotoxicity against Human Osteosarcoma Cells by a Novel Synthetic C-1 Analogue of 7-Deoxypancratistatin Is Potentiated by Curcumin. PLoS ONE 6:12, pages e28780.
Crossref
Erika Ferrari, Francesca Pignedoli, Carol Imbriano, Gaetano Marverti, Valentina Basile, Ettore Venturi & Monica Saladini. (2011) Newly Synthesized Curcumin Derivatives: Crosstalk between Chemico-physical Properties and Biological Activity. Journal of Medicinal Chemistry 54:23, pages 8066-8077.
Crossref
Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson & Rafat A Siddiqui. (2011) A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. BMC Cancer 11:1.
Crossref
Stacey L Fossey, Misty D Bear, Jiayuh Lin, Chenglong Li, Eric B Schwartz, Pui-Kai Li, James R Fuchs, Joelle Fenger, William C Kisseberth & Cheryl A London. (2011) The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC Cancer 11:1.
Crossref
Zhiyun He, Dharmalingam Subramaniam, Satish Ramalingam, Animesh Dhar, Russell G. PostierShahid Umar, Youcheng ZhangShrikant Anant. (2011) Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects. American Journal of Physiology-Gastrointestinal and Liver Physiology 301:5, pages G929-G937.
Crossref
Otito F. Iwuchukwu, Ronald J. Tallarida & Swati Nagar. (2011) Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells. Life Sciences 88:23-24, pages 1047-1054.
Crossref
Shailender Singh Kanwar, Yingjie Yu, Jyoti Nautiyal, Bhaumik B. Patel, Subhash Padhye, Fazlul H. Sarkar & Adhip P. N. Majumdar. (2010) Difluorinated-Curcumin (CDF): A Novel Curcumin Analog is a Potent Inhibitor of Colon Cancer Stem-Like Cells. Pharmaceutical Research 28:4, pages 827-838.
Crossref
Christine Kaefer & John Milner. 2011. Herbal Medicine. Herbal Medicine 361 382 .
Sigrid A Rajasekaran. (2011) Therapeutic potential of curcumin in gastrointestinal diseases. World Journal of Gastrointestinal Pathophysiology 2:1, pages 1.
Crossref
Murielle Mimeault & Surinder K Batra. (2011) Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Chinese Medicine 6:1, pages 31.
Crossref
Brian Markle, Elizabeth J. May & Adhip P. N. Majumdar. (2010) Do nutraceutics play a role in the prevention and treatment of colorectal cancer?. Cancer and Metastasis Reviews 29:3, pages 395-404.
Crossref

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