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Original Articles

The Effect of Secoisolariciresinol Diglucoside and Flaxseed Oil, Alone and in Combination, on MCF-7 Tumor Growth and Signaling Pathways

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Pages 533-542 | Received 30 Apr 2009, Accepted 05 Nov 2009, Published online: 27 Apr 2010

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Read on this site (7)

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Fernanda Cardoso da Silva, Douglas Cardoso Brandão, Everton Allan Ferreira, Raoni Pais Siqueira, Helen Soares Valença Ferreira, Ademar Alves Da Silva Filho & Thaise Gonçalves Araújo. (2023) Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer. Pharmaceuticals 16:10, pages 1466.
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Somaia Al-Madhagy, Naglaa S. Ashmawy, Ayat Mamdouh, Omayma A. Eldahshan & Mohamed A. Farag. (2023) A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils. European Journal of Medical Research 28:1.
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L. Bernard, Y. Chilliard, K. Hove, H. Volden, R.A. Inglingstad & M. Eknæs. (2022) Feeding of palm oil fatty acids or rapeseed oil throughout lactation: Effects on mammary gene expression and milk production in Norwegian dairy goats. Journal of Dairy Science 105:11, pages 8792-8805.
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Meltem Özgöçmen, Dilek Bayram, Gülçin Yavuz Türel, Vehbi Atahan Toğay & Nilüfer Şahin Calapoğlu. (2021) Secoisolariciresinol diglucoside induces caspase‐3‐mediated apoptosis in monolayer and spheroid cultures of human colon carcinoma cells. Journal of Food Biochemistry 45:5.
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Ahmed M. M. Gabr, Hoda B. Mabrok, Oksana Sytar & Iryna Smetanska. 2021. Exploring Plant Cells for the Production of Compounds of Interest. Exploring Plant Cells for the Production of Compounds of Interest 249 289 .
Carol J. Fabian, Seema A. Khan, Judy E. Garber, William C. Dooley, Lisa D. Yee, Jennifer R. Klemp, Jennifer L. Nydegger, Kandy R. Powers, Amy L. Kreutzjans, Carola M. Zalles, Trina Metheny, Teresa A. Phillips, Jinxiang Hu, Devin C. Koestler, Prabhakar Chalise, Nanda Kumar Yellapu, Cheryl Jernigan, Brian K. Petroff, Stephen D. Hursting & Bruce F. Kimler. (2020) Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer. Cancer Prevention Research 13:7, pages 623-634.
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Joana R. Campos, Patricia Severino, Classius S. Ferreira, Aleksandra Zielinska, Antonello Santini, Selma B. Souto & Eliana B. Souto. (2019) Linseed Essential Oil – Source of Lipids as Active Ingredients for Pharmaceuticals and Nutraceuticals. Current Medicinal Chemistry 26:24, pages 4537-4558.
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Alison L. Buckner, Carly A. Buckner, Sabine Montaut & Robert M. Lafrenie. (2019) Treatment with flaxseed oil induces apoptosis in cultured malignant cells. Heliyon 5:8, pages e02251.
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S. Franklyn De Silva & Jane Alcorn. (2019) Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets. Pharmaceuticals 12:2, pages 68.
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Shahira M. Ezzat, Samia A. Shouman, Abeer Elkhoely, Yasmin M. Attia, Mohamed S. Elsesy, Amira S. El Senousy, Mouchira A. Choucry, Sabah H. El Gayed, Abeer A. El Sayed, Essam Abdel Sattar & Nebal El Tanbouly. (2018) Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars. Scientific Reports 8:1.
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C. M. Lopes, A. Dourado & R. Oliveira. (2017) Phytotherapy and Nutritional Supplements on Breast Cancer. BioMed Research International 2017, pages 1-42.
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Matteo Ciocci, Egidio Iorio, Felicia Carotenuto, Haneen A. Khashoggi, Francesca Nanni & Sonia Melino. (2016) H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair. Oncotarget 7:51, pages 84338-84358.
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Saimi Tokunaga, Bruce R. Woodin & John J. Stegeman. (2016) Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities. Food and Chemical Toxicology 96, pages 160-166.
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Ryoiti Kiyama. (2016) Biological effects induced by estrogenic activity of lignans. Trends in Food Science & Technology 54, pages 186-196.
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Julie K. Mason-Ennis, Lauren P. LeMay-Nedjelski, Ashleigh K.A. Wiggins & Lilian U. Thompson. (2016) Exploration of mechanisms of α-linolenic acid in reducing the growth of oestrogen receptor positive breast cancer cells (MCF-7). Journal of Functional Foods 24, pages 513-519.
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Angela Sorice, Eliana Guerriero, Maria Volpe, Francesca Capone, Francesco La Cara, Gennaro Ciliberto, Giovanni Colonna & Susan Costantini. (2016) Differential Response of Two Human Breast Cancer Cell Lines to the Phenolic Extract from Flaxseed Oil. Molecules 21:3, pages 319.
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Julie K. Mason, Sukhpreet Klaire, Shikhil Kharotia, Ashleigh K A Wiggins & Lilian U. Thompson. (2015) α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. Lipids in Health and Disease 14:1.
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Ryoiti Kiyama & Yuko Wada-Kiyama. (2015) Estrogenic endocrine disruptors: Molecular mechanisms of action. Environment International 83, pages 11-40.
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Ashleigh K.A. Wiggins, Julie K. Mason & Lilian U. Thompson. (2015) Growth and gene expression differ over time in alpha-linolenic acid treated breast cancer cells. Experimental Cell Research 333:1, pages 147-154.
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Julie K. Mason, Minghua Fu, Jianmin Chen & Lilian U. Thompson. (2015) Flaxseed oil enhances the effectiveness of trastuzumab in reducing the growth of HER2-overexpressing human breast tumors (BT-474). The Journal of Nutritional Biochemistry 26:1, pages 16-23.
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Ankit Goyal, Vivek Sharma, Neelam Upadhyay, Sandeep Gill & Manvesh Sihag. (2014) Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology 51:9, pages 1633-1653.
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Julie K. MasonLilian U. Thompson. (2014) Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?. Applied Physiology, Nutrition, and Metabolism 39:6, pages 663-678.
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Ryoiti Kiyama & Yun Zhu. (2014) DNA microarray-based gene expression profiling of estrogenic chemicals. Cellular and Molecular Life Sciences 71:11, pages 2065-2082.
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Pramodkumar D. Jadhav, Denis P. Okinyo-Owiti, Pearson W.K. Ahiahonu & Martin J.T. Reaney. (2013) Detection, isolation and characterisation of cyclolinopeptides J and K in ageing flax. Food Chemistry 138:2-3, pages 1757-1763.
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Xing Ma, Rui Wang, Xin Zhao, Chong Zhang, Jiao Sun, Jianxin Li, Lu Zhang, Tuo Shao, Lina Ruan, Liang Chen, Ying Xu & Jianchun Pan. (2012) Antidepressant-like effect of flaxseed secoisolariciresinol diglycoside in ovariectomized mice subjected to unpredictable chronic stress. Metabolic Brain Disease 28:1, pages 77-84.
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Wendy Elizabeth Ward & Lilian U. Thompson. 2013. Nutrition and Diet in Menopause. Nutrition and Diet in Menopause 419 426 .
Susan E. McCann, Katie C. Hootman, Anne M. Weaver, Lilian U. Thompson, Carl Morrison, Helena Hwang, Stephen B. Edge, Christine B. Ambrosone, Peter J. Horvath & Swati A. Kulkarni. (2012) Dietary Intakes of Total and Specific Lignans Are Associated with Clinical Breast Tumor Characteristics3. The Journal of Nutrition 142:1, pages 91-98.
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H. B. Mabrok, R. Klopfleisch, K. Z. Ghanem, T. Clavel, M. Blaut & G. Loh. (2011) Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer. Carcinogenesis 33:1, pages 203-208.
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J. Angulo, L. Mahecha, K. Nuernberg, G. Nuernberg, D. Dannenberger, M. Olivera, M. Boutinaud, C. Leroux, E. Albrecht & L. Bernard. (2012) Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression. Animal 6:12, pages 1961-1972.
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Jianmin Chen, Jasdeep K. Saggar, Paul Corey & Lilian U. Thompson. (2010) Flaxseed cotyledon fraction reduces tumour growth and sensitises tamoxifen treatment of human breast cancer xenograft (MCF-7) in athymic mice. British Journal of Nutrition 105:3, pages 339-347.
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