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Original Articles

Garcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells

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Pages 456-465 | Received 01 Jul 2010, Accepted 03 Oct 2010, Published online: 31 Mar 2011

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Xin Chen, Xinyan Zhang, Ye Lu, Joong-Youn Shim, Shengmin Sang, Zheng Sun & Xiaoxin Chen. (2012) Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Hamster Cheek Pouch Carcinogenesis by a 5-Lipoxygenase Inhibitor, Garcinol. Nutrition and Cancer 64:8, pages 1211-1218.
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Xueying Wang, Jiling Feng, Rong Wu, Jiaqi Tan, Qing Huang, Yeelin Phang, Li Zhang, Wenwei Fu, Hongxi Xu & Changwu Zheng. (2023) Garcinol and its analogues: Synthesis, cytotoxic activity and mechanistic investigation. Bioorganic Chemistry 133, pages 106389.
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Amr Ahmed WalyEldeen, Salwa Sabet, Haidan M. El-Shorbagy, Ismail A. Abdelhamid & Sherif Abdelaziz Ibrahim. (2023) Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer. Chemico-Biological Interactions 369, pages 110297.
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Loganayaki Periyasamy, Bharathi Muruganantham, Woo-Yoon Park & Sridhar Muthusami. (2022) Phyto-targeting the CEMIP Expression as a Strategy to Prevent Pancreatic Cancer Metastasis. Current Pharmaceutical Design 28:11, pages 922-946.
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Patrycja Kopytko, Katarzyna Piotrowska, Joanna Janisiak & Maciej Tarnowski. (2021) Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug. International Journal of Molecular Sciences 22:6, pages 2828.
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Yuanyuan Zheng, Chuanyong Guo, Xiaoping Zhang, Xiaoli Wang & A'Ηuo Ma. (2020) Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway. Oncology Letters 20:1, pages 667-676.
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Vaishali Aggarwal, Hardeep Singh Tuli, Jagjit Kaur, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Samruddhi Kulkarni, Ginpreet Kaur, Katrin Sak, Manoj Kumar & Kwang Seok Ahn. (2020) Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells. Biomedicines 8:5, pages 103.
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Jie Zhang, Huan Fang, Jinguo Zhang, Wencai Guan & Guoxiong Xu. (2020) Garcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells. Dose-Response 18:2, pages 155932582092673.
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Geismann, Schäfer, Gundlach, Hauser, Egberts, Schneider & Arlt. (2019) NF-κB Dependent Chemokine Signaling in Pancreatic Cancer. Cancers 11:10, pages 1445.
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Mengyuan Huang, Jiangkun Huang, Yongcheng Zheng & Qiu Sun. (2019) Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism. European Journal of Medicinal Chemistry 178, pages 259-286.
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Xing-Wei Yang, Robert B. Grossman & Gang Xu. (2018) Research Progress of Polycyclic Polyprenylated Acylphloroglucinols. Chemical Reviews 118:7, pages 3508-3558.
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Wen-Chien Huang, Kuang-Tai Kuo, Bamodu Oluwaseun Adebayo, Chun-Hua Wang, Yu-Jen Chen, Ketao Jin, Tung-Hu Tsai & Chi-Tai Yeh. (2018) Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/β-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas. The Journal of Nutritional Biochemistry 54, pages 140-150.
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Sanjeev Banerjee, Mansi A. Parasramka & Shivani B. Paruthy. 2018. Role of Nutraceuticals in Chemoresistance to Cancer. Role of Nutraceuticals in Chemoresistance to Cancer 297 324 .
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Manjeshwar Shrinath Baliga, Suresh Rao, Pratima Rao, Krishnaprasad, Sanath Kumar Hegde, Kandel Codi Jalaluddin Akbar, Soniya Abraham, Thomas George & Princy Louis Palatty. 2018. Anticancer plants: Properties and Application. Anticancer plants: Properties and Application 57 76 .
Lavínia de C. Brito, Ana Luiza Rangel Berenger & Maria Raquel Figueiredo. (2017) An overview of anticancer activity of Garcinia and Hypericum. Food and Chemical Toxicology 109, pages 847-862.
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Parth Thakor, Ramalingam B. Subramanian, Sampark S. Thakkar, Arabinda Ray & Vasudev R. Thakkar. (2017) Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549). Biomedicine & Pharmacotherapy 92, pages 491-500.
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T Ranjbarnejad, M Saidijam, M sadat tafakh, M Pourjafar, F Talebzadeh & R Najafi. (2016) Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells. Human & Experimental Toxicology 36:7, pages 692-700.
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Chi‐Cheng Huang, Chien‐Min Lin, Yan‐Jiun Huang, Li Wei, Lei‐Li Ting, Chia‐Chun Kuo, Cheyu Hsu, Jeng‐Fong Chiou, Alexander T. H. Wu & Wei‐Hwa Lee. (2017) Garcinol downregulates Notch1 signaling via modulating miR‐200c and suppresses oncogenic properties of PANC‐1 cancer stem‐like cells. Biotechnology and Applied Biochemistry 64:2, pages 165-173.
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Thangaiyan Rabi & Carlo V. Catapano. (2016) Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells. Tumor Biology 37:9, pages 12455-12464.
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Sadhna Aggarwal & Satya N. Das. (2015) Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer. Tumor Biology 37:6, pages 7175-7184.
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Weiming Xia & Huanbiao Mo. (2016) Potential of tocotrienols in the prevention and therapy of Alzheimer's disease. The Journal of Nutritional Biochemistry 31, pages 1-9.
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Marisa Ionta, Guilherme Ferreira-Silva, Evandro Niero, Éderson Costa, Adam Martens, Welton Rosa, Marisi Soares, Gláucia Machado-Santelli, João Lago & Marcelo Santos. (2015) 7-Epiclusianone, a Benzophenone Extracted from Garcinia brasiliensis (Clusiaceae), Induces Cell Cycle Arrest in G1/S Transition in A549 Cells. Molecules 20:7, pages 12804-12816.
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Debarshi Kar Mahapatra, Sanjay Kumar Bharti & Vivek Asati. (2015) Anti-cancer chalcones: Structural and molecular target perspectives. European Journal of Medicinal Chemistry 98, pages 69-114.
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Chaoqun Liu, Paul Chi-Lui Ho, Fang Cheng Wong, Gautam Sethi, Ling Zhi Wang & Boon Cher Goh. (2015) Garcinol: Current status of its anti-oxidative, anti-inflammatory and anti-cancer effects. Cancer Letters 362:1, pages 8-14.
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Feng Li, Muthu K. Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H. Ong, Ser Yue Loo, Mahadeva M.M. Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui & Gautam Sethi. (2015) Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. Oncotarget 6:7, pages 5147-5163.
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Gautam Sethi, Snehajyoti Chatterjee, Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Kwong Fai Wong, Alan Prem Kumar, Parijat Senapati, Amit K Behera, Kam Man Hui, Jeelan Basha, Nagashayana Natesh, John M Luk & Tapas K Kundu. (2014) Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo. Molecular Cancer 13:1.
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Sheng-Yung Yu, Chiung-Ho Liao, Ming-Hsien Chien, Tsung-Yu TsaiJen-Kun Lin & Meng-Shih Weng. (2014) Induction of p21 Waf1/Cip1 by Garcinol via Downregulation of p38-MAPK Signaling in p53-Independent H1299 Lung Cancer . Journal of Agricultural and Food Chemistry 62:9, pages 2085-2095.
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Mansi A. Parasramka, Shadan Ali, Sanjeev Banerjee, Tara Deryavoush, Fazlul H Sarkar & SmitiV. Gupta. (2013) Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with micro RNA signatures . Molecular Nutrition & Food Research 57:2, pages 235-248.
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Li Oon Chuah, Wan Yong Ho, Boon Kee Beh & Swee Keong Yeap. (2013) Updates on Antiobesity Effect of Garcinia Origin (−)-HCA . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-17.
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Wenping Tang, Min-Hsiung Pan, Shengmin Sang, Shiming Li & Chi-Tang Ho. 2013. Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits. Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits 133 145 .
A. Ahmad, S. H. Sarkar, A. Aboukameel, S. Ali, B. Biersack, S. Seibt, Y. Li, B. Bao, D. Kong, S. Banerjee, R. Schobert, S. B. Padhye & F. H. Sarkar. (2012) Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling. Carcinogenesis 33:12, pages 2450-2456.
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Ravinder Abrol, Mouad Edderkaoui, William A. GoddardIIIIII & Stephen J. Pandol. (2012) Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells. Biochemical and Biophysical Research Communications 422:4, pages 596-601.
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Mansi A. Parasramka & Smiti Vaid Gupta. (2012) Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells. Journal of Oncology 2012, pages 1-8.
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Nadia Saadat & Smiti V. Gupta. (2012) Potential Role of Garcinol as an Anticancer Agent. Journal of Oncology 2012, pages 1-8.
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Aamir Ahmad, Subhash Padhye & Fazlul H. Sarkar. 2012. Nutraceuticals and Cancer. Nutraceuticals and Cancer 179 199 .

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