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Original Articles

Impact of Polyphenol Metabolites Produced by Colonic Microbiota on Expression of COX-2 and GSTT2 in Human Colon Cells (LT97)

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Pages 653-662 | Received 11 Jun 2010, Accepted 06 Dec 2010, Published online: 18 May 2011

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Crossref
Susanne M. Henning, Piwen Wang, Narine Abgaryan, Roberto Vicinanza, Daniela Moura de Oliveira, Yanjun Zhang, Ru‐Po Lee, Catherine L. Carpenter, William J. Aronson & David Heber. (2013) Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer. Molecular Nutrition & Food Research 57:3, pages 483-493.
Crossref
Kieran M. Tuohy, Lorenza Conterno, Mattia Gasperotti & Roberto Viola. (2012) Up-regulating the Human Intestinal Microbiome Using Whole Plant Foods, Polyphenols, and/or Fiber. Journal of Agricultural and Food Chemistry 60:36, pages 8776-8782.
Crossref
Ruth S. MacDonald & Kelly Wagner. (2012) Influence of Dietary Phytochemicals and Microbiota on Colon Cancer Risk. Journal of Agricultural and Food Chemistry 60:27, pages 6728-6735.
Crossref
Petra A.M.J. ScholtensRaish OozeerRocio MartinKaouther Ben AmorJan Knol. (2012) The Early Settlers: Intestinal Microbiology in Early Life. Annual Review of Food Science and Technology 3:1, pages 425-447.
Crossref
A. Wilhelm, F. Jahns, S. Böcker, H. Mothes, K.O. Greulich & M. Glei. (2012) Culturing explanted colon crypts highly improves viability of primary non-transformed human colon epithelial cells. Toxicology in Vitro 26:1, pages 133-141.
Crossref

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