261
Views
35
CrossRef citations to date
0
Altmetric
Original Articles

Induction of DNA Damage and Caspase-Independent Programmed Cell Death by Vitamin E

, , , , &
Pages 136-152 | Received 08 Nov 2010, Accepted 26 Jul 2011, Published online: 15 Dec 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Darren Chan, Maureen L. Meister, Chappell R. Madhani, Manal Elfakhani, Sophie T. Yount, Xiangming Ji, Rafaela G. Feresin, Desiree Wanders & Huanbiao Mo. (2021) Synergistic Impact of Xanthorrhizol and d-δ-Tocotrienol on the Proliferation of Murine B16 Melanoma Cells and Human DU145 Prostate Carcinoma Cells. Nutrition and Cancer 73:9, pages 1746-1757.
Read now
Constantina Constantinou, Christiana Charalambous, Dimitrios Kanakis, Ourania Kolokotroni & Andreas I. Constantinou. (2021) Update on the Anti-Cancer Potency of Tocotrienols and α-Tocopheryl Polyethylene Glycol 1000 Succinate on Leukemic Cell Lines. Nutrition and Cancer 73:8, pages 1302-1308.
Read now
Hoda Yeganehjoo, Russell DeBose-Boyd, Brian K. McFarlin & Huanbiao Mo. (2017) Synergistic Impact of d-δ-Tocotrienol and Geranylgeraniol on the Growth and HMG CoA Reductase of Human DU145 Prostate Carcinoma Cells. Nutrition and Cancer 69:4, pages 682-691.
Read now

Articles from other publishers (32)

Kader Turkekul & Suat Erdogan. (2023) Potent Suppression of Prostate Cancer Cell Growth and Eradication of Cancer Stem Cells by CD44-targeted Nanoliposome-quercetin Nanoparticles. Journal of Cancer Prevention 28:4, pages 160-174.
Crossref
Mamata Singh, Virendra Singh, Tushar S. Basu Baul & Biplob Koch. (2022) TPGS loaded triphenyltin (IV) micelles induced apoptosis by upregulating p53 in breast cancer cells and inhibit tumor progression in T-cell lymphoma bearing mice. Life Sciences 308, pages 120937.
Crossref
Pankaj Kumar Sharma, Hanuman Prasad Sharma, Chandrashekhar Mahadeo Chakole, Jaya Pandey & Meenakshi Kanwar Chauhan. (2022) Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient. Journal of the Indian Chemical Society 99:3, pages 100387.
Crossref
Adnan M. Jasim & Mohammed J. Jawad. 2021. Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects. Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects.
Javad Sharifi-Rad, Cristina Quispe, Zhazira Mukazhanova, Ewa Knut, Aknur Turgumbayeva, Aliya Kipchakbayeva, Gulnaz Seitimova, Mohamad Fawzi Mahomoodally, Devina Lobine, Aaron Koay, Jinfan Wang, Helen Sheridan, Gerardo Leyva-Gómez, María L. Del Prado-Audelo, Hernán Cortes, Antonio Rescigno, Paolo Zucca, Oksana Sytar, Muhammad Imran, Célia F. Rodrigues, Natália Cruz-Martins, Halina Ekiert, Manoj Kumar, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal & Agnieszka Szopa. (2021) Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer. Frontiers in Molecular Biosciences 8.
Crossref
Jazmin Calvo-Alvarez, Marlene Jimenez-Del-Rio & Carlos Velez-Pardo. (2021) Vitamin E TPGS 1000 Induces Apoptosis in the K562 Cell Line: Implications for Chronic Myeloid Leukemia. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
Crossref
Magdalena Grajzer, Benita Wiatrak, Tomasz Gębarowski, Aleksandra Boba, Edward Rój, Daiva Gorczyca & Anna Prescha. (2021) Bioactive Compounds of Raspberry Oil Emulsions Induced Oxidative Stress via Stimulating the Accumulation of Reactive Oxygen Species and NO in Cancer Cells. Oxidative Medicine and Cellular Longevity 2021, pages 1-16.
Crossref
Muhammad Asim Farooq, Huang Xinyu, Amna Jabeen, Anam Ahsan, Theodora Amanda Seidu, Perpetua Takunda Kutoka & Bo Wang. (2021) Enhanced cellular uptake and cytotoxicity of vorinostat through encapsulation in TPGS-modified liposomes. Colloids and Surfaces B: Biointerfaces 199, pages 111523.
Crossref
Yue Zhao, Tingting Fu, Gaoke Meng, Fangxia Qiao, Yanhui Hou, Yanhua Liu & Jianhong Yang. (2020) Characterization of Cepharanthin Nanosuspensions and Evaluation of Their In Vitro Activity for the HepG2 Hepatocellular Carcinoma Cell Line. Anti-Cancer Agents in Medicinal Chemistry 20:18, pages 2293-2303.
Crossref
Constantina Constantinou, Christiana Charalambous & Dimitrios Kanakis. (2019) Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols. European Journal of Nutrition 59:3, pages 845-857.
Crossref
S. Malathi, P.S. Pavithra, S. Sridevi & Rama S. Verma. (2020) Fabrication of nanopatterned PLGA films of curcumin and TPGS for skin cancer. International Journal of Pharmaceutics 578, pages 119100.
Crossref
Yidan Chen, Liqin Mo, Xuan Wang, Bi Chen, Yunfen Hua, Linyan Gong, Fei Yang, Yongqiang Li, Fangfang Chen, Guiting Zhu, Wei Ni, Cheng Zhang, Yuming Cheng, Yan Luo, Junping Shi, Mengsheng Qiu, Shixiu Wu, Zhou Tan & Kaifeng Wang. (2020) TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo. Aging 12:2, pages 1624-1642.
Crossref
Christiana M. Neophytou, Avgoustinos Mesaritis, Gregoria Gregoriou & Andreas I. Constantinou. (2019) d-a-Tocopheryl Polyethylene Glycol 1000 Succinate and a small-molecule Survivin suppressant synergistically induce apoptosis in SKBR3 breast cancer cells. Scientific Reports 9:1.
Crossref
Solange A. Valdes, Riyad F. Alzhrani, Andres Rodriguez, Dharmika S.P. Lansakara-P, Sachin G. Thakkar & Zhengrong Cui. (2019) A solid lipid nanoparticle formulation of 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine with increased solubility, stability, and antitumor activity. International Journal of Pharmaceutics 570, pages 118609.
Crossref
Fabrizio Fontana, Roberta Manuela Moretti, Michela Raimondi, Monica Marzagalli, Giangiacomo Beretta, Patrizia Procacci, Patrizia Sartori, Marina Montagnani Marelli & Patrizia Limonta. (2019) δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells. Cell Proliferation 52:3.
Crossref
Cristian Ruiz-Moreno, Carlos Velez-Pardo & Marlene Jimenez-Del-Rio. (2018) Vitamin E d -α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Provokes Cell Death in Human Neuroblastoma SK-N-SH Cells via a Pro-Oxidant Signaling Mechanism . Chemical Research in Toxicology 31:9, pages 945-953.
Crossref
Ahmed Abu‐Fayyad & Sami Nazzal. (2017) Extraction of Vitamin E Isomers from Palm Oil: Methodology, Characterization, and in Vitro Anti‐Tumor Activity . Journal of the American Oil Chemists' Society 94:9, pages 1209-1217.
Crossref
Hira Choudhury, Bapi Gorain, Manisha Pandey, Santosh Ashok Kumbhar, Rakesh Kumar Tekade, Arun K. Iyer & Prashant Kesharwani. (2017) Recent advances in TPGS-based nanoparticles of docetaxel for improved chemotherapy. International Journal of Pharmaceutics 529:1-2, pages 506-522.
Crossref
Ahmed Abu-Fayyad & Sami Nazzal. (2017) Gemcitabine-vitamin E conjugates: Synthesis, characterization, entrapment into nanoemulsions, and in-vitro deamination and antitumor activity. International Journal of Pharmaceutics 528:1-2, pages 463-470.
Crossref
Yan‑Bo Jia, Dian‑Ming Jiang, Yi‑Zhong Ren, Zi‑Hong Liang, Zhen‑Qun Zhao & Yu‑Xin Wang. (2017) Inhibitory effects of vitamin E on osteocyte apoptosis and DNA oxidative damage in bone marrow hemopoietic cells at early stage of steroid-induced femoral head necrosis. Molecular Medicine Reports.
Crossref
Mahalingam Rajamanickam Vijayakumar, Kiran Yellappa Vajanthri, Chelladurai Karthikeyan Balavigneswaran, Sanjeev Kumar Mahto, Nira Mishra, Madaswamy S. Muthu & Sanjay Singh. (2016) Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes. Colloids and Surfaces B: Biointerfaces 145, pages 479-491.
Crossref
Cristian Ruiz-Moreno, Marlene Jimenez-Del-Rio, Ligia Sierra-Garcia, Betty Lopez-Osorio & Carlos Velez-Pardo. (2016) Vitamin E synthetic derivate—TPGS—selectively induces apoptosis in jurkat t cells via oxidative stress signaling pathways: implications for acute lymphoblastic leukemia. Apoptosis 21:9, pages 1019-1032.
Crossref
Soumyasri Das Gupta & Nanjoo Suh. (2016) Tocopherols in cancer: An update. Molecular Nutrition & Food Research 60:6, pages 1354-1363.
Crossref
Ibrahim Babangida Abubakar, Kuan-Hon Lim, Toh-Seok Kam & Hwei-San Loh. (2016) Synergistic cytotoxic effects of combined δ-tocotrienol and jerantinine B on human brain and colon cancers. Journal of Ethnopharmacology 184, pages 107-118.
Crossref
Mahalingam Rajamanickam Vijayakumar, Ramoji Kosuru, Sanjay Kumar Singh, Chandra Bhushan Prasad, Gopeshwar Narayan, Madaswamy S. Muthu & Sanjay Singh. (2016) Resveratrol loaded PLGA: d -α-tocopheryl polyethylene glycol 1000 succinate blend nanoparticles for brain cancer therapy . RSC Advances 6:78, pages 74254-74268.
Crossref
Mahalingam Rajamanickam Vijayakumar, Lakshmi Kumari, Krishna Kumar Patel, Parameswara Rao Vuddanda, Kiran Yellappa Vajanthri, Sanjeev Kumar Mahto & Sanjay Singh. (2016) Intravenous administration of trans-resveratrol-loaded TPGS-coated solid lipid nanoparticles for prolonged systemic circulation, passive brain targeting and improved in vitro cytotoxicity against C6 glioma cell lines. RSC Advances 6:55, pages 50336-50348.
Crossref
Christiana M. Neophytou & Andreas I. Constantinou. (2015) Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives. BioMed Research International 2015, pages 1-16.
Crossref
Christiana M. Neophytou, Constantina Constantinou, Panagiotis Papageorgis & Andreas I. Constantinou. (2014) d-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells. Biochemical Pharmacology 89:1, pages 31-42.
Crossref
Masao Yamasaki, Misato Nishimura, Yoichi Sakakibara, Masahito Suiko, Kazuhiro Morishita & Kazuo Nishiyama. (2014) Delta-tocotrienol induces apoptotic cell death via depletion of intracellular squalene in ED40515 cells. Food Funct. 5:11, pages 2842-2849.
Crossref
Saeed Alqahtani, Alaadin Alayoubi, Sami Nazzal, Paul W. Sylvester & Amal Kaddoumi. (2013) Nonlinear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies. The AAPS Journal 15:3, pages 684-695.
Crossref
Ana Lúcia Vargas Arigony, Iuri Marques de Oliveira, Miriana Machado, Diana Lilian Bordin, Lothar Bergter, Daniel Prá & João Antonio Pêgas Henriques. (2013) The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability. BioMed Research International 2013, pages 1-22.
Crossref
Khaled Aziz & Phuoc Tran. 2012. Cancer Biomarkers. Cancer Biomarkers 321 343 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.