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Nutrition and Cancer Volume 64, 2012 - Issue 5
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Original Articles

Zyflamend, a Combination of Herbal Extracts, Attenuates Tumor Growth in Murine Xenograft Models of Prostate Cancer

E.-Chu Huang Department of Nutrition, University of Tennessee, Knoxville, Tennessee, USA
,
Michael F. McEntee Department of Pathobiology, University of Tennessee, Knoxville, Tennessee, USA
&
Jay Whelan Department of Nutrition and Tennessee Agricultural Experiment Station, University of Tennessee, Knoxville, Tennessee, USA
Pages 749-760 | Received 14 Jul 2011, Accepted 25 Apr 2012, Published online: 04 Jun 2012

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Dexter Puckett, Mohammed Alquraishi, Dina S. Alani, Samah Chahed, Victoria D. Frankel, Dallas Donohoe, Brynn Voy, Jay Whelan & Ahmed Bettaieb. (2020) Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK. Adipocyte 9:1, pages 454-471.
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Yanshi Xue, Lin Yang, Junzun Li, Yilin Yan, Qinghui Jiang, Lan Shen, Shuai Yang, Bing Shen, Ruimin Huang, Jun Yan & Hongqian Guo. (2018) Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway. OncoTargets and Therapy 11, pages 4413-4429.
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Articles from other publishers (24)

Rafael Abe da Rocha Miranda, Marcela Martins de Paula Oliveira, Maria Isadora Gabriel Sampaio, João Victor Dutra Gomes, Damaris Silveira, Eliete Neves Silva Guerra, Adriana Lofrano‐Porto, Cinthia Gabriel Meireles & Luiz Alberto Simeoni. (2022) Effects of medicinal plants and natural compounds in models of prostate cancer related to sex steroids: A systematic review. Phytotherapy Research 36:8, pages 3032-3079.
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Marisa Dunn, Danielle Mirda, Michael J. Whalen & Mikhail Kogan. (2022) An integrative active surveillance of prostate cancer. EXPLORE 18:4, pages 483-487.
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Melissa García-Caballero, José Antonio Torres-Vargas, Ana Dácil Marrero, Beatriz Martínez-Poveda, Miguel Ángel Medina & Ana R. Quesada. (2022) Angioprevention of Urologic Cancers by Plant-Derived Foods. Pharmaceutics 14:2, pages 256.
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Dexter L. Puckett, Mohammed Alquraishi, Dina Alani, Samah Chahed, Dallas Donohoe, Brynn Voy, Jay Whelan & Ahmed Bettaieb. (2020) Zyflamend induces apoptosis in pancreatic cancer cells via modulation of the JNK pathway. Cell Communication and Signaling 18:1.
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Jay Whelan. 2020. Nutritional Signaling Pathway Activities in Obesity and Diabetes. Nutritional Signaling Pathway Activities in Obesity and Diabetes 295 309 .
J. Whelan & Jay Whelan. (2020) Conversion of dietary polyunsaturated fats between humans and rodents: A review of allometric scaling models. Prostaglandins, Leukotrienes and Essential Fatty Acids 158, pages 102094.
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Michael R Buckley, Paul D Terry, Stacy S Kirkpatrick, Joshua D Arnold, Michael M McNally, Oscar H Grandas, Michael B Freeman, Mitchell H Goldman, Jay Whelan & Deidra JH Mountain. (2019) Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention. Nutrition Research 68, pages 34-44.
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Pao-Hwa Lin, William Aronson & Stephen J. Freedland. (2019) An update of research evidence on nutrition and prostate cancer. Urologic Oncology: Seminars and Original Investigations 37:6, pages 387-401.
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Amber F. MacDonald, Ahmed Bettaieb, Dallas R. Donohoe, Dina S. Alani, Anna Han, Yi Zhao & Jay Whelan. (2018) Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. BMC Complementary and Alternative Medicine 18:1.
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Eric D. TagueAllen K. BourdonAmber MacDonaldMaggie S. LookadooEdward D. KimWesley M. WhitePaul D. TerryShawn R. CampagnaBrynn H. VoyJay Whelan. (2018) Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend. Journal of Medicinal Food 21:3, pages 306-316.
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Priyadarshini & Abhishek Negi. 2018. Anticancer plants: Properties and Application. Anticancer plants: Properties and Application 539 558 .
Ali Mohammadi, Behzad Mansoori & Behzad Baradaran. (2017) Regulation of miRNAs by herbal medicine: An emerging field in cancer therapies. Biomedicine & Pharmacotherapy 86, pages 262-270.
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Jay Whelan, Yi Zhao, E-Chu Huang, Amber MacDonald & Dallas Donohoe. 2016. Complementary and Alternative Medicines in Prostate Cancer. Complementary and Alternative Medicines in Prostate Cancer 197 220 .
Courtney J. Berg, David J. Habibian, Aaron E. Katz, Kaitlin E. Kosinski, Anthony T. Corcoran & Andrew S. Fontes. (2016) Active Holistic Surveillance: The Nutritional Aspect of Delayed Intervention in Prostate Cancer. Journal of Nutrition and Metabolism 2016, pages 1-7.
Crossref
Pao-Hwa Lin, William Aronson & Stephen J Freedland. (2015) Nutrition, dietary interventions and prostate cancer: the latest evidence. BMC Medicine 13:1.
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Yi Zhao, Dallas Donohoe, E-Chu Huang & Jay Whelan. (2015) Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK. Journal of Functional Foods 18, pages 147-158.
Crossref
Wing Ho. 2015. Active Phytochemicals from Chinese Herbal Medicines. Active Phytochemicals from Chinese Herbal Medicines 1 14 .
Susan J. Burke, Michael D. Karlstad, Caroline P. Conley, Danielle Reel, Jay Whelan & J. Jason Collier. (2015) Dietary polyherbal supplementation decreases CD3+ cell infiltration into pancreatic islets and prevents hyperglycemia in nonobese diabetic mice. Nutrition Research 35:4, pages 328-336.
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Mehmet Asim Bilen, Sue-Hwa Lin, Dean G. Tang, Kinjal Parikh, Mong-Hong Lee, Sai-Ching J. Yeung & Shi-Ming Tu. (2015) Maintenance Therapy Containing Metformin and/or Zyflamend for Advanced Prostate Cancer: A Case Series. Case Reports in Oncological Medicine 2015, pages 1-5.
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E-Chu Huang, Yi Zhao, Guoxun Chen, Seung Joon Baek, Michael F McEntee, Steven Minkin, John P Biggerstaff & Jay Whelan. (2014) Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells. BMC Complementary and Alternative Medicine 14:1.
Crossref
Jay Whelan & Yi Zhao. (2014) The interaction of botanicals and AMPK signaling in the inhibition of castrate-resistant prostate cancer. Cancer & Metabolism 2:S1.
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Yiannis Philippou, Marios Hadjipavlou, Shahid Khan & Abhay Rane. (2013) Complementary and alternative medicine ( CAM ) in prostate and bladder cancer . BJU International 112:8, pages 1073-1079.
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Kotha Subbaramaiah, Erika Sue, Priya Bhardwaj, Baoheng Du, Clifford A. Hudis, Dilip Giri, Levy Kopelovich, Xi Kathy Zhou & Andrew J. Dannenberg. (2013) Dietary Polyphenols Suppress Elevated Levels of Proinflammatory Mediators and Aromatase in the Mammary Gland of Obese Mice. Cancer Prevention Research 6:9, pages 886-897.
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. (2013) Current World Literature. Current Opinion in Urology 23:3, pages 283-292.
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