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Nutrition and Cancer Volume 64, 2012 - Issue 7
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Original Articles

Cochinchina Momordica Seed Extract Induces Apoptosis and Cell Cycle Arrest in Human Gastric Cancer Cells Via PARP and p53 Signal Pathways

Hong-Rui Liu Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China
,
Lin-Yi Meng Department of Pharmacy, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China
,
Zhi-Yan Lin Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, China
,
Yang Shen Department of Pharmacy, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China
,
Yun-Qiu Yu Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, China
&
Yi-Zhun Zhu Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, China
Pages 1070-1077 | Received 08 Oct 2012, Accepted 12 Jul 2012, Published online: 28 Sep 2012

Citations (22)

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Zhengdong Ai, Chong Ma, Ruiming Wan, Jingyi Yin, Guiming Li, Yan Li & Li Chen. (2022) Anticancer Activity and Molecular Mechanism of Momordica cochinchinensis Seed Extract in Chronic Myeloid Leukemia Cells. Nutrition and Cancer 74:7, pages 2644-2656.
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Articles from other publishers (21)

Dao Nguyen, Jessica Holien, Chaitali Dekiwadia, Thilini Thrimawithana, Terrence Piva & Tien Huynh. (2023) Momordica cochinchinensis (Gấc) Seed Extracts Induce Apoptosis and Necrosis in Melanoma Cells. Pharmaceuticals 16:1, pages 100.
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Van-Anh Le. 2022. Gac Fruit. Gac Fruit 156 177 .
Dao Nguyen & Tien Huynh. 2022. Gac Fruit. Gac Fruit 15 24 .
Bhuwan C. Joshi, Vijay Juyal, Archana N. Sah, Piyush Verma & Minky Mukhija. (2022) Review on Documented Medicinal Plants used for the Treatment of Cancer. Current Traditional Medicine 8:2.
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Seksom Chainumnim, Audchara Saenkham, Kulvadee Dolsophon, Kittipong Chainok, Sunit Suksamrarn & Wanlaya Tanechpongtamb. (2022) Stem Extract from Momordica cochinchinensis Induces Apoptosis in Chemoresistant Human Prostate Cancer Cells (PC-3). Molecules 27:4, pages 1313.
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Ya-Sai Sun, Zi-Wei Wang, Zhe Gao, Wen Zhao, Kiran Thakur, Qian Zhong & Zhao-Jun Wei. (2022) Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells. Current Research in Food Science 5, pages 904-917.
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Chunyang Chen, He Wang, Xinyu Geng, Dongze Zhang, Zhengyu Zhu, Guangbo Zhang & Jianquan Hou. (2021) Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway. Cancer Cell International 21:1.
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Zheng‐Cai Du, Zhong‐Shang Xia, Yan‐Feng Huang, Yi Peng, Bing‐Bing Cao, Chun‐Qi Li, Yun‐Fei Liang, Fang‐Hui Zhao, Ming‐Zhe Zhang, Zhang‐Mei Chen, Xiao‐Tao Hou, Er‐Wei Hao & Jia‐Gang Deng. (2021) Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish . Journal of Applied Toxicology 41:8, pages 1222-1231.
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Rui Kong, Nan Wang, Wei Han, Wen Bao & Jie Lu. (2021) Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A. PPAR Research 2021, pages 1-20.
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Tien Huynh & Minh H. Nguyen. 2020. Bioactive Compounds in Underutilized Fruits and Nuts. Bioactive Compounds in Underutilized Fruits and Nuts 591 604 .
Thi Van Thanh Do, Liuping Fan, Wildan Suhartini & Mogos Girmatsion. (2019) Gac (Momordica cochinchinensis Spreng) fruit: A functional food and medicinal resource. Journal of Functional Foods 62, pages 103512.
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Xiao-Rong Xu, Chuan-Hong Luo, Bo Cao, Run-Chun Xu, Fang Wang, Xi-Chuan Wei, Ting Zhang, Li Han & Ding-Kun Zhang. (2019) A Potential Anti-Tumor Herb Bred in a Tropical Fruit: Insight into the Chemical Components and Pharmacological Effects of Momordicae Semen. Molecules 24:21, pages 3949.
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Hai-Yue Lan, Bin Zhao, Yu-Li Shen, Xiao-Qin Li, Su-Juan Wang, Li-Jun Zhang & Hong Zhang. (2019) Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis. Current Pharmaceutical Design 25:6, pages 715-728.
Crossref
Tien Huynh & Minh H. Nguyen. 2019. Bioactive Compounds in Underutilized Fruits and Nuts. Bioactive Compounds in Underutilized Fruits and Nuts 1 14 .
Qian Wang, Narayan Acharya, Zhongwei Liu, Xianmei Zhou, Meghan Cromie, Jia Zhu & Weimin Gao. (2018) Enhanced anticancer effects of Scutellaria barbata D. Don in combination with traditional Chinese medicine components on non-small cell lung cancer cells. Journal of Ethnopharmacology 217, pages 140-151.
Crossref
Shu-Yi Yin, Ning-Sun Yang & Tien-Jen Lin. (2017) Phytochemicals Approach for Developing Cancer Immunotherapeutics. Frontiers in Pharmacology 8.
Crossref
Ying Liu, Yu Zhang, Ying Zhao, Dongna Gao, Jing Xing & Hui Liu. (2016) High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. Oncology Letters 12:5, pages 3825-3835.
Crossref
Chih-Jung Yao, Jyh-Ming Chow, Pei-Chun Lin, Tsai-Shu Hu, Hui-Ching Kuo, Jhy-Shrian Huang, Kuan-Jen Bai & Gi-Ming Lai. (2016) Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-12.
Crossref
Hoang V. Chuyen, Minh H. Nguyen, Paul D. Roach, John B. Golding & Sophie E. Parks. (2015) Gac fruit ( Momordica cochinchinensis Spreng.): a rich source of bioactive compounds and its potential health benefits . International Journal of Food Science & Technology 50:3, pages 567-577.
Crossref
Yang Shen, Linyi Meng, Huajun Sun, Yizhun Zhu & Hongrui Liu. (2015) Cochinchina Momordica Seed Suppresses Proliferation and Metastasis in Human Lung Cancer Cells by Regulating Multiple Molecular Targets . The American Journal of Chinese Medicine 43:01, pages 149-166.
Crossref
Hua-Jun Sun, Lin-Yi Meng, Yang Shen, Yi-Zhun Zhu & Hong-Rui Liu. (2013) S-benzyl-cysteine-mediated Cell Cycle Arrest and Apoptosis Involving Activation of Mitochondrial-dependent Caspase Cascade through the p53 Pathway in Human Gastric Cancer SGC-7901 Cells. Asian Pacific Journal of Cancer Prevention 14:11, pages 6379-6384.
Crossref

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