514
Views
52
CrossRef citations to date
0
Altmetric
Original Articles

Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer

&
Pages 1058-1069 | Received 26 Feb 2012, Accepted 23 Jul 2012, Published online: 12 Oct 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Yulia Lipovka, Efrain Alday, Javier Hernandez & Carlos Velazquez. (2023) Molecular Mechanisms of Biologically Active Compounds from Propolis in Breast Cancer: State of the Art and Future Directions. Food Reviews International 39:5, pages 2931-2968.
Read now
Zhe Ma, Yuqi Fan, Yumei Wu, Dereje Kebebe, Bing Zhang, Peng Lu, Jiaxin Pi & Zhidong Liu. (2019) Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment. International Journal of Nanomedicine 14, pages 2029-2053.
Read now
Guan Yang, Shima Bibi, Min Du, Takuya Suzuki & Mei-Jun Zhu. (2017) Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective. Critical Reviews in Food Science and Nutrition 57:18, pages 3830-3839.
Read now
Omar S. Khan, Ajaz A. Bhat, Roopesh Krishnankutty, Ramzi M. Mohammad & Shahab Uddin. (2016) Therapeutic Potential of Resveratrol in Lymphoid Malignancies. Nutrition and Cancer 68:3, pages 365-373.
Read now
Jenny Leipert, Franziska Kässner, Susanne Schuster, Norman Händel, Antje Körner, Wieland Kiess & Antje Garten. (2016) Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity. Nutrition and Cancer 68:2, pages 342-349.
Read now

Articles from other publishers (47)

Mohammad Imran, Areeba Insaf, Nazeer Hasan, Vrushabh V. Sugandhi, Deumaya Shrestha, Keshav Raj Paudel, Saurav Kumar Jha, Philip M. Hansbro, Kamal Dua, Hari Prasad Devkota & Yousuf Mohammed. (2023) Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer. Molecules 28:8, pages 3475.
Crossref
Wamidh H. Talib, Dima Awajan, Reem Ali Hamed, Aya O. Azzam, Asma Ismail Mahmod & Intisar Hadi AL-Yasari. (2022) Combination Anticancer Therapies Using Selected Phytochemicals. Molecules 27:17, pages 5452.
Crossref
Zahra Karimi, Somayeh Taymouri, Mohsen Minaiyan & Mina Mirian. (2022) Evaluation of thermosensitive chitosan hydrogel containing gefitinib loaded cellulose acetate butyrate nanoparticles in a subcutaneous breast cancer model. International Journal of Pharmaceutics 624, pages 122036.
Crossref
Girish Rai & Sudhir Kumar Shekhar. 2022. Breast Cancer: Current Trends in Molecular Research. Breast Cancer: Current Trends in Molecular Research 196 218 .
Kumar Ganesan, Bing Du & Jianping Chen. (2022) Effects and mechanisms of dietary bioactive compounds on breast cancer prevention. Pharmacological Research 178, pages 105974.
Crossref
Zuomin Hu, Mengyuan Li, Yunyun Cao, Otobong Donald Akan, Tianyi Guo & Feijun Luo. (2021) Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention. Molecular Nutrition & Food Research 66:2.
Crossref
Manuel Humberto Cháirez-Ramírez, Karen Griselda de la Cruz-López & Alejandro García-Carrancá. (2021) Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways. Frontiers in Pharmacology 12.
Crossref
Nupur Shrivastava, Babar Iqbal, Javed Ali & Sanjula Baboota. 2021. Discovery and Development of Anti-Breast Cancer Agents from Natural Products. Discovery and Development of Anti-Breast Cancer Agents from Natural Products 231 281 .
Mirele da Silveira Vasconcelos, Luciana Maia Nogueira de Oliveira, Diana Célia Sousa Nunes-Pinheiro, Carolina de Araújo Viana, Ayrles Fernanda Brandão da Silva, Ana Débora Nunes Pinheiro, Semíramis Silva Santos, Joanna de Freitas Rocha, Erika Freitas Mota, Seid Mahdi Jafari, Ana Sanches Silva, Seyed Mohammad Nabavi & Dirce Fernandes de Melo. 2021. Nutraceuticals and Cancer Signaling. Nutraceuticals and Cancer Signaling 201 257 .
Kumar Ganesan, Muthukumaran Jayachandran & Baojun Xu. (2020) Diet-Derived Phytochemicals Targeting Colon Cancer Stem Cells and Microbiota in Colorectal Cancer. International Journal of Molecular Sciences 21:11, pages 3976.
Crossref
Ana Sanches-Silva, Lara Testai, Seyed Fazel Nabavi, Maurizio Battino, Kasi Pandima Devi, Silvia Tejada, Antoni Sureda, Suowen Xu, Bahman Yousefi, Maryam Majidinia, Gian Luigi Russo, Thomas Efferth, Seyed Mohammad Nabavi & Mohammad Hossein Farzaei. (2020) Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway. Pharmacological Research 152, pages 104626.
Crossref
Nethaji Muniraj, Sumit Siddharth & Dipali Sharma. (2019) Bioactive Compounds: Multi-Targeting Silver Bullets for Preventing and Treating Breast Cancer. Cancers 11:10, pages 1563.
Crossref
Arora, Sharma & Tollefsbol. (2019) Combinatorial Epigenetics Impact of Polyphenols and Phytochemicals in Cancer Prevention and Therapy. International Journal of Molecular Sciences 20:18, pages 4567.
Crossref
Abdelhafid Nani, Meriem Belarbi, Babar Murtaza, Chahid Benammar, Taha Merghoub, Mickaël Rialland, Naim Akhtar Khan & Aziz Hichami. (2019) Polyphenols from Pennisetum glaucum grains induce MAP kinase phosphorylation and cell cycle arrest in human osteosarcoma cells. Journal of Functional Foods 54, pages 422-432.
Crossref
Akhilendra Kumar Maurya & Manjula Vinayak. (2018) Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. In Vitro Cellular & Developmental Biology - Animal 55:1, pages 36-44.
Crossref
Danielle N. Kling, Evon M. DeBose-Scarlett, Leandro D. Teixeira, Salvador A. Gezan, Graciela L. Lorca & Claudio F. Gonzalez. (2018) Sex Modulates Lactobacillus johnsonii N6.2 and Phytophenol Effectiveness in Reducing High Fat Diet Induced mTOR Activation in Sprague-Dawley Rats. Frontiers in Microbiology 9.
Crossref
Nour Yahfoufi, Nawal Alsadi, Majed Jambi & Chantal Matar. (2018) The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients 10:11, pages 1618.
Crossref
Sumayah Al-Mahmood, Justin Sapiezynski, Olga B. Garbuzenko & Tamara Minko. (2018) Metastatic and triple-negative breast cancer: challenges and treatment options. Drug Delivery and Translational Research 8:5, pages 1483-1507.
Crossref
Seyung S. Chung, Pranabananda Dutta, David Austin, Piwen Wang, Adam Awad & Jaydutt V. Vadgama. (2018) Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Oncotarget 9:68, pages 32943-32957.
Crossref
Javed Iqbal, Banzeer Ahsan Abbasi, Riffat Batool, Tariq Mahmood, Barkat Ali, Ali Talha Khalil, Sobia Kanwal, Sayed Afzal Shah & Riaz Ahmad. (2018) Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch. European Journal of Pharmacology 827, pages 125-148.
Crossref
Sabira Mohammed & Kuzhuvelil B. Harikumar. 2018. Role of Nutraceuticals in Chemoresistance to Cancer. Role of Nutraceuticals in Chemoresistance to Cancer 61 76 .
María Losada-Echeberría, María Herranz-López, Vicente Micol & Enrique Barrajón-Catalán. (2017) Polyphenols as Promising Drugs against Main Breast Cancer Signatures. Antioxidants 6:4, pages 88.
Crossref
Yingqian Ci, Jinping Qiao & Mei Han. (2016) Molecular Mechanisms and Metabolomics of Natural Polyphenols Interfering with Breast Cancer Metastasis. Molecules 21:12, pages 1634.
Crossref
El Bairi Khalid, EL-Meghawry EL-Kenawy Ayman, Heshu Rahman, Guaadaoui Abdelkarim & Agnieszka Najda. (2016) Natural products against cancer angiogenesis. Tumor Biology 37:11, pages 14513-14536.
Crossref
Dona Sinha, Nivedita Sarkar, Jaydip Biswas & Anupam Bishayee. (2016) Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms. Seminars in Cancer Biology 40-41, pages 209-232.
Crossref
Amilcar Rivera Rivera, Linette Castillo-Pichardo, Yamil Gerena & Suranganie Dharmawardhane. (2016) Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade. PLOS ONE 11:6, pages e0157251.
Crossref
Cihan Erdogan & Ole Vang. (2016) Challenges in Analyzing the Biological Effects of Resveratrol. Nutrients 8:6, pages 353.
Crossref
Chandra K. Singh, Imtiaz A. Siddiqui, Sabah El‐Abd, Hasan Mukhtar & Nihal Ahmad. (2016) Combination chemoprevention with grape antioxidants. Molecular Nutrition & Food Research 60:6, pages 1406-1415.
Crossref
Nai-Wen Kan, Chin-Shan Ho, Yen-Shuo Chiu, Wen-Ching Huang, Pei-Yu Chen, Yu-Tang Tung & Chi-Chang Huang. (2016) Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice. Molecules 21:5, pages 661.
Crossref
Randall F. Holcombe. 2016. Grapes and Health. Grapes and Health 99 117 .
Madhulika Singh & Yogeshwer Shukla. 2015. Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods. Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods 185 217 .
Onat Kadioglu, Jingming Cao, Mohamed E. M. Saeed, Henry Johannes Greten & Thomas Efferth. (2014) Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals. Targeted Oncology 10:3, pages 337-353.
Crossref
KYOUNG JIN NHO, JIN MI CHUN, DONG-SEON KIM & HO KYOUNG KIM. (2015) Ampelopsis japonica ethanol extract suppresses migration and invasion in human MDA-MB-231 breast cancer cells. Molecular Medicine Reports 11:5, pages 3722-3728.
Crossref
Qi Li, Ting Huyan, Lin-Jie Ye, Ji Li, Jun-Ling Shi & Qing-Sheng Huang. (2014) Concentration-Dependent Biphasic Effects of Resveratrol on Human Natural Killer Cells in Vitro . Journal of Agricultural and Food Chemistry 62:45, pages 10928-10935.
Crossref
N. Suganya, E. Bhakkiyalakshmi, T. S. Subin, K. Krishnamurthi, S. Saravana Devi, K. Lau, T. V. Sekar, R. Paulmurugan & K. M. Ramkumar. (2014) Proteomic Identification of Pterostilbene-Mediated Anticancer Activities in HepG2 Cells. Chemical Research in Toxicology 27:7, pages 1243-1252.
Crossref
Jin-Ran Chen, Oxana P Lazarenko, Jian Zhang, Michael L Blackburn, Martin JJ Ronis & Thomas M Badger. (2014) Diet-Derived Phenolic Acids Regulate Osteoblast and Adipocyte Lineage Commitment and Differentiation in Young Mice. Journal of Bone and Mineral Research 29:5, pages 1043-1053.
Crossref
JUN WANG, JIAN-ZHE LI, AI-XIA LU, KE-FEN ZHANG & BAO-JIANG LI. (2014) Anticancer effect of salidroside on A549 lung cancer cells through inhibition of oxidative stress and phospho-p38 expression. Oncology Letters 7:4, pages 1159-1164.
Crossref
Raffaele Frazzi & Marco Tigano. (2014) The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia. International Journal of Molecular Sciences 15:3, pages 4977-4993.
Crossref
Hongzhong Li, Jing Huang, Bing Yang, Tingxiu Xiang, Xuedong Yin, Weiyan Peng, Wei Cheng, Jingyuan Wan, Fuling Luo, Hongyuan Li & Guosheng Ren. (2013) Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway. Toxicology and Applied Pharmacology 272:1, pages 180-190.
Crossref
Lei Tang, Yian Peng, Tiantian Xu, Xiaoqing Yi, Ying Liu, Yuchao Luo, Dong Yin & Ming He. (2013) The effects of quercetin protect cardiomyocytes from A/R injury is related to its capability to increasing expression and activity of PKCε protein. Molecular and Cellular Biochemistry 382:1-2, pages 145-152.
Crossref
Shin Sato, Yuuka Mukai, Mai Hamaya, Yongkun Sun & Masaaki Kurasaki. (2013) Long-term effect of green tea extract during lactation on AMPK expression in rat offspring exposed to fetal malnutrition. Nutrition 29:9, pages 1152-1158.
Crossref
Kristina Gaivelyte, Valdas Jakstas, Almantas Razukas & Valdimaras Janulis. (2013) Variation in the Contents of Neochlorogenic Acid, Chlorogenic Acid and Three Quercetin Glycosides in Leaves and Fruits of Rowan ( Sorbus ) Species and Varieties from Collections in Lithuania . Natural Product Communications 8:8, pages 1934578X1300800.
Crossref
Chandra K. Singh, Jasmine George & Nihal Ahmad. (2013) Resveratrol‐based combinatorial strategies for cancer management. Annals of the New York Academy of Sciences 1290:1, pages 113-121.
Crossref
Ruei-Er Wu, Wen-Ching Huang, Chen-Chung Liao, Yu-Kai Chang, Nai-Wen Kan & Chi-Chang Huang. (2013) Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice. Molecules 18:4, pages 4689-4702.
Crossref
Sanjeev Banerjee & Paulraj Rajamani. 2013. Natural Products. Natural Products 2175 2254 .
Jeffrey A Stuart & Ellen L RobbJeffrey A. Stuart & Ellen L. Robb. 2013. Bioactive Polyphenols from Wine Grapes. Bioactive Polyphenols from Wine Grapes 27 52 .
Jeffrey A Stuart & Ellen L RobbJeffrey A. Stuart & Ellen L. Robb. 2013. Bioactive Polyphenols from Wine Grapes. Bioactive Polyphenols from Wine Grapes 9 25 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.