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Original Articles

Diallyl Disulfide-Induced Apoptosis in a Breast-Cancer Cell Line (MCF-7) May Be Caused by Inhibition of Histone Deacetylation

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Pages 1251-1260 | Received 19 Aug 2011, Accepted 16 Jul 2012, Published online: 19 Nov 2012

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Loredana Cappellacci, Diego R. Perinelli, Filippo Maggi, Mario Grifantini & Riccardo Petrelli. (2020) Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents. Current Medicinal Chemistry 27:15, pages 2449-2493.
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Manasa Akella, Krishna Chaitanya Amajala & Rama Rao Malla. (2019) Bioinformatics analysis of regulatory elements of the CD151 gene and insilico docking of CD151 with diallyl sulfide. Gene Reports 17, pages 100551.
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Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi & Arshad H. Rahmani. (2019) Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways. Anti-Cancer Agents in Medicinal Chemistry 19:11, pages 1314-1324.
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Deyu Huang, LuQing Cui, Saeed Ahmed, Fatima Zainab, Qinghua Wu, Xu Wang & Zonghui Yuan. (2019) An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs. Food and Chemical Toxicology 123, pages 574-594.
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Sona Uramova, Peter Kubatka, Zuzana Dankova, Andrea Kapinova, Barbora Zolakova, Marek Samec, Pavol Zubor, Anthony Zulli, Vanda Valentova, Taeg Kyu Kwon, Peter Solar, Martin Kello, Karol Kajo, Dietrich Busselberg, Martin Pec & Jan Danko. (2018) Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach. EPMA Journal 9:4, pages 403-419.
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Santiago Lascano, Marie Lopez & Paola B. Arimondo. (2018) Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers. The Chemical Record 18:12, pages 1854-1876.
Crossref
Javed Iqbal, Banzeer Ahsan Abbasi, Riffat Batool, Tariq Mahmood, Barkat Ali, Ali Talha Khalil, Sobia Kanwal, Sayed Afzal Shah & Riaz Ahmad. (2018) Potential phytocompounds for developing breast cancer therapeutics: Nature’s healing touch. European Journal of Pharmacology 827, pages 125-148.
Crossref
Ran Liu, Ye‑Ning Yang, Lan Yi, Jing Qing, Qing‑Ye Li, Wen‑Song Wang, Juan Wang, Yu‑Xian Tang & Hui Tan. (2018) Diallyl disulfide effect on the invasion and migration ability of HL-60 cells with a high expression of DJ-1 in the nucleus through the suppression of the Src signaling pathway. Oncology Letters.
Crossref
Magdalena Izdebska, Wioletta Zielińska, Dariusz Grzanka & Maciej Gagat. (2018) The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. BioMed Research International 2018, pages 1-13.
Crossref
Xiaoli Peng, Hui Chang, Junli Chen, Qianyong Zhang, Xiaoping Yu & Mantian Mi. (2017) 3,6-Dihydroxyflavone regulates microRNA-34a through DNA methylation. BMC Cancer 17:1.
Crossref
Debojit Bhattacherjee, Chitra Basu, Queen Bhardwaj, Sourav Mal, Subhajit Sahu, Runa Sur & Krishna P. Bhabak. (2017) Design, Synthesis and Anti‐Cancer Activities of Benzyl Analogues of Garlic‐Derived Diallyl Disulfide (DADS) and the Corresponding Diselenides. ChemistrySelect 2:24, pages 7399-7406.
Crossref
Ya Li, Sha Li, Xiao Meng, Ren-You Gan, Jiao-Jiao Zhang & Hua-Bin Li. (2017) Dietary Natural Products for Prevention and Treatment of Breast Cancer. Nutrients 9:7, pages 728.
Crossref
Zhi-hui Zhou, Jie Yang & Ah-Ng Kong. (2017) Phytochemicals in Traditional Chinese Herbal Medicine: Cancer Prevention and Epigenetics Mechanisms. Current Pharmacology Reports 3:2, pages 77-91.
Crossref
Lan Yi, Jian Shan, Xin Chen, Guoqing Li, Linwei Li, Hui Tan & Qi Su. (2016) Involvement of calreticulin in cell proliferation, invasion and differentiation in diallyl disulfide-treated HL-60 cells. Oncology Letters 12:3, pages 1861-1867.
Crossref
Esma Yagdi, Claudia Cerella, Mario Dicato & Marc Diederich. (2016) Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?. Food and Chemical Toxicology 95, pages 219-233.
Crossref
Z Meng, L-F Jia & Y-H Gan. (2015) PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. Oncogene 35:18, pages 2333-2344.
Crossref
N Habib Tito, O Altonsy Mohammed, A Abd El Raheem Soheir & R Bakeer Yassmin. (2016) Diallyl disulfide protects against rectal cancer in vivo model of male rabbits: II-Analysis of histological and cytogenetic variations. Journal of Cancer Research and Experimental Oncology 8:1, pages 1-14.
Crossref
Alak Manna, Subrata Chattopadhyay & Mitali Chatterjee. 2016. 81 129 .
Gordana Supic, Darja Wagner & Zvonko Magic. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 153 181 .
Yue Guo, Zheng-Yuan Su & Ah-Ng Tony Kong. (2015) Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals. Current Pharmacology Reports 1:4, pages 245-257.
Crossref
Jing Huang, Bing Yang, Tingxiu Xiang, Weiyan Peng, Zhu Qiu, Jingyuan Wan, Li Zhang, Hongyuan Li, Hongzhong Li & Guosheng Ren. (2015) Diallyl disulfide inhibits growth and metastatic potential of human triple‐negative breast cancer cells through inactivation of the β‐catenin signaling pathway. Molecular Nutrition & Food Research 59:6, pages 1063-1075.
Crossref
S Ansar, M Iqbal & N AlJameil. (2014) Diallyl sulphide, a component of garlic, abrogates ferric nitrilotriacetate-induced oxidative stress and renal damage in rats. Human & Experimental Toxicology 33:12, pages 1209-1216.
Crossref
Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Feng Ye, Hailin Tang & Xiaoming Xie. (2014) Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a. PLoS ONE 9:11, pages e112720.
Crossref
XIAORAN YIN, RONG ZHANG, CHENG FENG, JUN ZHANG, DONG LIU, KUN XU, XIJING WANG, SHUQUN ZHANG, ZONGFANG LI, XINLIAN LIU & HONGBING MA. (2014) Diallyl disulfide induces G2/M arrest and promotes apoptosis through the p53/p21 and MEK-ERK pathways in human esophageal squamous cell carcinoma. Oncology Reports 32:4, pages 1748-1756.
Crossref
Xiaoran Yin, Jun Zhang, Xiaoning Li, Dong Liu, Cheng Feng, Rongrui Liang, Kun Zhuang, Chenlei Cai, Xinghuan Xue, Fuchun Jing, Xijing Wang, Jun Wang, Xinlian Liu & Hongbing Ma. (2014) DADS Suppresses Human Esophageal Xenograft Tumors through RAF/MEK/ERK and Mitochondria-Dependent Pathways. International Journal of Molecular Sciences 15:7, pages 12422-12441.
Crossref
X.Y. Lan, H.Y. Sun, J.J. Liu, Y. Lin, Z.Y. Zhu, X. Han, X. Sun, X.R. Li, H.C. Zhang & Z.Y. Tang. (2013) Effects of Garlic Oil on Pancreatic Cancer Cells. Asian Pacific Journal of Cancer Prevention 14:10, pages 5905-5910.
Crossref
Hailin Tang, Yanan Kong, Jiaoli Guo, Yi Tang, Xinhua Xie, Lu Yang, Qi Su & Xiaoming Xie. (2013) Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Letters 340:1, pages 72-81.
Crossref

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