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Original Articles

Nobiletin Induces Apoptosis and Potentiates the Effects of the Anticancer Drug 5-Fluorouracil in p53-Mutated SNU-16 Human Gastric Cancer Cells

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Pages 286-295 | Received 12 Mar 2012, Accepted 28 Nov 2012, Published online: 26 Feb 2013

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Yun-Yi Chen, Jiao-Jiao Liang, Deng-Liang Wang, Jie-Biao Chen, Jin-Ping Cao, Yue Wang & Chong-De Sun. (2023) Nobiletin as a chemopreventive natural product against cancer, a comprehensive review. Critical Reviews in Food Science and Nutrition 63:23, pages 6309-6329.
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Diana P. Sousa, Marta Pojo, Ana T. Pinto, Valeriano Leite, Ana Teresa Serra & Branca M. Cavaco. (2020) Nobiletin Alone or in Combination with Cisplatin Decreases the Viability of Anaplastic Thyroid Cancer Cell Lines. Nutrition and Cancer 72:2, pages 352-363.
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Gamze Guney Eskiler, Asuman Ozkan Deveci, Cemil Bilir & Suleyman Kaleli. (2019) Synergistic Effects of Nobiletin and Sorafenib Combination on Metastatic Prostate Cancer Cells. Nutrition and Cancer 71:8, pages 1299-1312.
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Hyeonji Kim, Jeong Yong Moon, Supawadee Burapan, Jaehong Han & Somi Kim Cho. (2018) Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4′-Trimethoxyflavone Isolated from Kaempferia parviflora Tea Infusion. Nutrition and Cancer 70:6, pages 984-996.
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Yijing Li, Jingyi Hong, Haowen Li, Xiaoyu Qi, Yifei Guo, Meihua Han & Xiangtao Wang. (2017) Genkwanin nanosuspensions: a novel and potential antitumor drug in breast carcinoma therapy. Drug Delivery 24:1, pages 1491-1500.
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Articles from other publishers (24)

Reza Moazamiyanfar, Sepideh Rezaei, Hasan AliAshrafzadeh, Nima Rastegar-Pouyani, Emad Jafarzadeh, Kave Mouludi, Ehsan Khodamoradi, Mohsen Zhaleh, Shahram Taeb & Masoud Najafi. (2023) Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives. Current Pharmaceutical Design 29:22, pages 1713-1728.
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Yu Wang, Haidong Guo & Feng He. (2022) Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets. Cancer and Metastasis Reviews 42:1, pages 297-322.
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Ying Tan, Heping Wang, Bowen Xu, Xiaoxiao Zhang, Guanghui Zhu, Yuansha Ge, Taicheng Lu, Ruike Gao & Jie Li. (2022) Chinese herbal medicine combined with oxaliplatin-based chemotherapy for advanced gastric cancer: A systematic review and meta-analysis of contributions of specific medicinal materials to tumor response. Frontiers in Pharmacology 13.
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Jun Huang, Zaoshang Chang, Quzhe Lu, Xuedong Chen & Masoud Najafi. (2022) Nobiletin as an inducer of programmed cell death in cancer: a review. Apoptosis 27:5-6, pages 297-310.
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Yuan Wu, Chien-shan Cheng, Qiong Li, Jing-xian Chen, Ling-ling Lv, Jia-yue Xu, Kai-yuan Zhang & Lan Zheng. (2021) The Application of Citrus folium in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-15.
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Mahboubeh Tajaldini & Jahanbakhsh Asadi. (2021) The Use of Bio-Active Compounds of Citrus Fruits as Chemopreventive Agents and Inhibitor of Cancer Cells Viability. Anti-Cancer Agents in Medicinal Chemistry 21:9, pages 1058-1068.
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Siddharth S. Kesharwani, Pooja Mallya, Vadikari Arun Kumar, Vikas Jain, Swagat Sharma & Surajit Dey. (2020) Nobiletin as a Molecule for Formulation Development: An Overview of Advanced Formulation and Nanotechnology-Based Strategies of Nobiletin. AAPS PharmSciTech 21:6.
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Milad Ashrafizadeh, Ali Zarrabi, Sedigheh Saberifar, Farid Hashemi, Kiavash Hushmandi, Fardin Hashemi, Ebrahim Rahmani Moghadam, Reza Mohammadinejad, Masoud Najafi & Manoj Garg. (2020) Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways. Biomedicines 8:5, pages 110.
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Eman H. Yousef, Mohamed E El-Mesery, Maha R Habeeb & Laila A Eissa. (2020) Polo-like kinase 1 as a promising diagnostic biomarker and potential therapeutic target for hepatocellular carcinoma. Tumor Biology 42:4, pages 101042832091447.
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Goh, Tan, Goh, Chan, Pusparajah, Lee & Goh. (2019) Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention. Cancers 11:6, pages 867.
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Jeong Moon, Le Manh Hung, Tatsuya Unno & Somi Cho. (2018) Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3β/β–Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells. Nutrients 10:12, pages 1829.
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Guoyuan Qi, Rui Guo, Haoyu Tian, Lixia Li, Hua Liu, Yashi Mi & Xuebo Liu. (2018) Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863:6, pages 549-562.
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Libin Liu & Xing wei Wu. (2018) Nobiletin protects human retinal pigment epithelial cells from hydrogen peroxide–induced oxidative damage. Journal of Biochemical and Molecular Toxicology 32:5.
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Ho Hyun, Jeong Moon & Somi Cho. (2018) Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. Molecules 23:2, pages 209.
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Chulwon Kim, Il Ho Lee, Ho Bong Hyun, Jong-Chan Kim, Rajendra Gyawali, Seok-Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Somi K. Cho & Kwang Seok Ahn. (2016) Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model . Integrative Cancer Therapies 16:2, pages 227-243.
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Santa Cirmi, Nadia Ferlazzo, Giovanni Lombardo, Alessandro Maugeri, Gioacchino Calapai, Sebastiano Gangemi & Michele Navarra. (2016) Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?. Nutrients 8:11, pages 698.
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Jeong Moon & Somi Cho. (2016) Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells. Molecules 21:7, pages 914.
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Hsin-Lin Cheng, Ming-Ju Hsieh, Jia-Sin Yang, Chiao-Wen Lin, Ko-Haung Lue, Ko-Hsiu Lu & Shun-Fa Yang. (2016) Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget 7:23, pages 35208-35223.
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Hao Huang, Linfu Li, Weimei Shi, Hai Liu, Jianqiong Yang, Xiaoliang Yuan & Longhuo Wu. (2016) The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro . Evidence-Based Complementary and Alternative Medicine 2016, pages 1-14.
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Ogunc Meral, Merve Alpay, Gorkem Kismali, Funda Kosova, Dilek Ulker Cakir, Mert Pekcan, Serbulent Yigit & Tevhide Sel. (2014) Capsaicin inhibits cell proliferation by cytochrome c release in gastric cancer cells. Tumor Biology 35:7, pages 6485-6492.
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Xue Jin, Xiurong Hu, Qiwen Wang, Kai Wang, Qi Yao, Guping Tang & Paul K. Chu. (2014) Multifunctional cationic polymer decorated and drug intercalated layered silicate (NLS) for early gastric cancer prevention. Biomaterials 35:10, pages 3298-3308.
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Ayaka Ikeda, Shingo Miyata, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degawa & Kiyomitsu Nemoto. (2014) Estimation of endoplasmic reticulum stress-inducing ability of nobiletin, a citrus polymethoxyflavonoid, in SK-N-SH human neuroblastoma cells. Fundamental Toxicological Sciences 1:4, pages 169-172.
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Yeon Woo Song, Sanggyu Park, Somi K. Cho, Dongsoo Koh & Moonjae Cho. (2013) Synergistic effect of the novel benzochalcone derivative DK-78 and doxorubicin on MCF7-VN breast cancer stem cells. Journal of the Korean Society for Applied Biological Chemistry 56:5, pages 631-635.
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Yeonwoo Song, Keun Sik Moon & Somi Kim Cho. (2013) Antioxidant Activity and Nutrient Content of Ethanol and Hot-Water Extracts of Citrus unshiu Pomace. Journal of the Korean Society of Food Science and Nutrition 42:9, pages 1345-1350.
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