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Review Articles

Chemopreventive and Anti-Cancer Efficacy of Silibinin Against Growth and Progression of Lung Cancer

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Pages 3-11 | Received 17 Jul 2012, Accepted 06 Sep 2012, Published online: 17 May 2013

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Niloufar Keyhanmehr, Hossein Motedayyen & Nahid Eskandari. (2019) The Effects of Silymarin and Cyclosporine A on the Proliferation and Cytokine Production of Regulatory T Cells. Immunological Investigations 48:5, pages 533-548.
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Xing-Xing Zhu, Ya-Hui Ding, Yi Wu, Lin-Yan Qian, Hai Zou & Qiang He. (2016) Silibinin: a potential old drug for cancer therapy. Expert Review of Clinical Pharmacology 9:10, pages 1323-1330.
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BRUNA COROMINAS-FAJA, Cristina Oliveras-Ferraros, ELISABET CUYÀS, Antonio Segura-Carretero, Jorge Joven, Begoña Martin-Castillo, ENRIQUE BARRAJÓN-CATALÁN, Vicente Micol, Joaquim Bosch-Barrera & JAVIERABEL MENENDEZ MENENDEZ. (2013) Stem cell-like ALDHbright cellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin. Cell Cycle 12:21, pages 3390-3404.
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Yibin Zhou, Fenglan Wang, Guangda Li, Jing Xu, Jingjing Zhang, Elizabeth Gullen, Jie Yang & Jing Wang. (2024) From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer. Frontiers in Immunology 15.
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Abhishek Wahi, Priti Jain, Apurba Sinhari & Hemant R. Jadhav. (2023) Progress in discovery and development of natural inhibitors of histone deacetylases (HDACs) as anti-cancer agents. Naunyn-Schmiedeberg's Archives of Pharmacology 397:2, pages 675-702.
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Elif Ayazoglu Demir, Ahmet Mentese, Hatice Kucuk, Nihal Turkmen Alemdar & Selim Demir. (2023) The therapeutic effect of silibinin against 5‐fluorouracil‐induced ovarian toxicity in rats. Journal of Biochemical and Molecular Toxicology 37:9.
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Hemlata Bhardwaj, Neeru Vasudeva & Sunil Sharma. (2023) Possible Mechanism and Pharmacological Activities of a Flavolignan Silibinin. Current Bioactive Compounds 19:7.
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Chetna Gupta, Aadya Jaipuria & Nikesh Gupta. (2022) Inhalable Formulations to Treat Non-Small Cell Lung Cancer (NSCLC): Recent Therapies and Developments. Pharmaceutics 15:1, pages 139.
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Sally Abou Taleb, Yassmin Moatasim, Mohamed GabAllah & Marwa Hasanein Asfour. (2022) Quercitrin loaded cyclodextrin based nanosponge as a promising approach for management of lung cancer and COVID-19. Journal of Drug Delivery Science and Technology 77, pages 103921.
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Rangnath Ravi, Md. Zeyaullah, Shubhrima Ghosh, Mohiuddin Khan Warsi, Renu Baweja, Abdullah M. AlShahrani, Abhijeet Mishra & Razi Ahmad. (2022) Use of gold nanoparticle-silibinin conjugates: A novel approach against lung cancer cells. Frontiers in Chemistry 10.
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Sedat KAÇAR & Nuriye Ezgi BEKTUR AYKANAT. (2021) Silimarin SLIT2 Proteinini Aktive Ederek ve CXCR4 Ekspresyonunu Baskılayarak A549 Hücrelerini İnhibe EttiSilymarin Inhibited A549 Cells by Activating SLIT2 Protein and Suppressing Expression of CXCR4. Uludağ Üniversitesi Tıp Fakültesi Dergisi 47:3, pages 327-334.
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Aviram Trachtenberg, Katarzyna Sidoryk, Somaya Alreate, Suchismita Muduli, Andrzej Leś, Marcin Cybulski & Michael Danilenko. (2021) Structure-Activity Relationship of Hydroxycinnamic Acid Derivatives for Cooperating with Carnosic Acid and Calcitriol in Acute Myeloid Leukemia Cells. Biomedicines 9:11, pages 1517.
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Hardeep Singh Tuli, Sonam Mittal, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Sushil Kumar Upadhyay, Tushar Singh Barwal, Aklank Jain, Ginpreet Kaur, Raj Savla, Katrin Sak, Manoj Kumar, Mehmet Varol, Ashif Iqubal & Anil Kumar Sharma. (2021) Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance. Seminars in Cancer Biology 73, pages 196-218.
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Alexis Rugamba, Dong Young Kang, Nipin Sp, Eun Seong Jo, Jin-Moo Lee, Se Won Bae & Kyoung-Jin Jang. (2021) Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells. Cells 10:7, pages 1632.
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Sara Verdura, Elisabet Cuyàs, Verónica Ruiz-Torres, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera & Javier A. Menendez. (2021) Lung Cancer Management with Silibinin: A Historical and Translational Perspective. Pharmaceuticals 14:6, pages 559.
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Tingting Wen, Lei Song & Shucheng Hua. (2021) Perspectives and controversies regarding the use of natural products for the treatment of lung cancer. Cancer Medicine 10:7, pages 2396-2422.
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Rabia Akram, Haseeb Anwar, Azhar Rasul, Shoaib Ahmad Malik, Javeria Maqbool, Faiqa Sajid & Ghulam Hussain. 2021. Medicinal Plants for Lung Diseases. Medicinal Plants for Lung Diseases 229 256 .
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Suyan Xu, Hongyan Zhang, Aifeng Wang, Yongcheng Ma, Yuan Gan & Guofeng Li. (2020) Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1. Cellular & Molecular Biology Letters 25:1.
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Meirong Huo, Honglan Wang, Ying Zhang, Han Cai, Pan Zhang, Lingchao Li, Jianping Zhou & Tingjie Yin. (2020) Co-delivery of silybin and paclitaxel by dextran-based nanoparticles for effective anti-tumor treatment through chemotherapy sensitization and microenvironment modulation. Journal of Controlled Release 321, pages 198-210.
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Ramesh K. Bonta. (2020) Dietary Phenolic Acids and Flavonoids as Potential Anti-Cancer Agents: Current State of the Art and Future Perspectives. Anti-Cancer Agents in Medicinal Chemistry 20:1, pages 29-48.
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Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohammadinejad, Tahereh Farkhondeh & Saeed Samarghandian. (2020) Nano-soldiers Ameliorate Silibinin Delivery: A Review Study. Current Drug Delivery 17:1, pages 15-22.
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Dominique Reed, Komal Raina & Rajesh Agarwal. 2020. Natural Products for Cancer Chemoprevention. Natural Products for Cancer Chemoprevention 161 208 .
Liyue Qin, Ziyu Chen, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Weiqi Zhang, Qi Xu, Fei Huang & Xiaojun Wu. (2019) Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice. Toxicology 426, pages 152256.
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Elisabet Cuyàs, Sara Verdura, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera, José Antonio Encinar & Javier A. Menendez. (2019) Revisiting silibinin as a novobiocin-like Hsp90 C-terminal inhibitor: Computational modeling and experimental validation. Food and Chemical Toxicology 132, pages 110645.
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Altaf Mohammed, Jennifer T Fox & Mark Steven Miller. (2019) Cancer Chemoprevention: Preclinical In Vivo Alternate Dosing Strategies to Reduce Drug Toxicities. Toxicological Sciences 170:2, pages 251-259.
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Nataliya B. Feldman, Tatiana I. Gromovykh, Natalia E. Sedyakina, Ivan I. KrasnyukJrJr & Sergey V. Lutsenko. (2018) Cytotoxic and Antitumor Activity of Liposomal Silibinin. BioNanoScience 8:4, pages 971-976.
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Zohreh Jahanafrooz, Nasrin Motamed, Beate Rinner, Ahad Mokhtarzadeh & Behzad Baradaran. (2018) Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator. Life Sciences 213, pages 236-247.
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Hong-rui Zhang. (2018) Artesunate Improves Drug Resistance of Lung Carcinomas Via Regulation of MiR-493-5p. Clinical surgery research communications 2:2.
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Wen-qing Ge. (2018) MiR-539 Inhibits Inflammation in Renal Transplant Iscemia-Reperfusion Injury Via Blocking the MyD88/NF-κB Pathway. Clinical surgery research communications 2:2.
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Dongjie Ma, Shanqing Li, Yushang Cui, Li Li, Hongsheng Liu, Yeye Chen & Xiaoyun Zhou. (2018) Paclitaxel increases the sensitivity of lung cancer cells to lobaplatin via PI3K/Akt pathway. Oncology Letters.
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Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu & Ying Xie. (2018) Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. Pharmacological Research 128, pages 153-166.
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Jiyeon Ham, Whasun Lim, Fuller W. Bazer & Gwonhwa Song. (2017) Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells. Journal of Cellular Physiology 233:2, pages 1638-1649.
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Zhuan-Li Bai, Vincent Tay, Shu-Zhong Guo, Juan Ren & Mao-Guo Shu. (2018) Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP. BioMed Research International 2018, pages 1-10.
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Cha Kuen, Sharida Fakurazi, Siti Othman & Mas Masarudin. (2017) Increased Loading, Efficacy and Sustained Release of Silibinin, a Poorly Soluble Drug Using Hydrophobically-Modified Chitosan Nanoparticles for Enhanced Delivery of Anticancer Drug Delivery Systems. Nanomaterials 7:11, pages 379.
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Camila Ribeiro de Avelar, Emile Miranda Pereira, Priscila Ribas de Farias Costa, Rosângela Passos de Jesus & Lucivalda Pereira Magalhães de Oliveira. (2017) Effect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis. World Journal of Gastroenterology 23:27, pages 5004.
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Cynthia Tilley, Gagan Deep & Rajesh Agarwal. (2015) Chemopreventive opportunities to control basal cell carcinoma: Current perspectives. Molecular Carcinogenesis 54:9, pages 688-697.
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Joaquim Bosch-Barrera & Javier A. Menendez. (2015) Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. Cancer Treatment Reviews 41:6, pages 540-546.
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Zeynep Birsu Cincin, Miray Unlu, Bayram Kiran, Elif Sinem Bireller, Yusuf Baran & Bedia Cakmakoglu. (2015) Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells. Cellular Oncology 38:3, pages 195-204.
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Feng Li, Zhenkun Ma, Zhenfeng Guan, Yule Chen, Kaijie Wu, Peng Guo, Xinyang Wang, Dalin He & Jin Zeng. (2015) Autophagy Induction by Silibinin Positively Contributes to Its Anti-Metastatic Capacity via AMPK/mTOR Pathway in Renal Cell Carcinoma. International Journal of Molecular Sciences 16:12, pages 8415-8429.
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