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Nutrition and Cancer Volume 66, 2014 - Issue 3
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Original Articles

In Vitro and In Vivo Antitumor Activity of Bulbus Fritillariae Cirrhosae and Preliminary Investigation of Its Mechanism

Dong-Dong Wang Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, Chengdu, PR China
,
Yong Feng Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, PR China
,
Zu Li Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, Chengdu, PR China
,
Li Zhang Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, Chengdu, PR China
,
Shu Wang Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, Chengdu, PR China
,
Chao-Yang Zhang Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, Chengdu, PR China
,
Xiao-Xia Wang Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, Chengdu, PR China
&
Zi-Yu Liu Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, Chengdu, PR China
 show all
Pages 441-452 | Received 17 Jun 2013, Accepted 10 Nov 2013, Published online: 28 Feb 2014

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Meilan Xian, Jiaoyuan Xu, Yamei Zheng, Lei Zhang, Jie Zhao, Jie Chen, Siguang Li, Lingsang Lin, Yi Zhong, Zehua Yang, Tian Xie, Linhui Huang & Yipeng Ding. (2024) Network Pharmacology and Experimental Verification Reveal the Regulatory Mechanism of Chuanbeimu in Treating Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 19, pages 799-813.
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Articles from other publishers (27)

Pengyan Qi, Yuna Zhang, Chunsheng Zhao, Linlin Sun, Ronglu Bai, Lizhi Wang & Chao Sun. (2023) Research progress on biological regulation and biosynthesis of isosteroid alkaloids in Fritillaria. Plant Growth Regulation 101:3, pages 599-615.
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Leihao Hu, Jiamin Luo, Guiqing Wen, Lingling Sun, Wei Liu, Hao Hu, Jing Li, Lisheng Wang, Weiwei Su & Lizhu Lin. (2023) Identification of the active compounds in the Yi-Fei-San-Jie formula using a comprehensive strategy based on cell extraction/UPLC-MS/MS, network pharmacology, and molecular biology techniques. Phytomedicine 115, pages 154843.
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Demei Huang, Zherui Shen, Sijing Zhao, Caixia Pei, Nan Jia, Yilan Wang, Yongcan Wu, Xiaomin Wang, Shihua Shi, Yacong He, Zhenxing Wang & Fei Wang. (2023) Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway. Chemico-Biological Interactions 376, pages 110448.
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Xiaomu Zhu, Ting Zhou, Shu Wang, Bengui Ye, Rajeev K. Singla, Devesh Tewari, Atanas G. Atanasov, Dongdong Wang & Simei Liu. (2023) LC–MS/MS Coupled with Chemometric Analysis as an Approach for the Differentiation of Fritillariae cirrhosae Bulbus and Fritillariae pallidiflorae Bulbus. Separations 10:2, pages 75.
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语诗 林. (2023) Advances in the Study of Anti-Inflammatory Effects of Fritillariae cirrhosae Bulbus and Its Main Components. Advances in Clinical Medicine 13:06, pages 10212-10219.
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Qiuxia Lu, Rui Li, Jiaqing Liao, Yuqin Hu, Yundong Gao, Mingcheng Wang, Jian Li & Qi Zhao. (2022) Integrative analysis of the steroidal alkaloids distribution and biosynthesis of bulbs Fritillariae Cirrhosae through metabolome and transcriptome analyses. BMC Genomics 23:1.
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Basharat Ahmad Bhat, Wajahat Rashid Mir, Bashir Ahmad Sheikh, Mustafa Alkanani & Manzoor Ahmad Mir. (2022) Metabolite fingerprinting of phytoconstituents from Fritillaria cirrhosa D. Don and molecular docking analysis of bioactive peonidin with microbial drug target proteins. Scientific Reports 12:1.
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Yunyun Quan, Li Li, Zhujun Yin, Shilong Chen, Jing Yi, Jirui Lang, Lu Zhang, Qianhua Yue & Junning Zhao. (2022) Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?. Frontiers in Pharmacology 12.
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Lin Yang, Mengrui Zhang, Tiechui Yang, Tse Wai Ming, Tse Kathy Wai Gaun & Bengui Ye. (2021) LC–MS/MS coupled with chemometric analysis as an approach for the differentiation of bulbus Fritillaria unibracteata and Fritillaria ussuriensis . Phytochemical Analysis 32:6, pages 957-969.
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Ishrat Rashid & Ubaid Yaqoob. (2021) Traditional uses, phytochemistry and pharmacology of genus Fritillaria—a review. Bulletin of the National Research Centre 45:1.
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Ting Chen, Furong Zhong, Cheng Yao, Jia Chen, Yiqing Xiang, Jijing Dong, Zhuyun Yan & Yuntong Ma. (2020) A Systematic Review on Traditional Uses, Sources, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Fritillariae Cirrhosae Bulbus. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-26.
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Rui Li, Yang Zhang, Yucheng Wang, Kejia Huang, Qianye Yang, Tiantian Zhang, Kun Xie, Jian Li & Qi Zhao. (2020) Aqueous extract of Fritillariae cirrhosae induces cellular apoptosis through activation of STATs-mediated immunomodulation. Journal of Ethnopharmacology 261, pages 112338.
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Ying Guo, Nan Jiang, Li Zhang & Min Yin. (2020) Green synthesis of gold nanoparticles from Fritillaria cirrhosa and its anti-diabetic activity on Streptozotocin induced rats. Arabian Journal of Chemistry 13:4, pages 5096-5106.
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Xihan Guo, Xiayu Wu, Juan Ni, Ling Zhang, Jinglun Xue & Xu Wang. (2020) Aqueous extract of bulbus Fritillaria cirrhosa induces cytokinesis failure by blocking furrow ingression in human colon epithelial NCM460 cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 850-851, pages 503147.
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Hailin Tan, Guiming Zhang, Xuecheng Yang, Tao Jing, Daqing Shen & Xinsheng Wang. (2019) Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca 2+ /CaMKII/JNK pathway . Journal of Cellular Biochemistry 121:1, pages 81-92.
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Zhenhua Yin, Juanjuan Zhang, Qingfeng Guo, Lin Chen, Wei Zhang & Wenyi Kang. (2019) Pharmacological Effects of Verticine: Current Status. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-8.
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Mostafa Kardan, Zahra Yazdani, Zaher Morsaljahan, MohammadAli Ebrahimzadeh & Alireza Rafiei. (2019) Cytotoxic effect of methanolic extracts of Fritillaria imperialis bulbs and Eryngium caucasicum leaves on hepatoma and colon cancer cells. Asian Pacific Journal of Tropical Biomedicine 9:8, pages 353.
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Te-Mao Li, Yang-Hao Yu, Fuu-Jen Tsai, Chi-Fung Cheng, Yang-Chang Wu, Tsung-Jung Ho, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang & Ying-Ju Lin. (2018) Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan. Journal of Ethnopharmacology 213, pages 92-100.
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Hadiya Shafi, Irshad Ahmad Nawchoo, Saqib Ahmad Shah & Zahoor Ahmad Kaloo. (2016) Ex Situ Conservation Strategies for Fritillaria cirrhosa D. Don (Liliaceae): A Critically Endangered Medicinal Herb of Kashmir Himalaya. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 88:1, pages 33-41.
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Dongdong Wang, Xiong Chen, Atanas G. Atanasov, Xiao Yi & Shu Wang. (2017) Plant Resource Availability of Medicinal Fritillaria Species in Traditional Producing Regions in Qinghai-Tibet Plateau. Frontiers in Pharmacology 8.
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Xihan Guo, Juan Ni, Jinglun Xue & Xu Wang. (2017) Extract of bulbus Fritillaria cirrhosa perturbs spindle assembly checkpoint, induces mitotic aberrations and genomic instability in human colon epithelial cell line. Experimental and Toxicologic Pathology 69:3, pages 163-171.
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Mengge Zhou, Xiaoyao Ma, Guoyu Ding, Zengyong Wang, Dan Liu, Yongling Tong, Hong Zhou, Jie Gao, Yuanyuan Hou, Min Jiang & Gang Bai. (2017) Comparison and evaluation of antimuscarinic and anti-inflammatory effects of five Bulbus fritillariae species based on UPLC-Q/TOF integrated dual-luciferase reporter assay, PCA and ANN analysis. Journal of Chromatography B 1041-1042, pages 60-69.
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Dongdong Wang, Jie Yang, Qingdan Du, Houcong Li & Shu Wang. (2016) The total alkaloid fraction of bulbs of Fritillaria cirrhosa displays anti-inflammatory activity and attenuates acute lung injury. Journal of Ethnopharmacology 193, pages 150-158.
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Dongdong Wang, Qingdan Du, Houcong Li & Shu Wang. (2016) The Isosteroid Alkaloid Imperialine from Bulbs of Fritillaria cirrhosa Mitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model . Mediators of Inflammation 2016, pages 1-17.
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By Feng Pan, Xuemei Su, Bo Hu, Nan Yang, Que Chen & Wei Wu. (2015) Fusarium redolens 6WBY3, an endophytic fungus isolated from Fritillaria unibracteata var. wabuensis, produces peimisine and imperialine-3β-d-glucoside. Fitoterapia 103, pages 213-221.
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Lihua Chen, Dongxun Li, Guosong Zhang, Wei Zhang, Lihua Zhang, Yongmei Guan, Weifeng Zhu & Hongning Liu. (2014) Pharmacokinetics, tissue distribution and excretion of peimisine in rats assessed by liquid chromatography-tandem mass spectrometry. Archives of Pharmacal Research 38:6, pages 1138-1146.
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Dongdong Wang, Shu Wang, Qingdan Du, Nanyi Wang, Simei Liu, Xiaoxia Wang & Jinghui Jiang. (2014) Optimization of Extraction and Enrichment of Steroidal Alkaloids from Bulbs of Cultivated Fritillaria cirrhosa . BioMed Research International 2014, pages 1-15.
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