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Original Articles

Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells

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Pages 435-440 | Received 01 Jul 2013, Accepted 10 Dec 2013, Published online: 28 Feb 2014

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Crossref
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Crossref
Massimo Stefani & Stefania Rigacci. (2014) Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation. BioFactors 40:5, pages 482-493.
Crossref

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