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Original Articles

Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53

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Pages 408-418 | Received 30 Jul 2013, Accepted 02 Dec 2013, Published online: 28 Feb 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Mohammed M Mehanna, Rana Sarieddine, Jana K Alwattar, Racha Chouaib & Hala Gali-Muhtasib. (2020) Anticancer Activity of Thymoquinone Cubic Phase Nanoparticles Against Human Breast Cancer: Formulation, Cytotoxicity and Subcellular Localization. International Journal of Nanomedicine 15, pages 9557-9570.
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Articles from other publishers (48)

Mohamad Hesam Shahrajabian & Wenli Sun. (2024) Importance of Thymoquinone, Sulforaphane, Phloretin, and Epigallocatechin and their Health Benefits. Letters in Drug Design & Discovery 21:2, pages 209-225.
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Shatha Khaled Haif, Lina T. Al Kury & Wamidh H. Talib. (2023) Combination of Thymoquinone and Intermittent Fasting as a Treatment for Breast Cancer Implanted in Mice. Plants 13:1, pages 35.
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Farhad Sheikhnia, Vahid Rashidi, Hossein Maghsoudi & Maryam Majidinia. (2023) Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer. Cancer Cell International 23:1.
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Sawsan Elgohary, Reda A. Eissa & Hend M. El Tayebi. (2023) Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients. International Journal of Molecular Sciences 24:18, pages 14254.
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Ashraf A. El-Shehawy, Alaa Elmetwalli, Ali H. El-Far, Sahar Abd El-Razik Mosallam, Afrah Fatthi Salama, Ahmad O. Babalghith, Mohammad A. Mahmoud, Hany Mohany, Mohamed Gaber & Tarek El-Sewedy. (2023) Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches. BMC Complementary Medicine and Therapies 23:1.
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Pankaj Garg, Rachana Garg, David Horne, Sanjay Awasthi, Ravi Salgia & Sharad S. Singhal. (2023) Prognostic significance of natural products against multidrug tumor resistance. Cancer Letters 557, pages 216079.
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Madhumita Roy, Jaydip Biswas & Amitava DattaMadhumita Roy, Jaydip Biswas & Amitava Datta. 2023. Genetics and Epigenetics of Breast Cancer. Genetics and Epigenetics of Breast Cancer 59 87 .
Dibya Ranjan Jalli & Debasmita Pankaj Alone. 2023. Biomedical Applications and Toxicity of Nanomaterials. Biomedical Applications and Toxicity of Nanomaterials 229 256 .
Mina Homayoonfal, Zatollah Asemi & Bahman Yousefi. (2022) Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis. Cellular & Molecular Biology Letters 27:1.
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Reem J. Abdualmjid & Consolato M. Sergi. (2022) Mitochondrial Dysfunction and Induction of Apoptosis in Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines by Thymoquinone. International Journal of Molecular Sciences 23:23, pages 14669.
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Seyithan Taysi, Firas Shawqi Algburi, Zaid Rakan Mohammed, Omeed Akbar Ali & Muhammed Enes Taysi. (2022) Thymoquinone: A Review on its Pharmacological Importance, and its Association with Oxidative Stress, COVID-19, and Radiotherapy. Mini-Reviews in Medicinal Chemistry 22:14, pages 1847-1875.
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Getinet M. Adinew, Samia S. Messeha, Equar Taka, Ramesh B. Badisa, Lovely M. Antonie & Karam F. A. Soliman. (2022) Thymoquinone Alterations of the Apoptotic Gene Expressions and Cell Cycle Arrest in Genetically Distinct Triple-Negative Breast Cancer Cells. Nutrients 14:10, pages 2120.
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Kristina Andrijauskaite & Michael J. Wargovich. (2022) Role of natural products in breast cancer related symptomology: Targeting chronic inflammation. Seminars in Cancer Biology 80, pages 370-378.
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Meiling Zheng, Zhiqiang Mei, Md. Junaid, Mousumi Tania, Junjiang Fu, Han-Chun Chen & Md. Asaduzzaman Khan. (2022) Synergistic Role of Thymoquinone on Anticancer Activity of 5-Fluorouracil in Triple Negative Breast Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry 22:6, pages 1111-1118.
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Md. Rezaul Islam, Fahadul Islam, Mohamed H. Nafady, Muniya Akter, Saikat Mitra, Rajib Das, Humaira Urmee, Sheikh Shohag, Aklima Akter, Kumarappan Chidambaram, Fahad A. Alhumaydhi, Talha Bin Emran & Simona Cavalu. (2022) Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint. Molecules 27:7, pages 2165.
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Mohammed Kaleem, Maryam Perwaiz, Suza Mohammad Nur, Abdulrasheed O. Abdulrahman, Wasim Ahmad, Fahad A. Al-Abbasi, Vikas Kumar, Mohammad Amjad Kamal & Firoz Anwar. (2022) Epigenetics of Triple-Negative Breast Cancer via Natural Compounds. Current Medicinal Chemistry 29:8, pages 1436-1458.
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Shahid Karim, Abdulhadi S. Burzangi, Aftab Ahmad, Nasir Ali Siddiqui, Ibrahim M. Ibrahim, Priyanka Sharma, Walaa A. Abualsunun & Gamal A. Gabr. (2022) PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer. International Journal of Molecular Sciences 23:4, pages 2305.
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Getinet M. Adinew, Equar Taka, Bereket Mochona, Ramesh B. Badisa, Elizabeth A. Mazzio, Rashid Elhag & Karam F. A. Soliman. (2021) Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment. Nutrients 14:1, pages 79.
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Mahmoud Alhosin, Omeima Abdullah, Asaad Kayali & Ziad Omran. (2021) A Fast Ubiquitination of UHRF1 Oncogene Is a Unique Feature and a Common Mechanism of Thymoquinone in Cancer Cells. Applied Sciences 11:16, pages 7633.
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Qiuxia Fan, Cheng Liu, Zhenpeng Gao, Zhongqiu Hu, Zhouli Wang, Jianbo Xiao, Yahong Yuan & Tianli Yue. (2021) Inactivation Effect of Thymoquinone on Alicyclobacillus acidoterrestris Vegetative Cells, Spores, and Biofilms. Frontiers in Microbiology 12.
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Johura Ansary, Francesca Giampieri, Tamara Y. Forbes-Hernandez, Lucia Regolo, Denise Quinzi, Santos Gracia Villar, Eduardo Garcia Villena, Kilian Tutusaus Pifarre, José M. Alvarez-Suarez, Maurizio Battino & Danila Cianciosi. (2021) Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules 26:8, pages 2108.
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Rohini Gomathinayagam, Ji Hee Ha, Muralidharan Jayaraman, Yong Sang Song, Ciro Isidoro & Danny N. Dhanasekaran. (2020) Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets. Journal of Cancer Prevention 25:3, pages 136-151.
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Rumana Ahmad, Mohsin A. Khan, A.N. Srivastava, Anamika Gupta, Aditi Srivastava, Tanvir R. Jafri, Zainab Siddiqui, Sunaina Chaubey, Tahmeena Khan & Arvind K. Srivastava. (2020) Anticancer Potential of Dietary Natural Products: A Comprehensive Review. Anti-Cancer Agents in Medicinal Chemistry 20:2, pages 122-236.
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Joseph Pushpa Sweety, Surendran Sowparani, Padmanaban Mahalakshmi, Nandakumar Selvasudha, Dhayandamoorthy Yamini, Karuppasamy Geetha & Kandasamy Ruckmani. (2020) Fabrication of stimuli gated nanoformulation for site-specific delivery of thymoquinone for colon cancer treatment – Insight into thymoquinone’s improved physicochemical properties. Journal of Drug Delivery Science and Technology 55, pages 101334.
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J.G. Costa, V. Keser, C. Jackson, N. Saraiva, Í. Guerreiro, N. Almeida, S.P. Camões, R. Manguinhas, M. Castro, J.P. Miranda, A.S. Fernandes & N.G. Oliveira. (2020) A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells. Food and Chemical Toxicology 136, pages 111076.
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Sewara J. Mohammed, Hassan H. H. Amin, Shujahadeen B. Aziz, Aram M. Sha, Sarwar Hassan, Jeza M. Abdul Aziz & Heshu S. Rahman. (2019) Structural Characterization, Antimicrobial Activity, and In Vitro Cytotoxicity Effect of Black Seed Oil . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-9.
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M. Zakariyyah Aumeeruddy & M. Fawzi Mahomoodally. (2019) Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone. Cancer 125:10, pages 1600-1611.
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Raffaele Pezzani, Bahare Salehi, Sara Vitalini, Marcello Iriti, Felipe Zuñiga, Javad Sharifi-Rad, Miquel Martorell & Natália Martins. (2019) Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective. Medicina 55:4, pages 110.
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Muhammad Imran, Abdur Rauf, Imtiaz Ali Khan, Muhammad Shahbaz, Tahira Batool Qaisrani, Sri Fatmawati, Tareq Abu-Izneid, Ali Imran, Khaliq Ur Rahman & Tanweer Aslam Gondal. (2018) Thymoquinone: A novel strategy to combat cancer: A review. Biomedicine & Pharmacotherapy 106, pages 390-402.
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Nashwa Kabil, Recep Bayraktar, Nermin Kahraman, Hamada A. Mokhlis, George A. Calin, Gabriel Lopez-Berestein & Bulent Ozpolat. (2018) Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer. Breast Cancer Research and Treatment 171:3, pages 593-605.
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Fabliha Ahmed Chowdhury, Md Kamal Hossain, A. G. M. Mostofa, Maruf Mohammad Akbor & Muhammad Shahdaat Bin Sayeed. (2018) Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways. BioMed Research International 2018, pages 1-15.
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Md. Asaduzzaman Khan, Mousumi Tania, Shangyi Fu & Junjiang Fu. (2017) Thymoquinone, as an anticancer molecule: from basic research to clinical investigation. Oncotarget 8:31, pages 51907-51919.
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Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Srivani Ravoori, Manicka Vadhanam, David Schultz & Ramesh Gupta. (2017) Chemoprevention of Rat Mammary Carcinogenesis by Apiaceae Spices. International Journal of Molecular Sciences 18:2, pages 425.
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Md Soriful Islam, James H. Segars, Mario Castellucci & Pasquapina Ciarmela. (2017) Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target. Pharmacological Reports 69:1, pages 57-70.
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Mariah L. Scott, Mary F. Adams, Joseph J. Karchesy & Janet C. McAllister. (2016) Insecticidal Activity of Thymoquinone and Related Compounds Against Culex quinquefasciatus (Diptera: Culicidae) . Journal of Medical Entomology, pages tjw181.
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Lida Zhang, Yangqiu Bai & Yuxiu Yang. (2016) Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB. Oncology Letters 12:4, pages 2840-2845.
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Min Ji Bak, Soumyasri Das Gupta, Joseph Wahler & Nanjoo Suh. (2016) Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. Seminars in Cancer Biology 40-41, pages 170-191.
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Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li & Hua-Bin Li. (2016) Spices for Prevention and Treatment of Cancers. Nutrients 8:8, pages 495.
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A. Alyoussef & M. M. H. Al-Gayyar. (2016) Thymoquinone ameliorates testicular tissue inflammation induced by chronic administration of oral sodium nitrite. Andrologia 48:5, pages 501-508.
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Abdelkader E. Ashour, Atallah F. Ahmed, Ashok Kumar, Khairy M. A. Zoheir, Mourad A. Aboul-Soud, Sheikh F. Ahmad, Sabry M. Attia, Adel R. A. Abd-Allah, Vino T. Cheryan & Arun K. Rishi. (2016) Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-κB signaling and IL-8 expression. Molecular and Cellular Biochemistry 416:1-2, pages 141-155.
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?a?r? ?akalar, Kenan ?zgi, Banu ?skender, Sedat Sezen, Huriye Aksu, Mustafa ?ak?r, B??ra Kurt, Ali Turan & Halit Canatan. (2015) The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer. Tumor Biology 37:4, pages 4467-4477.
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Qian Zhao, Wen-ting Xu & Tuluhong Shalieer. (2016) Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer. Disease Markers 2016, pages 1-8.
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Irfana Muqbil & Ramzi M. Mohammad. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 199 212 .
Md. Asaduzzaman Khan, Mousumi Tania, Chunli Wei, Zhiqiang Mei, Shelly Fu, Jingliang Cheng, Jianming Xu & Junjiang Fu. (2015) Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. Oncotarget 6:23, pages 19580-19591.
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Ya-Wen Zeng, Juan Du, Xiao-Ying Pu, Jia-Zhen Yang, Tao Yang, Shu-Ming Yang & Xiao-Meng Yang. (2015) Coevolution between Human's Anticancer Activities and Functional Foods from Crop Origin Center in the World. Asian Pacific Journal of Cancer Prevention 16:6, pages 2119-2128.
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Yong Yang, Ting Bai, Peng Sun, Li-Hua Lian, You-Li Yao, Hui-Xing Zheng, Xin Li, Jin-Bin Li, Yan-Ling Wu & Ji-Xing Nan. (2015) Thymoquinone, a bioactive component of Nigella sativa Linn seeds or traditional spice, attenuates acute hepatic failure and blocks apoptosis via the MAPK signaling pathway in mice. RSC Advances 5:10, pages 7285-7290.
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Mohd Ishtikhar, Gulam Rabbani, Shawez Khan & Rizwan Hasan Khan. (2015) Biophysical investigation of thymoquinone binding to ‘N’ and ‘B’ isoforms of human serum albumin: exploring the interaction mechanism and radical scavenging activity. RSC Advances 5:24, pages 18218-18232.
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Nehal M. Elsherbiny & Mohamed El-Sherbiny. (2014) Thymoquinone attenuates Doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4. Chemico-Biological Interactions 223, pages 102-108.
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