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Nutrition and Cancer Volume 66, 2014 - Issue 4
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Original Articles

Leptin Induces a Proliferative Response in Breast Cancer Cells but Not in Normal Breast Cells

Virginie DuboisClermont-Université, Université d’Auvergne, Unité de Nutrition Humaine, BP10448, F-63000Clermont-Ferrand, France and INRA, UMR 1019, UNH, ECREIN, CRNH Auvergne, Clermont-Ferrand, France
,
Thierry JardéClermont-Université, Université d’Auvergne, Unité de Nutrition Humaine, BP10448, F-63000Clermont-Ferrand, France and INRA, UMR 1019, UNH, ECREIN, CRNH Auvergne, Clermont-Ferrand, France;Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia
,
Laetitia DelortClermont-Université, Université d’Auvergne, Unité de Nutrition Humaine, BP10448, F-63000Clermont-Ferrand, France and INRA, UMR 1019, UNH, ECREIN, CRNH Auvergne, Clermont-Ferrand, France
,
Hermine BillardClermont-Université, Université d’Auvergne, Unité de Nutrition Humaine, BP10448, F-63000Clermont-Ferrand, France and INRA, UMR 1019, UNH, ECREIN, CRNH Auvergne, Clermont-Ferrand, France
,
Dominique Bernard-GallonCentre Jean-Perrin, EA 4677, Clermont-Ferrand, France
,
Emmanuelle BergerINSERM U.1060/INRA U. 1235/INSA, Lyon, France
,
Alain GeloenINSERM U.1060/INRA U. 1235/INSA, Lyon, France
,
Marie-Paule VassonClermont-Université, Université d’Auvergne, Unité de Nutrition Humaine, BP10448, F-63000Clermont-Ferrand, France and INRA, UMR 1019, UNH, ECREIN, CRNH Auvergne, Clermont-Ferrand, France;CLARA, Région Lyon Auvergne Rhône-Alpes, France
&
Florence Caldefie-ChezetClermont-Université, Université d’Auvergne, Unité de Nutrition Humaine, BP10448, F-63000Clermont-Ferrand, France and INRA, UMR 1019, UNH, ECREIN, CRNH Auvergne, Clermont-Ferrand, France;CLARA, Région Lyon Auvergne Rhône-Alpes, FranceCorrespondence[email protected]
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Pages 645-655 | Received 15 Nov 2012, Accepted 31 Jan 2014, Published online: 16 Apr 2014

Citations (43)

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Mohamad Nidal Khabaz, Imtiaz Ahmad Qureshi & Jaudah Ahmad Al-Maghrabi. (2021) Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma. Libyan Journal of Medicine 16:1.
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Articles from other publishers (42)

Alin García-Miranda, José Benito Montes-Alvarado, Fabiola Lilí Sarmiento-Salinas, Verónica Vallejo-Ruiz, Eduardo Castañeda-Saucedo, Napoleón Navarro-Tito & Paola Maycotte. (2024) Regulation of mitochondrial metabolism by autophagy supports leptin-induced cell migration. Scientific Reports 14:1.
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Khouloud Ayed, Lamis Nabi, Rym Akrout, Hela Mrizak, Amal Gorrab, Dhouha Bacha, Hamouda Boussen & Asma Gati. (2023) Obesity and cancer: focus on leptin. Molecular Biology Reports 50:7, pages 6177-6189.
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Julia Holmes, Mohamed Gaber, Mónica Z. Jenks, Adam Wilson, Tucker Loy, Cassandra Lepetit, Mara Z. Vitolins, Brittney-Shea Herbert, Katherine L. Cook & Pierre-Alexandre Vidi. (2023) Reversion of breast epithelial polarity alterations caused by obesity. npj Breast Cancer 9:1.
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Liang Li, Xingchen Meng, Liyuan Liu, Yujuan Xiang, Fei Wang, Lixiang Yu, Fei Zhou, Chao Zheng, Wenzhong Zhou, Shude Cui, Fuguo Tian, Zhimin Fan, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang, Hong Liang, Shu Wang, Hongchuan Jiang, Xuening Duan, Haibo Wang, Guolou Li, Qitang Wang, Jianguo Zhang, Feng Jin, Jinhai Tang, Liang Li, Shiguang Zhu, Wenshu Zuo, Chunmiao Ye, Gengshen Yin, Zhongbing Ma, Shuya Huang & Zhigang Yu. (2022) Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case–Control Study in Chinese Females. Frontiers in Oncology 12.
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Paola de Candia, Francesco Prattichizzo, Silvia Garavelli, Carlo Alviggi, Antonio La Cava & Giuseppe Matarese. (2021) The pleiotropic roles of leptin in metabolism, immunity, and cancer. Journal of Experimental Medicine 218:5.
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Alin García-Miranda, Karen Aylín Solano-Alcalá, José Benito Montes-Alvarado, Arely Rosas-Cruz, Julio Reyes-Leyva, Napoleón Navarro-Tito, Paola Maycotte & Eduardo Castañeda-Saucedo. (2021) Autophagy Mediates Leptin-Induced Migration and ERK Activation in Breast Cancer Cells. Frontiers in Cell and Developmental Biology 9.
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Georgia Argyrakopoulou, Maria Dalamaga, Nikolaos Spyrou & Alexander Kokkinos. (2021) Gender Differences in Obesity-Related Cancers. Current Obesity Reports 10:2, pages 100-115.
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Laetitia Delort, Lauriane Bougaret, Juliette Cholet, Marion Vermerie, Hermine Billard, Caroline Decombat, Céline Bourgne, Marc Berger, Charles Dumontet & Florence Caldefie-Chezet. (2019) Hormonal Therapy Resistance and Breast Cancer: Involvement of Adipocytes and Leptin. Nutrients 11:12, pages 2839.
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Iliana Tenvooren, Mónica Z. Jenks, Hamza Rashid, Katherine L. Cook, Joëlle K. Muhlemann, Christopher Sistrunk, Julia Holmes, Kevin Wang, Keith Bonin, Kurt Hodges, Hui-Wen Lo, Ayaz Shaikh, Ignacio G. Camarillo, Sophie A. Lelièvre, Victoria Seewaldt & Pierre-Alexandre Vidi. (2019) Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland. Oncogene 38:20, pages 3855-3870.
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Sinda Mahbouli, Jérémie Talvas, Audrey der Vartanian, Sophie Ortega, Stéphanie Rougé, Marie-Paule Vasson & Adrien Rossary. (2018) Activation of antioxidant defences of human mammary epithelial cells under leptin depend on neoplastic state. BMC Cancer 18:1.
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Monserrat Olea-Flores, Juan Juárez-Cruz, Miguel Mendoza-Catalán, Teresita Padilla-Benavides & Napoleón Navarro-Tito. (2018) Signaling Pathways Induced by Leptin during Epithelial–Mesenchymal Transition in Breast Cancer. International Journal of Molecular Sciences 19:11, pages 3493.
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Amitabha Ray. (2018) Cancer and comorbidity: The role of leptin in breast cancer and associated pathologies. World Journal of Clinical Cases 6:12, pages 483-492.
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Jaudah Ahmed Al-Maghrabi, Imtiaz Ahmad Qureshi & Mohamad Nidal Khabaz. (2018) Expression of leptin in colorectal adenocarcinoma showed significant different survival patterns associated with tumor size, lymphovascular invasion, distant metastasis, local recurrence, and relapse of disease in the western province of Saudi Arabia. Medicine 97:34, pages e12052.
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Céline Gérard & Kristy A. Brown. (2018) Obesity and breast cancer – Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue. Molecular and Cellular Endocrinology 466, pages 15-30.
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Yuxue Zhao, Kenji Onda, Bo Yuan, Sachiko Tanaka, Anna Kiyomi, Kentaro Sugiyama, Munetoshi Sugiura, Norio Takagi & Toshihiko Hirano. (2018) Arsenic disulfide‑induced apoptosis and its potential mechanism in two‑ and three‑dimensionally cultured human breast cancer MCF‑7 cells. International Journal of Oncology.
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Pawan Kumar Raut, Dong Young Choi, Sang Hyun Kim, Jin Tae Hong, Taeg Kyu Kwon, Jee Heon Jeong & Pil-Hoon Park. (2017) Estrogen receptor signaling mediates leptin-induced growth of breast cancer cells via autophagy induction. Oncotarget 8:65, pages 109417-109435.
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