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Nutrition and Cancer Volume 66, 2014 - Issue 5
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Original Articles

Cancer Chemopreventive Effects of the Flavonoid-Rich Fraction Isolated from Papaya Seeds

Neelam PathakDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India
,
Saba KhanDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India;School of Biological Sciences, Dr. HS Gour Central University, Sagar, India
,
Arpit BhargavaDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India;School of Biological Sciences, Dr. HS Gour Central University, Sagar, India;Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India
,
Gorantla V. RaghuramDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India;School of Biological Sciences, Dr. HS Gour Central University, Sagar, India;Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India
,
Deepika JainDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India;School of Biological Sciences, Dr. HS Gour Central University, Sagar, India;Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India
,
Hariom PanwarDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India;School of Biological Sciences, Dr. HS Gour Central University, Sagar, India;School of Studies in Zoology & Biotechnology, Vikram University, Ujjain, India
,
Ravindra M. SamarthDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India;Department of Zoology, University of Rajasthan, Jaipur, India
,
Subodh K. JainSchool of Biological Sciences, Dr. HS Gour Central University, Sagar, India
,
Kewal K. MaudarDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India
,
Dinesh K. MishraDepartment of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur, India
&
Pradyumna K. MishraDepartment of Research, Bhopal Memorial Hospital & Research Centre, Bhopal, India;School of Biological Sciences, Dr. HS Gour Central University, Sagar, India;Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, IndiaCorrespondence[email protected]
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Pages 857-871 | Received 10 Dec 2013, Accepted 03 Feb 2014, Published online: 12 May 2014

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Rebecca A. Haber, Reicelle D. Garcia, Jamie N. Hernandez, Sarah Jamieson, Arijit Mondal & Anupam Bishayee. (2023) Papaya (Carica papaya L.) for cancer prevention: Progress and promise. Critical Reviews in Food Science and Nutrition 63:30, pages 10499-10519.
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Sherif Shaheen, Charis M. Galanakis & Mohamed A. Farag. (2023) Carica papaya biowaste valorization: Biorefinery advances and extraction optimization. Food Reviews International 39:7, pages 4745-4760.
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Saurabh Pandey, Peter J. Cabot, P. Nicholas Shaw & Amitha K. Hewavitharana. (2016) Anti-inflammatory and immunomodulatory properties of Carica papaya. Journal of Immunotoxicology 13:4, pages 590-602.
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Articles from other publishers (30)

Nadia S. Mahrous & Enas A. Noseer. (2023) Anticancer potential of Carica papaya Linn black seed extract against human colon cancer cell line: in vitro study. BMC Complementary Medicine and Therapies 23:1.
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Eziuche A. Ugbogu, Emmanuel D. Dike, Miracle Ebubechi Uche, Lotanna R. Etumnu, Benedict C. Okoro, Ositadinma C. Ugbogu, Oluwapelumi E. Adurosakin, Chiemela Enyinna Chinma, Esther Ohaeri & Emeka J. Iweala. (2023) Ethnomedicinal uses, nutritional composition, phytochemistry and potential health benefits of Carica papaya. Pharmacological Research - Modern Chinese Medicine 7, pages 100266.
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Teresa Vargas-CortezDaniel A. Jacobo-Velázquez & Jorge Benavides. (2022) Therapeutic Plants with Immunoregulatory Activity and Their Applications: A Scientific Vision of Traditional Medicine in Times of COVID-19. Journal of Medicinal Food 25:12, pages 1074-1085.
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Yoon A Jeon, Sun Woo Chung, Seong Cheol Kim & Young Jae Lee. (2022) Comprehensive Assessment of Antioxidant and Anti-Inflammatory Properties of Papaya Extracts. Foods 11:20, pages 3211.
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Mark S. D'Arcy. (2022) A review of biologically active flavonoids as inducers of autophagy and apoptosis in neoplastic cells and as cytoprotective agents in non‐neoplastic cells. Cell Biology International 46:8, pages 1179-1195.
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Akshay Anilkumar & Alisha Bhanu P A. (2022) In vitro anticancer activity of “Methanolic extract of papaya blackseeds” (MPB) in Hep G2 cell lines and its effect in the regulation of bcl-2, caspase-3 and p53 gene expression. Advances in Cancer Biology - Metastasis 4, pages 100025.
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Arunaksharan Narayanankutty. (2022) Pharmacological Potentials and Nutritional Values of Tropical and Subtropical Fruits of India: Emphasis on their Anticancer Bioactive Components. Recent Patents on Anti-Cancer Drug Discovery 17:2, pages 124-135.
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Thanh-Diem Nguyen, Ly Le, Tu-Binh Vo, Kim-Lan Vo, Hoang-Minh Le & Huyen-Trang Vu. (2022) Evaluation of Colorectal Cancer Inhibition Ability of Rosmarinus officinalis L. via Molecular Docking and Pharmacophore Analysis. International Journal of Pharmacology 18:2, pages 262-278.
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Nurizzati Mohd Daud, Nicky Rahmana Putra, Roslina Jamaludin, Nur Salsabila Md Norodin, Nurul Syaza Sarkawi, Muhammad Hamiz Syukri Hamzah, Hasmida Mohd Nasir, Dayang Norulfairuz Abang Zaidel, Mohd Azizi Che Yunus & Liza Md Salleh. (2022) Valorisation of plant seed as natural bioactive compounds by various extraction methods: A review. Trends in Food Science & Technology 119, pages 201-214.
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Isaac Kyei-Barffour, Roselind Kyei Baah Kwarkoh, Desmond Omane Acheampong, Augustine Suurinobah Brah, Samuel Addo Akwetey & Benjamin Aboagye. (2021) Alkaloidal extract from Carica papaya seeds ameliorates CCl4-induced hepatocellular carcinoma in rats. Heliyon 7:8, pages e07849.
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Yew Rong Kong, Yong Xin Jong, Manisha Balakrishnan, Zhui Ken Bok, Janice Kwan Kah Weng, Kai Ching Tay, Bey Hing Goh, Yong Sze Ong, Kok Gan Chan, Learn Han Lee & Kooi Yeong Khaw. (2021) Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review. Biology 10:4, pages 287.
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Seong Min Kim, Preethi Vetrivel, Sang Eun Ha, Hun Hwan Kim, Jin-A Kim & Gon Sup Kim. (2020) Apigetrin induces extrinsic apoptosis, autophagy and G2/M phase cell cycle arrest through PI3K/AKT/mTOR pathway in AGS human gastric cancer cell. The Journal of Nutritional Biochemistry 83, pages 108427.
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Ajay G. Namdeo, Sai H.S. Boddu, Haneen Amawi, Charles R. AshbyJr.Jr., Diwakar B. Tukaramrao, Piyush Trivedi, R. Jayachandra Babu & Amit K. Tiwari. (2020) Flavonoids as Multi-Target Compounds: A Special Emphasis on their Potential as Chemo-adjuvants in Cancer Therapy. Current Pharmaceutical Design 26:15, pages 1712-1728.
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José Villacís‐Chiriboga, Kathy Elst, John Van Camp, Edwin Vera & Jenny Ruales. (2020) Valorization of byproducts from tropical fruits: Extraction methodologies, applications, environmental, and economic assessment: A review (Part 1: General overview of the byproducts, traditional biorefinery practices, and possible applications). Comprehensive Reviews in Food Science and Food Safety 19:2, pages 405-447.
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Xiangping Deng, Yijiao Peng, Jingduo Zhao, Xiaoyong Lei, Xing Zheng, Zhizhong Xie & Guotao Tang. (2020) Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway. Current Organic Chemistry 23:26, pages 2945-2959.
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IBRAHIM HALIL GECIBESLER & MURAT AYDIN. (2020) Plasma Protein Binding of Herbal-Flavonoids to Human Serum Albumin and Their Anti-proliferative Activities. Anais da Academia Brasileira de Ciências 92:1.
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Sugiharto Sugiharto. (2020) Papaya (Carica papaya L.) seed as a potent functional feedstuff for poultry – A review. Veterinary World 13:8, pages 1613-1619.
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Ali H. Amin, Faisal A. Bughdadi, Mabrouk A. Abo‐Zaid, Ahmed H. Ismail, Sherif A. El‐Agamy, Alaa Alqahtani, Hassan I. H. El‐Sayyad, Bashir Mahmoud Rezk & Mohamed Fawzy Ramadan. (2019) Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress . Journal of Food Biochemistry 43:12.
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Dave Heena & Trivedi Sunil. (2019) Carica papaya: Potential Implications in Human Health. Current Traditional Medicine 5:4, pages 321-336.
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Y. Desjardins. (2019) Health effects and potential mode of action of papaya ( Carica papaya L.) bioactive chemicals . Acta Horticulturae:1250, pages 197-208.
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Abdulrazaq B. Nafiu, Abdul-musawwir Alli-Oluwafuyi, Abdulraheem Haleemat, Ibrahim S. Olalekan & Mohammad T. Rahman. 2019. Nonvitamin and Nonmineral Nutritional Supplements. Nonvitamin and Nonmineral Nutritional Supplements 335 359 .
W S Adayani, R Subahar, Fatmawaty & Slamet. (2018) Effect of treatment using Carica papaya seed extract with Ag–TiO 2 nanocomposite on the mortality of Aedes aegypti larvae . Journal of Physics: Conference Series 1073, pages 032035.
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Anu Singh, P.K. Dutta, Hridyesh Kumar, Amit Kumar Kureel & Ambak Kumar Rai. (2018) Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities. Carbohydrate Polymers 193, pages 99-107.
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Demetrio Raffa, Benedetta Maggio, Maria Valeria Raimondi, Fabiana Plescia & Giuseppe Daidone. (2017) Recent discoveries of anticancer flavonoids. European Journal of Medicinal Chemistry 142, pages 213-228.
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Jhoti Somanah, Emmanuel Bourdon & Theeshan Bahorun. (2017) Extracts of Mauritian Carica papaya (var. solo) protect SW872 and HepG2 cells against hydrogen peroxide induced oxidative stress. Journal of Food Science and Technology 54:7, pages 1917-1927.
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Cedar H.A. Boakye, Ketan Patel, Ravi Doddapaneni, Arvind Bagde, Gautam Behl, Nusrat Chowdhury, Stephen Safe & Mandip Singh. (2016) Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention. Colloids and Surfaces B: Biointerfaces 143, pages 156-167.
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Jhoti Somanah, Srishti Ramsaha, Shalini Verma, Ashok Kumar, Poornima Sharma, Ranjan Kumar Singh, Okezie I. Aruoma, Emmanuel Bourdon & Theeshan Bahorun. (2016) Fermented papaya preparation modulates the progression of N -methyl- N -nitrosourea induced hepatocellular carcinoma in Balb/c mice. Life Sciences 151, pages 330-338.
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Arpit Bhargava, Naveen Kumar Khare, Neha Bunkar, Rajesh Kumar Lenka & Pradyumna Kumar Mishra. (2016) Role of mitochondrial oxidative stress on lymphocyte homeostasis in patients diagnosed with extra-pulmonary tuberculosis. Cell Biology International 40:2, pages 166-176.
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Ya-Wen Zeng, Juan Du, Xiao-Ying Pu, Jia-Zhen Yang, Tao Yang, Shu-Ming Yang & Xiao-Meng Yang. (2015) Coevolution between Human's Anticancer Activities and Functional Foods from Crop Origin Center in the World. Asian Pacific Journal of Cancer Prevention 16:6, pages 2119-2128.
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