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Original Articles

Glutamine in Alleviation of Radiation-Induced Severe Oral Mucositis: A Meta-Analysis

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Pages 734-742 | Received 12 May 2015, Accepted 01 Feb 2016, Published online: 04 Apr 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Svyatoslav Dvoretskiy, Suzette L. Pereira & Tapas Das. (2022) Efficacy of Nutrients in Reducing the Symptoms of Radiation Induced Oral Mucositis in a Hamster Model. Nutrition and Cancer 74:3, pages 1079-1089.
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Gang Tang, Wang Huang, Linyu Zhang & Zhengqiang Wei. (2022) Role of Glutamine in the Management of Oral Mucositis in Patients with Cancer: A Meta-Analysis of Randomized Controlled Trials. Nutrition and Cancer 74:2, pages 482-495.
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Yu-Hsiang Chang, Ming-Sun Yu, Kang-Hsi Wu, Mao-Chou Hsu, Yee-Hsuan Chiou, Han-Ping Wu, Ching-Tien Peng & Yu-Hua Chao. (2017) Effectiveness of Parenteral Glutamine on Methotrexate-induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia. Nutrition and Cancer 69:5, pages 746-751.
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Articles from other publishers (33)

Shu Zhang, Juejin Li, Yun Zhang, Xia Li, Yalin Zhang, Yunhuan Li, Lin Zhou & Xiaolin Hu. (2024) Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials. Journal of Clinical Nursing 33:6, pages 2030-2049.
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Reza Amiri Khosroshahi, Sepide Talebi, Sheida Zeraattalab-Motlagh, Hossein Imani, Amirabbas Rashidi, Nikolaj Travica & Hamed Mohammadi. (2023) Nutritional interventions for the prevention and treatment of cancer therapy-induced oral mucositis: an umbrella review of systematic reviews and meta-analysis. Nutrition Reviews 81:9, pages 1200-1212.
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Anmar Al-Taie & Aygül Koseoglu. (2023) Potential therapeutic effects of different mouthwashes for alleviation and treatment of oral complications of 5-fluorouracil-based chemotherapy in patients with colon cancer. European Journal of Hospital Pharmacy 30:4, pages 202-207.
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Stefane Caroline Carvalho Moura e Vasconcelos, Eliete Neves Silva Guerra, Amanda Gomes de Menêses, Paula Elaine Diniz dos Reis & Elaine Barros Ferreira. (2023) Effects of oral supplementation to manage radiation dermatitis in cancer patients: a systematic review. Supportive Care in Cancer 31:4.
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Ying-Sheng Lin, Seyed Abolghasem Mousavi & Hung-Chi Chen. (2022) Free Colon Tissue Transfer for the Management of Xerostomia in Head and Neck Cancer Patients: A Bacteriological Study and Clinical Case Series. Journal of Plastic, Reconstructive & Aesthetic Surgery 75:8, pages 2676-2683.
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Sameep S. Shetty, Meghana Maruthi, Vasantha Dhara, José Alcides Almeida de Arruda, Lucas Guimarães Abreu, Ricardo Alves Mesquita, Antonio Lucio Teixeira, Tarcília Aparecida Silva & Yash Merchant. (2022) Oral mucositis: Current knowledge and future directions. Disease-a-Month 68:5, pages 101300.
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Chih-Chun Wang, Tzer-Zen Hwang, Chuan-Chien Yang, Ching-Feng Lien, Chien-Chung Wang, Yu-Chen Shih, Shyh-An Yeh & Meng-Che Hsieh. (2022) Impact of Parenteral Glutamine Supplement on Oncologic Outcomes in Patients with Nasopharyngeal Cancer Treated with Concurrent Chemoradiotherapy. Nutrients 14:5, pages 997.
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Akio Suzuki. 2022. Inflammation and Oral Cancer. Inflammation and Oral Cancer 183 197 .
Gouthaman Shanmugasundaram & Ramkumar Dhanasekaran. 2022. Prehabilitation for Cancer Surgery. Prehabilitation for Cancer Surgery 311 336 .
Simon Andreas Müller, Roland Giger, Urs Müller-Richter & Zeno Stanga. 2022. Medikamentöse Tumortherapie von Kopf-Hals-Tumoren. Medikamentöse Tumortherapie von Kopf-Hals-Tumoren 317 334 .
Amalia Papanikolopoulou, Nikolaos Syrigos, Louisa Vini, Maria Papasavva, Georgios Lazopoulos, Stelios Kteniadakis, Demetrios Spandidos, Adrianni Charpidou & Nikolaos Drakoulis. (2021) Use of oral glutamine in radiation‑induced adverse effects in patients with thoracic and upper aerodigestive malignancies: Results of a prospective observational study. Oncology Letters 23:1.
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Hemail M. Alsubaie, Albaraa Y. Alsini, Khaled M. Alsubaie, Ahmed Abu‐Zaid, Faisal R. Alzahrani, Suhail Sayed, Alok K. Pathak & Khaled H. Alqahtani. (2021) Glutamine for prevention and alleviation of radiation‐induced oral mucositis in patients with head and neck squamous cell cancer: Systematic review and meta‐analysis of controlled trials. Head & Neck 43:10, pages 3199-3213.
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Tzu-Rong Peng, Hung-Hong Lin, Li-Jou Yang & Ta-Wei Wu. (2021) Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials. Supportive Care in Cancer 29:8, pages 4885-4892.
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Wakako Yatsuoka, Takao Ueno, Kanako Miyano, Ayame Enomoto, Sana Ota, Masahiro Sugimoto & Yasuhito Uezono. (2021) Time-Course of Salivary Metabolomic Profiles during Radiation Therapy for Head and Neck Cancer. Journal of Clinical Medicine 10:12, pages 2631.
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Amanda de Sousa Melo, Juliana Borges de Lima Dantas, Alena Ribeiro Alves Peixoto Medrado, Hayana Ramos Lima, Gabriela Botelho Martins & Manoela Carrera. (2021) Nutritional supplements in the management of oral mucositis in patients with head and neck cancer: Narrative literary review. Clinical Nutrition ESPEN 43, pages 31-38.
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Areti Gkantaifi, Emmanouil Vardas, Filippo Alongi, Nikolaos Tsoukalas, Haytham Hamed Saraireh, Nikolaos Charalampakis, Jozsef Lövey, Jiannis Hajiioannou, Efthymios Kyrodimos, Konstantinos Tsanadis, Davide Mauri, Christos Christopoulos, George Iliadis & Maria Tolia. (2021) Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients. Five Years Literature Review. Reviews on Recent Clinical Trials 16:2, pages 151-165.
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Catrina Davy & Sharron Heathcote. (2020) A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients. Supportive Care in Cancer 29:4, pages 2187-2202.
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Xiaoya Zheng, Kaili Yu, Guiyue Wang, Miao Liu, Yuhang Li, Pulin Yu, Mengyuan Yang, Nana Guo, Xiaohui Ma, Yue Bu, Yahui Peng, Ci Han, Kaijiang Yu & Changsong Wang. (2019) Effects of Immunonutrition on Chemoradiotherapy Patients: A Systematic Review and Meta‐Analysis. Journal of Parenteral and Enteral Nutrition 44:5, pages 768-778.
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Ting Shuai, Xu Tian, Ling-Li Xu, Wei-Qing Chen, Yuan-Ping Pi, Lin Zhang, Qiao-Qin Wan & Xiu-E Li. (2020) Oral Glutamine May Have No Clinical Benefits to Prevent Radiation-Induced Oral Mucositis in Adult Patients With Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials. Frontiers in Nutrition 7.
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Preyanate Wilairat, Kirati Kengkla, Thanatchai Kaewpanan, Jirapat Kaewthong, Sorave Ruankon, Chulalak Subthaweesin, David D Stenehjem & Surasak Saokaew. (2020) Comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis in adult cancer patients: a systematic review and network meta-analysis. European Journal of Hospital Pharmacy 27:2, pages 103-110.
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Amanda Gomes de Menêses, Ana Gabriela Costa Normando, Isabela Porto de Toledo, Paula Elaine Diniz Reis & Eliete Neves Silva Guerra. (2019) Effects of oral supplementation in the management of oral mucositis in cancer patients: A meta‐analysis of randomized clinical trials. Journal of Oral Pathology & Medicine 49:2, pages 117-125.
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Diana J. Lu, Michael Luu, Anthony T. Nguyen, Kevin S. Scher, Jon Mallen-St. Clair, Alain Mita, Stephen L. Shiao, Allen S. Ho & Zachary S. Zumsteg. (2019) Survival outcomes with concomitant chemoradiotherapy in older adults with oropharyngeal carcinoma in an era of increasing human papillomavirus (HPV) prevalence. Oral Oncology 99, pages 104472.
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Karsten Münstedt & Heidrun Männle. (2019) Using Bee Products for the Prevention and Treatment of Oral Mucositis Induced by Cancer Treatment. Molecules 24:17, pages 3023.
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Chih-Jen Huang, Ming-Yii Huang, Pen-Tzu Fang, Frank Chen, Yu-Tsang Wang, Chung-Ho Chen, Shyng-Shiou Yuan, Chun-Ming Huang, Kuei-Hau Luo, Hung-Yi Chuang, Yen-Yun Wang & Hsin-Hua Lee. (2019) Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients. The American Journal of Clinical Nutrition 109:3, pages 606-614.
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Fatemeh Mazhari, Alireza Sarraf Shirazi & Mahboubeh Shabzendehdar. (2018) Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta‐analysis. Pediatric Blood & Cancer 66:3.
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Karsten Münstedt, Felix Momm & Jutta Hübner. (2019) Honey in the management of side effects of radiotherapy- or radio/chemotherapy-induced oral mucositis. A systematic review. Complementary Therapies in Clinical Practice 34, pages 145-152.
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Michael Thomsen & Luis Vitetta. (2018) Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis. Integrative Cancer Therapies 17:4, pages 1027-1047.
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Keith I. BlockPenny B. BlockCharlotte Gyllenhaal. (2018) Integrative Treatment for Colorectal Cancer: A Comprehensive Approach. The Journal of Alternative and Complementary Medicine 24:9-10, pages 890-901.
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Denise Ackerman, Meghan Laszlo, Arlene Provisor & Adern Yu. 2018. Multidisciplinary Care of the Head and Neck Cancer Patient. Multidisciplinary Care of the Head and Neck Cancer Patient 187 208 .
Farideh Koohian, Ahmad Shanei, Daryoush Shahbazi-Gahrouei, Seyed Hossein Hejazi, Amirhossein Ahmadi & Mohammadreza Sharifi. (2017) The effect of resveratrol administration in irradiated mice on the induction of micronuclei in bone marrow. Journal of Radiation Oncology 6:4, pages 423-427.
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L Hu, Y Wang, AP Cotrim, Z Zhu, R Gao, C Zheng, CM Goldsmith, L Jin, C Zhang, JB Mitchell, BJ Baum & S Wang. (2017) Effect of Tempol on the prevention of irradiation‐induced mucositis in miniature pigs. Oral Diseases 23:6, pages 801-808.
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David Lopez-Vaquero, Lucia Gutierrez-Bayard, Juan-Andres Rodriguez-Ruiz, Monica Saldaña-Valderas & Pedro Infante-Cossio. (2017) Double-blind randomized study of oral glutamine on the management of radio/chemotherapy-induced mucositis and dermatitis in head and neck cancer. Molecular and Clinical Oncology 6:6, pages 931-936.
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De-dong Cao, Hui-lin Xu, Min Xu, Xiang-yun Qian, Zhu-cheng Yin & Wei Ge. (2017) Therapeutic role of glutamine in management of radiation enteritis: a meta-analysis of 13 randomized controlled trials. Oncotarget 8:18, pages 30595-30605.
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