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Nutrition and Cancer Volume 70, 2018 - Issue 2
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Original Articles

Polymethoxylated Flavones from Orange Peels Inhibit Cell Proliferation in a 3D Cell Model of Human Colorectal Cancer

Inês SilvaIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, PortugalView further author information
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Marta F. EstradaIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal;ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, PortugalView further author information
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Carolina V. PereiraIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, PortugalView further author information
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Andreia Bento da SilvaITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, PortugalView further author information
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Maria R. BronzeIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal;ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal;iMED, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, PortugalView further author information
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Paula M. AlvesIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal;ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, PortugalView further author information
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Catarina M.M. DuarteIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal;ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, PortugalView further author information
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Catarina BritoIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal;ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, PortugalCorrespondence[email protected]
View further author information
&
Ana Teresa SerraIBET-Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal;ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, PortugalCorrespondence[email protected]
View further author information
 show all
Pages 257-266 | Received 08 Feb 2017, Accepted 12 Oct 2017, Published online: 09 Jan 2018

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Yun-Yi Chen, Jiao-Jiao Liang, Deng-Liang Wang, Jie-Biao Chen, Jin-Ping Cao, Yue Wang & Chong-De Sun. (2023) Nobiletin as a chemopreventive natural product against cancer, a comprehensive review. Critical Reviews in Food Science and Nutrition 63:23, pages 6309-6329.
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He Bao, Nanbo Zheng, Zhuanting Li & Yuan Zhi. (2020) Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers. Drug Design, Development and Therapy 14, pages 3057-3068.
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Diana P. Sousa, Marta Pojo, Ana T. Pinto, Valeriano Leite, Ana Teresa Serra & Branca M. Cavaco. (2020) Nobiletin Alone or in Combination with Cisplatin Decreases the Viability of Anaplastic Thyroid Cancer Cell Lines. Nutrition and Cancer 72:2, pages 352-363.
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Articles from other publishers (24)

Yonglu Li, Ping Li, Xin Yu, Xiaodong Zheng & Qing Gu. (2023) Exploitation of In Vivo -Emulated In Vitro System in Advanced Food Science . Journal of Agricultural and Food Chemistry.
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Carmela Sorrentino, Martina Di Gisi, Giulia Gentile, Fabrizio Licitra, Rosa D’Angiolo, Pia Giovannelli, Antimo Migliaccio, Gabriella Castoria & Marzia Di Donato. (2022) Agri-Food By-Products in Cancer: New Targets and Strategies. Cancers 14:22, pages 5517.
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Hari Babu Bollikolla, Ranjini Tyagi, Maheswara Rao Gokada, Rambabu Anandam, Jyothi K Kasthuri, Vijaya Durga T, M. Mujahid Alam & Krishna Murthy Mannam. (2022) Flavones as Important Scaffolds for Anticancer, Antioxidant and Anti-Tubercular Activities: An Overview of Reports 2015–2020. Moscow University Chemistry Bulletin 77:5, pages 269-285.
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Shreya Raghavan. (2022) How inclusive are cell lines in preclinical engineered cancer models?. Disease Models & Mechanisms 15:5.
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Deepak Bharadwaj Pemmaraju, Aparajita Ghosh, Jagadeesh Kumar Gangasani, U.S.N. Murthy, V.G.M. Naidu & Aravind Kumar Rengan. 2022. Herbal Biomolecules in Healthcare Applications. Herbal Biomolecules in Healthcare Applications 525 549 .
Shimaa Mohammad Yousof, Rasha Atta, Islam A. Khalil, Mohamed A. Zayed & Asmaa Seddek. 2022. Mediterranean Fruits Bio-wastes. Mediterranean Fruits Bio-wastes 261 285 .
Gianfranco Fontana. 2021. Citrus - Research, Development and Biotechnology. Citrus - Research, Development and Biotechnology.
Milda Pukalskienė, Audrius Pukalskas, Lijana Dienaitė, Simona Revinytė, Carolina V. Pereira, Ana A. Matias & Petras Rimantas Venskutonis. (2021) Recovery of Bioactive Compounds from Strawberry (Fragaria × ananassa) Pomace by Conventional and Pressurized Liquid Extraction and Assessment Their Bioactivity in Human Cell Cultures. Foods 10:8, pages 1780.
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Paula Rossini Augusti, Andréia Quatrin, Renius Mello, Vivian Caetano Bochi, Eliseu Rodrigues, Inês D. Prazeres, Ana Catarina Macedo, Sheila Cristina Oliveira-Alves, Tatiana Emanuelli, Maria Rosário Bronze & Ana Teresa Serra. (2021) Antiproliferative Effect of Colonic Fermented Phenolic Compounds from Jaboticaba (Myrciaria trunciflora) Fruit Peel in a 3D Cell Model of Colorectal Cancer. Molecules 26:15, pages 4469.
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Jingwen Xu, Guangyan Qi, Weiqun Wang & Xiuzhi Susan Sun. (2021) Advances in 3D peptide hydrogel models in cancer research. npj Science of Food 5:1.
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Ye Liu, Zahra Mohri, Wissal Alsheikh & Umber Cheema. (2021) The Role of Biomimetic Hypoxia on Cancer Cell Behaviour in 3D Models: A Systematic Review. Cancers 13:6, pages 1334.
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El-Shaimaa A. Arafa, Noura T. Shurrab & Manal A. Buabeid. (2021) Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways. Advances in Pharmacological and Pharmaceutical Sciences 2021, pages 1-15.
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Lijana Dienaitė, Milda Pukalskienė, Carolina V. Pereira, Ana A. Matias & Petras Rimantas Venskutonis. (2020) Valorization of European Cranberry Bush (Viburnum opulus L.) Berry Pomace Extracts Isolated with Pressurized Ethanol and Water by Assessing Their Phytochemical Composition, Antioxidant, and Antiproliferative Activities. Foods 9:10, pages 1413.
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Chong‐Xiang Lin, Cheng‐Wei Tu, Yi‐Ke Ma, Peng‐Cheng Ye, Xia Shao, Zhao‐An Yang & Yi‐Ming Fang. (2020) Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA‐CREB pathway in oral squamous cell carcinoma. Food Science & Nutrition 8:7, pages 3515-3524.
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Balwinder Singh, Jatinder Pal Singh, Amritpal Kaur & Narpinder Singh. (2020) Phenolic composition, antioxidant potential and health benefits of citrus peel. Food Research International 132, pages 109114.
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Milad Ashrafizadeh, Ali Zarrabi, Sedigheh Saberifar, Farid Hashemi, Kiavash Hushmandi, Fardin Hashemi, Ebrahim Rahmani Moghadam, Reza Mohammadinejad, Masoud Najafi & Manoj Garg. (2020) Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways. Biomedicines 8:5, pages 110.
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A.M.R.C. Alexandre, A.T. Serra, A.A. Matias, C.M.M. Duarte & M.R. Bronze. (2020) Supercritical fluid extraction of Arbutus unedo distillate residues – Impact of process conditions on antiproliferative response of extracts. Journal of CO2 Utilization 37, pages 29-38.
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Lijana Dienaitė, Audrius Pukalskas, Milda Pukalskienė, Carolina V. Pereira, Ana A. Matias & Petras Rimantas Venskutonis. (2020) Phytochemical Composition, Antioxidant and Antiproliferative Activities of Defatted Sea Buckthorn (Hippophaë rhamnoides L.) Berry Pomace Fractions Consecutively Recovered by Pressurized Ethanol and Water. Antioxidants 9:4, pages 274.
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Ahmed H.E. Hassan, Kyung-Tae Lee & Yong Sup Lee. (2020) Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations. European Journal of Medicinal Chemistry 187, pages 111965.
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Jingwen Xu, Guangyan Qi, Chunxia Sui, Weiqun Wang & Xiuzhi Sun. (2019) 3D h9e peptide hydrogel: An advanced three-dimensional cell culture system for anticancer prescreening of chemopreventive phenolic agents. Toxicology in Vitro 61, pages 104599.
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Carolina V. Pereira, Joana M. Silva, Liliana Rodrigues, Rui L. Reis, Alexandre Paiva, Ana Rita C. Duarte & Ana Matias. (2019) Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents. Scientific Reports 9:1.
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Jeehye Sung, Joon Hyuk Suh & Yu Wang. (2019) Effects of heat treatment of mandarin peel on flavonoid profiles and lipid accumulation in 3T3-L1 adipocytes. Journal of Food and Drug Analysis 27:3, pages 729-735.
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Goh, Tan, Goh, Chan, Pusparajah, Lee & Goh. (2019) Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention. Cancers 11:6, pages 867.
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Carolina Pereira, Marlene Duarte, Patrícia Silva, Andreia Bento da Silva, Catarina Duarte, Alejandro Cifuentes, Virginia García-Cañas, Maria Bronze, Cristina Albuquerque & Ana Serra. (2019) Polymethoxylated Flavones Target Cancer Stemness and Improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer. Nutrients 11:2, pages 326.
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