5,089
Views
72
CrossRef citations to date
0
Altmetric
Original Articles

Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study

, , , , &
Pages 627-634 | Received 12 Feb 2019, Accepted 26 Jul 2019, Published online: 09 Sep 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Alireza Amanollahi, Maryam Khazdouz, Mahsa Malekahmadi, Rainer J. Klement, Derek Lee & Adeleh Khodabakhshi. (2023) Effect of Ketogenic Diets on Cardio-Metabolic Outcomes in Cancer Patients: A Systematic Review and Meta-Analysis of Controlled Clinical Trials. Nutrition and Cancer 75:1, pages 95-111.
Read now
Shurui Wang, Ting Yang, Wanmin Qiang, Aomei Shen, Zihan Zhao & Xiaofeng Liu. (2022) Benefits of Dietary Management in Breast Cancer Patients: A Systematic Review and Meta-Analysis. Nutrition and Cancer 74:5, pages 1580-1592.
Read now
Mohammad Reza Amini, Azadeh Aminianfar, Sina Naghshi, Bagher Larijani & Ahmad Esmaillzadeh. (2022) The effect of ketogenic diet on body composition and anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition 62:13, pages 3644-3657.
Read now
Marzieh Taftian, Sara Beigrezaei, Vahid Arabi & Amin Salehi-Abargouei. (2022) The Effect of Ketogenic Diet on Weight Loss in Adult Patients with Cancer: A Systematic Review and Meta-Analysis of Controlled Clinical Trials. Nutrition and Cancer 74:4, pages 1222-1234.
Read now
Luigi Barrea, Massimiliano Caprio, Dario Tuccinardi, Eleonora Moriconi, Laura Di Renzo, Giovanna Muscogiuri, Annamaria Colao & Silvia Savastano. (2022) Could ketogenic diet “starve” cancer? Emerging evidence. Critical Reviews in Food Science and Nutrition 62:7, pages 1800-1821.
Read now
Giovanna Muscogiuri, Luigi Barrea, Federica Campolo, Emilia Sbardella, Concetta Sciammarella, Maria Grazia Tarsitano, Filomena Bottiglieri, Annamaria Colao & Antongiulio Faggiano. (2022) Ketogenic diet: a tool for the management of neuroendocrine neoplasms?. Critical Reviews in Food Science and Nutrition 62:4, pages 1035-1045.
Read now
Mohammed Jemal, Tewodros Shibabaw Molla & Tadesse Asmamaw Dejenie. (2021) Ketogenic Diets and their Therapeutic Potential on Breast Cancer: A Systemic Review. Cancer Management and Research 13, pages 9147-9155.
Read now
Simona Minzer. (2021) Effectiveness of Ketogenic Diets on the Survival of Adult Oncological Patients. Nutrition and Cancer 73:11-12, pages 2155-2165.
Read now

Articles from other publishers (64)

  Neha & Rishabh Chaudhary. (2024) Ketogenic diet as a treatment and prevention strategy for cancer: A therapeutic alternative. Nutrition 124, pages 112427.
Crossref
Acadia W. Buro, Tam Nguyen, Michael Abaskaron, Mary Katherine Haver & Tiffany L. Carson. (2024) Lifestyle interventions with dietary strategies after breast cancer diagnosis: a systematic review. Breast Cancer Research and Treatment.
Crossref
Otília Menyhárt & Balázs Győrffy. (2024) Dietary approaches for exploiting metabolic vulnerabilities in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1879:2, pages 189062.
Crossref
Syed Zamzam, Suad Said, Juman Yaghi, Fathima Sahar Faisal, Dana Hassan, Safa Abdul Majeed, Ala Al Rajabi & Reema Tayyem. (2024) Dietary Patterns Associated with Breast Cancer in the Middle East: A Scoping Review. Nutrients 16:5, pages 579.
Crossref
Konstancja Grabowska, Mateusz Grabowski, Marta Przybyła, Natalia Pondel, Jarosław J. Barski, Marta Nowacka-Chmielewska & Daniela Liśkiewicz. (2024) Ketogenic diet and behavior: insights from experimental studies. Frontiers in Nutrition 11.
Crossref
Antonio Paoli, Grant M. Tinsley, Mark P. Mattson, Immaculata De Vivo, Ravi Dhawan & Tatiana Moro. (2024) Common and divergent molecular mechanisms of fasting and ketogenic diets. Trends in Endocrinology & Metabolism 35:2, pages 125-141.
Crossref
Alex Buga, David G. Harper, Teryn N. Sapper, Parker N. Hyde, Brandon Fell, Ryan Dickerson, Justen T. Stoner, Madison L. Kackley, Christopher D. Crabtree, Drew D. Decker, Bradley T. Robinson, Gerald Krystal, Katherine Binzel, Maryam B. Lustberg & Jeff S. Volek. (2024) Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial. PLOS ONE 19:1, pages e0296523.
Crossref
Meret Grube, Arno Dimmler, Anja Schmaus, Rafael Saup, Tabea Wagner, Boyan K. Garvalov, Jonathan P. Sleeman & Wilko Thiele. (2023) Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice. Clinical & Experimental Metastasis.
Crossref
Chun Ni & Jian Li. (2023) Take metabolic heterogeneity into consideration when applying dietary interventions to cancer therapy: A review. Heliyon 9:12, pages e22814.
Crossref
Christine Kudiarasu, Pedro Lopez, Daniel A. Galvão, Robert U. Newton, Dennis R. Taaffe, Lorna Mansell, Brianna Fleay, Christobel Saunders, Caitlin Fox‐Harding & Favil Singh. (2023) What are the most effective exercise, physical activity and dietary interventions to improve body composition in women diagnosed with or at high‐risk of breast cancer? A systematic review and network meta‐analysis. Cancer 129:23, pages 3697-3712.
Crossref
Ayah Kamel Saeed Kamal & Wamidh H. Talib. (2023) Combination of ketogenic diet and probiotics inhibits breast cancer in mice by immune system modulation and reduction of Insulin growth factor-1. Pharmacia 70:4, pages 1411-1422.
Crossref
Aleyna Nur Küçük & Seda Çiftçi. (2023) The role of intermittent fasting and the ketogenic diet in cancer disease: can they replace the Mediterranean diet?. European Journal of Cancer Prevention 32:6, pages 533-543.
Crossref
Stephanie Nagy, Stephanie N Petrosky, Michelle Demory Beckler & Marc M Kesselman. (2023) The Impact of Modern Dietary Practices on Cancer Risk and Progression: A Systematic Review. Cureus.
Crossref
Wamidh H. Talib, Anfal Al-Dalaeen & Asma Ismail Mahmod. (2023) Ketogenic diet in cancer management. Current Opinion in Clinical Nutrition & Metabolic Care 26:4, pages 369-376.
Crossref
Carlos Martínez-Garay & Nabil Djouder. (2023) Dietary interventions and precision nutrition in cancer therapy. Trends in Molecular Medicine 29:7, pages 489-511.
Crossref
Doaa N. Al-Jada, Hamed R. Takruri & Wamidh H. Talib. (2023) From antiepileptic therapy to promising adjuvant in medical oncology: A historical view of the ketogenic diet. PharmaNutrition 24, pages 100340.
Crossref
Izabela Bolesławska, Magdalena Kowalówka, Natasza Bolesławska-Król & Juliusz Przysławski. (2023) Ketogenic Diet and Ketone Bodies as Clinical Support for the Treatment of SARS-CoV-2—Review of the Evidence. Viruses 15:6, pages 1262.
Crossref
Ryuichiro Egashira, Michiko Matsunaga, Akimitsu Miyake, Sayaka Hotta, Naoko Nagai, Chise Yamaguchi, Mariko Takeuchi, Misaki Moriguchi, Satoko Tonari, Mai Nakano, Hitomi Saito & Keisuke Hagihara. (2023) Long-Term Effects of a Ketogenic Diet for Cancer. Nutrients 15:10, pages 2334.
Crossref
Mengshu You, Zhuolin Xie, Nan Zhang, Yixuan Zhang, Desheng Xiao, Shuang Liu, Wei Zhuang, Lili Li & Yongguang Tao. (2023) Signaling pathways in cancer metabolism: mechanisms and therapeutic targets. Signal Transduction and Targeted Therapy 8:1.
Crossref
Helen M Parsons, Mary L Forte, Hamdi I Abdi, Sallee Brandt, Amy M Claussen, Timothy Wilt, Mark Klein, Elizabeth Ester, Adrienne Landsteiner, Aasma Shaukut, Shalamar S Sibley, Joanne Slavin, Catherine Sowerby, Weiwen Ng & Mary Butler. (2023) Nutrition as prevention for improved cancer health outcomes: a systematic literature review. JNCI Cancer Spectrum 7:3.
Crossref
Yu Jin, Shuoqing Fan, Wenna Jiang, Jingya Zhang, Lexin Yang, Jiawei Xiao, Haohua An & Li Ren. (2022) Two effective models based on comprehensive lipidomics and metabolomics can distinguish BC versus HCs, and TNBC versus non‐TNBC. PROTEOMICS – Clinical Applications 17:3.
Crossref
Magie Tamraz, Najib Al Ghossaini & Sally Temraz. (2023) The Ketogenic Diet in Colorectal Cancer: A Means to an End. International Journal of Molecular Sciences 24:4, pages 3683.
Crossref
Yafeng Liu & Jibin Lu. (2023) A bibliometric analysis of Mediterranean diet on cancer from 2012 to 2021. Frontiers in Nutrition 10.
Crossref
Penny Kechagioglou & Nina Fuller-ShavelPenny Kechagioglou & Nina Fuller-Shavel. 2023. Integrative Oncology in Breast Cancer Care. Integrative Oncology in Breast Cancer Care 95 112 .
Qiuju Xiao, Bo Deng, Abolfazl Akbari, Qisheng Liu & Bisheng Zhu. (2022) The ketogenic diet could improve the efficacy of curcumin and Oldenlandia diffusa extract in the treatment of gastric cancer by increasing miR340 expression and apoptosis mediated by autophagy, oxidative stress, and angiogenesis . Journal of Food Biochemistry 46:12.
Crossref
Kaleem Imdad, Turki Abualait, Ammara Kanwal, Ziyad Tareq AlGhannam, Shahab Bashir, Anum Farrukh, Sahir Hameed Khattak, Raidah Albaradie & Shahid Bashir. (2022) The Metabolic Role of Ketogenic Diets in Treating Epilepsy. Nutrients 14:23, pages 5074.
Crossref
Marie Guinhut & Bruno Raynard. (2022) Régime cétogène et cancer. Médecine des Maladies Métaboliques 16:7, pages 614-619.
Crossref
Diwakar Davar & Hassane M. Zarour. (2022) Facts and Hopes for Gut Microbiota Interventions in Cancer Immunotherapy. Clinical Cancer Research 28:20, pages 4370-4384.
Crossref
Cara Miller, Karina Austin, Lawren Fischer, Eleah Stringer & Satnam Sidhu. (2022) The Ketogenic Diet: Considerations for Cancer Survivorship. Current Nutrition Reports 11:4, pages 682-694.
Crossref
Haobin Zhao, Han Jin, Junfang Xian, Zhifu Zhang, Junling Shi & Xiaosu Bai. (2022) Effect of Ketogenic Diets on Body Composition and Metabolic Parameters of Cancer Patients: A Systematic Review and Meta-Analysis. Nutrients 14:19, pages 4192.
Crossref
Léa Montégut, Rafael de Cabo, Laurence Zitvogel & Guido Kroemer. (2022) Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer. Cancer Discovery 12:10, pages 2258-2279.
Crossref
Giovanna Muscogiuri, Luigi Barrea, Maria Celeste Cantone, Valentina Guarnotta, Rossella Mazzilli, Ludovica Verde, Claudia Vetrani, Annamaria Colao & Antongiulio Faggiano. (2022) Neuroendocrine Tumors: A Comprehensive Review on Nutritional Approaches. Cancers 14:18, pages 4402.
Crossref
Adeleh Khodabakhshi, Thomas N. Seyfried, Miriam Kalamian & Sayed Hossein Davoodi. (2022) Answer to the critical remarks to the article by Khodabakhshi and colleagues reporting results from a randomized study on ketogenic diet. Clinical Nutrition 41:9, pages 2063-2066.
Crossref
Sherry Shen & Neil M. Iyengar. (2022) Insulin-Lowering Diets in Metastatic Cancer. Nutrients 14:17, pages 3542.
Crossref
Noushin Mohammadifard, Fahimeh Haghighatdoost, Mehran Rahimlou, Ana Paula Santos Rodrigues, Mohammadamin Khajavi Gaskarei, Paria Okhovat, Cesar de Oliveira, Erika Aparecida Silveira & Nizal Sarrafzadegan. (2022) The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer. Nutrients 14:17, pages 3499.
Crossref
Maria Cuevas-Cervera, Jose Perez-Montilla, Ana Gonzalez-Muñoz, Maria Garcia-Rios & Santiago Navarro-Ledesma. (2022) The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review. International Journal of Environmental Research and Public Health 19:11, pages 6698.
Crossref
Yan Lan, Chaonan Jin, Pavitra Kumar, Xia Yu, Cameron Lenahan & Jifang Sheng. (2022) Ketogenic Diets and Hepatocellular Carcinoma. Frontiers in Oncology 12.
Crossref
J. Huebner, C. Keinki & L. Käsmann. (2022) Critical remarks to the article by Khodabakhshi and colleagues reporting results from a randomized study on ketogenic diet. Clinical Nutrition 41:5, pages 1149.
Crossref
Shubham Nimbkar, M. Maria Leena, J. A. Moses & C. Anandharamakrishnan. (2022) Medium chain triglycerides (MCT): State‐of‐the‐art on chemistry, synthesis, health benefits and applications in food industry. Comprehensive Reviews in Food Science and Food Safety 21:2, pages 843-867.
Crossref
Rainer J. Klement, Detlef Meyer, Stefan Kanzler & Reinhart A. Sweeney. (2021) Ketogenic diets consumed during radio-chemotherapy have beneficial effects on quality of life and metabolic health in patients with rectal cancer. European Journal of Nutrition 61:1, pages 69-84.
Crossref
Weiyi Shen, Jiamin He, Tongyao Hou, Jianmin Si & Shujie Chen. (2022) Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions. Aging and disease 13:4, pages 1063.
Crossref
Sebastian J. Hofer, Guido Kroemer & Oliver Kepp. 2022. Nutrition and Cancer. Nutrition and Cancer 125 158 .
Maximilian Römer, Jennifer Dörfler & Jutta Huebner. (2021) The use of ketogenic diets in cancer patients: a systematic review. Clinical and Experimental Medicine 21:4, pages 501-536.
Crossref
Jordin Lane, Nashira I. Brown, Shanquela Williams, Eric P. Plaisance & Kevin R. Fontaine. (2021) Ketogenic Diet for Cancer: Critical Assessment and Research Recommendations. Nutrients 13:10, pages 3562.
Crossref
Jutta Hübner, Matthias Beckmann, Markus Follmann, Monika Nothacker, Franz Josef Prott & Bernhard Wörmann. (2021) Complementary medicine in the treatment of cancer patients. Deutsches Ärzteblatt international.
Crossref
Irina Kareva & Joel S. Brown. (2021) Estrogen as an Essential Resource and the Coexistence of ER+ and ER– Cancer Cells. Frontiers in Ecology and Evolution 9.
Crossref
Julia Tulipan & Barbara Kofler. (2021) Implementation of a Low-Carbohydrate Diet Improves the Quality of Life of Cancer Patients – An Online Survey. Frontiers in Nutrition 8.
Crossref
Wamidh H. Talib, Asma Ismail Mahmod, Ayah Kamal, Hasan M. Rashid, Aya M. D. Alashqar, Samar Khater, Duaa Jamal & Mostafa Waly. (2021) Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities. Current Issues in Molecular Biology 43:2, pages 558-589.
Crossref
Rainer J. Klement, Petra S. Koebrunner, Detlef Meyer, Stefan Kanzler & Reinhart A. Sweeney. (2021) Impact of a ketogenic diet intervention during radiotherapy on body composition: IV. Final results of the KETOCOMP study for rectal cancer patients. Clinical Nutrition 40:7, pages 4674-4684.
Crossref
Jing Li, Haiyan Zhang & Zhu Dai. (2021) Cancer Treatment With the Ketogenic Diet: A Systematic Review and Meta-analysis of Animal Studies. Frontiers in Nutrition 8.
Crossref
Ya-Feng Yang, Preety Babychen Mattamel, Tanya Joseph, Jian Huang, Qian Chen, Babatunde O. Akinwunmi, Casper J. P. Zhang & Wai-Kit Ming. (2021) Efficacy of Low-Carbohydrate Ketogenic Diet as an Adjuvant Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 13:5, pages 1388.
Crossref
Ulrike Kämmerer, Rainer J. Klement, Fabian T. Joos, Marc Sütterlin & Monika Reuss-Borst. (2021) Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer. Nutrients 13:3, pages 1029.
Crossref
Adeleh Khodabakhshi, Mohammad Esmaeil Akbari, Hamid Reza Mirzaei, Thomas N. Seyfried, Miriam Kalamian & Sayed Hossein Davoodi. (2021) Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial. Clinical Nutrition 40:3, pages 751-758.
Crossref
Raushan K. Kumisbekova, Nasrulla A. Shanazarov, Bakytdjan R. Bimbetov, Lira T. Gilmutdinova & Mukhtar E. Tuleutaev. (2021) Nutritional nutrition in rehabilitation of cancer patients. Russian Journal of Physiotherapy, Balneology and Rehabilitation 20:1, pages 69-77.
Crossref
Adeleh Khodabakhshi, Maryam Mahmoudi, Hassan Mehrad Majd & Sayed Hossein Davoodi. (2021) Possible Nutrition-Related Mechanisms of Metabolic Management in Cancer Treatment. International Journal of Cancer Management 14:1.
Crossref
Adeleh Khodabakhshi & Mohammad reza Rooholamini. (2021) Is There any Possible Association Between Trimethylamine N-Oxide (TMAO) and Cancer? A Review Study. Journal of Occupational Health and Epidemiology 10:1, pages 17-23.
Crossref
Rajesh N. GaccheRajesh N. Gacche. 2021. Dietary Research and Cancer. Dietary Research and Cancer 9 18 .
Rainer J. Klement, Colin E. Champ, Ulrike Kämmerer, Petra S. Koebrunner, Kelley Krage, Gabriele Schäfer, M. Weigel & Reinhart A. Sweeney. (2020) Impact of a ketogenic diet intervention during radiotherapy on body composition: III—final results of the KETOCOMP study for breast cancer patients. Breast Cancer Research 22:1.
Crossref
Adeleh Khodabakhshi, Thomas N. Seyfried, Miriam Kalamian, Maryam Beheshti & Sayed Hossein Davoodi. (2020) Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial. Nutrition Journal 19:1.
Crossref
John R. Moffett, Narayanan Puthillathu, Ranjini Vengilote, Diane M. Jaworski & Aryan M. Namboodiri. (2020) Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease. Frontiers in Physiology 11.
Crossref
Thomas N. Seyfried, Purna Mukherjee, Mehmet S. Iyikesici, Abdul Slocum, Miriam Kalamian, Jean-Pierre Spinosa & Christos Chinopoulos. (2020) Consideration of Ketogenic Metabolic Therapy as a Complementary or Alternative Approach for Managing Breast Cancer. Frontiers in Nutrition 7.
Crossref
Rainer J. Klement, Nanina Brehm & Reinhart A. Sweeney. (2020) Ketogenic diets in medical oncology: a systematic review with focus on clinical outcomes. Medical Oncology 37:2.
Crossref
Anouk Charlot, Ombline Conrad & Joffrey Zoll. (2020) Le régime cétogène : une stratégie alimentaire efficace en complément des traitements contre le cancer ?. Biologie Aujourd’hui 214:3-4, pages 115-123.
Crossref
Tone Hoel Lende, Marie Austdal, Tone Frost Bathen, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Nina G. Egeland, Siri Lunde, Lars A. Akslen, Kristin Jonsdottir, Emiel A. M. Janssen, Håvard Søiland & Jan P. A. Baak. (2019) Metabolic consequences of perioperative oral carbohydrates in breast cancer patients — an explorative study. BMC Cancer 19:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.