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Nutrition and Cancer Volume 73, 2021 - Issue 5
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Research Article

Phenolic Extraction of Moringa Oleifera Leaves Induces Caspase-Dependent and Caspase-Independent Apoptosis through the Generation of Reactive Oxygen Species and the Activation of Intrinsic Mitochondrial Pathway in Human Melanoma Cells

Bich Hang Doa Faculty of Biotechnology, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City, Vietnam;b Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam;c Department of Animal Biotechnology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, VietnamView further author information
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Nghia Son Hoanga Faculty of Biotechnology, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City, Vietnam;c Department of Animal Biotechnology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, VietnamView further author information
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Thi Phuong Thao Nguyena Faculty of Biotechnology, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City, Vietnam;c Department of Animal Biotechnology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, VietnamView further author information
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Nguyen Quynh Chi Hoc Department of Animal Biotechnology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, VietnamView further author information
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Thanh Long Lea Faculty of Biotechnology, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City, Vietnam;c Department of Animal Biotechnology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, VietnamView further author information
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Chinh Chung Doana Faculty of Biotechnology, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi City, Vietnam;c Department of Animal Biotechnology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, VietnamCorrespondence[email protected] [email protected]
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Pages 869-888 | Received 10 Oct 2019, Accepted 22 May 2020, Published online: 12 Jun 2020

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Nabila Bibi, Nadia Rahman, Muhammad Qasim Ali, Noormazlinah Ahmad & Farzana Sarwar. (2023) Nutritional value and therapeutic potential of Moringa oleifera: a short overview of current research. Natural Product Research 0:0, pages 1-19.
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Doan Chinh Chung, Thanh Long Le, Nguyen Quynh Chi Ho, Thi Thuy Nguyen, Dang Giap Do, Duc Thang Do, Thi Phuong Mai Nguyen, Thi Phuong Thao Nguyen & Nghia Son Hoang. (2021) Evaluation of in vitro cytotoxicity and in vivo potential toxicity of the extract from in vitro cultivated Anoectochilus roxburghii Lindl. Journal of Toxicology and Environmental Health, Part A 84:24, pages 987-1003.
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Articles from other publishers (10)

Jiaqi Wang, Chuchu Ma, Zhongyuan Tang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang & Qiying Yao. (2024) Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma. Cancer Cell International 24:1.
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Ping Wei, Yue Zhang, Yao-Ying Wang, Jin-Feng Dong, Bi-Ni Liao, Zhi-Cheng Su, Wu Li, Ju-Cai Xu, Wen-Yong Lou, Hui-Hui Su & Chao Peng. (2023) Efficient extraction, excellent activity, and microencapsulation of flavonoids from Moringa oleifera leaves extracted by deep eutectic solvent. Biomass Conversion and Biorefinery 13:16, pages 15095-15109.
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Xinyue Su, Guanzheng Lu, Liang Ye, Ruyu Shi, Maomao Zhu, Xinming Yu, Zhiyong Li, Xiaobin Jia & Liang Feng. (2023) Moringa oleifera Lam.: a comprehensive review on active components, health benefits and application . RSC Advances 13:35, pages 24353-24384.
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Ping Wei, Yue Zhang, Yao-Ying Wang, Jin-Feng Dong, Zi-Hao Lin, Wu Li, Lei Liu, Shuang-Lan Hu, Lin Zhang, Wen-Yong Lou & Chao Peng. (2023) Efficient extraction and excellent activity of flavonoid from Moringa oleifera leaves and its microencapsulation. LWT 184, pages 115021.
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Fikile T. Mthiyane, Phiwayinkosi V. Dludla, Khanyisani Ziqubu, Sinenhlanhla X. H. Mthembu, Ndivhuwo Muvhulawa, Nokulunga Hlengwa, Bongani B. Nkambule & Sithandiwe E. Mazibuko-Mbeje. (2022) A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets. Frontiers in Pharmacology 13.
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Weigang Chen, Xianhong Cai, Qiang Sun, Xinhua Guo, Chunmei Liang, Hong Tang, Heming Huang, Hui Luo, Lanmei Chen & Jincan Chen. (2022) Design and synthesis of aptamer-cyclometalated iridium(III) complex conjugate targeting cancer cells. European Journal of Medicinal Chemistry 236, pages 114335.
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Chinh Chung Doan, Thanh Long Le, Nguyen Quynh Chi Ho, Thi Hong Lan La, Viet Cuong Nguyen, Van Dong Le, Thi Phuong Thao Nguyen & Nghia Son Hoang. (2022) Bioactive chemical constituents, in vitro anti-proliferative activity and in vivo toxicity of the extract of Curcuma singularis Gagnep rhizomes. Journal of Ethnopharmacology 284, pages 114803.
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Yu-Yao Wu, Yan-Ming Xu & Andy T. Y. Lau. (2021) Anti-Cancer and Medicinal Potentials of Moringa Isothiocyanate. Molecules 26:24, pages 7512.
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Nguyen Hoai Nguyen, Minh Tan Nguyen, Hiep Dinh Nguyen, Phuoc Dien Pham, Ut Dong Thach, Binh T. D. Trinh, Ly T. T. Nguyen, Son V. Dang, Anh Thu Do & Bich Hang Do. (2021) Antioxidant and Antimicrobial Activities of the Extracts from Different Garcinia Species. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-9.
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Jing Xie, Lin-jie Peng, Ming-rong Yang, Wei-wei Jiang, Jia-ying Mao, Chong-ying Shi, Yang Tian & Jun Sheng. (2021) Alkaloid Extract of Moringa oleifera Lam. Exerts Antitumor Activity in Human Non-Small-Cell Lung Cancer via Modulation of the JAK2/STAT3 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-12.
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