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Original Articles

Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells

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Pages 668-681 | Received 09 Jun 2009, Accepted 05 Nov 2009, Published online: 22 Jun 2010

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Tamara Y. Forbes-Hernandez, Massimiliano Gasparrini, Sadia Afrin, Stefano Bompadre, Bruno Mezzetti, Josè L. Quiles, Francesca Giampieri & Maurizio Battino. (2016) The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity?. Critical Reviews in Food Science and Nutrition 56:sup1, pages S46-S59.
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Articles from other publishers (27)

Habiba Khan, Juhi Rais, Mohammad Afzal & Md Arshad. (2023) Elucidating molecular and cellular targets and the antiprostate cancer potentials of promising phytochemicals: a review. Anti-Cancer Drugs 34:8, pages 910-915.
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Eskandar Qaed, Bandar Al-Hamyari, Ahmed Al-Maamari, Abdullah Qaid, Haneen Alademy, Marwan Almoiliqy, Jean Claude Munyemana, Murad Al-Nusaif, Jameel Alafifi, Eman Alyafeai, Mohammed Safi, Zhaohong Geng, Zeyao Tang & Xiaodong Ma. (2023) Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies. Global Medical Genetics 10:03, pages 205-220.
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Hitesh Chopra, Shabana Bibi, Rajat Goyal, Rupesh K. Gautam, Rashmi Trivedi, Tarun Kumar Upadhyay, Mohd Hasan Mujahid, Mohammad Ajmal Shah, Muhammad Haris, Kartik Bhairu Khot, Gopika Gopan, Inderbir Singh, Jin Kyu Kim, Jobin Jose, Mohamed M. Abdel-Daim, Fahad A. Alhumaydhi, Talha Bin Emran & Bonglee Kim. (2022) Chemopreventive Potential of Dietary Nanonutraceuticals for Prostate Cancer: An Extensive Review. Frontiers in Oncology 12.
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Mohammad Fahad Ullah, Aamir Ahmad, Showket H. Bhat, Faisel M. Abuduhier, Syed Khalid Mustafa & Shazia Usmani. (2022) Diet-derived small molecules (nutraceuticals) inhibit cellular proliferation by interfering with key oncogenic pathways: an overview of experimental evidence in cancer chemoprevention. Biologia Futura 73:1, pages 55-69.
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Felice Crocetto, Erika di Zazzo, Carlo Buonerba, Achille Aveta, Savio Domenico Pandolfo, Biagio Barone, Francesco Trama, Vincenzo Francesco Caputo, Luca Scafuri, Matteo Ferro, Vincenzo Cosimato, Ferdinando Fusco, Ciro Imbimbo & Giuseppe Di Lorenzo. (2021) Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature. Nutrients 13:11, pages 3750.
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Garima Sharma, Shalu Nim, Madhusudhan Alle, Azamal Husen & Jin-Chul Kim. 2021. Smart Nanomaterials in Biomedical Applications. Smart Nanomaterials in Biomedical Applications 61 100 .
Muhammad Imran, Farhan Saeed, Syed Amir Gilani, Mohammad Ali Shariati, Ali Imran, Muhammad Afzaal, Muhammad Atif, Tabussam Tufail & Faqir M. Anjum. (2020) Fisetin: An anticancer perspective. Food Science & Nutrition 9:1, pages 3-16.
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Seyhan ŞAHAN FIRAT & Meryem TEMİZ RESİTOGLU. (2019) Yaşa bağlı gelişen bozukluklarda polifenoller ve hedefleri; mTOR sinyal ileti yoluPolyphenols and targets in age-related disorders; mTOR signalling pathway. Mersin Üniversitesi Sağlık Bilimleri Dergisi 12:3, pages 542-552.
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Fulya Pak & Pinar Oztopcu-Vatan. (2019) Fisetin effects on cell proliferation and apoptosis in glioma cells. Zeitschrift für Naturforschung C 74:11-12, pages 295-302.
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Xue Xiao, Juan Zou, Yin Fang, Yibo Meng, Chao Xiao, Jiaxin Fu, Shiyu Liu, Peng Bai & Yuan Yao. (2018) Fisetin and polymeric micelles encapsulating fisetin exhibit potent cytotoxic effects towards ovarian cancer cells. BMC Complementary and Alternative Medicine 18:1.
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Xiang Li, Changde Zhang, Shanchun Guo, Pravien Rajaram, Maizie Lee, Guanglin Chen, Ryan Fong, Aaron Gonzalez, Qiang Zhang, Shilong Zheng, Guangdi Wang & Qiao-Hong Chen. (2018) Structure-activity relationship and pharmacokinetic studies of 3-O-substitutedflavonols as anti-prostate cancer agents. European Journal of Medicinal Chemistry 157, pages 978-993.
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Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli & Mauro Provinciali. (2018) Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy. Mediators of Inflammation 2018, pages 1-32.
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Kiruthika Sundarraj, Azhwar Raghunath & Ekambaram Perumal. (2018) A review on the chemotherapeutic potential of fisetin: In vitro evidences. Biomedicine & Pharmacotherapy 97, pages 928-940.
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Xiang Li, Maizie Lee, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang & Qiao-Hong Chen. (2017) 3-O-Substituted-3′,4′,5′-trimethoxyflavonols: Synthesis and cell-based evaluation as anti-prostate cancer agents. Bioorganic & Medicinal Chemistry 25:17, pages 4768-4777.
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Chen‐Hsuan Su, Chao‐Lin Kuo, Kung‐Wen Lu, Fu‐Shun Yu, Yi‐Shih Ma, Jiun‐Long Yang, Yung‐Lin Chu, Fu‐Shin Chueh, Kuo‐Ching Liu & Jing‐Gung Chung. (2017) Fisetin‐induced apoptosis of human oral cancer SCC‐4 cells through reactive oxygen species production, endoplasmic reticulum stress, caspase‐, and mitochondria‐dependent signaling pathways. Environmental Toxicology 32:6, pages 1725-1741.
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Eiman Mukhtar, Vaqar Mustafa Adhami, Imtiaz Ahmad Siddiqui, Ajit Kumar Verma & Hasan Mukhtar. (2016) Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells. Molecular Cancer Therapeutics 15:12, pages 2863-2874.
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Hamidreza Pazoki-Toroudi, Hamed Amani, Marjan Ajami, Seyed Fazel Nabavi, Nady Braidy, Pandima Devi Kasi & Seyed Mohammad Nabavi. (2016) Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing. Ageing Research Reviews 31, pages 55-66.
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Deeba N. Syed, Vaqar Mustafa Adhami, Naghma Khan, Mohammad Imran Khan & Hasan Mukhtar. (2016) Exploring the molecular targets of dietary flavonoid fisetin in cancer. Seminars in Cancer Biology 40-41, pages 130-140.
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Thamaraiselvan Rengarajan & Nik Soriani Yaacob. (2016) The flavonoid fisetin as an anticancer agent targeting the growth signaling pathways. European Journal of Pharmacology 789, pages 8-16.
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Xiang Li, Guanglin Chen, Xiaojie Zhang, Qiang Zhang, Shilong Zheng, Guangdi Wang & Qiao-Hong Chen. (2016) A new class of flavonol-based anti-prostate cancer agents: Design, synthesis, and evaluation in cell models. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4241-4245.
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Ju-Suk Nam, Ashish Sharma, Lich Nguyen, Chiranjib Chakraborty, Garima Sharma & Sang-Soo Lee. (2016) Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine. Molecules 21:1, pages 108.
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C. U. F. Kelly Hill, Shaban E. A. Saad, Robert G. Britton, Andreas J. Gescher, Stewart Sale, Karen Brown & Lynne M. Howells. (2015) Inhibition of prostate cancer cell growth by 3′,4′,5′-trimethoxyflavonol (TMFol). Cancer Chemotherapy and Pharmacology 76:1, pages 179-185.
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Ruey-Hwang Chou, Shu-Ching Hsieh, Yung-Luen Yu, Min-Hsien Huang, Yi-Chang Huang & Yi-Hsien Hsieh. (2013) Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway. PLoS ONE 8:8, pages e71983.
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Naghma KhanDeeba N. SyedNihal AhmadHasan Mukhtar. (2013) Fisetin: A Dietary Antioxidant for Health Promotion. Antioxidants & Redox Signaling 19:2, pages 151-162.
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Vijay Mohan, Dhanya Nambiar, Raosaheb K. Kale & Rana P. Singh. 2013. Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy. Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy 61 84 .
Vaqar Mustafa Adhami, Deeba Nadeem Syed, Naghma Khan & Hasan Mukhtar. (2012) Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochemical Pharmacology 84:10, pages 1277-1281.
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Tsung-Ho Ying, Shun-Fa Yang, Su-Ju Tsai, Shu-Ching Hsieh, Yi-Chang Huang, Da-Tian Bau & Yi-Hsien Hsieh. (2011) Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway. Archives of Toxicology 86:2, pages 263-273.
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