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Studies of immunomodulating actions of carotenoids. I. Effects of β‐carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system

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Pages 93-105 | Received 11 Oct 1990, Accepted 29 Apr 1991, Published online: 04 Aug 2009

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Hasina Begum, Fatimah MD. Yusoff, Sanjoy Banerjee, Helena Khatoon & Mohamed Shariff. (2016) Availability and Utilization of Pigments from Microalgae. Critical Reviews in Food Science and Nutrition 56:13, pages 2209-2222.
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Carmen Rioboo, Óscar González-Barreiro, Julio Abalde & Ángeles Cid. (2011) Flow cytometric analysis of the encystment process induced by paraquat exposure in Haematococcus pluvialis (Chlorophyceae). European Journal of Phycology 46:2, pages 89-97.
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Harumi Jyonouchi, Sining Sun, Koji Iijima & Myron D. Gross. (2000) Antitumor Activity of Astaxanthin and Its Mode of Action. Nutrition and Cancer 36:1, pages 59-65.
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Harumi Jyonouchim, Sining Sun & Yoshifumi Tomita. (1996) Actions of β-Carotene on T-Helper Cell Functions for Antibody Production. Journal of Nutritional Immunology 3:4, pages 21-34.
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Harumi Jyonouchi, Sining Sun, Munetaka Mizokami & MyronD. Gross. (1996) Effects of various carotenoids on cloned, effector‐stage T‐helper cell activity. Nutrition and Cancer 26:3, pages 313-324.
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Harumi Jyonouchi, Lei Zhang, Myron Gross & Yoshifumi Tomita. (1994) Immunomodulating actions of carotenoids: Enhancement of in vivo and in vitro antibody production to T‐dependent antigens. Nutrition and Cancer 21:1, pages 47-58.
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Yoshifumi Tomita, Harumi Jyonouchi, Robert W. Engelman, Noorbibi K. Day & Robert A. Good. (1993) Preventive Action of Carotenoids on the Development of Lymphadenopathy and Proteinuria in MSL-lpr/lpr Mice. Autoimmunity 16:2, pages 95-102.
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Yang Doris Liu, Jun He, Weiying Luan, Yanfeng Xu, Qianqian Li, Lishan Pan & Jianguo Liu. (2023) A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury. Algal Research 72, pages 103107.
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Ming-Li Teoh, Wu-Thong Choo, Syazana Anuwar, Ching-Yee Wong & Peter Convey. 2023. Handbook of Food and Feed from Microalgae. Handbook of Food and Feed from Microalgae 279 290 .
Apurva D. Patil, Pramod J. Kasabe & Padma B. Dandge. (2022) Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin. Natural Products and Bioprospecting 12:1.
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Rajeev K. Singla, Vivek Dhir, Reecha Madaan, Deepak Kumar, Simranjit Singh Bola, Monika Bansal, Suresh Kumar, Ankit Kumar Dubey, Shailja Singla & Bairong Shen. (2022) The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives. Frontiers in Pharmacology 13.
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Pinar Buket Demirel & Bilge Guvenc Tuna. 2021. Global Perspectives on Astaxanthin. Global Perspectives on Astaxanthin 427 445 .
Han-A Park, Mary Margaret Hayden, Sydni Bannerman, Joseph Jansen & Kristi M. Crowe-White. (2020) Anti-Apoptotic Effects of Carotenoids in Neurodegeneration. Molecules 25:15, pages 3453.
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Takshma Bhatt & Kirtan Patel. (2020) Carotenoids: Potent to Prevent Diseases Review. Natural Products and Bioprospecting 10:3, pages 109-117.
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Jaison Jeevanandam, Vandana Choudhary, Jaya Divya Selvam & Michael K. Danquah. 2020. Pigments from Microalgae Handbook. Pigments from Microalgae Handbook 325 362 .
Gargi Ghoshal. 2018. Advances in Biotechnology for Food Industry. Advances in Biotechnology for Food Industry 27 54 .
Alireza Milani, Marzieh Basirnejad, Sepideh Shahbazi & Azam Bolhassani. (2017) Carotenoids: biochemistry, pharmacology and treatment. British Journal of Pharmacology 174:11, pages 1290-1324.
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Malgorzata Baranska, Jan Cz. Dobrowolski & Grzegorz Zajac. 2016. Carotenoids. Carotenoids 131 146 .
Michael A. Packer, Graham C. Harris & Serean L. Adams. 2016. Algae Biotechnology. Algae Biotechnology 217 247 .
Kuan-Hung Lin, Kao-Chang Lin, Wan-Jung Lu, Philip-Aloysius Thomas, Thanasekaran Jayakumar & Joen-Rong Sheu. (2015) Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo. International Journal of Molecular Sciences 17:1, pages 44.
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Rama Sowmya & Nakkarike Manjabhat Sachindra. (2015) Enhancement of non-specific immune responses in common carp, Cyprinus carpio , by dietary carotenoids obtained from shrimp exoskeleton . Aquaculture Research 46:7, pages 1562-1572.
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Chitralekha Nag Dasgupta. 2015. Algal Biorefinery: An Integrated Approach. Algal Biorefinery: An Integrated Approach 253 276 .
Ranga Ambati, Siew-Moi Phang, Sarada Ravi & Ravishankar Aswathanarayana. (2014) Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review. Marine Drugs 12:1, pages 128-152.
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Agnieszka Kaczor & Marta Pilarczyk. 2014. Optical Spectroscopy and Computational Methods in Biology and Medicine. Optical Spectroscopy and Computational Methods in Biology and Medicine 309 326 .
Rita C. Macedo, Anaysa P. Bolin, Douglas P. Marin & Rosemari Otton. (2010) Astaxanthin addition improves human neutrophils function: in vitro study. European Journal of Nutrition 49:8, pages 447-457.
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Rosemari Otton, Douglas Popp Marin, Anaysa Paola Bolin, Rita de Cássia Macedo dos Santos, Tatiana Geraldo Polotow, Sandra Coccuzzo Sampaio & Marcelo Paes de Barros. (2010) Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats. Chemico-Biological Interactions 186:3, pages 306-315.
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Mariana Ferreira Leite, Amanda Martins de Lima, Monica Miyuki Massuyama & Rosemari Otton. (2010) Astaxanthin restores the enzymatic antioxidant profile in salivary gland of alloxan-induced diabetic rats. Archives of Oral Biology 55:7, pages 479-485.
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Joseph J. Wakshlag, Cheryl A. Balkman, Stewart K. Morgan & Margaret C. McEntee. (2010) Evaluation of the protective effects of all-trans-astaxanthin on canine osteosarcoma cell lines. American Journal of Veterinary Research 71:1, pages 89-96.
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Hiroshige ITAKURA, Jiro TAKAHASHIAkitoshi KITAMURA. (2008) Astaxanthin for Complementary and Alternative Medicine補完代替医療素材としてのアスタキサンチン. Japanese Journal of Complementary and Alternative Medicine 5:3, pages 173-182.
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Hyun-Seok Youn, Myong-Kyun Roh, Andreas Weber, Gordon T. Wilkinson & Byung-Soo Chun. (2007) Solubility of astaxanthin in supercritical carbon dioxide. Korean Journal of Chemical Engineering 24:5, pages 831-834.
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Laurent Dufossé, Patrick Galaup, Anina Yaron, Shoshana Malis Arad, Philippe Blanc, Kotamballi N. Chidambara Murthy & Gokare A. Ravishankar. (2005) Microorganisms and microalgae as sources of pigments for food use: a scientific oddity or an industrial reality?. Trends in Food Science & Technology 16:9, pages 389-406.
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J. Fábregas, A. Domínguez, A. Maseda & A. Otero. (2003) Interactions between irradiance and nutrient availability during astaxanthin accumulation and degradation in Haematococcus pluvialis. Applied Microbiology and Biotechnology 61:5-6, pages 545-551.
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