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The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro

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Pages 121-130 | Received 26 Jul 1994, Accepted 10 Oct 1994, Published online: 04 Aug 2009

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F. Khallouki, R. Haubner, W.E. Hull, G. Erben, B. Spiegelhalder, H. Bartsch & R.W. Owen. (2007) Isolation, purification and identification of ellagic acid derivatives, catechins, and procyanidins from the root bark of Anisophyllea dichostyla R. Br.. Food and Chemical Toxicology 45:3, pages 472-485.
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D.A. VATTEM & K. SHETTY. (2005) BIOLOGICAL FUNCTIONALITY OF ELLAGIC ACID: A REVIEW. Journal of Food Biochemistry 29:3, pages 234-266.
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Mario Falsaperla, Giuseppe Morgia, Alfredo Tartarone, Raffaele Ardito & Giampiero Romano. (2005) Support Ellagic Acid Therapy in Patients with Hormone Refractory Prostate Cancer (HRPC) on Standard Chemotherapy Using Vinorelbine and Estramustine Phosphate. European Urology 47:4, pages 449-455.
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Alexander Deterding, Fiona A. Dungey, Katy-Anne Thompson & Dietmar Steverding. (2005) Anti-trypanosomal activities of DNA topoisomerase inhibitors. Acta Tropica 93:3, pages 311-316.
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D. Gary Gilliland, Craig T. Jordan & Carolyn A. Felix. (2004) The Molecular Basis of Leukemia. Hematology 2004:1, pages 80-97.
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Ya-ming Xu, Jing-Zhen Deng, Ji Ma, Shao-Nong Chen, Rebekah Marshall, Shannon H Jones, Randall K Johnson & Sidney M Hecht. (2003) DNA damaging activity of ellagic acid derivatives. Bioorganic & Medicinal Chemistry 11:7, pages 1593-1596.
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C. Gerhäuser & N. Frank. 2003. Mechanisms in Carcinogenesis and Cancer Prevention. Mechanisms in Carcinogenesis and Cancer Prevention 289 305 .
Elisabeth M Perchellet, Bonnie J Sperfslage, Ghassan Qabaja, Graham B Jones & Jean-Pierre Perchellet. (2001) Quinone isomers of the WS-5995 antibiotics: synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation, and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro. Anti-Cancer Drugs 12:5, pages 401-417.
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Lynnette R. Ferguson. (2001) Role of plant polyphenols in genomic stability. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 475:1-2, pages 89-111.
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Peter W. Thulstrup, Thorsten Thormann, Jens Spanget-Larsen & Hanne Cathrine Bisgaard. (1999) Interaction between Ellagic Acid and Calf Thymus DNA Studied with Flow Linear Dichroism UV–VIS Spectroscopy. Biochemical and Biophysical Research Communications 265:2, pages 416-421.
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Laura Bravo. (2009) Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance. Nutrition Reviews 56:11, pages 317-333.
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Mariscal Brice Tchatat Tali, Darline Dize, Steven Collins Njonte Wouamba, Patrick Valere Tsouh Fokou, Rodrigue Keumoe, Cyrille Njanpa Ngansop, Michelle Sidoine Nguembou Njionhou, Cedric Derick Jiatsa Mbouna, Lauve Rachel Yamthe Tchokouaha, Vinesh Maharaj, Ndivhuwo Kevin Khorommbi, Dashnie Naidoo-Maharaj, Jean Claude Tchouankeu & Fabrice Boyom. (2022) Anti-Plasmodium Activity-Directed Investigation and UPLC–MS Fingerprint of Promising Extracts and Fractions from Terminalia Ivorensis a. Chev and Terminalia Brownii Fresen. SSRN Electronic Journal.
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