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Nutrition and Cancer Volume 25, 1996 - Issue 3
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Modulation of rat hepatic cytochrome P‐450 activity by garlic organosulfur compounds

Maria M. Reicks 162 Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St. Paul, MN, 55108 Phone: (612) 624–4735 Fax: (612) 624–4735
&
Duane L. Crankshaw Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, 55108
Pages 241-248 | Received 17 Aug 1995, Accepted 30 Nov 1995, Published online: 04 Aug 2009

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Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu & James W. Paxton. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews 35:1, pages 35-98.
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C. Ioannides. (2002) Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32:6, pages 451-478.
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Lee-Yan Sheen, Haw-Wen Chen, Yun-Lan Kung, Cheng-Tzu Liu & Chong-Kuei Lii. (1999) Effects of Garlic Oil and Its Organosulfur Compounds on the Activities of Hepatic Drug-Metabolizing and Antioxidant Enzymes in Rats Fed High- and Low-Fat Diets. Nutrition and Cancer 35:2, pages 160-166.
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COSTAS IOANNIDES. (1999) Effect of diet and nutrition on the expression of cytochromes P450. Xenobiotica 29:2, pages 109-154.
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Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, Jin-Young Shin, Jeong-Won Kim, In-Sik Shin, Changjong Moon, Jeong-Doo Heo, Jong-Choon Kim & In-Chul Lee. (2017) Protective effect and mechanism of action of diallyl disulfide against acetaminophen-induced acute hepatotoxicity. Food and Chemical Toxicology 109, pages 28-37.
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Kaiming Wang, Ying Wang, Qiuchen Qi, Fang Zhang, Yongchun Zhang, Xiaosong Zhu, Guangpu Liu, Yuxia Luan, Zhongxi Zhao, Jianhua Cai, Jimin Cao & Shanzhong Li. (2016) Inhibitory effects of S -allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells. International Immunopharmacology 34, pages 37-43.
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T. K. LimT. K. Lim. 2015. Edible Medicinal and Non Medicinal Plants. Edible Medicinal and Non Medicinal Plants 210 360 .
Chunxia Wang, Houkai Li, Qingshu Meng, Ying Du, Fei Xiao, Qian Zhang, Junjie Yu, Kai Li, Shanghai Chen, Zhiying Huang, Bin Liu & Feifan Guo. (2013) ATF 4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP 2E1 expression . Journal of Cellular and Molecular Medicine 18:1, pages 80-90.
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Yashika Bhalla, Vinay Kumar Gupta & Vikas Jaitak. (2013) Anticancer activity of essential oils: a review. Journal of the Science of Food and Agriculture 93:15, pages 3643-3653.
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Javed Iqbal, Duangkamon Sakloetsakun & Andreas Bernkop-Schnürch. (2011) Thiomers: Inhibition of cytochrome P450 activity. European Journal of Pharmaceutics and Biopharmaceutics 78:3, pages 361-365.
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S. Melino, R. Sabelli & M. Paci. (2010) Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy. Amino Acids 41:1, pages 103-112.
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S.H. Omar & N.A. Al-Wabel. (2010) Organosulfur compounds and possible mechanism of garlic in cancer. Saudi Pharmaceutical Journal 18:1, pages 51-58.
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Eugenia Teodor, Wanda Buzgariu, Alexandrina Rugina, Mirela Diaconu & G. L. Radu. 2009. Innovations in Chemical Biology. Innovations in Chemical Biology 353 360 .
Yogeshwer Shukla & Neetu Kalra. (2007) Cancer chemoprevention with garlic and its constituents. Cancer Letters 247:2, pages 167-181.
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. (2006) Effect of Allium sativum on cytochrome P450 and possible drug interactions. Oriental Pharmacy and Experimental Medicine 6:4, pages 274-285.
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Ingrid Arnault & Jacques Auger. (2006) Seleno-compounds in garlic and onion. Journal of Chromatography A 1112:1-2, pages 23-30.
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John T. Pinto & Richard S. Rivlin. 2004. Nutraceuticals. Nutraceuticals 177 187 .
A Singh, A Arora & Y Shukla. (2004) Modulation of altered hepatic foci induction by diallyl sulphide in Wistar rats. European Journal of Cancer Prevention 13:4, pages 263-269.
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Mosbah M. Kushad, John Masiunas, Kathy Eastman, Wilhelmina Kalt & Mary A. L. Smith. 2002. Horticultural Reviews. Horticultural Reviews 125 185 .
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C Teyssier, M.-J Amiot, N Mondy, J Auger, R Kahane & M.-H Siess. (2001) Effect of onion consumption by rats on hepatic drug-metabolizing enzymes. Food and Chemical Toxicology 39:10, pages 981-987.
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C.C Wu, L.Y Sheen, H.-W Chen, S.-J Tsai & C.-K Lii. (2001) Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells. Food and Chemical Toxicology 39:6, pages 563-569.
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Haw-Wen Chen, Chia-Wen Tsai, Chu-Chyn Ou, Chong-Kuei Lii, Jaw-Ji Yang, Jyh-Jong Wu & Lee-Yan Sheen. (2001) Dietary Fat and Garlic Oil Independently Regulate Hepatic Cytochrome P450 2B1 and the Placental Form of Glutathione S-Transferase Expression in Rats. The Journal of Nutrition 131:5, pages 1438-1443.
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Martin J. Ronis, J. Craig Rowlands, Reza Hakkak & Thomas M. Badger. (2001) Inducibility of Hepatic CYP1A Enzymes by 3-Methylcholanthrene and Isosafrole Differs in Male Rats Fed Diets Containing Casein, Soy Protein Isolate or Whey from Conception to Adulthood. The Journal of Nutrition 131:4, pages 1180-1188.
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Gary W Barone, Bill J Gurley, Beverley L Ketel, Meredith L Lightfoot & Sameh R Abul-Ezz. (2016) Authors' Reply. Annals of Pharmacotherapy 35:1, pages 124-125.
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John T. Pinto, Sameer Lapsia, Amy Shah, Harsha Santiago & Grace Kim. 2001. Nutrition and Cancer Prevention. Nutrition and Cancer Prevention 83 106 .
A.-M. Le Bon,M.-H. Siess,. (2000) Organosulfur Compounds from Allium and the Chemoprevention of Cancer. Drug Metabolism and Drug Interactions 17:1-4, pages 51-80.
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T.J. Smith,C.S. Yang,. (2000) Effect of Organosulfur Compounds from Garlic and Cruciferous Vegetables on Drug Metabolism Enzymes. Drug Metabolism and Drug Interactions 17:1-4, pages 23-50.
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M. Afzal, M. Ali, M. Thomson & D. Armstrong. (2000) Garlic and its medicinal potential. InflammoPharmacology 8:2, pages 123-148.
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Hye Gwang Jeong. (1999) Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury. Toxicology Letters 105:3, pages 215-222.
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Bo Han Wang, Katherine A. Zuzel, Khalid Rahman & David Billington. (1999) Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices. Toxicology 132:2-3, pages 215-225.
Crossref
L.O. Dragsted. 1999. Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease. Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease 385 394 .
Hye Gwang Jeong & Yong Woo Lee. (1998) Protective effects of diallyl sulfide on N-nitrosodimethylamine-induced immunosuppression in mice. Cancer Letters 134:1, pages 73-79.
Crossref
Cheng-Tzu Liu, Haw-Wen Chen, Lee-Yan Sheen, Yun-Lan Kung, Paul Chih-Hsueh Chen & Chong-Kuei Lii. (1998) Effect of Garlic Oil on Hepatic Arachidonic Acid Content and Immune Response in Rats. Journal of Agricultural and Food Chemistry 46:11, pages 4642-4647.
Crossref
CONG ZHAO & HITOSHI SHICHI. (1998) Prevention of Acetaminophen-induced Cataract by a Combination of Diallyl Disulfide and N-acetylcysteine. Journal of Ocular Pharmacology and Therapeutics 14:4, pages 345-355.
Crossref
Bo Han Wang, Katherine A Zuzel, Khalid Rahman & David Billington. (1998) Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices. Toxicology 126:3, pages 213-222.
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Marie-Hélène Siess, Anne-Marie Le Bon, Marie-Chantal Canivenc-Lavier & Marc Suschetet. (1997) Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides. Cancer Letters 120:2, pages 195-201.
Crossref

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