186
Views
89
CrossRef citations to date
0
Altmetric
Reports

Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide

Pages 157-162 | Received 03 Jun 1997, Accepted 08 Sep 1997, Published online: 04 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Sakine Tuncay & Özgen Özer. (2013) Investigation of different emulsion systems for dermal delivery of nicotinamide. Pharmaceutical Development and Technology 18:6, pages 1417-1423.
Read now
Nancy H Kim & Robert S Kirsner. (2010) Nicotinamide in dermatology. Expert Review of Dermatology 5:1, pages 23-29.
Read now
JenniferC. Spronck, JenniferL. Nickerson & JamesB. Kirkland. (2007) Niacin Deficiency Alters p53 Expression and Impairs Etoposide-Induced Cell Cycle Arrest and Apoptosis in Rat Bone Marrow Cells. Nutrition and Cancer 57:1, pages 88-99.
Read now
Helen L. Gensler, Tedine Williams, Arnold C. Huang & Elaine L. Jacobson. (1999) Oral Niacin Prevents Photocarcinogenesis and Photoimmunosuppression in Mice. Nutrition and Cancer 34:1, pages 36-41.
Read now

Articles from other publishers (85)

Verena Isak, Shayan Azizi, Xi K. Zhou, Devina Mehta, Wanhong Ding, Zakir Bulmer, Daniella S. Aivazi, Ryan W. Dellinger & Richard D. Granstein. (2024) Inhibition of UVB radiation‐induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene . Photodermatology, Photoimmunology & Photomedicine 40:3.
Crossref
Elena Dănilă, Durmuș Alpaslan Kaya, Valentina Anuța, Lăcrămioara Popa, Alina Elena Coman, Ciprian Chelaru, Rodica Roxana Constantinescu, Cristina Dinu-Pîrvu, Mădălina Georgiana Albu Kaya & Mihaela Violeta Ghica. (2024) Formulation and Characterization of Niacinamide and Collagen Emulsion and Its Investigation as a Potential Cosmeceutical Product. Cosmetics 11:2, pages 40.
Crossref
Mariana M. Reza, Jesús Durán-Hernández, Beatriz González-Cano, Jesús Jara-Cortés, Rafael López-Arteaga, Andrea Cadena-Caicedo, Leonardo Muñoz-Rugeles, Jesús Hernández-Trujillo & Jorge Peon. (2023) Primary Photophysics of Nicotinamide Chromophores in Their Oxidized and Reduced Forms. The Journal of Physical Chemistry B 127:39, pages 8432-8445.
Crossref
Celina Pihl, Katja M.S. Bendtsen, Henrik E. Jensen, Flemming Andersen, Peter Bjerring, Merete Haedersdal & Catharina M. Lerche. (2023) Oral phytochemicals as photoprotectants in UVR exposed hairless mice: A study of hesperidin methyl chalcone, phloroglucinol, and syringic acid. Journal of Photochemistry and Photobiology B: Biology 246, pages 112760.
Crossref
Ziyi Wei, Weiguo Wang, Hao Feng, Wenping Xu, Liming Tao, Zhong Li, Yang Zhang & Xusheng Shao. (2023) Investigation on the immunotoxicity induced by Emamectin benzoate on THP ‐1 macrophages based on metabolomics analysis . Environmental Toxicology 38:5, pages 1053-1062.
Crossref
Samantha Vicki Hunt, Aaron Jamison & Raman Malhotra. (2022) Oral nicotinamide for non-melanoma skin cancers: A review. Eye 37:5, pages 823-829.
Crossref
Akanksha Rohan Sanghvi. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 31 .
Joon Suk Bae, Seung Min Nam, Han Gyu Cha & Eun Soo Park. (2022) A split-face study to evaluate the efficacy of a dissolving microneedle-encapsulated niacinamide skin patch for the reduction of facial hyperpigmentation. Archives of Aesthetic Plastic Surgery 28:4, pages 113-118.
Crossref
Dalibor Mijaljica, Fabrizio Spada & Ian P. Harrison. 2022. Psoriasis - New Research. Psoriasis - New Research.
Aaron Jamison & Raman Malhotra. (2022) Nicotinamide and Nonmelanoma Skin Cancers. Ophthalmic Plastic & Reconstructive Surgery 38:3, pages 304-305.
Crossref
Victoria Stoj, Neda Shahriari, Kimberly Shao & Hao Feng. (2022) Nutrition and nonmelanoma skin cancers. Clinics in Dermatology 40:2, pages 173-185.
Crossref
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Josef Rudolf Schlatter, Henk van Loveren, Océane Albert, Agnès de Sesmaisons Lecarré & Helle Katrine Knutsen. (2021) Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA Journal 19:11.
Crossref
Ofir Artzi, Tamir Horovitz, Efrat Bar‐Ilan, Waseem Shehadeh, Amir Koren, Lior Zusmanovitch, Joseph N. Mehrabi, Fares Salameh, Gila Isman Nelkenbaum, Eyal Zur, Eli Sprecher & Jacob Mashiah. (2021) The pathogenesis of melasma and implications for treatment. Journal of Cosmetic Dermatology 20:11, pages 3432-3445.
Crossref
Roberto Campagna, Valentina Pozzi, Davide Sartini, Eleonora Salvolini, Valerio Brisigotti, Elisa Molinelli, Anna Campanati, Annamaria Offidani & Monica Emanuelli. (2021) Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers. Cancers 13:19, pages 4943.
Crossref
Celina Pihl, Katrine Togsverd-Bo, Flemming Andersen, Merete Haedersdal, Peter Bjerring & Catharina Margrethe Lerche. (2021) Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins. Cancers 13:15, pages 3684.
Crossref
Sharlo Bayless, Jeffrey Travers, Ravi Sahu & Craig Rohan. (2021) Inhibition of photodynamic therapy induced‑immunosuppression with aminolevulinic acid leads to enhanced outcomes of tumors and pre‑cancerous lesions (Review). Oncology Letters 22:3.
Crossref
Serena Giacalone, Cristina B. Spigariolo, Paolo Bortoluzzi & Gianluca Nazzaro. (2021) Oral nicotinamide: The role in skin cancer chemoprevention. Dermatologic Therapy 34:3.
Crossref
Aitziber Buqué, Norma Bloy, Guido Kroemer & Lorenzo Galluzzi. (2020) Possible mechanisms of cancer prevention by nicotinamide. British Journal of Pharmacology 178:10, pages 2034-2040.
Crossref
Luca Fania, Dario Didona, Roberto Morese, Irene Campana, Valeria Coco, Francesca Romana Di Pietro, Francesca Ricci, Sabatino Pallotta, Eleonora Candi, Damiano Abeni & Elena Dellambra. (2020) Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches. Biomedicines 8:11, pages 449.
Crossref
Peihua Luo, Hao Yan, Xueqin Chen, Ying Zhang, Ziying Zhao, Ji Cao, Yi Zhu, Jiangxia Du, Zhifei Xu, Xiaochen Zhang, Su Zeng, Bo Yang, Shenglin Ma & Qiaojun He. (2020) s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand–foot skin reaction that can be reversed by nicotinamide. Cell Research 30:9, pages 779-793.
Crossref
Nady Braidy & Yue Liu. (2020) NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis. Experimental Gerontology 132, pages 110831.
Crossref
Ilias P. Nikas, Stavroula A. Paschou & Han Suk Ryu. (2020) The Role of Nicotinamide in Cancer Chemoprevention and Therapy. Biomolecules 10:3, pages 477.
Crossref
Luca Fania, Cinzia Mazzanti, Elena Campione, Eleonora Candi, Damiano Abeni & Elena Dellambra. (2019) Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention. International Journal of Molecular Sciences 20:23, pages 5946.
Crossref
Chye Ling Tan, Toby Chin, Christina Yan Ru Tan, Holly A. Rovito, Ling Shih Quek, John E. Oblong & Sophie Bellanger. (2019) Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes. Journal of Investigative Dermatology 139:8, pages 1638-1647.e3.
Crossref
A. Rosenthal, M. Stoddard, L. Chipps & J. Herrmann. (2019) Skin cancer prevention: a review of current topical options complementary to sunscreens. Journal of the European Academy of Dermatology and Venereology 33:7, pages 1261-1267.
Crossref
Arthur R. Galbraith, Donna E. Seabloom, Beverly R. Wuertz, Jennifer D. Antonides, Vernon E. Steele, Lee W. Wattenberg & Frank G. Ondrey. (2019) Chemoprevention of Lung Carcinogenesis by Dietary Nicotinamide and Inhaled Budesonide. Cancer Prevention Research 12:2, pages 69-78.
Crossref
Victoria A. Snaidr, Diona L. Damian & Gary M. Halliday. (2019) Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology 28:S1, pages 15-22.
Crossref
Nady BraidyJade BergJames ClementFatemeh KhorshidiAnne PoljakTharusha JayasenaRoss GrantPerminder Sachdev. (2019) Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. Antioxidants & Redox Signaling 30:2, pages 251-294.
Crossref
Mohammad Ali Nilforoushzadeh, Mohammad Amir Amirkhani, Payam Zarrintaj, Abolfazl Salehi Moghaddam, Tina Mehrabi, Shiva Alavi & Mahsa Mollapour Sisakht. (2018) Skin care and rejuvenation by cosmeceutical facial mask. Journal of Cosmetic Dermatology 17:5, pages 693-702.
Crossref
Luis Rajman, Karolina Chwalek & David A. Sinclair. (2018) Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism 27:3, pages 529-547.
Crossref
Diona L Damian. (2017) Nicotinamide for skin cancer chemoprevention. Australasian Journal of Dermatology 58:3, pages 174-180.
Crossref
Sang Min Park, Tricia Li, Shaowei Wu, Wen‐Qing Li, Martin Weinstock, Abrar A. Qureshi & Eunyoung Cho. (2017) Niacin intake and risk of skin cancer in US women and men. International Journal of Cancer 140:9, pages 2023-2031.
Crossref
Lily Talakoub, Isaac M. Neuhaus & Siegrid S. Yu. 2016. International Textbook of Aesthetic Surgery. International Textbook of Aesthetic Surgery 1183 1209 .
Scott N. Byrne & Gary M. Halliday. 2016. Skin Stress Response Pathways. Skin Stress Response Pathways 211 234 .
John E. Oblong. (2014) The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging. DNA Repair 23, pages 59-63.
Crossref
Andrew C Chen & Diona L Damian. (2014) Nicotinamide and the skin. Australasian Journal of Dermatology 55:3, pages 169-175.
Crossref
Andrew C. Chen, Diona L. Damian & Gary M. Halliday. (2014) Oral and systemic photoprotection. Photodermatology, Photoimmunology & Photomedicine 30:2-3, pages 102-111.
Crossref
Suzanne M. Pilkington, Neil K. Gibbs, Peter S. Friedmann & Lesley E. Rhodes. (2014) Nutritional abrogation of photoimmunosuppression: in vivo investigations . Photodermatology, Photoimmunology & Photomedicine 30:2-3, pages 112-127.
Crossref
Johannes Wohlrab & Daniela Kreft. (2014) Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology. Skin Pharmacology and Physiology 27:6, pages 311-315.
Crossref
Hudson C. Polonini, Rafael M.P. Dias, Isabela O. Souza, Karla Mara Gonçalves, Tiago B.B. Gomes, Nádia R.B. Raposo & Adilson David da Silva. (2013) Quinolines derivatives as novel sunscreening agents. Bioorganic & Medicinal Chemistry Letters 23:16, pages 4506-4510.
Crossref
H.A. Rovito & J.E. Oblong. (2013) Nicotinamide preferentially protects glycolysis in dermal fibroblasts under oxidative stress conditions. British Journal of Dermatology 169, pages 15-24.
Crossref
S.M. Thanos, G.M. Halliday & D.L. Damian. (2012) Nicotinamide reduces photodynamic therapy-induced immunosuppression in humans. British Journal of Dermatology 167:3, pages 631-636.
Crossref
John E. Oblong. (2012) Male skin care: Shaving and moisturization needs. Dermatologic Therapy 25:3, pages 238-243.
Crossref
Josefina Navarrete-Solís, Juan Pablo Castanedo-Cázares, Bertha Torres-Álvarez, Cuauhtemoc Oros-Ovalle, Cornelia Fuentes-Ahumada, Francisco Javier González, Juan David Martínez-Ramírez & Benjamin Moncada. (2011) A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice 2011, pages 1-5.
Crossref
Joohong Park, Gary M. Halliday, Devita Surjana & Diona L. Damian. (2010) Nicotinamide Prevents Ultraviolet Radiation‐induced Cellular Energy Loss. Photochemistry and Photobiology 86:4, pages 942-948.
Crossref
Anna Ciebiada-Adamiec, Eugeniusz Małafiej & Ireneusz Ciebiada. (2010) Inhibitory effect of nicotinamide on enzymatic activity of selected fungal strains causing skin infection. Mycoses 53:3, pages 204-207.
Crossref
F. Moloney, M. Vestergaard, B. Radojkovic & D. Damian. (2010) Randomized, double-blinded, placebo controlled study to assess the effect of topical 1% nicotinamide on actinic keratoses. British Journal of Dermatology 162:5, pages 1138-1139.
Crossref
Diona L. Damian. (2010) Photoprotective effects of nicotinamide. Photochemical & Photobiological Sciences 9:4, pages 578-585.
Crossref
Neil S Sadick, Mary P Lupo, Diane S Berson & Zoe Diana DraelosLaurel Naversen Geraghty, Diane S Berson & Ranella Hirsch. 2010. Cosmeceutical Science in Clinical Practice. Cosmeceutical Science in Clinical Practice 1 15 .
Devita Surjana, Gary M. Halliday & Diona L. Damian. (2010) Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair. Journal of Nucleic Acids 2010, pages 1-13.
Crossref
Diona L. Damian & Gary M. Halliday. 2011. Nutrition for Healthy Skin. Nutrition for Healthy Skin 119 128 .
G. Sivapirabu, E. Yiasemides, G.M. Halliday, J. Park & D.L Damian. (2009) Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans. British Journal of Dermatology 161:6, pages 1357-1364.
Crossref
P.D. ChakrabortyD. DeS. BandyopadhyayD. Bhattacharyya. (2009) Human aqueous placental extract as a wound healer. Journal of Wound Care 18:11, pages 462-467.
Crossref
Lily Talakoub, Isaac M. Neuhaus & Siegrid S. Yu. 2009. Cosmetic Dermatology. Cosmetic Dermatology 7 34 .
E. Yiasemides, G. Sivapirabu, G. M. Halliday, J. Park & D. L. Damian. (2008) Oral nicotinamide protects against ultraviolet radiation-induced immunosuppression in humans. Carcinogenesis 30:1, pages 101-105.
Crossref
Diona L. Damian, Clare R.S. Patterson, Michael Stapelberg, Joohong Park, Ross St.C. Barnetson & Gary M. Halliday. (2008) UV Radiation-Induced Immunosuppression Is Greater in Men and Prevented by Topical Nicotinamide. Journal of Investigative Dermatology 128:2, pages 447-454.
Crossref
Pin‐Chi Chiu, Chih‐Chieh Chan, Hui‐Min Lin & Hsien‐Ching Chiu. (2007) The clinical anti‐aging effects of topical kinetin and niacinamide in Asians: a randomized, double‐blind, placebo‐controlled, split‐face comparative trial. Journal of Cosmetic Dermatology 6:4, pages 243-249.
Crossref
Mohammad R. Namazi. (2007) Nicotinamide in dermatology: a capsule summary. International Journal of Dermatology 46:12, pages 1229-1231.
Crossref
Dušan Valigura, Jan Moncol, Maria Korabik, Zuzana Púčeková, Tadeusz Lis, Jerzy Mroziński & Milan Melník. (2006) New Dimeric Copper(II) Complex [Cu(5‐MeOsal) 2 (μ‐nia)(H 2 O)] 2 with Magnetic Exchange Interactions through H‐Bonds . European Journal of Inorganic Chemistry 2006:19, pages 3813-3817.
Crossref
Christine M. Choi & Diane S. Berson. (2006) Cosmeceuticals. Seminars in Cutaneous Medicine and Surgery 25:3, pages 163-168.
Crossref
N. Otte, C. Borelli & H. C. Korting. (2005) Nicotinamide – biologic actions of an emerging cosmetic ingredient. International Journal of Cosmetic Science 27:5, pages 255-261.
Crossref
. (2016) Final Report of the Safety Assessment of Niacinamide and Niacin1. International Journal of Toxicology 24:5_suppl, pages 1-31.
Crossref
Donald L. Bissett, John E. Oblong & Cynthia A. Berge. (2005) Niacinamide. Dermatologic Surgery 31:s1, pages 860-866.
Crossref
Amanda Greatens, Tomohiro Hakozaki, Amy Koshoffer, Howard Epstein, Sandy Schwemberger, George Babcock, Donald Bissett, Hirotsugu Takiwaki, Seiji Arase, R. Randall Wickett & Raymond E. Boissy. (2005) Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible. Experimental Dermatology 14:7, pages 498-508.
Crossref
C. Bayerl. (2005) Topische Externa in der HautalterungTopical treatment of skin aging. Der Hautarzt 56:4, pages 328-339.
Crossref
. 2005. Cosmeceuticals and Active Cosmetics. Cosmeceuticals and Active Cosmetics 441 460 .
Yoshinao Soma, Masato Kashima, Akiko Imaizumi, Hideto Takahama, Tamihiro Kawakami & Masako Mizoguchi. (2004) Moisturizing effects of topical nicotinamide on atopic dry skin. International Journal of Dermatology 44:3, pages 197-202.
Crossref
D. L. Bissett, K. Miyamoto, P. Sun, J. Li & C. A. Berge. (2004) Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin 1 . International Journal of Cosmetic Science 26:5, pages 231-238.
Crossref
W Gehring. (2004) Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology 3:2, pages 88-93.
Crossref
Kwang Seok Ahn, Ki-Young Moon, Jinseon Lee & Yeong Shik Kim. (2003) Downregulation of NF-κB activation in human keratinocytes by melanogenic inhibitors. Journal of Dermatological Science 31:3, pages 193-201.
Crossref
Mohammad Reza Namazi. (2003) Nicotinamide-containing sunscreens for use in Australasian countries and cancer-provoking conditions. Medical Hypotheses 60:4, pages 544-545.
Crossref
Ronni Wolf, Edith Orion, Hagit Matz, Yalcin Tüzün & Binnur Tüzün. (2002) Miscellaneous treatments, II: niacin and heparin: unapproved uses, dosages, or indications. Clinics in Dermatology 20:5, pages 547-557.
Crossref
T. Hakozaki, L. Minwalla, J. Zhuang, M. Chhoa, A. Matsubara, K. Miyamoto, A. Greatens, G.G. Hillebrand, D.L. Bissett & R.E. Boissy. (2002) The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. British Journal of Dermatology 147:1, pages 20-31.
Crossref
Elaine L Jacobson, Paolo U Giacomoni, Michael J Roberts, Georg T Wondrak & Myron K Jacobson. (2001) Optimizing the energy status of skin cells during solar radiation. Journal of Photochemistry and Photobiology B: Biology 63:1-3, pages 141-147.
Crossref
Mary P Lupo. (2001) Antioxidants and vitamins in cosmetics. Clinics in Dermatology 19:4, pages 467-473.
Crossref
G.J Hageman & R.H Stierum. (2001) Niacin, poly(ADP-ribose) polymerase-1 and genomic stability. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 475:1-2, pages 45-56.
Crossref
Rolph Pfundt, Ivonne van Vlijmen-Willems, Mieke Bergers, Miriam Wingens, Wendy Cloin & Joost Schalkwijk. (2001) In situ demonstration of phosphorylated c-jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin. The Journal of Pathology 193:2, pages 248-255.
Crossref
Elaine L. Jacobson, Paolo U. Giacomoni, Michael J. Roberts, Georg T. Wondrak & Myron K. Jacobson. 2001. Sun Protection in Man. Sun Protection in Man 677 690 .
Homer S. Black & Lesley E. Rhodes. 2001. Sun Protection in Man. Sun Protection in Man 573 591 .
Zoe Diana Draelos. (2000) THERAPEUTIC MOISTURIZERS. Dermatologic Clinics 18:4, pages 597-607.
Crossref
Zoe Diana Draelos. (2000) Novel topical therapies in cosmetic dermatology. Current Problems in Dermatology 12:5, pages 235-239.
Crossref
C L Crowley, C M Payne, H Bernstein, C Bernstein & D Roe. (2000) The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate. Cell Death & Differentiation 7:3, pages 314-326.
Crossref
Mark Berneburg & Jean Krutmann. (2000) Photoimmunology, DNA repair and photocarcinogenesis. Journal of Photochemistry and Photobiology B: Biology 54:2-3, pages 87-93.
Crossref
Yezhou Sheng, Carl Bryngelsson & Ronald W Pero. (2000) Enhanced DNA repair, immune function and reduced toxicity of C-MED-100™, a novel aqueous extract from Uncaria tomentosa. Journal of Ethnopharmacology 69:2, pages 115-126.
Crossref
Abigail Jacobs, Javier Avalos, Paul Brown & Jonathan Wilkin. (2016) Does Photosensitivity Predict Photococarcinogenicity?. International Journal of Toxicology 18:3, pages 191-198.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.