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Original Articles

Urinary corticoid/creatinine ratios in the differentiation between pituitary‐dependent hyperadrenocorticism and hyperadrenocorticism due to adrenocortical tumour in the dog

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Pages 17-20 | Accepted 29 Oct 1996, Published online: 01 Nov 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Tera Pijnacker, Marieke Knies, Sara Galac, Karin Sanders, Jan A Mol & Hans S Kooistra. (2018) TRH-induced secretion of adrenocorticotropin and cortisol in dogs with pituitary-dependent hypercortisolism. Veterinary Quarterly 38:1, pages 72-78.
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Sarah J. van Rijn, Marianna A. Tryfonidou, Jeanette M. Hanson, Louis C. Penning & Björn P. Meij. (2013) Stem cells in the canine pituitary gland and in pituitary adenomas. Veterinary Quarterly 33:4, pages 217-224.
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Articles from other publishers (47)

Bart Eduardus Wilhelmus Ruijter, Céline Anne Bik, Imogen Schofield & Stijn Johannes Maria Niessen. (2023) External validation of a United Kingdom primary‐care Cushing's prediction tool in a population of referred Dutch dogs. Journal of Veterinary Internal Medicine 37:6, pages 2052-2063.
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Marit F. van den Berg, Hans S. Kooistra, Guy C. M. Grinwis, Sebastiaan A. van Nimwegen, Martijn van Faassen, Ido P. Kema, Erik Teske & Sara Galac. (2023) Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma. Journal of Veterinary Internal Medicine 37:1, pages 173-183.
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Krista van Blokland‐Post, Guy Grinwis, Anna Tellegen & Björn Meij. (2022) Transsphenoidal hypophysectomy as a treatment for Rathke's cleft cyst in a dog. Veterinary Record Case Reports 10:3.
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I. Schofield, D. C. Brodbelt, S. J. M. Niessen, D. B. Church, R. F. Geddes & D. G. O'Neill. (2021) Frequency and risk factors for naturally occurring Cushing's syndrome in dogs attending UK primary‐care practices . Journal of Small Animal Practice 63:4, pages 265-274.
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Noriyuki NAGATA, Hiryu SAWAMURA, Keitaro MORISHITA, Kenji HOSOYA, Nozomu YOKOYAMA, Kazuyoshi SASAOKA, Noboru SASAKI, Kensuke NAKAMURA, Yoshinori IKENAKA & Mitsuyoshi TAKIGUCHI. (2022) Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism. Journal of Veterinary Medical Science 84:7, pages 954-959.
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Sara Del Magno, Sarah van Rijn, Stefano Azzariti, Chiara Valtolina, Jiske l' Ami & Björn P. Meij. (2021) Plasma sodium and potassium concentrations after hypophysectomy in dogs with corticotroph adenomas. Journal of Veterinary Internal Medicine 36:1, pages 39-48.
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Dana A. Neelis, John S. Mattoon & Rance K. Sellon. 2021. Small Animal Diagnostic Ultrasound. Small Animal Diagnostic Ultrasound 566 582 .
Michael Bennaim, Robert E. Shiel & Carmel T. Mooney. (2019) Diagnosis of spontaneous hyperadrenocorticism in dogs. Part 2: Adrenal function testing and differentiating tests. The Veterinary Journal 252, pages 105343.
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Sara Del MagnoFederico FracassiGuy C.M. GrinwisLuciana MandrioliGualtiero GandiniFederica RossiRubina SirriLuciano PisoniMarianna A. TryfonidouBjörn P. Meij. (2019) Sequential Treatment of a Large Pituitary Corticotroph Neoplasm and Associated Neurological Signs in a Dog. Journal of the American Animal Hospital Association 55:2.
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Kirsten L. van Bokhorst, Hans S. Kooistra, Susanne A.E.B. Boroffka & Sara Galac. (2018) Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism. Journal of Veterinary Internal Medicine 33:1, pages 72-78.
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D.D. Miceli, O.P. Pignataro & V.A. Castillo. (2017) Concurrent hyperadrenocorticism and diabetes mellitus in dogs. Research in Veterinary Science 115, pages 425-431.
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Silviu Sbiera, Marianna A. Tryfonidou, Isabel Weigand, Guy C. M. Grinwis, Bart Broeckx, Sabine Herterich, Bruno Allolio, Timo Deutschbein, Martin Fassnacht & Björn P. Meij. (2016) Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas. PLOS ONE 11:12, pages e0169009.
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Sara Del Magno, Guy C.M. Grinwis, George Voorhout & Björn P. Meij. (2016) Dynamic computed tomography of the pituitary gland using a single slice scanner in dogs with pituitary-dependent hypercortisolism. Research in Veterinary Science 107, pages 42-49.
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S.J. van Rijn, S. Galac, M.A. Tryfonidou, J.W. Hesselink, L.C. Penning, H.S. Kooistra & B.P. Meij. (2016) The Influence of Pituitary Size on Outcome After Transsphenoidal Hypophysectomy in a Large Cohort of Dogs with Pituitary‐Dependent Hypercortisolism. Journal of Veterinary Internal Medicine 30:4, pages 989-995.
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Sarah J. van Rijn, Marianne G. Pouwer, Marianna A. Tryfonidou, Guy C.M. Grinwis, Joanne E.E. van der Bend, Pauline E.P.F. Beukers, Nadie Vastenhout, Jacques Drouin, Louis C. Penning & Björn P. Meij. (2015) Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. The Veterinary Journal 204:3, pages 315-321.
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S.J. van Rijn, J.M. Hanson, D. Zierikzee, H.S. Kooistra, L.C. Penning, M.A. Tryfonidou & B.P. Meij. (2015) The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas . Journal of Veterinary Internal Medicine 29:3, pages 869-876.
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Ellen N. Behrend. 2015. Canine and Feline Endocrinology. Canine and Feline Endocrinology 377 451 .
Thomas G. Nyland, Dana A. Neelis & John S. Mattoon. 2015. Small Animal Diagnostic Ultrasound. Small Animal Diagnostic Ultrasound 541 556 .
D.D. Miceli, M.F. Cabrera Blatter, M.F. Gallelli, O.P. Pignataro & V.A. Castillo. (2014) Involvement of glucagon-like peptide 1 in the glucose homeostasis regulation in obese and pituitary-dependent hyperadrenocorticism affected dogs. Research in Veterinary Science 97:2, pages 211-217.
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Sarah J. van Rijn, Frank M. Riemers, Douwe van den Heuvel, Jeannette Wolfswinkel, Leo Hofland, Bj?rn P. Meij & Louis C. Penning. (2013) Expression Stability of Reference Genes for Quantitative RT-PCR of Healthy and Diseased Pituitary Tissue Samples Varies Between Humans, Mice, and Dogs. Molecular Neurobiology 49:2, pages 893-899.
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Andrew C. Bugbee, Jo R. Smith & Cynthia R. Ward. (2013) Effect of dexamethasone or synthetic ACTH administration on endogenous ACTH concentrations in healthy dogs. American Journal of Veterinary Research 74:11, pages 1415-1420.
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E.N. Behrend, H.S. Kooistra, R. Nelson, C.E. Reusch & J.C. Scott‐Moncrieff. (2013) Diagnosis of Spontaneous Canine Hyperadrenocorticism: 2012 ACVIM Consensus Statement (Small Animal). Journal of Veterinary Internal Medicine 27:6, pages 1292-1304.
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Elaine C. Naan, Jolle Kirpensteijn, Gilles P. Dupré, Sara Galac & MaryAnn G. Radlinsky. (2013) Innovative Approach to Laparoscopic Adrenalectomy for Treatment of Unilateral Adrenal Gland Tumors in Dogs. Veterinary Surgery 42:6, pages 710-715.
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Pascalline Pey, Sylvie Daminet, Pascale Marcel Yvonne Smets, Luc Duchateau, Pauline De Fornel-Thibaud, Dan Rosenberg & Jimmy C. H. Saunders. (2013) Contrast-enhanced ultrasonographic evaluation of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism. American Journal of Veterinary Research 74:3, pages 417-425.
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M.F. Cabrera Blatter, B. del Prado, D.D. Miceli, N. Gomez, J. Ivanic, B. Di Tollo, M.F. Gallelli & V.A. Castillo. (2012) Interleukin-6 and insulin incrase and nitric oxide and adiponectin decrease in blind dogs with pituitary-dependent hyperadrenocorticism. Research in Veterinary Science 93:3, pages 1195-1202.
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D.D. Miceli, M.F. Gallelli, M.F. Cabrera Blatter, B. Martiarena, M.M. Brañas, L.R. Ortemberg, N.V. Gómez & V.A. Castillo. (2012) Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism. Research in Veterinary Science 93:1, pages 114-120.
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M.F. Cabrera Blatter, A. del Prado, M.F. Gallelli, E. D’Anna, J. Ivanic, M. Esarte, D.D. Miceli, N.V. Gómez & V.A. Castillo. (2012) Blindness in dogs with pituitary dependent hyperadrenocorticism: Relationship with glucose, cortisol and triglyceride concentration and with ophthalmic blood flow. Research in Veterinary Science 92:3, pages 387-392.
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P.M.Y. SmetsH.P. LefebvreB.P. MeijS. CroubelsE. MeyerI. Van de MaeleS. Daminet. (2012) Long‐Term Follow‐Up of Renal Function in Dogs after Treatment for ACTH ‐Dependent Hyperadrenocorticism . Journal of Veterinary Internal Medicine 26:3, pages 565-574.
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Hans S. Kooistra & Sara Galac. (2012) Recent Advances in the Diagnosis of Cushing's Syndrome in Dogs. Topics in Companion Animal Medicine 27:1, pages 21-24.
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Chen Gilor & Thomas K. Graves. (2011) Interpretation of Laboratory Tests for Canine Cushing's Syndrome. Topics in Companion Animal Medicine 26:2, pages 98-108.
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S.J. van Rijn, G.C.M. Grinwis, L.C. Penning & B.P. Meij. (2010) Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas. Domestic Animal Endocrinology 38:4, pages 244-252.
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Rosario Cerundolo. (2010) Canine hyperadrenocorticism: Part 1. Companion Animal 15:2, pages 51-57.
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Hans S. Kooistra & Sara Galac. (2010) Recent Advances in the Diagnosis of Cushing's Syndrome in Dogs. Veterinary Clinics of North America: Small Animal Practice 40:2, pages 259-267.
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M.F. Gallelli, M.F. Cabrera Blatter & V. Castillo. (2010) A comparative study by age and gender of the pituitary adenoma and ACTH and α-MSH secretion in dogs with pituitary-dependent hyperadrenocorticism. Research in Veterinary Science 88:1, pages 33-40.
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Sara Galac, Jenny J.C.W.M. Buijtels, Jan A. Mol & Hans S. Kooistra. (2010) Effects of trilostane on the pituitary-adrenocortical and renin–aldosterone axis in dogs with pituitary-dependent hypercortisolism. The Veterinary Journal 183:1, pages 75-80.
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S. Galac, J.J.C.W.M. Buijtels & H.S. Kooistra. (2009) Urinary Corticoid : Creatinine Ratios in Dogs with Pituitary‐Dependent Hypercortisolism during Trilostane Treatment. Journal of Veterinary Internal Medicine 23:6, pages 1214-1219.
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V.A. Castillo, M.F. Cabrera Blatter, N.V. G?mez, V. Sinatra, M.F. Gallelli & M.C. Ghersevich. (2009) Diurnal ACTH and plasma cortisol variations in healthy dogs and in those with pituitary-dependent Cushing?s syndrome before and after treatment with retinoic acid. Research in Veterinary Science 86:2, pages 223-229.
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V.A. Castillo, N.V. Gómez, J.C. Lalia, M.F. Cabrera Blatter & J.D. García. (2008) Cushing’s disease in dogs: Cabergoline treatment. Research in Veterinary Science 85:1, pages 26-34.
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F. Zeugswetter, M.T. Hoyer, M. Pagitz, T. Benesch, K.M. Hittmair & J.G. Thalhammer. (2008) The desmopressin stimulation test in dogs with Cushing's syndrome. Domestic Animal Endocrinology 34:3, pages 254-260.
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J.M. Hanson, J.A. Mol, P.A.J. Leegwater, S. Bilodeau, J. Drouin & B.P. Meij. (2008) Expression and mutation analysis of Tpit in the canine pituitary gland and corticotroph adenomas. Domestic Animal Endocrinology 34:3, pages 217-222.
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Jeanette M. Hanson, Erik Teske, George Voorhout, Sara Galac, Hans S. Kooistra & Björn P. Meij. (2007) Prognostic factors for outcome after transsphenoidal hypophysectomy in dogs with pituitary-dependent hyperadrenocorticism. Journal of Neurosurgery 107:4, pages 830-840.
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Mark E. Peterson. (2007) Diagnosis of Hyperadrenocorticism in Dogs. Clinical Techniques in Small Animal Practice 22:1, pages 2-11.
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B.A. Schotanus, B.P. Meij, I.H.C. Vos, H.S. Kooistra & M.E. Everts. (2006) Na+, K+-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology 30:4, pages 320-332.
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N.J Schoemaker, J Wolfswinkel, J.A Mol, G Voorhout, M.J.L Kik, J.T Lumeij & A Rijnberk. (2004) Urinary glucocorticoid excretion in the diagnosis of hyperadrenocorticism in ferrets. Domestic Animal Endocrinology 27:1, pages 13-24.
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S.F.M Bhatti, S.P De Vliegher, L Van Ham & H.S Kooistra. (2002) Effects of growth hormone-releasing peptides in healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism. Molecular and Cellular Endocrinology 197:1-2, pages 97-103.
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Ellen N. Behrend, Robert J. Kemppainen, Terrence P. Clark, M. D. Salman & Mark E. Peterson. (2002) Diagnosis of hyperadrenocorticism in dogs: a survey of internists and dermatologists. Journal of the American Veterinary Medical Association 220:11, pages 1643-1649.
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E. den Hertog, J. C. A. Braakman, E. Teske, H. S. Kooistra & A. Rijnberk. (1999) Results of non‐selective adrenocorticolysis by O,p'‐DDD in 129 dogs with pituitary‐dependent hyperadrenocorticism. Veterinary Record 144:1, pages 12-17.
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