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Neuro-Ophthalmology Volume 45, 2021 - Issue 1
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Original Article

Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight

Thomas H. Madera COL(R) US Army, Moab, Utah, USACorrespondence[email protected]
,
C. Robert Gibsonb Coastal Eye Associates, Webster, Texas, USA;c KBR, Houston, Texas, USA
,
Michael R. Barrattd NASA Johnson Space Center, Houston, Texas, USA
,
Neil R. Millere Wilmer Eye Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
,
Prem S. Subramanianf Department of Ophthalmology, Sue Anschutz-Rodgers UCHealth Eye Center, University of Colorado School of Medicine, Aurora, Colorado, USA
,
Hanspeter E. Killerg Department of Ophthalmology, Kantonsspital Aarau, Aarau, Switzerland
,
William J. Tarverh NASA Johnson Space Center, Space Medicine, Houston, Texas, USA
,
Ashot E. Sargsyanc KBR, Houston, Texas, USA
,
Kathleen Garciac KBR, Houston, Texas, USA
,
Stephen F. Harth NASA Johnson Space Center, Space Medicine, Houston, Texas, USA
,
Larry A. Krameri Department of Diagnostic Imaging and Intervention, University of Texas Health Science Center, Houston, Texas, USA
,
Roy Riascosi Department of Diagnostic Imaging and Intervention, University of Texas Health Science Center, Houston, Texas, USA
,
Tyson J. Brunstetterj CAPT, US Navy, Detailed to NASA Johnson Space Center, Houston, Texas, USA
,
William Lipskyb Coastal Eye Associates, Webster, Texas, USA
,
Peter Wostynk Department of Psychiatry, PC Sint-Amandus, Beernem, Belgium
&
Andrew G. Leel Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, USA;m Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA;n Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, New York, USA;o Department of Ophthalmology, University of Texas Medical Branch, Galveston, Texas, USA;p Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA;q Department of Ophthalmology; University of Texas MD Anderson Cancer Center, Houston, Texas, USA;r Department of Ophthalmology, Texas A and M College of Medicine, Bryan, Texas, USA
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Pages 29-35 | Received 09 Mar 2020, Accepted 28 Jun 2020, Published online: 03 Sep 2020

Citations (23)

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Anas Elgenidy, Aya Hesham, Mostafa Atef, Ahmed K. Awad, Abdullah Emad, Omar Alomari, Ramez M. Odat & Andrew G. Lee. (2024) Spaceflight associated neuro-ocular syndrome (SANS): a systematic review, implications for the sans case definition. Expert Review of Ophthalmology 19:1, pages 77-86.
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Articles from other publishers (22)

Sutton B. Richmond, Rachael D. Seidler, Jeffrey J. Iliff, Daniel L. Schwartz, Madison Luther, Lisa C. Silbert, Scott J. Wood, Jacob J. Bloomberg, Edwin Mulder, Jessica K. Lee, Alberto De Luca & Juan Piantino. (2024) Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest. npj Microgravity 10:1.
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Alexander J. Dontre. (2024) Weighing the impact of microgravity on vestibular and visual functions. Life Sciences in Space Research 40, pages 51-61.
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Yuan Xie, Yingdi Fu, Yaqi Shao, Lina Qu, Jiangang Yang, Chengjia Yang, Kun Zhou, Kai Li, Zi Xu, Dong Xu, Kai Cao, Ning Tian, Ke Lv, Linjie Wang, Yaping Wang, Ningli Wang & Yinghui Li. (2024) Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest. npj Microgravity 10:1.
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Arman Zarnegar, Joshua Ong, Sumit Randhir Singh & Jay Chhablani. 2024. Retinal and Choroidal Vascular Diseases of the Eye. Retinal and Choroidal Vascular Diseases of the Eye 273 281 .
Dallin C. Milner & Prem S. Subramanian. (2023) Insights into spaceflight-associated neuro-ocular syndrome with review of intraocular and orbital findings. Current Opinion in Ophthalmology 34:6, pages 493-499.
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Shanshan Wang, Tao Wang, Xian Zeng, Xinyi Chu, Dongzhi Zhuoma, Yufen Zhao & Yu Zong Chen. (2023) Exploring outer space biophysical phenomena via SpaceLID. Scientific Reports 13:1.
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Joshua Ong, Thomas H. Mader, C. Robert Gibson, Sara S. Mason & Andrew G. Lee. (2023) Spaceflight associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development. Eye 37:12, pages 2409-2415.
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Yuxue Mu, Dongyu Wei, Lilingxuan Yao, Xinyue Xu, Shaoheng Li, Ruidan Cao, Tao Chen & Zuoming Zhang. (2023) Choroidal circulation disturbance is an initial factor in outer retinal degeneration in rats under simulated weightlessness. Frontiers in Physiology 14.
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Zarana S. Patel, C. Robert Gibson, Thomas H. Mader, Alexandra M. Whitmire, Jason R. Norcross, Moriah S. Thompson, Ashley S. Nemec-Bakk, Marjan Boerma & Janice L. Huff. 2023. The Planning and Execution of Human Missions to the Moon and Mars. The Planning and Execution of Human Missions to the Moon and Mars 487 542 .
Diego Rossinelli, Hanspeter Esriel Killer, Peter Meyer, Graham Knott, Gilles Fourestey, Vartan Kurtcuoglu, Corina Kohler, Philipp Gruber, Luca Remonda, Albert Neutzner & Jatta Berberat. (2023) Large-scale morphometry of the subarachnoid space of the optic nerve. Fluids and Barriers of the CNS 20:1.
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Udit Gupta, Sheharyar Baig, Arshad Majid & Simon M Bell. (2023) The neurology of space flight; How does space flight effect the human nervous system?. Life Sciences in Space Research 36, pages 105-115.
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Connor R. Ferguson, Laura P. Pardon, Steven S. Laurie, Millennia H. Young, C. Robert Gibson, Tyson J. Brunstetter, William J. Tarver, Sara S. Mason, Patrick A. Sibony & Brandon R. Macias. (2023) Incidence and Progression of Chorioretinal Folds During Long-Duration Spaceflight. JAMA Ophthalmology 141:2, pages 168.
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Joshua Ong, William Tarver, Tyson Brunstetter, Thomas Henry Mader, C Robert Gibson, Sara S Mason & Andrew Lee. (2023) Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures. British Journal of Ophthalmology, pages bjo-2022-322892.
Crossref
Chayakrit Krittanawong, Nitin Kumar Singh, Richard A. Scheuring, Emmanuel Urquieta, Eric M. Bershad, Timothy R. Macaulay, Scott Kaplin, Carly Dunn, Stephen F. Kry, Thais Russomano, Marc Shepanek, Raymond P. Stowe, Andrew W. Kirkpatrick, Timothy J. Broderick, Jean D. Sibonga, Andrew G. Lee & Brian E. Crucian. (2022) Human Health during Space Travel: State-of-the-Art Review. Cells 12:1, pages 40.
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Stuart H. Sater, Gabryel Conley Natividad, Akari J. Seiner, Audrey Q. Fu, Dev Shrestha, Eric M. Bershad, Karina Marshall-Goebel, Steven S. Laurie, Brandon R. Macias & Bryn A. Martin. (2022) MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation. Journal of Applied Physiology 133:6, pages 1349-1355.
Crossref
Dylan A. Fall, Andrew G. Lee, Eric M. Bershad, Larry A. Kramer, Thomas H. Mader, Jonathan B. Clark & Mohammad I. Hirzallah. (2022) Optic nerve sheath diameter and spaceflight: defining shortcomings and future directions. npj Microgravity 8:1.
Crossref
Achmed Pircher, Margherita Montali, Jatta Berberat, Andreas Huber, Neil R Miller, Thomas H Mader, C Robert Gibson, Albert Neutzner, Luca Remonda & Hanspeter E Killer. (2022) Elevated perioptic lipocalin-type prostaglandin D synthase concentration in patients with idiopathic intracranial hypertension. Brain Communications 4:5.
Crossref
Joshua Ong, Alireza Tavakkoli, Nasif Zaman, Sharif Amit Kamran, Ethan Waisberg, Nikhil Gautam & Andrew G. Lee. (2022) Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome. npj Microgravity 8:1.
Crossref
Thomas H. Mader & C. Robert Gibson. 2022. Spaceflight Associated Neuro-Ocular Syndrome. Spaceflight Associated Neuro-Ocular Syndrome 9 21 .
Luis Nunez, Azin Aein & Roy Riascos. 2022. Spaceflight Associated Neuro-Ocular Syndrome. Spaceflight Associated Neuro-Ocular Syndrome 43 53 .
Stuart H. Sater, Austin M. Sass, Jesse J. Rohr, Karina Marshall-Goebel, Robert J. Ploutz-Snyder, C. Ross Ethier, Michael B. Stenger, Larry A. Kramer, Bryn A. Martin & Brandon R. Macias. (2021) Automated MRI-based quantification of posterior ocular globe flattening and recovery after long-duration spaceflight. Eye 35:7, pages 1869-1878.
Crossref
Joshua Ong, Andrew G. Lee & Heather E. Moss. (2021) Head-Down Tilt Bed Rest Studies as a Terrestrial Analog for Spaceflight Associated Neuro-Ocular Syndrome. Frontiers in Neurology 12.
Crossref

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