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The International Journal on Orbital Disorders, Oculoplastic and Lacrimal Surgery
Volume 38, 2019 - Issue 3
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Case Report

Pembrolizumab and epacadostat induced fatal myocarditis and myositis presenting as a case of ptosis and ophthalmoplegia

Justin B. HellmanDepartment of Ophthalmology and Vision Science, University of California Davis Health Eye Center, Sacramento, CA, USA
,
Ilana TraynisDepartment of Ophthalmology and Vision Science, University of California Davis Health Eye Center, Sacramento, CA, USA
&
Lily Koo LinDepartment of Ophthalmology and Vision Science, University of California Davis Health Eye Center, Sacramento, CA, USACorrespondence[email protected]
Pages 244-247 | Received 13 Feb 2018, Accepted 13 Jun 2018, Published online: 09 Jul 2018

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Filip Stefanovic, Andres Gomez-Caminero, David M Jacobs, Poornima Subramanian, Igor Puzanov, Maya R Chilbert, Steven G Feuerstein, Yan Yatsynovich, Benjamin Switzer & Jerome J Schentag. (2022) Neural Net Modeling of Checkpoint Inhibitor Related Myocarditis and Steroid Response. Clinical Pharmacology: Advances and Applications 14, pages 69-90.
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Ruby A. Parikh, Benjamin C. Chaon & Meghan K. Berkenstock. (2021) Ocular Complications of Checkpoint Inhibitors and Immunotherapeutic Agents: A Case Series. Ocular Immunology and Inflammation 29:7-8, pages 1585-1590.
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Caberry W Yu, Matthew Yau, Natalie Mezey, Ishraq Joarder & Jonathan A Micieli. (2020) Neuro-ophthalmic Complications of Immune Checkpoint Inhibitors: A Systematic Review. Eye and Brain 12, pages 139-167.
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Articles from other publishers (11)

R. Saad, A. Ghaddar & R. M. Zeenny. (2024) Pembrolizumab-induced myocarditis with complete atrioventricular block and concomitant myositis in a metastatic bladder cancer patient: a case report and review of the literature. Journal of Medical Case Reports 18:1.
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Abha Banerjee, Chandrakala Aluganti Narasimhulu & Dinender K. Singla. (2023) Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications. American Journal of Physiology-Heart and Circulatory Physiology 325:4, pages H751-H767.
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Elena Giovannini, Maria Paola Bonasoni, Michele D’Aleo, Ione Tamagnini, Matteo Tudini, Paolo Fais & Susi Pelotti. (2023) Pembrolizumab-Induced Fatal Myasthenia, Myocarditis, and Myositis in a Patient with Metastatic Melanoma: Autopsy, Histological, and Immunohistochemical Findings—A Case Report and Literature Review. International Journal of Molecular Sciences 24:13, pages 10919.
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Liudmila Zotova. (2023) Immune Checkpoint Inhibitors-Related Myocarditis: A Review of Reported Clinical Cases. Diagnostics 13:7, pages 1243.
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A. Martens, P. P. Schauwvlieghe, A. Madoe, I. Casteels & S. Aspeslagh. (2023) Ocular adverse events associated with immune checkpoint inhibitors, a scoping review. Journal of Ophthalmic Inflammation and Infection 13:1.
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Oliver Dugena, Chaolan Zheng, Jennifer Taylor & Annie Wong. (2022) Pembrolizumab-induced Myasthenia Gravis: Literature Review of Ocular Manifestations and a Refractory Case. Journal of Immunotherapy 45:6, pages 267-273.
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Naoki Hamada, Ayaka Maeda, Kaoru Takase-Minegishi, Yohei Kirino, Yumiko Sugiyama, Ho Namkoong, Nobuyuki Horita, Ryusuke Yoshimi & Hideaki Nakajima. (2021) Incidence and Distinct Features of Immune Checkpoint Inhibitor-Related Myositis From Idiopathic Inflammatory Myositis: A Single-Center Experience With Systematic Literature Review and Meta-Analysis. Frontiers in Immunology 12.
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Ranjan Pathak, Anjan Katel, Erminia Massarelli, Victoria M Villaflor, Virginia Sun & Ravi Salgia. (2021) Immune Checkpoint Inhibitor–Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases. The Oncologist 26:12, pages 1052-1061.
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Hotaka Matsui, Taketo Kawai, Yusuke Sato, Junichi Ishida, Hiroshi Kadowaki, Yoshiyuki Akiyama, Yuta Yamada, Masaki Nakamura, Daisuke Yamada, Hiroshi Akazawa, Motofumi Suzuki, Issei Komuro & Haruki Kume. (2020) A Fatal Case of Myocarditis Following Myositis Induced by Pembrolizumab Treatment for Metastatic Upper Urinary Tract Urothelial Carcinoma. International Heart Journal 61:5, pages 1070-1074.
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Vivian Paraskevi Douglas, Konstantinos A.A. Douglas & Dean M. Cestari. (2019) Immune checkpoint inhibitors. Current Opinion in Ophthalmology 30:6, pages 426-433.
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. (2019) Epacadostat/pembrolizumab. Reactions Weekly 1764:1, pages 126-126.
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