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Journal of Adhesion Science and Technology Volume 27, 2013 - Issue 3
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Articles

The effects of geometry on skin penetration and failure of polymer microneedles

Shaun D. Gittard Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, 27695, USA; Department of Nanotechnology, Laser Zentrum Hannover, Hollerithalle 8, 30419, Hannover, GermanyCorrespondence[email protected]
,
Bo Chen Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, 27695, USA
,
Huadong Xu Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, 27695, USA
,
Aleksandr Ovsianikov Department of Nanotechnology, Laser Zentrum Hannover, Hollerithalle 8, 30419, Hannover, Germany
,
Boris N. Chichkov Department of Nanotechnology, Laser Zentrum Hannover, Hollerithalle 8, 30419, Hannover, Germany
,
Nancy A. Monteiro-Riviere Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, 27695, USA; Department of Clinical Sciences, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, 27607, USA
&
Roger J. Narayan Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, 27695, USACorrespondence[email protected]
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Pages 227-243 | Received 30 May 2011, Accepted 03 Mar 2012, Published online: 06 Aug 2012

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Niha Sultana, Ayesha Waheed, Asad Ali, Samreen Jahan, Mohd Aqil, Yasmin Sultana & Mohd. Mujeeb. (2023) Exploring new frontiers in drug delivery with minimally invasive microneedles: fabrication techniques, biomedical applications, and regulatory aspects. Expert Opinion on Drug Delivery 20:6, pages 739-755.
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Hye-Rin Jeong, Han-Sol Lee, In-Jeong Choi & Jung-Hwan Park. (2017) Considerations in the use of microneedles: pain, convenience, anxiety and safety. Journal of Drug Targeting 25:1, pages 29-40.
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Articles from other publishers (114)

Rawan Fitaihi, Shorooq Abukhamees, Se Hun Chung & Duncan Q.M. Craig. (2024) Optimization of stereolithography 3D printing of microneedle micro-molds for ocular drug delivery. International Journal of Pharmaceutics 658, pages 124195.
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Benchaphorn Limcharoen, Supason Wanichwecharungruang, Marius Kröger, Titiporn Sansureerungsikul, Johannes Schleusener, Anna Lena Klein, Wijit Banlunara, Martina C. Meinke & Maxim E. Darvin. (2024) Dissolvable microneedles in the skin: Determination the impact of barrier disruption and dry skin on dissolution. European Journal of Pharmaceutics and Biopharmaceutics 199, pages 114303.
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Anshul Chaudhary, Samiksha Sharma & Arti R. Thakkar. (2024) 3D Printing – A Revolution in Modern Healthcare: Recent Achievements & Challenges. Current Drug Therapy 19:3, pages 279-288.
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Ismail Eş, Abdullah Kafadenk & Fatih Inci. (2024) A high-precision method for manufacturing tunable solid microneedles using dicing saw and xenon difluoride-induced dry etching. Journal of Materials Processing Technology 325, pages 118268.
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Hossein Mohammadi, Arash Ebrahimian & Nima Maftoon. (2023) Finite-Element Modelling of Needle-Tissue Interactions. Archives of Computational Methods in Engineering 31:3, pages 1363-1404.
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Seung-Yeon Jeong, Ye-Seul Lee, Ji-Yeun Park, Jung-Hwan Park, Hi-Joon Park & Song-Yi Kim. (2024) Designing a Placebo Microneedle Stamp: Modeling and Validation in a Clinical Control Trial. Pharmaceutics 16:3, pages 395.
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Daisuke Ando, Megumi Miyatsuji, Hideyuki Sakoda, Eiichi Yamamoto, Tamaki Miyazaki, Tatsuo Koide, Yoji Sato & Ken-ichi Izutsu. (2024) Mechanical Characterization of Dissolving Microneedles: Factors Affecting Physical Strength of Needles. Pharmaceutics 16:2, pages 200.
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Taher Abbasiasl, Fariborz Mirlou, Hadi Mirzajani, Mohammad Javad Bathaei, Emin Istif, Narges Shomalizadeh, Rümeysa Emine Cebecioğlu, Ecem Ezgi Özkahraman, Umut Can Yener & Levent Beker. (2023) A Wearable Touch‐Activated Device Integrated with Hollow Microneedles for Continuous Sampling and Sensing of Dermal Interstitial Fluid. Advanced Materials 36:2.
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Baoling Jia, Tiandong Xia, Xiaohui Wang, Yangtao Xu & Zhenyu Guo. (2023) Morphology design of polymer microneedle arrays: Key factors from the application perspective. Journal of Drug Delivery Science and Technology 88, pages 104883.
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Jackie Fule Liu, Amin GhavamiNejad, Brian Lu, Sako Mirzaie, Melisa Samarikhalaj, Adria Giacca & Xiao Yu Wu. (2023) “Smart” Matrix Microneedle Patch Made of Self‐Crosslinkable and Multifunctional Polymers for Delivering Insulin On‐Demand. Advanced Science 10:30.
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Shuai Xu, Wenyuan Liu, Mingwei Peng, Dewei Ma, Zhixiang Liu, Lingfeng Tang, Xiaoniu Li & Siyuan Chen. (2023) Biodegradable Microneedles Array with Dual-Release Behavior and Parameter Optimization by Finite Element Analysis. Journal of Pharmaceutical Sciences 112:9, pages 2506-2515.
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Maria Dul, Mohammed Alali, Mahmoud Ameri, Matthew Douglas Burke, Christine M. Craig, Benjamin Paul Creelman, Lisa Dick, Ryan F. Donnelly, Michael N. Eakins, Collrane Frivold, Angus Harry Forster, Philippe-Alexandre Gilbert, Stefan Henke, Sebastien Henry, Desmond Hunt, Hayley Lewis, Howard I. Maibach, Jessica Joyce Mistilis, Jung-Hwan Park, Mark R. Prausnitz, David Kenneth Robinson, Carmen Amelia Rodriguez Hernandez, Charles Ross, Juyeop Shin, Tycho Joseph Speaker, Kevin Michael Taylor, Darin Zehrung, James C. Birchall, Courtney Jarrahian & Sion A. Coulman. (2023) Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product. Journal of Controlled Release 361, pages 236-245.
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Akmal Hidayat Bin Sabri, Qonita Kurnia Anjani, Pratik Gurnani, Juan Domínguez-Robles, Natalia Moreno-Castellanos, Li Zhao, Aaron R.J. Hutton & Ryan F. Donnelly. (2023) Fabrication and characterisation of poly(sulfonated) and poly(sulfonic acid) dissolving microneedles for delivery of antibiotic and antifungal agents. International Journal of Pharmaceutics 644, pages 123292.
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Xiaojin Luo, Li Yang & Yue Cui. (2023) Microneedles: materials, fabrication, and biomedical applications. Biomedical Microdevices 25:3.
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Shuang Liang, Zekun Li, Cheng Bao, Bin Liu, Huijuan Zhang, Yu Yuan, Huiling Yan, Shanan Chen, Hui Zhang, Wenbiao Shi, Fazheng Ren & Yuan Li. (2023) Non‐Cardiotoxic Tetradecanoic Acid‐2,4‐Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti‐Obesity Effect by Regulating Adipocyte Browning and Lipogenesis. Small 19:39.
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Ismail Eş, Abdullah Kafadenk, M. Burak Gormus & Fatih Inci. (2023) Xenon Difluoride Dry Etching for the Microfabrication of Solid Microneedles as a Potential Strategy in Transdermal Drug Delivery. Small 19:27.
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Suhair S. Al-Nimry & Rawand M. Daghmash. (2023) Three Dimensional Printing and Its Applications Focusing on Microneedles for Drug Delivery. Pharmaceutics 15:6, pages 1597.
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Sanjukta Duarah, Manisha Sharma, Shuo Chen, Thomas K Proft, Jacelyn Loh & Jingyuan Wen. (2023) Design, optimization and evaluation of dexamethasone-loaded microneedles for inflammatory disorders. International Journal of Pharmaceutics 635, pages 122690.
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Usanee Detamornrat, Emma McAlister, Aaron R. J. Hutton, Eneko Larrañeta & Ryan F. Donnelly. (2022) The Role of 3D Printing Technology in Microengineering of Microneedles. Small 18:18.
Crossref
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Crossref
Shrey A. Shah, Robert S. Oakes, Senta M. Kapnick & Christopher M. Jewell. (2022) Mapping the Mechanical and Immunological Profiles of Polymeric Microneedles to Enable Vaccine and Immunotherapy Applications. Frontiers in Immunology 13.
Crossref
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Crossref
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Crossref
Vahid Ebrahiminejad, Philip D. Prewett, Graham J. Davies & Zahra Faraji Rad. (2022) Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration. Advanced Materials Interfaces 9:6.
Crossref
Ismaiel A. Tekko, Lalitkumar K. Vora, Fabiana Volpe‐Zanutto, Kurtis Moffatt, Courtney Jarrahian, Helen O. McCarthy & Ryan F. Donnelly. (2021) Novel Bilayer Microarray Patch‐Assisted Long‐Acting Micro‐Depot Cabotegravir Intradermal Delivery for HIV Pre‐Exposure Prophylaxis. Advanced Functional Materials 32:9.
Crossref
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Crossref
Thanachita Sumontha, Peerachat Veeraphan, Jeerapond Leelawattanachai & Darapond Triampo. (2022) Swellable microneedles for nitrate detection in food. Materials Today: Proceedings 66, pages 3191-3197.
Crossref
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Crossref
Mayuri Dalvi, Pratik Kharat, Pradip Thakor, Valamla Bhavana, Shashi Bala Singh & Neelesh Kumar Mehra. (2021) Panorama of dissolving microneedles for transdermal drug delivery. Life Sciences 284, pages 119877.
Crossref
Zahra Faraji Rad, Philip D Prewett & Graham J Davies. (2021) An overview of microneedle applications, materials, and fabrication methods. Beilstein Journal of Nanotechnology 12, pages 1034-1046.
Crossref
Zahra Faraji Rad, Philip D. Prewett & Graham J. Davies. (2021) High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays. Microsystems & Nanoengineering 7:1.
Crossref
Yaping Chen, Maria Alba, Terence Tieu, Ziqiu Tong, Rajpreet Singh Minhas, David Rudd, Nicolas H. Voelcker, Anna Cifuentes-Rius & Roey Elnathan. (2021) Engineering Micro–Nanomaterials for Biomedical Translation. Advanced NanoBiomed Research 1:9.
Crossref
Faisal Khaled Aldawood, Abhay Andar & Salil Desai. (2021) A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications. Polymers 13:16, pages 2815.
Crossref
Guangsheng Du, Penghui He, Jiaxuan Zhao, Chunting He, Min Jiang, Zhihua Zhang, Zhibing Zhang & Xun Sun. (2021) Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment. Journal of Controlled Release 336, pages 537-548.
Crossref
Rupali S. Bhadale & Vaishali Y. Londhe. (2021) A systematic review of carbohydrate-based microneedles: current status and future prospects. Journal of Materials Science: Materials in Medicine 32:8.
Crossref
Merima Sirbubalo, Amina Tucak, Kenan Muhamedagic, Lamija Hindija, Ognjenka Rahić, Jasmina Hadžiabdić, Ahmet Cekic, Derzija Begic-Hajdarevic, Maida Cohodar Husic, Almir Dervišević & Edina Vranić. (2021) 3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery. Pharmaceutics 13:7, pages 924.
Crossref
Davira P. Widianto, Benjamin G. Stewart, Juan L. Mena-Lapaix, Richard H. Shafer, Andrew Burns, Mark R. Prausnitz, Azar Alizadeh & Suresh K. Sitaraman. (2021) Microneedle Insertion into Visco-Hyperelastic Model for Skin for Healthcare Application. Microneedle Insertion into Visco-Hyperelastic Model for Skin for Healthcare Application.
Guangsheng Du, Zhihua Zhang, Penghui He, Zhibing Zhang & Xun Sun. (2021) Determination of the mechanical properties of polymeric microneedles by micromanipulation. Journal of the Mechanical Behavior of Biomedical Materials 117, pages 104384.
Crossref
Jingjing He, Zichen Zhang, Xianzi Zheng, Lu Li, Jianping Qi, Wei Wu & Yi Lu. (2021) Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride. Pharmaceutics 13:4, pages 579.
Crossref
Suman Pahal, Kedar Badnikar, Vivek Ghate, Utkarsh Bhutani, Mangalore Manjunatha Nayak, Dinesh Narasimhaiah Subramanyam & Praveen Kumar Vemula. (2021) Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare. European Journal of Pharmaceutics and Biopharmaceutics 159, pages 151-169.
Crossref
Joseph G. Turner, Leah R. White, Pedro Estrela & Hannah S. Leese. (2020) Hydrogel‐Forming Microneedles: Current Advancements and Future Trends. Macromolecular Bioscience 21:2.
Crossref
Sophia Economidou, Cristiane Pissinato Pere, Michael Okereke & Dennis Douroumis. (2021) Optimisation of Design and Manufacturing Parameters of 3D Printed Solid Microneedles for Improved Strength, Sharpness, and Drug Delivery. Micromachines 12:2, pages 117.
Crossref
Motia Azmana, Syed Mahmood, Ayah Rebhi Hilles, Uttam Kumar Mandal, Khater Ahmed Saeed Al-Japairai & Subashini Raman. (2020) Transdermal drug delivery system through polymeric microneedle: A recent update. Journal of Drug Delivery Science and Technology 60, pages 101877.
Crossref
Moyuan Qu, Han-Jun Kim, Xingwu Zhou, Canran Wang, Xing Jiang, Jixiang Zhu, Yumeng Xue, Peyton Tebon, Shima A. Sarabi, Samad Ahadian, Mehmet R. Dokmeci, Songsong Zhu, Zhen Gu, Wujin Sun & Ali Khademhosseini. (2020) Biodegradable microneedle patch for transdermal gene delivery. Nanoscale 12:32, pages 16724-16729.
Crossref
Mathilde Champeau, Dorothée Jary, Laurent Mortier, Serge Mordon & Séverine Vignoud. (2020) A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid. International Journal of Pharmaceutics 586, pages 119554.
Crossref
Hye-Rin Jeong, Hyesun Jun, Hye-Ran Cha, Jae Lee & Jung-Hwan Park. (2020) Safe Coated Microneedles with Reduced Puncture Occurrence after Administration. Micromachines 11:8, pages 710.
Crossref
Seng Han Lim, Wen Jun Tiew, Junying Zhang, Paul Chi-Lui Ho, Nezamoddin N. Kachouie & Lifeng Kang. (2020) Geometrical optimisation of a personalised microneedle eye patch for transdermal delivery of anti-wrinkle small peptide. Biofabrication 12:3, pages 035003.
Crossref
Xiao-Xi Yang, Pengfei Feng, Jing Cao, Weisheng Liu & Yu Tang. (2020) Composition-Engineered Metal–Organic Framework-Based Microneedles for Glucose-Mediated Transdermal Insulin Delivery. ACS Applied Materials & Interfaces 12:12, pages 13613-13621.
Crossref
Md Jasim Uddin, Nicolaos Scoutaris, Sophia N. Economidou, Clementine Giraud, Babur Z. Chowdhry, Ryan F. Donnelly & Dennis Douroumis. (2020) 3D printed microneedles for anticancer therapy of skin tumours. Materials Science and Engineering: C 107, pages 110248.
Crossref
Khalil Moussi, Abdullah Bukhamsin, Tania Hidalgo & Jurgen Kosel. (2019) Biocompatible 3D Printed Microneedles for Transdermal, Intradermal, and Percutaneous Applications. Advanced Engineering Materials 22:2.
Crossref
Lei Ren, Bin Liu, Wei Zhou & Lelun Jiang. (2020) A Mini Review of Microneedle Array Electrode for Bio-Signal Recording: A Review. IEEE Sensors Journal 20:2, pages 577-590.
Crossref
Kyung Ju Lee, Seong Sik Jeong, Dong Hyun Roh, Dong Yeong Kim, Hoo-Kyun Choi & Eun Hee Lee. (2020) A practical guide to the development of microneedle systems – In clinical trials or on the market. International Journal of Pharmaceutics 573, pages 118778.
Crossref
Min Wang, Yiyuan Han, Xiaojun Yu, Liangliang Liang, Hao Chang, David C. Yeo, Christian Wiraja, Mei Ling Wee, Linbo Liu, Xiaogang Liu & Chenjie Xu. (2019) Upconversion Nanoparticle Powered Microneedle Patches for Transdermal Delivery of siRNA. Advanced Healthcare Materials 9:2.
Crossref
Anika Trautmann, Gian-Luca Roth, Benedikt Nujiqi, Thomas Walther & Ralf Hellmann. (2019) Towards a versatile point-of-care system combining femtosecond laser generated microfluidic channels and direct laser written microneedle arrays. Microsystems & Nanoengineering 5:1.
Crossref
Eman M. Migdadi & Ryan F. Donnelly. 2019. Imaging Technologies and Transdermal Delivery in Skin Disorders. Imaging Technologies and Transdermal Delivery in Skin Disorders 223 270 .
Xiaoxiang He, Jingyao Sun, Jian Zhuang, Hong Xu, Ying Liu & Daming Wu. (2019) Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects. Dose-Response 17:4, pages 155932581987858.
Crossref
Rohan S.J. Ingrole & Harvinder Singh Gill. (2019) Microneedle Coating Methods: A Review with a Perspective. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 555-569.
Crossref
Sophia N. Economidou, Cristiane Patricia Pissinato Pere, Andrew Reid, Md. Jasim Uddin, James F.C. Windmill, Dimitrios A. Lamprou & Dennis Douroumis. (2019) 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Materials Science and Engineering: C 102, pages 743-755.
Crossref
Daniela F.S. Fonseca, Carla Vilela, Armando J.D. Silvestre & Carmen S.R. Freire. (2019) A compendium of current developments on polysaccharide and protein-based microneedles. International Journal of Biological Macromolecules 136, pages 704-728.
Crossref
Andrew Kjar & Yu Huang. (2019) Application of Micro-Scale 3D Printing in Pharmaceutics. Pharmaceutics 11:8, pages 390.
Crossref
Aung Than, Chenghao Liu, Hao Chang, Phan Khanh Duong, Chui Ming Gemmy Cheung, Chenjie Xu, Xiaomeng Wang & Peng Chen. (2018) Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nature Communications 9:1.
Crossref
Eneko Larrañeta & Thakur Raghu Raj Singh. 2018. Microneedles for Drug and Vaccine Delivery and Patient Monitoring. Microneedles for Drug and Vaccine Delivery and Patient Monitoring 21 70 .
Aaron McConville, Catherine Hegarty & James Davis. (2018) Mini-Review: Assessing the Potential Impact of Microneedle Technologies on Home Healthcare Applications. Medicines 5:2, pages 50.
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Cristiane Patricia Pissinato Pere, Sophia N. Economidou, Gurprit Lall, Clémentine Ziraud, Joshua S. Boateng, Bruce D. Alexander, Dimitrios A. Lamprou & Dennis Douroumis. (2018) 3D printed microneedles for insulin skin delivery. International Journal of Pharmaceutics 544:2, pages 425-432.
Crossref
Alexey S. Rzhevskiy, Thakur Raghu Raj Singh, Ryan F. Donnelly & Yuri G. Anissimov. (2018) Microneedles as the technique of drug delivery enhancement in diverse organs and tissues. Journal of Controlled Release 270, pages 184-202.
Crossref
James Coyne, Brandon Davis, David Kauffman, Nan Zhao & Yong Wang. (2017) Polymer Microneedle Mediated Local Aptamer Delivery for Blocking the Function of Vascular Endothelial Growth Factor. ACS Biomaterials Science & Engineering 3:12, pages 3395-3403.
Crossref
Aung Than, Ke Liang, Shaohai Xu, Lei Sun, Hongwei Duan, Fengna Xi, Chenjie Xu & Peng Chen. (2017) Transdermal Delivery of Anti‐Obesity Compounds to Subcutaneous Adipose Tissue with Polymeric Microneedle Patches. Small Methods 1:11.
Crossref
Samuel Clark Ligon, Robert Liska, Jürgen Stampfl, Matthias Gurr & Rolf Mülhaupt. (2017) Polymers for 3D Printing and Customized Additive Manufacturing. Chemical Reviews 117:15, pages 10212-10290.
Crossref
Martha Chege, Aaron McConville & James Davis. (2017) Microneedle drug delivery systems: Appraising opportunities for improving safety and assessing areas of concern. Journal of Chemical Health & Safety 24:2, pages 6-14.
Crossref
Xiuli Hu, Jicheng Yu, Chenggen Qian, Yue Lu, Anna R. Kahkoska, Zhigang Xie, Xiabin Jing, John B. Buse & Zhen Gu. (2017) H 2 O 2 -Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery . ACS Nano 11:1, pages 613-620.
Crossref
Min Wang, Lianzhe Hu & Chenjie Xu. (2017) Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing. Lab on a Chip 17:8, pages 1373-1387.
Crossref
Adriano J. G. Otuka, Vinicius Tribuzi, Daniel S. Correa & Cleber R. Mendonça. 2016. Multiphoton Lithography. Multiphoton Lithography 355 376 .
V. Leeladurga, U. Chandra Teja, S. K. Ashraf Sultana, K. Sudeep, V. Sai Sri Anusha, Tao Han, Buchi N. Nalluri & Diganta B. Das. (2015) Application of Microneedle Arrays for Enhancement of Transdermal Permeation of Insulin: In Vitro Experiments, Scaling Analyses and Numerical Simulations. AAPS PharmSciTech 17:4, pages 915-922.
Crossref
Eneko Larrañeta, Rebecca E.M. Lutton, A. David Woolfson & Ryan F. Donnelly. (2016) Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Materials Science and Engineering: R: Reports 104, pages 1-32.
Crossref
Chao Wang, Yanqi Ye, Gabrielle M. Hochu, Hasan Sadeghifar & Zhen Gu. (2016) Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody. Nano Letters 16:4, pages 2334-2340.
Crossref
Bon Kang GuDong Jin ChoiSang Jun ParkMin Sup KimChang Mo KangChun-Ho Kim. (2016) 3-dimensional bioprinting for tissue engineering applications. Biomaterials Research 20:1.
Crossref
Rebecca E.M. Lutton, Eneko Larrañeta, Mary-Carmel Kearney, Peter Boyd, A.David Woolfson & Ryan F. Donnelly. (2015) A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays. International Journal of Pharmaceutics 494:1, pages 417-429.
Crossref
Rebecca E. M. Lutton, Jessica Moore, Eneko Larrañeta, Stephen Ligett, A. David Woolfson & Ryan F. Donnelly. (2015) Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation. Drug Delivery and Translational Research 5:4, pages 313-331.
Crossref
N. Raja Rajeswari & P. Malliga. (2015) Analytical approach for optimization design of MEMS based microneedles in drug delivery system. Journal of Mechanical Science and Technology 29:8, pages 3405-3415.
Crossref
Akira Kasuya, Isao Ohta & Yoshiki Tokura. (2015) Structural and Immunological Effects of Skin Cryoablation in a Mouse Model. PLOS ONE 10:3, pages e0123906.
Crossref
A.M. Römgens, D.L. Bader, J.A. Bouwstra, F.P.T. Baaijens & C.W.J. Oomens. (2014) Monitoring the penetration process of single microneedles with varying tip diameters. Journal of the Mechanical Behavior of Biomedical Materials 40, pages 397-405.
Crossref
Bing Cai, Wei Xia, Susanne Bredenberg & Håkan Engqvist. (2014) Self-setting bioceramic microscopic protrusions for transdermal drug delivery. J. Mater. Chem. B 2:36, pages 5992-5998.
Crossref
Jaspreet Singh Kochhar, Ten Cheer Quek, Wei Jun Soon, Jaewoong Choi, Shui Zou & Lifeng Kang. (2013) Effect of Microneedle Geometry and Supporting Substrate on Microneedle Array Penetration into Skin. Journal of Pharmaceutical Sciences 102:11, pages 4100-4108.
Crossref
Yusuf K. Demir, Zafer Akan & Oya Kerimoglu. (2013) Characterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery. PLoS ONE 8:10, pages e77289.
Crossref
Yusuf K. Demir, Zafer Akan & Oya Kerimoglu. (2012) WITHDRAWN: Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays. International Journal of Pharmaceutics.
Crossref
Cem Bulent Ustundag, Dilruba Baykara, Tuba Bedir, Elif Ilhan, Mehmet Eren Mutlu, Oguzhan Gunduz & Roger Narayan. (2022) Fabrication and Optimization of 3d Printed Gelatin Methacryloyl Microneedle Arrays Based on Vat Photopolymerization. SSRN Electronic Journal.
Crossref

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