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Experimental Lung Research Volume 46, 2020 - Issue 3-4
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Original Articles

Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis

Ajaz AhmadDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Correspondence[email protected]
,
Khalid M. AlkharfyDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Correspondence[email protected]
,
Basit Latief JanDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;
,
Abdul AhadDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;
,
Mushtaq Ahmad AnsariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
,
Fahad I. Al-JenoobiDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;
&
Mohammad RaishDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Correspondence[email protected]
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Pages 53-63 | Received 11 Dec 2018, Accepted 03 Feb 2020, Published online: 13 Feb 2020

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Emin Kaymak, Emel Öztürk, Ali Tuğrul Akİn, Derya Karabulut & Birkan Yakan. (2022) Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis. Biotechnic & Histochemistry 97:8, pages 622-634.
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Osama A Badary, Marwa S Hamza & Rajiv Tikamdas. (2021) Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure. Drug Design, Development and Therapy 15, pages 1819-1833.
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Nashwa Amin, Xiaoxue Du, Shijia Chen, Qiannan Ren, Azhar B. Hussien, Benson O.A. Botchway, Zhiying Hu & Marong Fang. (2021) Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway. Expert Opinion on Therapeutic Targets 25:7, pages 597-612.
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Articles from other publishers (27)

Maha Badr Salem, Naglaa Mohamed El-Lakkany, Sayed Hassan Seif el-Din, Olfat Ali Hammam & Safia Samir. (2024) Diosmin alleviates ulcerative colitis in mice by increasing Akkermansia muciniphila abundance, improving intestinal barrier function, and modulating the NF-κB and Nrf2 pathways. Heliyon 10:6, pages e27527.
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Mohamad Hesam Shahrajabian & Wenli Sun. (2024) Importance of Thymoquinone, Sulforaphane, Phloretin, and Epigallocatechin and their Health Benefits. Letters in Drug Design & Discovery 21:2, pages 209-225.
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Ehsan Sadeghi, Mohsen Imenshahidi & Hossein Hosseinzadeh. (2023) Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review. Molecular Biology Reports 50:6, pages 5439-5454.
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Khalid M. Alkharfy, Ajaz Ahmad, Mohammad Mairaj Siddiquei, Mohammad Ghulam & Ahmed Abu El-Asrar. (2023) Thymoquinone Attenuates Retinal Expression of Mediators and Markers of Neurodegeneration in a Diabetic Animal Model. Current Molecular Pharmacology 16:2, pages 188-196.
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Jia Li, Wu Chen, Huimin Liu, Hong Liu, Sirui Xiang, Fengming You, Yifang Jiang, Junzhi Lin, Dingkun Zhang & Chuan Zheng. (2023) Pharmacologic effects approach of essential oils and their components on respiratory diseases. Journal of Ethnopharmacology 304, pages 115962.
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Qi Wang, Wenjun Li, Haibo Hu, Xuechao Lu & Song Qin. (2023) Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis. Biomedicine & Pharmacotherapy 159, pages 114226.
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Hayfa Hussin Ali Hijazy, Naief Dahran, Hussam A. Althagafi, Fahad Alharthi, Ola A. Habotta, Atif Abdulwahab A. Oyouni, Mohammad Algahtani, Abdulrahman Theyab, Osama Al-Amer, Maha S. Lokman, Khalaf F. Alsharif, Ashraf Albrakati, Hatem K. Amin, Shauq Mumtaz Dawood, Rami B. Kassab & Rania A. Ellethy. (2022) Thymoquinone counteracts oxidative and inflammatory machinery in carrageenan-induced murine paw edema model. Environmental Science and Pollution Research 30:6, pages 16597-16611.
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Yueguo Wang, Wenwen Wang, Shusheng Zhou, Yulan Wang, Obed Cudjoe, Yu Cha, Chunyan Wang, Xiaoguang Cao, Wei Liu & Kui Jin. (2022) Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway. Frontiers in Pharmacology 13.
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Yu Wang, Juan Wei, Huimin Deng, Li Zheng, Hao Yang & Xin Lv. (2022) The Role of Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches. Antioxidants 11:9, pages 1685.
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Manzar Alam, Gulam Mustafa Hasan, Md Meraj Ansari, Rishi Sharma, Dharmendra Kumar Yadav & Md Imtaiyaz Hassan. (2022) Therapeutic implications and clinical manifestations of thymoquinone. Phytochemistry 200, pages 113213.
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Sameh S. Elhady, Marwa S. Goda, Eman T. Mehanna, Mahmoud A. Elfaky, Abdulrahman E. Koshak, Ahmad O. Noor, Hanin A. Bogari, Rania T. Malatani, Reda F. A. Abdelhameed & Alaa S. Wahba. (2022) Meleagrin Isolated from the Red Sea Fungus Penicillium chrysogenum Protects against Bleomycin-Induced Pulmonary Fibrosis in Mice. Biomedicines 10:5, pages 1164.
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Lokesh Gambhir, Garima Tyagi, Richa Bhardwaj, Neha Kapoor & Gaurav Sharma. 2022. Reactive Oxygen Species. Reactive Oxygen Species.
Eman Zmaily Dahmash, Dalia Khalil Ali, Hamad S. Alyami, Hussien AbdulKarim, Mohammad H. Alyami & Alhassan H. Aodah. (2022) Novel Thymoquinone Nanoparticles Using Poly(ester amide) Based on L-Arginine-Targeting Pulmonary Drug Delivery. Polymers 14:6, pages 1082.
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Nur Musfirah Mahmud, Luminita Paraoan, Nurliza Khaliddin & Tengku Ain Kamalden. (2022) Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways. Frontiers in Cellular Neuroscience 16.
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Wen Gao, Lin Guo, Yan Yang, Yu Wang, Shuang Xia, Hui Gong, Bi-Kui Zhang & Miao Yan. (2022) Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity. Frontiers in Cell and Developmental Biology 9.
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Fatma Abo-Elghiet, Hanan M. Alharbi & Abeer Temraz. (2022) Natural Products and Their Promise Against COVID 19: Review. Current Nutrition & Food Science 18:2, pages 103-119.
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Xin-Fang Leong, Ker Woon Choy & Aspalilah Alias. (2021) Anti-Inflammatory Effects of Thymoquinone in Atherosclerosis: A Mini Review. Frontiers in Pharmacology 12.
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Ajaz Ahmad, Mohammad Raish & Khalid M. Alkharfy. (2021) The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19. Vascular Pharmacology 141, pages 106899.
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Jooyeon Lee, Jimin Jang, Sung-Min Park & Se-Ran Yang. (2021) An Update on the Role of Nrf2 in Respiratory Disease: Molecular Mechanisms and Therapeutic Approaches. International Journal of Molecular Sciences 22:16, pages 8406.
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Chandan Sarkar, Sarmin Jamaddar, Tawhida Islam, Milon Mondal, Muhammad Torequl Islam & Mohammad S. Mubarak. (2021) Therapeutic perspectives of the black cumin component thymoquinone: A review. Food & Function 12:14, pages 6167-6213.
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Ajaz Ahmad, Khalid M. Alkharfy, Yousef A. Bin Jardan, Mudassar Shahid, Mushtaq Ahmad Ansari, Saeed Alqahtani, Basit L. Jan, Fahad I. Al‐Jenoobi & Mohammad Raish. (2021) Sinapic acid mitigates methotrexate‐induced hepatic injuries in rats through modulation of Nrf‐2/ HO ‐1 signaling . Environmental Toxicology 36:7, pages 1261-1268.
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Sultan A. M. Saghir, Naif A. Al-Gabri, Abdelmoniem A. Ali, Al-Sayed R. Al-Attar, Mosa’d Al-Sobarry, Omar Y. A. Al-shargi, Amal Alotaibi, Mohammed Al-zharani, Fahd A. Nasr, Nader Al-Balagi, Mahfoudh A. M. Abdulghani, Sulaiman M. Alnaimat, Osama Y. Althunibat & Ayman M. Mahmoud. (2021) Ameliorative Effect of Thymoquinone-Loaded PLGA Nanoparticles on Chronic Lung Injury Induced by Repetitive Intratracheal Instillation of Lipopolysaccharide in Rats. Oxidative Medicine and Cellular Longevity 2021, pages 1-12.
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Md. Abdul Hannan, Md. Ataur Rahman, Abdullah Al Mamun Sohag, Md. Jamal Uddin, Raju Dash, Mahmudul Hasan Sikder, Md. Saidur Rahman, Binod Timalsina, Yeasmin Akter Munni, Partha Protim Sarker, Mahboob Alam, Md. Mohibbullah, Md. Nazmul Haque, Israt Jahan, Md. Tahmeed Hossain, Tania Afrin, Md. Mahbubur Rahman, Md. Tahjib-Ul-Arif, Sarmistha Mitra, Diyah Fatimah Oktaviani, Md Kawsar Khan, Ho Jin Choi, Il Soo Moon & Bonglee Kim. (2021) Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Nutrients 13:6, pages 1784.
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Sha Li, Chien-Shan Cheng, Cheng Zhang, Guo-Yi Tang, Hor-Yue Tan, Hai-Yong Chen, Ning Wang, Agnes Yuen-Kwan Lai & Yibin Feng. (2021) Edible and Herbal Plants for the Prevention and Management of COVID-19. Frontiers in Pharmacology 12.
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Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh & Saeed Samarghandian. (2020) Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway. Phytotherapy Research 35:4, pages 1739-1753.
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Esmé Jansen van Vuren, Stephan F. Steyn, Christiaan B. Brink, Marisa Möller, Francois P. Viljoen & Brian H. Harvey. (2021) The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment. Biomedicine & Pharmacotherapy 135, pages 111200.
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Ajaz Ahmad, Muneeb U. Rehman, Parvaiz Ahmad & Khalid M. Alkharfy. (2020) Covid‐19 and thymoquinone: Connecting the dots. Phytotherapy Research 34:11, pages 2786-2789.
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