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Biotechnology and Genetic Engineering Reviews Volume 34, 2018 - Issue 1: Virology – Reviews from the frontline of the Alberta Virology Conference; Guest Editors: Trushar Patel and Guido Van Marle
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Original Articles

DEAD-box helicases: the Yin and Yang roles in viral infections

Vanessa Meier-StephensonDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, Canada;Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, CanadaORCID Iconhttp://orcid.org/0000-0003-4004-4940
ORCID Icon,
Tyler MrozowichDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, CanadaORCID Iconhttp://orcid.org/0000-0002-1077-9682
ORCID Icon,
Mimi PhamDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, CanadaORCID Iconhttp://orcid.org/0000-0002-1992-8402
ORCID Icon &
Trushar R. PatelDepartment of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, Canada;Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada;Faculty of Medicine & Dentistry, DiscoveryLab, University of Alberta, Edmonton, CanadaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-0627-2923
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Pages 3-32 | Received 11 Sep 2017, Accepted 17 Apr 2018, Published online: 09 May 2018

Citations (29)

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Jia Li, Yanrong Zhou, Wenkai Zhao, Jiao Liu, Rizwan Ullah, Puxian Fang, Liurong Fang & Shaobo Xiao. (2023) Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity. Autophagy 19:8, pages 2257-2274.
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Deniz Lengerli, Kübra Ibis, Yahya Nural & Erden Banoglu. (2022) The 1,2,3-triazole ‘all-in-one’ ring system in drug discovery: a good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool. Expert Opinion on Drug Discovery 17:11, pages 1209-1236.
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Articles from other publishers (27)

Mélanie Messmer, Louison Pierson, Charline Pasquier, Nikola Djordjevic, Johana Chicher, Philippe Hammann, Sébastien Pfeffer & Erika Girardi. (2024) DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection. Virology Journal 21:1.
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Chunhui Yin, Haomiao Zhao, Xiaoyi Xia, Zhengyang Pan, Daoqun Li & Leiliang Zhang. (2024) Picornavirus 2C proteins: structure-function relationships and interactions with host factors. Frontiers in Cellular and Infection Microbiology 14.
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Dannielle L. Gemmill, Corey R. Nelson, Maulik D. Badmalia, Higor S. Pereira, Liam Kerr, Michael T. Wolfinger & Trushar R. Patel. (2024) The 3′ terminal region of Zika virus RNA contains a conserved G-quadruplex and is unfolded by human DDX17. Biochemistry and Cell Biology 102:1, pages 96-105.
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Sonali Tayal & Sonika Bhatnagar. (2023) Role of molecular mimicry in the SARS-CoV-2-human interactome for pathogenesis of cardiovascular diseases: An update to ImitateDB. Computational Biology and Chemistry 106, pages 107919.
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Tyler Mrozowich, Sean M Park, Maria Waldl, Amy Henrickson, Scott Tersteeg, Corey R Nelson, Anneke De Klerk, Borries Demeler, Ivo L Hofacker, Michael T Wolfinger & Trushar R Patel. (2023) Investigating RNA–RNA interactions through computational and biophysical analysis. Nucleic Acids Research 51:9, pages 4588-4601.
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Erika Girardi, Mélanie Messmer, Paula Lopez, Aurélie Fender, Johana Chicher, Béatrice Chane-Woon-Ming, Philippe Hammann & Sébastien Pfeffer. (2023) Proteomics-based determination of double-stranded RNA interactome reveals known and new factors involved in Sindbis virus infection. RNA 29:3, pages 361-375.
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Satarupa Sarkar, Kannan Balakrishnan, Kumaraswami Chintala, Krishnaveni Mohareer, Tom Luedde, Ananda Ayyappan Jaguva Vasudevan, Carsten Münk & Sharmistha Banerjee. (2022) Tough Way In, Tough Way Out: The Complex Interplay of Host and Viral Factors in Nucleocytoplasmic Trafficking during HIV-1 Infection. Viruses 14:11, pages 2503.
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Wei Wen, Zixuan Zheng, Haoyuan Wang, Qiongqiong Zhao, Mengge Yin, Huanchun Chen, Xiangmin Li & Ping Qian. (2022) Seneca Valley Virus Induces DHX30 Cleavage to Antagonize Its Antiviral Effects. Journal of Virology 96:17.
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Lucas Prescott. (2022) SARS-CoV-2 3CLpro whole human proteome cleavage prediction and enrichment/depletion analysis. Computational Biology and Chemistry 98, pages 107671.
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Sonali Tayal, Venugopal Bhatia, Tanya Mehrotra & Sonika Bhatnagar. (2022) ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions. Amino Acids 54:6, pages 923-934.
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Jia Li, Dang Wang, Puxian Fang, Yu Pang, Yanrong Zhou, Liurong Fang & Shaobo Xiao. (2022) DEAD-Box RNA Helicase 21 (DDX21) Positively Regulates the Replication of Porcine Reproductive and Respiratory Syndrome Virus via Multiple Mechanisms. Viruses 14:3, pages 467.
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Rizwan Ullah, Jia Li, Puxian Fang, Shaobo Xiao & Liurong Fang. (2022) DEAD/H-box helicases:Anti-viral and pro-viral roles during infections. Virus Research 309, pages 198658.
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Natalia Sveshnikova & Michele D. Piercey-Normore. (2021) Transcriptome Comparison of Secondary Metabolite Biosynthesis Genes Expressed in Cultured and Lichenized Conditions of Cladonia rangiferina. Diversity 13:11, pages 529.
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Sahibzada Waheed Abdullah, Jin’en Wu, Yun Zhang, Manyuan Bai, Junyong Guan, Xiangtao Liu, Shiqi Sun & Huichen Guo. (2021) DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication. Viruses 13:9, pages 1765.
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Mohamed A.M. Ali. (2021) DEAD-box RNA helicases: The driving forces behind RNA metabolism at the crossroad of viral replication and antiviral innate immunity. Virus Research 296, pages 198352.
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Ryan A. Flynn, Julia A. Belk, Yanyan Qi, Yuki Yasumoto, Jin Wei, Mia Madel Alfajaro, Quanming Shi, Maxwell R. Mumbach, Aditi Limaye, Peter C. DeWeirdt, Cameron O. Schmitz, Kevin R. Parker, Elizabeth Woo, Howard Y. Chang, Tamas L. Horvath, Jan E. Carette, Carolyn R. Bertozzi, Craig B. Wilen & Ansuman T. Satpathy. (2021) Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell 184:9, pages 2394-2411.e16.
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Corey Nelson, Tyler Mrozowich, Darren L. Gemmill, Sean M. Park & Trushar R. Patel. (2021) Human DDX3X Unwinds Japanese Encephalitis and Zika Viral 5′ Terminal Regions. International Journal of Molecular Sciences 22:1, pages 413.
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Paul T. WinnardJr.Jr., Farhad Vesuna & Venu Raman. (2021) Targeting host DEAD-box RNA helicase DDX3X for treating viral infections. Antiviral Research 185, pages 104994.
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Corey R. Nelson, Tyler Mrozowich, Sean M. Park, Simmone D’souza, Amy Henrickson, Justin R. J. Vigar, Hans-Joachim Wieden, Raymond J. Owens, Borries Demeler & Trushar R. Patel. (2020) Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs. International Journal of Molecular Sciences 22:1, pages 54.
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Suchismita Behera, Rajesh Raghunath Pharande, R. Rajendra Reddy, Sharmila B. Majee, Sandeepan Mukherjee & Amol Ratnakar Suryawanshi. (2020) Quantitative proteomics leads to identify dog brain proteins involved in rabies virus infection: implication in understanding viral pathophysiology. Journal of Proteins and Proteomics 11:4, pages 241-257.
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Maulik D. Badmalia, M. Quadir Siddiqui, Tyler Mrozowich, Darren L. Gemmill & Trushar R. Patel. (2020) Analytical ultracentrifuge: an ideal tool for characterization of non-coding RNAs. European Biophysics Journal 49:8, pages 809-818.
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Valentina Riva, Anna Garbelli, Annalaura Brai, Federica Casiraghi, Roberta Fazi, Claudia I. Trivisani, Adele Boccuto, Francesco Saladini, Ilaria Vicenti, Francesco Martelli, Maurizio Zazzi, Simone Giannecchini, Elena Dreassi, Maurizio Botta & Giovanni Maga. (2020) Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses. Journal of Medicinal Chemistry 63:17, pages 9876-9887.
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Annalaura Brai, Valentina Riva, Francesco Saladini, Claudio Zamperini, Claudia Immacolata Trivisani, Anna Garbelli, Carla Pennisi, Alessia Giannini, Adele Boccuto, Francesca Bugli, Maurizio Martini, Maurizio Sanguinetti, Maurizio Zazzi, Elena Dreassi, Maurizio Botta & Giovanni Maga. (2020) DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins. European Journal of Medicinal Chemistry 200, pages 112319.
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Tyler Mrozowich, Amy Henrickson, Borries Demeler & Trushar R Patel. (2020) Nanoscale Structure Determination of Murray Valley Encephalitis and Powassan Virus Non-Coding RNAs. Viruses 12:2, pages 190.
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Marjolein Kikkert. (2020) Innate Immune Evasion by Human Respiratory RNA Viruses. Journal of Innate Immunity 12:1, pages 4-20.
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Fernando V. Bauermann, Ben Hause, Alaine R. Buysse, Lok R. Joshi & Diego G. Diel. (2019) Identification and genetic characterization of a porcine hepe-astrovirus (bastrovirus) in the United States. Archives of Virology 164:9, pages 2321-2326.
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Ying Xue, Xuebing Jia, Lei Li, Xiao Dong, Jing Ling, Jian Yuan & Qi Li. (2018) DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway. Biochemical and Biophysical Research Communications 503:4, pages 2885-2891.
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