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Original Articles

Azaspiracid shellfish poisoning: unusual toxin dynamics in shellfish and the increased risk of acute human intoxications

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Pages 555-561 | Published online: 10 Nov 2010

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K. J. James , M. J. Fidalgo Sáez, A. Furey & M. Lehane. (2004) Azaspiracid poisoning, the food-borne illness associated with shellfish consumption. Food Additives & Contaminants 21:9, pages 879-892.
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Articles from other publishers (48)

Jiaping Yang, Weiqin Sun, Mingjuan Sun, Yunyi Cui & Lianghua Wang. (2024) Current Research Status of Azaspiracids. Marine Drugs 22:2, pages 79.
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Amechi S. Nwankwegu, Lei Zhang, Deti Xie, Okugbe E. Ohore, Yiping Li, Guanglang Yang, Xuexing Yao, Zenghui Song & Qing Yang. (2023) Metabolites dynamics exacerbated by external nutrients inputs into a Ceratium hirundinella-dominated bloom in the Pengxi River, Three Gorges Reservoir, China. Aquatic Toxicology 258, pages 106507.
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Pablo Estevez & Ana Gago-Martinez. (2023) Contribution of Mass Spectrometry to the Advances in Risk Characterization of Marine Biotoxins: Towards the Characterization of Metabolites Implied in Human Intoxications. Toxins 15:2, pages 103.
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Naghmeh Kamali, Feras Abbas, Mary Lehane, Michael Griew & Ambrose Furey. (2022) A Review of In Situ Methods—Solid Phase Adsorption Toxin Tracking (SPATT) and Polar Organic Chemical Integrative Sampler (POCIS) for the Collection and Concentration of Marine Biotoxins and Pharmaceuticals in Environmental Waters. Molecules 27:22, pages 7898.
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Xingyi Jiang, Yaqi Zhao, Chunya Tang, Megan Appelbaum & Qinchun Rao. (2022) Aquatic food animals in the United States: Status quo and challenges. Comprehensive Reviews in Food Science and Food Safety 21:2, pages 1336-1382.
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Santosh Kumar SarkarSantosh Kumar Sarkar. 2018. Marine Algal Bloom: Characteristics, Causes and Climate Change Impacts. Marine Algal Bloom: Characteristics, Causes and Climate Change Impacts 111 170 .
Juan Blanco, Fabiola Arévalo, Ángeles Moroño, Jorge Correa, Susana Muñíz, Carmen Mariño & Helena Martín. (2017) Presence of azaspiracids in bivalve molluscs from Northern Spain. Toxicon 137, pages 135-143.
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Haiyan Wu, Jianhua Yao, Mengmeng Guo, Zhijun Tan, Deqing Zhou & Yuxiu Zhai. (2015) Distribution of Marine Lipophilic Toxins in Shellfish Products Collected from the Chinese Market. Marine Drugs 13:7, pages 4281-4295.
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Samanta S. Khora. 2015. Hb25_Springer Handbook of Marine Biotechnology. Hb25_Springer Handbook of Marine Biotechnology 789 814 .
Daniel O'Driscoll, Zuzana Škrabáková & Kevin J. James. (2014) Confirmation of extensive natural distribution of azaspiracids in the tissue compartments of mussels (Mytilus edulis). Toxicon 92, pages 123-128.
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Liyang Zhuo, Wusheng Fu, Yiqiang Yang, Bin Qiu, Zhenyu Lin, Liyang Shan, Lemin Zheng, Jianrong Li & Guonan Chen. (2014) Simultaneous determination of biotoxins DSP and AZAs in bivalve molluscs and fish by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 28:13, pages 1479-1488.
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Ljerka Prester. 2013. Bioactive Compounds from Marine Foods. Bioactive Compounds from Marine Foods 395 430 .
Rex Munday & John Reeve. (2013) Risk Assessment of Shellfish Toxins. Toxins 5:11, pages 2109-2137.
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Daniel O’Driscoll, Zuzana Škrabáková, John O’Halloran, Frank N. A. M. van Pelt & Kevin J. James. (2011) Mussels Increase Xenobiotic (Azaspiracid) Toxicity Using a Unique Bioconversion Mechanism. Environmental Science & Technology 45:7, pages 3102-3108.
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Zuzana Škrabáková, John O'Halloran, Frank N.A.M. van Pelt & Kevin J. James. (2010) Food contaminant analysis at ultra‐high mass resolution: application of hybrid linear ion trap – orbitrap mass spectrometry for the determination of the polyether toxins, azaspiracids, in shellfish. Rapid Communications in Mass Spectrometry 24:20, pages 2966-2974.
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Isa Ruppen Canás, Keith O’Callaghan, Cian Moroney, Brett Hamilton, Kevin J. James & Ambrose Furey. (2010) The development of a rapid method for the isolation of four azaspiracids for use as reference materials for quantitative LC–MS–MS methods. Analytical and Bioanalytical Chemistry 398:3, pages 1477-1491.
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Ambrose Furey, Sinead O'Doherty, Keith O'Callaghan, Mary Lehane & Kevin J. James. (2010) Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations. Toxicon 56:2, pages 173-190.
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Arjen Gerssen, Erik H. W. van Olst, Patrick P. J. Mulder & Jacob de Boer. (2010) In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration. Analytical and Bioanalytical Chemistry 397:7, pages 3079-3088.
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K. J. JAMES, B. CAREY, J. O'HALLORAN, F. N. A. M. van PELT & Z. ŠKRABÁKOVÁ. (2010) Shellfish toxicity: human health implications of marine algal toxins. Epidemiology and Infection 138:7, pages 927-940.
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Jianhua YAO, Zhijun TAN, Deqing ZHOU, Mengmeng GUO, Lihong XING & Shouguo YANG. (2010) Determination of azaspiracid-1 in shellfishes by liquid chromatography with tandem mass spectrometry. Chinese Journal of Chromatography 28:4, pages 363-367.
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Arjen Gerssen, Irene E. Pol-Hofstad, Marnix Poelman, Patrick P.J. Mulder, Hester J. Van den Top & Jacob De Boer. (2010) Marine Toxins: Chemistry, Toxicity, Occurrence and Detection, with Special Reference to the Dutch Situation. Toxins 2:4, pages 878-904.
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A. López-Rivera, K. O’Callaghan, M. Moriarty, D. O’Driscoll, B. Hamilton, M. Lehane, K.J. James & A. Furey. (2010) First evidence of azaspiracids (AZAs): A family of lipophilic polyether marine toxins in scallops (Argopecten purpuratus) and mussels (Mytilus chilensis) collected in two regions of Chile. Toxicon 55:4, pages 692-701.
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Luis M Botana, M. Carmen Louzao, Amparo Alfonso, Ana M Botana, Mercedes R Vieytes, Natalia Viñariño & Carmen Vale. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
Judith K. Nzoughet, John T.G. Hamilton, Catherine H. Botting, Alastair Douglas, Lynda Devine, John Nelson & Christopher T. Elliott. (2009) Proteomics Identification of Azaspiracid Toxin Biomarkers in Blue Mussels, Mytilus edulis. Molecular & Cellular Proteomics 8:8, pages 1811-1822.
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Michael O. Frederick , Sandra De Lamo Marin, Kim D. Janda, K. C. Nicolaou  & Tobin J. Dickerson. (2009) Monoclonal Antibodies with Orthogonal Azaspiracid Epitopes. ChemBioChem 10:10, pages 1625-1629.
Crossref
Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 218 221 .
. (2008) Marine biotoxins in shellfish – Azaspiracid group ‐ Scientific Opinion of the Panel on Contaminants in the Food chain. EFSA Journal 6:10.
Crossref
Da-Zhi Wang. (2008) Neurotoxins from Marine Dinoflagellates: A Brief Review. Marine Drugs 6:2, pages 349-371.
Crossref
K.J. Nzoughet, J.T.G. Hamilton, S.D. Floyd, A. Douglas, J. Nelson, L. Devine & C.T. Elliott. (2008) Azaspiracid: First evidence of protein binding in shellfish. Toxicon 51:7, pages 1255-1263.
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Michael Twiner, Nils Rehmann, Philipp Hess & Gregory Doucette. (2008) Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts. Marine Drugs 6:2, pages 39-72.
Crossref
Carmen Alfonso, Amparo Alfonso, Paz Otero, Paula Rodríguez, Mercedes R. Vieytes, Chris Elliot, Cowan Higgins & Luis M. Botana. (2008) Purification of five azaspiracids from mussel samples contaminated with DSP toxins and azaspiracids. Journal of Chromatography B 865:1-2, pages 133-140.
Crossref
Juan Blanco, Carmen Mariño, Helena Martín & Carmen P. Acosta. (2007) Anatomical distribution of diarrhetic shellfish poisoning (DSP) toxins in the mussel Mytilus galloprovincialis. Toxicon 50:8, pages 1011-1018.
Crossref
Natalia Vilariño. 2007. Phycotoxins: Chemistry and Biochemistry. Phycotoxins: Chemistry and Biochemistry 311 318 .
Craig J. Forsyth, Jianyan Xu, Son T. Nguyen, Ingunn A. Samdal, Lyn R. Briggs, Thomas Rundberget, Morten Sandvik & Christopher O. Miles. (2006) Antibodies with Broad Specificity to Azaspiracids by Use of Synthetic Haptens. Journal of the American Chemical Society 128:47, pages 15114-15116.
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Philipp Hess, Lai Nguyen, John Aasen, Myra Keogh, Jane Kilcoyne, Pearse McCarron & Tore Aune. (2005) Tissue distribution, effects of cooking and parameters affecting the extraction of azaspiracids from mussels, Mytilus edulis, prior to analysis by liquid chromatography coupled to mass spectrometry. Toxicon 46:1, pages 62-71.
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Michael J. Twiner, Philipp Hess, Marie-Yasmine Bottein Dechraoui, Terry McMahon, Melissa S. Samons, Masayuki Satake, Takeshi Yasumoto, John S. Ramsdell & Gregory J. Doucette. (2005) Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines. Toxicon 45:7, pages 891-900.
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Jamie R. Colman, Michael J. Twiner, Philipp Hess, Terry McMahon, Masayuki Satake, Takeshi Yasumoto, Gregory J. Doucette & John S. Ramsdell. (2005) Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos. Toxicon 45:7, pages 881-890.
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Amparo Alfonso, Yolanda Román, Mercedes R. Vieytes, Katsuya Ofuji, Masayuki Satake, Takeshi Yasumoto & Luis M. Botana. (2005) Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes. Biochemical Pharmacology 69:11, pages 1627-1636.
Crossref
Ann-Sofi Rehnstam-Holm & Bodil Hernroth. (2005) Shellfish and Public Health: A Swedish Perspective. AMBIO: A Journal of the Human Environment 34:2, pages 139-144.
Crossref
Lisa K. Geisler, Son Nguyen & Craig J. Forsyth. (2004) Synthesis of the Azaspiracid-1 Trioxadispiroketal. Organic Letters 6:23, pages 4159-4162.
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H.M. Aukema, J.D. House, N. Bankovic-Calic & M.R. Ogborn. (2004) Increased Renal Fibrosis and Expression of Renal Phosphatidylinositol 4-Kinase-β and Phospholipase C<sub>γ1</sub> Proteins in Piglets Exposed to Ochratoxin-A. Nephron Physiology 96:1, pages p19-p25.
Crossref
Mary Lehane, Marı́a José Fidalgo Sáez, Ana Braña Magdalena, Isabel Ruppén Cañás, Mónica Dı́az Sierra, Brett Hamilton, Ambrose Furey & Kevin J James. (2004) Liquid chromatography—multiple tandem mass spectrometry for the determination of ten azaspiracids, including hydroxyl analogues in shellfish. Journal of Chromatography A 1024:1-2, pages 63-70.
Crossref
Moira M. Brett. (2003) Food poisoning associated with biotoxins in fish and shellfish. Current Opinion in Infectious Diseases 16:5, pages 461-465.
Crossref
Pearl K. S. Blay, Stephan Brombacher & Dietrich A. Volmer. (2003) Studies on azaspiracid biotoxins. III. Instrumental validation for rapid quantification of AZA 1 in complex biological matrices. Rapid Communications in Mass Spectrometry 17:18, pages 2153-2159.
Crossref
Ambrose Furey, Cian Moroney, Ana Braña Magdalena, Maria José Fidalgo Saez, Mary Lehane & Kevin J. James. (2003) Geographical, Temporal, and Species Variation of the Polyether Toxins, Azaspiracids, in Shellfish. Environmental Science & Technology 37:14, pages 3078-3084.
Crossref
Ana Braña Magdalena, Mary Lehane, Sophie Krys, Mariá Luisa Fernández, Ambrose Furey & Kevin J James. (2003) The first identification of azaspiracids in shellfish from France and Spain. Toxicon 42:1, pages 105-108.
Crossref
Kevin J. James, Monica Diaz Sierra, Mary Lehane, Ana Braña Magdalena & Ambrose Furey. (2003) Detection of five new hydroxyl analogues of azaspiracids in shellfish using multiple tandem mass spectrometry. Toxicon 41:3, pages 277-283.
Crossref
Kevin J James, Cian Moroney, Cilian Roden, Masayuki Satake, Takeshi Yasumoto, Mary Lehane & Ambrose Furey. (2003) Ubiquitous ‘benign’ alga emerges as the cause of shellfish contamination responsible for the human toxic syndrome, azaspiracid poisoning. Toxicon 41:2, pages 145-151.
Crossref

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