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Original Articles

Ochratoxin A: Potential epigenetic mechanisms of toxicity and carcinogenicity

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Pages 88-93 | Published online: 09 Aug 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Amany M. Diab, Salem R.M.El-Keredy M.S. Abeer, Gehan I.E. Ali & Nagwan El-Habashi. (2018) Experimental ochratoxicosis A in Nile tilapia and its amelioration by some feed additives. International Journal of Veterinary Science and Medicine 6:2, pages 149-158.
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Julia Bellver Soto, María-José Ruiz, Lara Manyes & Ana Juan-García. (2016) Blood, breast milk and urine: potential biomarkers of exposure and estimated daily intake of ochratoxin A: a review. Food Additives & Contaminants: Part A 33:2, pages 313-328.
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Lois A. Haighton, Barry S. Lynch, Bernadene A. Magnuson & Earle R. Nestmann. (2012) A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model. Critical Reviews in Toxicology 42:2, pages 147-168.
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Daniel Krewski, Daniel Acosta$suffix/text()$suffix/text(), Melvin Andersen, Henry Anderson, John C. Bailar$suffix/text()$suffix/text(), Kim Boekelheide, Robert Brent, Gail Charnley, Vivian G. Cheung, Sidney Green$suffix/text()$suffix/text(), Karl T. Kelsey, Nancy I. Kerkvliet, Abby A. Li, Lawrence McCray, Otto Meyer, Reid D. Patterson, William Pennie, Robert A. Scala, Gina M. Solomon, Martin Stephens, James Yager, Lauren Zeise & Staff of Committee on Toxicity Testing and Assessment of Environmental Agents. (2010) Toxicity Testing in the 21st Century: A Vision and a Strategy. Journal of Toxicology and Environmental Health, Part B 13:2-4, pages 51-138.
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S.C. Duarte, J.M.V. Bento, A. Pena & C.M. Lino. (2009) Ochratoxin A exposure assessment of the inhabitants of Lisbon during winter 2007/2008 through bread and urine analysis. Food Additives & Contaminants: Part A 26:10, pages 1411-1420.
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M. Jestoi & M. Kokkonen. (2008) Comparison of Two Sample Preparation Techniques for the Determination of Ochratoxin A in Grains. Journal of Liquid Chromatography & Related Technologies 31:6, pages 912-925.
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Articles from other publishers (32)

Akhileshwar Kumar Srivastava, Dhruv Kumar, Divya Singh & Rajesh Kumar Singh. 2022. Xenobiotics in Chemical Carcinogenesis. Xenobiotics in Chemical Carcinogenesis 127 153 .
Liang Gong, Hong Zhu, Taotao Li, Guangfeng Ming, Xuewu Duan, Jiasheng Wang & Yueming Jiang. (2019) Molecular signatures of cytotoxic effects in human embryonic kidney 293 cells treated with single and mixture of ochratoxin A and citrinin. Food and Chemical Toxicology 123, pages 374-384.
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Alessandra Mezzelani. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 2125 2144 .
N Gulfam, M Zahoor, M Khisroom & FA Khan. (2018) In Vivo Detoxification of Ochratoxin A by Highly Porous Magnetic Nanocomposites Prepared from Coconut Shell. Brazilian Journal of Poultry Science 20:4, pages 675-698.
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Jamshid Tabeshpour, Soghra Mehri, Fatemeh Shaebani Behbahani & Hossein Hosseinzadeh. (2018) Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review . Phytotherapy Research 32:11, pages 2164-2190.
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Ukpai A. Eze, John Huntriss, Michael N. Routledge & Yun Yun Gong. (2018) Toxicological effects of regulated mycotoxins and persistent organochloride pesticides: In vitro cytotoxic assessment of single and defined mixtures on MA-10 murine Leydig cell line. Toxicology in Vitro 48, pages 93-103.
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Elisabeth Limbeck, Jens T. Vanselow, Julian Hofmann, Andreas Schlosser & Angela Mally. (2017) Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. Archives of Toxicology 92:2, pages 995-1014.
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Yajiao Zhou, Fang Gan, Lili Hou, Xuan Zhou, Yassin Abdulrahim Adam Ibrahim & Kehe Huang. (2017) Modulations of DNMT1 and HDAC1 are involved in the OTA-induced cytotoxicity and apoptosis in vitro. Chemico-Biological Interactions 278, pages 170-178.
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Daniela Eliza Marin, Cornelia Braicu, Mihai Alexandru Gras, Gina Cecilia Pistol, Roxana Cojocneanu Petric, Ioana Berindan Neagoe, Mihai Palade & Ionelia Taranu. (2017) Low level of ochratoxin A affects genome-wide expression in kidney of pig. Toxicon 136, pages 67-77.
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Alessandra Mezzelani. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 20 .
A.H. Heussner & T. Paget. (2016) Evaluation of renal in vitro models used in ochratoxin research . World Mycotoxin Journal 9:3, pages 435-454.
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João G. Costa, Nuno Saraiva, Patrícia S. Guerreiro, Henriqueta Louro, Maria J. Silva, Joana P. Miranda, Matilde Castro, Ines Batinic-Haberle, Ana S. Fernandes & Nuno G. Oliveira. (2016) Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints. Food and Chemical Toxicology 87, pages 65-76.
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Shanel Raghubeer, Savania Nagiah, Alisa Phulukdaree & Anil Chuturgoon. (2015) The Phytoalexin Resveratrol Ameliorates Ochratoxin A Toxicity in Human Embryonic Kidney (HEK293) Cells. Journal of Cellular Biochemistry 116:12, pages 2947-2955.
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Lucia Rutigliano, Luisa Valentini, Nicola Antonio Martino, Flavia Pizzi, Antonina Zanghì, Maria Elena Dell'Aquila & Fiorenza Minervini. (2015) Ochratoxin A at low concentrations inhibits in vitro growth of canine umbilical cord matrix mesenchymal stem cells through oxidative chromatin and DNA damage. Reproductive Toxicology 57, pages 121-129.
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Alexandra Heussner & Lewis Bingle. (2015) Comparative Ochratoxin Toxicity: A Review of the Available Data. Toxins 7:10, pages 4253-4282.
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Zeynep Özcan, Gizem Gül & Ibrahim Yaman. (2014) Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells. Archives of Toxicology 89:8, pages 1313-1327.
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Tiago Vieira, Sara Cunha & Susana Casal. 2015. Coffee in Health and Disease Prevention. Coffee in Health and Disease Prevention 225 233 .
Cyndia A. González-Arias, Alma B. Benitez-Trinidad, Monserrat Sordo, Lourdes Robledo-Marenco, Irma M. Medina-Díaz, Briscia S. Barrón-Vivanco, Sonia Marín, Vicente Sanchis, Antonio J. Ramos & Aurora E. Rojas-García. (2014) Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes. Food and Chemical Toxicology 74, pages 249-254.
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Frederick Guilford & Janette Hope. (2014) Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness. Toxins 6:2, pages 608-623.
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Valeria Sorrenti, Claudia Di Giacomo, Rosaria Acquaviva, Ignazio Barbagallo, Matteo Bognanno & Fabio Galvano. (2013) Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review. Toxins 5:10, pages 1742-1766.
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S.C. Duarte, M.R. Alves, A. Pena & C.M. Lino. (2012) Determinants of ochratoxin A exposure—A one year follow-up study of urine levels. International Journal of Hygiene and Environmental Health 215:3, pages 360-367.
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Kristin Czakai, Katja Müller, Pasquale Mosesso, Gaetano Pepe, Markus Schulze, Antje Gohla, Debasis Patnaik, Wolfgang Dekant, Jonathan M.G. Higgins & Angela Mally. (2011) Perturbation of Mitosis through Inhibition of Histone Acetyltransferases: The Key to Ochratoxin A Toxicity and Carcinogenicity?. Toxicological Sciences 122:2, pages 317-329.
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M. Marin-Kuan, V. Ehrlich, T. Delatour, C. Cavin & B. Schilter. (2011) Evidence for a Role of Oxidative Stress in the Carcinogenicity of Ochratoxin A. Journal of Toxicology 2011, pages 1-15.
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Martin Chopra, Pascal Link, Christine Michels & Dieter Schrenk. (2009) Characterization of ochratoxin A-induced apoptosis in primary rat hepatocytes. Cell Biology and Toxicology 26:3, pages 239-254.
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Lada Rumora & Tihana Grubišić. (2009) A Journey Through Mitogen-Activated Protein Kinase and Ochratoxin A Interactions. Archives of Industrial Hygiene and Toxicology 60:4, pages 449-456.
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Mosaad A. Abdel-Wahhab, Sekena H. Abdel-Azim & Aziza A. El-Nekeety. (2008) Inula crithmoides extract protects against ochratoxin A-induced oxidative stress, clastogenic and mutagenic alterations in male rats. Toxicon 52:4, pages 566-573.
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Maricel Marin-Kuan, Christophe Cavin, Thierry Delatour & Benoît Schilter. (2008) Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms. Toxicon 52:2, pages 195-202.
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Leire Arbillaga, Ariane Vettorazzi, Ana G Gil, Joost HM van Delft, José Antonio García-Jalón & Adela López de Cerain. (2008) Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration. Toxicology and Applied Pharmacology 230:2, pages 197-207.
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Eva Rached, Gordon C. Hard, Kai Blumbach, Klaus Weber, Regina Draheim, Werner K. Lutz, Sibel Özden, Ulrich Steger, Wolfgang Dekant & Angela Mally. (2007) Ochratoxin A: 13-Week Oral Toxicity and Cell Proliferation in Male F344/N Rats. Toxicological Sciences 97:2, pages 288-298.
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Leire Arbillaga, Amaia Azqueta, Joost H.M. van Delft & Adela López de Cerain. (2007) In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A. Toxicology and Applied Pharmacology 220:2, pages 216-224.
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. (2006) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to ochratoxin A in food. EFSA Journal 4:6, pages 365.
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Abdelouahed Hajjaji, Mostafa El Otmani, Driss Bouya, Amina Bouseta, Florence Mathieu, Sonia Collin & Ahmed Lebrihi. (2006) Occurrence of mycotoxins (ochratoxin A, deoxynivalenol) and toxigenic fungi in Moroccan wheat grains: impact of ecological factors on the growth and ochratoxin A production. Molecular Nutrition & Food Research 50:6, pages 494-499.
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