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Original Articles

Ochratoxin A: Comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans)

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Pages 45-52 | Published online: 09 Aug 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Larissa Tuanny Franco, Amin Mousavi Khaneghah, Sarah Hwa In Lee & Carlos Augusto Fernandes Oliveira. (2021) Biomonitoring of mycotoxin exposure using urinary biomarker approaches: a review. Toxin Reviews 40:4, pages 383-403.
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Aksel Bernhoft, Helga R. Høgåsen, Grethe Rosenlund, Lada Ivanova, Marc H. G. Berntssen, Jan Alexander, Gunnar Sundstøl Eriksen & Christiane Kruse Fæste. (2017) Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar). Food Additives & Contaminants: Part A 34:7, pages 1211-1224.
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Lois A. Haighton, Barry S. Lynch, Bernadene A. Magnuson & Earle R. Nestmann. (2012) A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model. Critical Reviews in Toxicology 42:2, pages 147-168.
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M.A. Elaroussi, F.R. Mohamed, E.M. El Barkouky, A.M. Atta, A.M. Abdou & M.H. Hatab. (2006) Experimental ochratoxicosis in broiler chickens. Avian Pathology 35:4, pages 263-269.
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Articles from other publishers (50)

Rahim Khan, Farooq Anwar & Farinazleen Mohamad Ghazali. (2024) A comprehensive review of mycotoxins: Toxicology, detection, and effective mitigation approaches. Heliyon 10:8, pages e28361.
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Stoycho D. Stoev. (2024) Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses. Frontiers in Nutrition 11.
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Shakil Ahmed Saghir & Rais Ahmed Ansari. (2024) HLA gene variations and mycotoxin toxicity: Four case reports. Mycotoxin Research 40:1, pages 159-173.
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Ryota Ojiro, Hiromu Okano, Shunsuke Ozawa, Hiroshi Yamagata, Xinyu Zou, Qian Tang, Meilan Jin, Kazuaki Sasaki, Toshinori Yoshida, Tomoya Yoshinari & Makoto Shibutani. (2023) Pharmacokinetics and 28-day repeated-dose toxicity of enniatin B after oral administration in mice. Food and Chemical Toxicology 177, pages 113814.
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Chinaza Godseill Awuchi, Erick Nyakundi Ondari, Sarah Nwozo, Grace Akinyi Odongo, Ifie Josiah Eseoghene, Hannington Twinomuhwezi, Chukwuka U. Ogbonna, Anjani K. Upadhyay, Ademiku O. Adeleye & Charles Odilichukwu R. Okpala. (2022) Mycotoxins’ Toxicological Mechanisms Involving Humans, Livestock and Their Associated Health Concerns: A Review. Toxins 14:3, pages 167.
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Jochem Louisse, Jean Lou C.M Dorne & Luca Dellafiora. (2022) Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations. Toxicology Letters 355, pages 19-30.
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Agnieszka Tkaczyk, Piotr Jedziniak, Łukasz Zielonka, Michał Dąbrowski, Piotr Ochodzki & Adrianna Rudawska. (2021) Biomarkers of Deoxynivalenol, Citrinin, Ochratoxin A and Zearalenone in Pigs after Exposure to Naturally Contaminated Feed Close to Guidance Values. Toxins 13:11, pages 750.
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Agnieszka Tkaczyk & Piotr Jedziniak. (2021) Mycotoxin Biomarkers in Pigs—Current State of Knowledge and Analytics. Toxins 13:8, pages 586.
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Delphine Payros, Marion Garofalo, Alix Pierron, Laura Soler-Vasco, Carine Al-Ayoubi, Viviane M. Maruo, Imourana Alassane-Kpembi, Philippe Pinton & Isabelle P. Oswald. (2021) Les mycotoxines en alimentation humaine : un défi pour la recherche. Cahiers de Nutrition et de Diététique 56:3, pages 170-183.
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Dieter Schrenk, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Jan Alexander, Chiara Dall'Asta, Angela Mally, Manfred Metzler, Marco Binaglia, Zsuzsanna Horváth, Hans Steinkellner & Margherita Bignami. (2020) Risk assessment of ochratoxin A in food. EFSA Journal 18:5.
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Eva Warensjö Lemming, Andrea Montano Montes, Jessica Schmidt, Benedikt Cramer, Hans-Ulrich Humpf, Lotta Moraeus & Monica Olsen. (2019) Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics. Mycotoxin Research 36:2, pages 193-206.
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Alessandro Guerrini, Alberto Altafini & Paola Roncada. (2020) Assessment of Ochratoxin A Exposure in Ornamental and Self-Consumption Backyard Chickens. Veterinary Sciences 7:1, pages 18.
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Elif Mine Öncü Kaya, Orhan Tansel Korkmaz, Duygu Yeniceli Uğur, Erol Şener, A. Neşe Tunçel & Muzaffer Tunçel. (2019) Determination of Ochratoxin-A in the brain microdialysates and plasma of awake, freely moving rats using ultra high performance liquid chromatography fluorescence detection method. Journal of Chromatography B 1125, pages 121700.
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Shahzad Akbar Khan, Emerson J. Venancio, Mario A. Ono, Eduardo V. Fernandes, Elisa Y. Hirooka, Cleverson F. Shimizu, Alexandre Oba, Karina K. M. C. Flaiban & Eiko N. Itano. (2019) Effects of Subcutaneous Ochratoxin-A Exposure on Immune System of Broiler Chicks. Toxins 11:5, pages 264.
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Genevieve S. Bondy, Laurie Coady, Nikia Ross, Don Caldwell, Anne Marie Gannon, Keri Kwong, Stephen Hayward, David E. Lefebvre, Virginia Liston, Jayadev Raju, Peter Pantazopoulos & Ivan Curran. (2018) A reproductive and developmental screening study of the fungal toxin ochratoxin A in Fischer rats. Mycotoxin Research 34:4, pages 241-255.
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L. Soler & I.P. Oswald. (2018) The importance of accounting for sex in the search of proteomic signatures of mycotoxin exposure. Journal of Proteomics 178, pages 114-122.
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Mathias Devreese, Siska Croubels, Siegrid De Baere, Ronette Gehring & Gunther Antonissen. (2018) Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species. Journal of Agricultural and Food Chemistry 66:9, pages 2129-2135.
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Daniela E. Marin, Gina C. Pistol, Mihai A. Gras, Mihai L. Palade & Ionelia Taranu. (2017) Comparative effect of ochratoxin A on inflammation and oxidative stress parameters in gut and kidney of piglets. Regulatory Toxicology and Pharmacology 89, pages 224-231.
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Stoycho D. Stoev. (2017) Balkan Endemic Nephropathy – Still continuing enigma, risk assessment and underestimated hazard of joint mycotoxin exposure of animals or humans. Chemico-Biological Interactions 261, pages 63-79.
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Laura Pastor, Ariane Vettorazzi, Javier Campión, Paul Cordero & Adela López de Cerain. (2016) Gene expression kinetics of renal transporters induced by ochratoxin A in male and female F344 rats. Food and Chemical Toxicology 98, pages 169-178.
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Eman Zahran, Bruce Manning, Jung-Kil Seo & Edward J. Noga. (2016) The effect of Ochratoxin A on antimicrobial polypeptide expression and resistance to water mold infection in channel catfish (Ictalurus punctatus). Fish & Shellfish Immunology 57, pages 60-67.
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Jelka Pleadin, Nina Kudumija, Dragan Kovačević, Giampiero Scortichini, Salvatore Milone & Ivana Kmetič. (2016) Comparison of ochratoxin A levels in edible pig tissues and in biological fluids after exposure to a contaminated diet. Mycotoxin Research 32:3, pages 145-151.
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A.H. Heussner & T. Paget. (2016) Evaluation of renalin vitro models used in ochratoxin research. World Mycotoxin Journal 9:3, pages 435-454.
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Lucia Rutigliano, Luisa Valentini, Nicola Antonio Martino, Flavia Pizzi, Antonina Zanghì, Maria Elena Dell'Aquila & Fiorenza Minervini. (2015) Ochratoxin A at low concentrations inhibits in vitro growth of canine umbilical cord matrix mesenchymal stem cells through oxidative chromatin and DNA damage. Reproductive Toxicology 57, pages 121-129.
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Alexandra Heussner & Lewis Bingle. (2015) Comparative Ochratoxin Toxicity: A Review of the Available Data. Toxins 7:10, pages 4253-4282.
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Sara Armorini, Khaled Mefleh Al-Qudah, Alberto Altafini, Anna Zaghini & Paola Roncada. (2015) Biliary ochratoxin A as a biomarker of ochratoxin exposure in laying hens: An experimental study after administration of contaminated diets. Research in Veterinary Science 100, pages 265-270.
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Clara Y. Chan & Bruce J. Kelman. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 1283 1294 .
A. Vettorazzi, E. González-Peñas & A. López de Cerain. (2014) Ochratoxin A kinetics: A review of analytical methods and studies in rat model. Food and Chemical Toxicology 72, pages 273-288.
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Firdevs Mor, Mehmet A. Kilic, Ozlem Ozmen, Mesut Yilmaz, Ilknur Eker & Kemal Uran. (2014) The effects of orchidectomy on toxicological responses to dietary ochratoxin A in Wistar rats. Experimental and Toxicologic Pathology 66:5-6, pages 267-275.
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Frederick Guilford & Janette Hope. (2014) Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness. Toxins 6:2, pages 608-623.
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Sofia Cancela Duarte, Celeste de Matos Lino & Angelina Lopes Simões PenaSofia Cancela DuarteAngelina Lopes Simões PenaCeleste de Matos Lino. 2014. Mycotoxins and their Implications in Food Safety. Mycotoxins and their Implications in Food Safety 20 35 .
Ariane Vettorazzi, Joost van Delft & Adela López de Cerain. (2013) A review on ochratoxin A transcriptomic studies. Food and Chemical Toxicology 59, pages 766-783.
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Zheng Han, Zhiyong Zhao, Jianxin Shi, Yucai Liao, Zhihui Zhao, Dabing Zhang, Yongning Wu, Sarah De Saeger & Aibo Wu. (2013) Combinatorial approach of LC–MS/MS and LC–TOF-MS for uncovering in vivo kinetics and biotransformation of ochratoxin A in rat. Journal of Chromatography B 925, pages 46-53.
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N. Perši, J. Pleadin, A. Vulić, I. Kmetić & B. Šimić. (2012) Determination of ochratoxin A in serum and urine of pigs. World Mycotoxin Journal 5:4, pages 351-356.
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L.A. Corcuera, A. Vettorazzi, L. Arbillaga, E. González-Peñas & A. López de Cerain. (2012) An approach to the toxicity and toxicokinetics of aflatoxin B1 and ochratoxin A after simultaneous oral administration to fasted F344 rats. Food and Chemical Toxicology 50:10, pages 3440-3446.
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Jelka Pleadin, Nina Perši, Mario Mitak, Svjetlana Terzić, Dinka Milić, Ana Vulić & Mate Brstilo. (2012) Biochemical Changes in Pig Serum After Ochratoxin A Exposure. Bulletin of Environmental Contamination and Toxicology 88:6, pages 1043-1047.
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Shashi Nandar Kumar, Avinash Gopal Telang, Karan Pal Singh, Arun Kumar Jain, Masarrat Afroz & Rajendra Damu Patil. (2011) Experimentally Induced Toxicity of Ochratoxin A and Endosulfan in Male Wistar Rats: A Hormonal Disorder. Journal of Animal and Veterinary Advances 10:13, pages 1750-1755.
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Sofia C. Duarte, Celeste M. Lino & Angelina Pena. (2011) Ochratoxin A in feed of food-producing animals: An undesirable mycotoxin with health and performance effects. Veterinary Microbiology 154:1-2, pages 1-13.
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R.T. Riley, K.A. Voss, R.A. Coulombe, J.J. Pestka & D.E. Williams. 2011. Determining Mycotoxins and Mycotoxigenic Fungi in Food and Feed. Determining Mycotoxins and Mycotoxigenic Fungi in Food and Feed 245 275 .
A. Vettorazzi, I.F. Trocóniz, E. Gonzalez-Peñas, L.A. Corcuera, L. Arbillaga, A.G. Gil, J.M. Nagy, P.G. Mantle & A. López de Cerain. (2010) Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats. Food and Chemical Toxicology 48:11, pages 3159-3166.
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I. Stratakou & H. van der Fels-Klerx. (2010) Mycotoxins in grapes and wine in Europe: occurrence, factors affecting the occurrence and related toxicological effects. World Mycotoxin Journal 3:3, pages 283-300.
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Naohiko Anzai, Promsuk Jutabha & Hitoshi Endou. (2010) Molecular Mechanism of Ochratoxin A Transport in the Kidney. Toxins 2:6, pages 1381-1398.
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A. Vettorazzi, E. Gonzalez-Peñas, I.F. Trocóniz, L. Arbillaga, L.A. Corcuera, A.G. Gil & A. López de Cerain. (2009) A different kinetic profile of ochratoxin A in mature male rats. Food and Chemical Toxicology 47:8, pages 1921-1927.
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Yasser Said El-Sayed, Riad Hassan Khalil & Talaat Talaat Saad. (2009) Acute toxicity of ochratoxin-A in marine water-reared sea bass (Dicentrarchus labrax L.). Chemosphere 75:7, pages 878-882.
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Melanie Adler, Katja Müller, Eva Rached, Wolfgang Dekant & Angela Mally. (2009) Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. Carcinogenesis 30:4, pages 711-719.
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Dragan MilicevicR.R., Verica JuricB.B., Dubravka VukovicZ.Z., Miodrag MandicM.M. & Tatjana BalticM.M.. (2009) Residue of ochratoxin A in swine tissues: Risk assessment. Archive of Oncology Arhiv za onkologiju 17:3-4, pages 56-60.
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N. Aoudia, E.K. Tangni & Y. Larondelle. (2008) Distribution of ochratoxin A in plasma and tissues of rats fed a naturally contaminated diet amended with micronized wheat fibres: Effectiveness of mycotoxin sequestering activity. Food and Chemical Toxicology 46:3, pages 871-878.
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Rajendra D. Patil, Prabhaker Dwivedi & Anil K. Sharma. (2006) Critical period and minimum single oral dose of ochratoxin A for inducing developmental toxicity in pregnant Wistar rats. Reproductive Toxicology 22:4, pages 679-687.
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. (2006) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to ochratoxin A in food. EFSA Journal 4:6, pages 365.
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Marcel Castegnaro, Delphine Canadas, Terry Vrabcheva, Theodora Petkova‐Bocharova, Ivan N. Chernozemsky & Annie Pfohl‐Leszkowicz. (2006) Balkan endemic nephropathy: Role of ochratoxins A through biomarkers. Molecular Nutrition & Food Research 50:6, pages 519-529.
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