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Original Articles

Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A

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Pages 58-64 | Published online: 09 Aug 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Frantisek Malir, Vladimir Ostry & Eva Novotna. (2013) Toxicity of the mycotoxin ochratoxin A in the light of recent data. Toxin Reviews 32:2, pages 19-33.
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Lois A. Haighton, Barry S. Lynch, Bernadene A. Magnuson & Earle R. Nestmann. (2012) A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model. Critical Reviews in Toxicology 42:2, pages 147-168.
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Peter Mantle & Elena Kulinskaya. (2010) Lifetime, low-dose ochratoxin A dietary study on renal carcinogenesis in male Fischer rats. Food Additives & Contaminants: Part A 27:11, pages 1566-1573.
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T. Kuiper-Goodman, C. Hilts, S.M. Billiard, Y. Kiparissis, I.D.K. Richard & S. Hayward. (2010) Health risk assessment of ochratoxin A for all age-sex strata in a market economy. Food Additives & Contaminants: Part A 27:2, pages 212-240.
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Articles from other publishers (70)

Peter Mantle. (2023) Optimised Fermentation Production of Radiolabelled Ochratoxin A by Aspergillus ochraceus with Maximum 14C in the Pentaketide Moiety for Exploring Its Rat Renal Toxicology. Toxins 16:1, pages 8.
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Peter Mantle, Andrew Roberts & Claire Beaumont. (2023) Notoamide R: A Prominent Diketopiperazine Fermentation Metabolite amongst Others of Aspergillus ochraceus in the Absence of Ochratoxins. Molecules 28:8, pages 3518.
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İzzet Erdal & S. Songül Yalçın. (2022) The relationship between ochratoxin A and blood pressure in adolescents. Environmental Toxicology and Pharmacology 95, pages 103959.
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Tetyana Kobets, Benjamin P. C. Smith & Gary M. Williams. (2022) Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk. Foods 11:18, pages 2828.
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Stoycho D. Stoev. (2022) New Evidences about the Carcinogenic Effects of Ochratoxin A and Possible Prevention by Target Feed Additives. Toxins 14:6, pages 380.
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Ait Sidi Brahim Malika, Kiai Hajar, Benidire Loubna, Omar El Hiba, Makbal Rachida, Benidire Leila, Sellami Souad & Rais S Hanane. 2022. Research Anthology on Advancements in Women's Health and Reproductive Rights. Research Anthology on Advancements in Women's Health and Reproductive Rights 357 397 .
Yuseok Moon, Tamás Korcsmáros, Arulkumar Nagappan & Navin Ray. (2022) MicroRNA target-based network predicts androgen receptor-linked mycotoxin stress. Ecotoxicology and Environmental Safety 230, pages 113130.
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Stoycho D. Stoev. (2021) Follow up long term preliminary studies on carcinogenic and toxic effects of ochratoxin A in rats and the putative protection of phenylalanine. Toxicon 190, pages 41-49.
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Stoycho D Stoev. (2020) Long term preliminary studies on toxic and carcinogenic effect of individual or simultaneous exposure to ochratoxin A and penicillic acid in mice. Toxicon 184, pages 192-201.
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C. OteroC. ArredondoA. Echeverría-VegaF. Gordillo-Fuenzalida. (2020) Penicillium spp. mycotoxins found in food and feed and their health effects. World Mycotoxin Journal 13:3, pages 323-344.
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Dieter Schrenk, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Jan Alexander, Chiara Dall'Asta, Angela Mally, Manfred Metzler, Marco Binaglia, Zsuzsanna Horváth, Hans Steinkellner & Margherita Bignami. (2020) Risk assessment of ochratoxin A in food. EFSA Journal 18:5.
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Diana Herman & Peter Mantle. (2019) Immunohistochemical Review of Leydig Cell Lesions in Ochratoxin A-Treated Fischer Rats and Controls. Toxins 11:8, pages 480.
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Ait Sidi Brahim Malika, Kiai Hajar, Benidire Loubna, Omar El Hiba, Makbal Rachida, Benidire Leila, Sellami Souad & Rais S Hanane. 2019. Handbook of Research on Global Environmental Changes and Human Health. Handbook of Research on Global Environmental Changes and Human Health 152 192 .
Oday S. Abbas, Dalia A. Abdul-Shaheed & Rand M. Anwer. (2018) Induce Cancer by Ochratoxin A. Journal of Pure and Applied Microbiology 12:4, pages 1825-1828.
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Laura Pastor, Ariane Vettorazzi, Jose Manuel Enciso, Elena González-Peñas, Jose Antonio García-Jalón, Jose Ignacio Monreal & Adela López de Cerain. (2018) Sex differences in ochratoxin a toxicity in F344 rats after 7 and 21 days of daily oral administration. Food and Chemical Toxicology 111, pages 363-373.
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V. Bunel, F. Souard, M.-H. Antoine, C. Stévigny & J.L. Nortier. 2018. Comprehensive Toxicology. Comprehensive Toxicology 340 379 .
A.-M. Domijan & M. Peraica. 2018. Comprehensive Toxicology. Comprehensive Toxicology 154 167 .
Diana Herman & Peter Mantle. (2017) Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A. Toxins 9:12, pages 384.
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Vladimir Ostry, Frantisek Malir, Jakub Toman & Yann Grosse. (2016) Mycotoxins as human carcinogens—the IARC Monographs classification. Mycotoxin Research 33:1, pages 65-73.
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Laura Pastor, Ariane Vettorazzi, Javier Campión, Paul Cordero & Adela López de Cerain. (2016) Gene expression kinetics of renal transporters induced by ochratoxin A in male and female F344 rats. Food and Chemical Toxicology 98, pages 169-178.
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Frantisek Malir, Vladimir Ostry, Annie Pfohl-Leszkowicz, Jan Malir & Jakub Toman. (2016) Ochratoxin A: 50 Years of Research. Toxins 8:7, pages 191.
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A.H. Heussner & T. Paget. (2016) Evaluation of renalin vitro models used in ochratoxin research. World Mycotoxin Journal 9:3, pages 435-454.
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Haila Abassi, Imen Ayed‐Boussema, Sarah Shirley, Salwa Abid & Hassen Bacha. (2016) Ochratoxin A and T‐2 Toxin Induce Clonogenicity and Cell Migration in Human Colon Carcinoma and Fetal Lung Fibroblast Cell Lines. Journal of Biochemical and Molecular Toxicology 30:3, pages 128-135.
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Ariane Vettorazzi & Adela López de Cerain. 2016. Environmental Mycology in Public Health. Environmental Mycology in Public Health 261 298 .
Ömür Şengül, Fatma KOCASARI ŞAHİNDOKUYUCU, Özlem Özmen & Firdevs Mor. (2015) Okratoksin A ve Etkileri. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 34:1-2, pages 71-76.
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Zeynep Özcan, Gizem Gül & Ibrahim Yaman. (2014) Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells. Archives of Toxicology 89:8, pages 1313-1327.
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A. Vettorazzi, E. González-Peñas & A. López de Cerain. (2014) Ochratoxin A kinetics: A review of analytical methods and studies in rat model. Food and Chemical Toxicology 72, pages 273-288.
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Firdevs Mor, Mehmet A. Kilic, Ozlem Ozmen, Mesut Yilmaz, Ilknur Eker & Kemal Uran. (2014) The effects of orchidectomy on toxicological responses to dietary ochratoxin A in Wistar rats. Experimental and Toxicologic Pathology 66:5-6, pages 267-275.
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Takashi Umemura. (2014) Possible Carcinogenic Mechanisms Underlying Renal Carcinogens in Food. Food Safety 2:2, pages 17-30.
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Ken Kuroda, Daisuke Hibi, Yuji Ishii, Shinji Takasu, Aki Kijima, Kohei Matsushita, Ken-ichi Masumura, Maiko Watanabe, Yoshiko Sugita-Konishi, Hiroki Sakai, Tokuma Yanai, Takehiko Nohmi, Kumiko Ogawa & Takashi Umemura. (2014) Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats. Mutagenesis 29:1, pages 27-36.
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Ariane Vettorazzi, Robin Wait, Judit Nagy, Jose Ignacio Monreal & Peter Mantle. (2013) Changes in male rat urinary protein profile during puberty: a pilot study. BMC Research Notes 6:1.
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Ariane Vettorazzi, Joost van Delft & Adela López de Cerain. (2013) A review on ochratoxin A transcriptomic studies. Food and Chemical Toxicology 59, pages 766-783.
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Daisuke Hibi, Aki Kijima, Ken Kuroda, Yuta Suzuki, Yuji Ishii, Meilan Jin, Masahiro Nakajima, Yoshiko Sugita-Konishi, Tokuma Yanai, Takehiko Nohmi, Akiyoshi Nishikawa & Takashi Umemura. (2013) Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression. The Journal of Toxicological Sciences 38:1, pages 57-69.
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S.S. Palabiyik, P. Erkekoglu, N.D. Zeybek, M. Kızılgun, G. Sahin & B. Kocer Giray. (2012) Ochratoxin A causes oxidative stress and cell death in rat liver. World Mycotoxin Journal 5:4, pages 377-384.
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L.A. Corcuera, A. Vettorazzi, L. Arbillaga, E. González-Peñas & A. López de Cerain. (2012) An approach to the toxicity and toxicokinetics of aflatoxin B1 and ochratoxin A after simultaneous oral administration to fasted F344 rats. Food and Chemical Toxicology 50:10, pages 3440-3446.
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Patrycja Gazinska, Diana Herman, Cheryl Gillett, Sarah Pinder & Peter Mantle. (2012) Comparative Immunohistochemical Analysis of Ochratoxin A Tumourigenesis in Rats and Urinary Tract Carcinoma in Humans; Mechanistic Significance of p-S6 Ribosomal Protein Expression. Toxins 4:9, pages 643-662.
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Zengning Li, Xianghong Zhang, Jinfeng Cui & Weijun Kang. (2012) Assessment on pollution of ochratoxin a in grain in China and its apoptosis effect on vitro‐cultured human tubular kidney cells. Journal of Biochemical and Molecular Toxicology 26:4, pages 139-146.
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Annie Pfohl-Leszkowicz & Richard A. Manderville. (2011) An Update on Direct Genotoxicity as a Molecular Mechanism of Ochratoxin A Carcinogenicity. Chemical Research in Toxicology 25:2, pages 252-262.
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Takashi UMEMURA. (2012) Approach to understanding the modes of action underlying ochratoxin A-induced renal carcinogenesis. Mycotoxins 62:2, pages 143-148.
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Daisuke Hibi, Yuta Suzuki, Yuji Ishii, Meilan Jin, Maiko Watanabe, Yoshiko Sugita-Konishi, Tokuma Yanai, Takehiko Nohmi, Akiyoshi Nishikawa & Takashi Umemura. (2011) Site-Specific In Vivo Mutagenicity in the Kidney of gpt Delta Rats Given a Carcinogenic Dose of Ochratoxin A. Toxicological Sciences 122:2, pages 406-414.
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Peter G. Mantle, Andrew W. Nicholls & John P. Shockcor. (2011) 1H NMR Spectroscopy-Based Metabolomic Assessment of Uremic Toxicity, with Toxicological Outcomes, in Male Rats Following an Acute, Mid-Life Insult from Ochratoxin A. Toxins 3:6, pages 504-519.
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A. Vettorazzi, I.F. Trocóniz, E. Gonzalez-Peñas, L.A. Corcuera, L. Arbillaga, A.G. Gil, J.M. Nagy, P.G. Mantle & A. López de Cerain. (2010) Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats. Food and Chemical Toxicology 48:11, pages 3159-3166.
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Gary G. Schwartz, Richard A. Manderville & Annie Pfohl-Leszkowicz. (2010) Response to Comments of Peter G. Mantle. Toxins 2:10, pages 2337-2339.
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Peter G. Mantle. (2010) Comments on “Ochratoxin A: In utero Exposure in Mice Induces Adducts in Testicular DNA. Toxins 2010, 2, 1428–1444”—Mis-Citation of Rat Literature to Justify a Hypothetical Role for Ochratoxin A in Testicular Cancer. Toxins 2:10, pages 2333-2336.
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Jamie E. Jennings-Gee, Mariana Tozlovanu, Richard Manderville, Mark Steven Miller, Annie Pfohl-Leszkowicz & Gary G. Schwartz. (2010) Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA. Toxins 2:6, pages 1428-1444.
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Peter Mantle & Christopher Nolan. (2010) Pathological Outcomes in Kidney and Brain in Male Fischer Rats Given Dietary Ochratoxin A, Commencing at One Year of Age. Toxins 2:5, pages 1100-1110.
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Lalini Reddy & Kanti Bhoola. (2010) Ochratoxins—Food Contaminants: Impact on Human Health. Toxins 2:4, pages 771-779.
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Stoycho D. Stoev. (2010) Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks. Toxins 2:4, pages 649-664.
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Peter G. Mantle, Miloslav Dobrota, Cheryl E. Gillett, Edward W. Odell & Sarah E. Pinder. (2010) Oncological Outcomes in Rats Given Nephrocarcinogenic Exposure to Dietary Ochratoxin A, Followed by the Tumour Promoter Sodium Barbital for Life: A Pilot Study. Toxins 2:4, pages 552-571.
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Peter G. Mantle, Cyrille Amerasinghe, Amy L. Brown, Diana Herman, Thomas Horn, Thoger Krogh, Edward W. Odell, Tomas Rosenbaum & Calin A. Tatu. (2010) A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology. Toxins 2:3, pages 326-340.
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Peter G. MantleVirginie Faucet-MarquisRichard A. MandervilleBianca SquillaciAnnie Pfohl-Leszkowicz. (2009) Structures of Covalent Adducts between DNA and Ochratoxin A: A New Factor in Debate about Genotoxicity and Human Risk Assessment. Chemical Research in Toxicology 23:1, pages 89-98.
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A.-M. Domijan & M. Peraica. 2010. Comprehensive Toxicology. Comprehensive Toxicology 125 137 .
K.G. Dickman & A.P. Grollman. 2010. Comprehensive Toxicology. Comprehensive Toxicology 433 458 .
Annie Pfohl-Leszkowicz. (2009) Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours. Archives of Industrial Hygiene and Toxicology 60:4, pages 465-483.
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Peter G. Mantle. (2009) Minimum tolerable exposure period and maximum threshold dietary intake of ochratoxin A for causing renal cancer in male Dark Agouti rats. Food and Chemical Toxicology 47:10, pages 2419-2424.
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A. Vettorazzi, E. Gonzalez-Peñas, I.F. Trocóniz, L. Arbillaga, L.A. Corcuera, A.G. Gil & A. López de Cerain. (2009) A different kinetic profile of ochratoxin A in mature male rats. Food and Chemical Toxicology 47:8, pages 1921-1927.
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A. Pfohl-Leszkowicz. (2009) Mycotoxines : facteur de risque de cancersMycotoxins: a cancer risk factor. Journal africain du cancer / African Journal of Cancer 1:1, pages 42-55.
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Maricel Marin-Kuan, Christophe Cavin, Thierry Delatour & Benoît Schilter. (2008) Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms. Toxicon 52:2, pages 195-202.
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Frédéric D. Debelle, Jean-Louis Vanherweghem & Joëlle L. Nortier. (2008) Aristolochic acid nephropathy: A worldwide problem. Kidney International 74:2, pages 158-169.
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Leire Arbillaga, Ariane Vettorazzi, Ana G Gil, Joost HM van Delft, José Antonio García-Jalón & Adela López de Cerain. (2008) Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration. Toxicology and Applied Pharmacology 230:2, pages 197-207.
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Peter Mantle & Judit Nagy. (2008) Binding of Ochratoxin A to a Urinary Globulin: A New Concept to Account for Gender Difference in Rat Nephrocarcinogenic Responses. International Journal of Molecular Sciences 9:5, pages 719-735.
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Peter G. Mantle. (2008) Interpretation of the pharmacokinetics of ochratoxin A in blood plasma of rats, during and after acute or chronic ingestion. Food and Chemical Toxicology 46:5, pages 1808-1816.
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A. Mally, G.C. Hard & W. Dekant. (2007) Ochratoxin A as a potential etiologic factor in endemic nephropathy: Lessons from toxicity studies in rats. Food and Chemical Toxicology 45:11, pages 2254-2260.
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Amy L. Brown, Edward W. Odell & Peter G. Mantle. (2007) DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A. Experimental and Toxicologic Pathology 59:2, pages 85-95.
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Anna Lanzoni, Alessandro Piaia, Jeffrey Everitt, Ivo Faustinelli, Rossella Defazio, Luca Cavaliere & Patrizia Cristofori. (2016) Early Onset of Spontaneous Renal Preneoplastic and Neoplastic Lesions in Young Conventional Rats in Toxicity Studies. Toxicologic Pathology 35:4, pages 589-593.
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Annie Pfohl‐Leszkowicz & Richard A. Manderville. (2006) Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans. Molecular Nutrition & Food Research 51:1, pages 61-99.
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. (2006) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to ochratoxin A in food. EFSA Journal 4:6, pages 365.
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Annie Pfohl‐Leskowicz. (2006) Mycotoxins – Food Safety Aspects Euro‐Maghrebin Symposium. Molecular Nutrition & Food Research 50:6, pages 467-469.
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M. Marin-Kuan, S. Nestler, C. Verguet, C. Bezençon, D. Piguet, R. Mansourian, J. Holzwarth, M. Grigorov, T. Delatour, P. Mantle, C. Cavin & B. Schilter. (2006) A Toxicogenomics Approach to Identify New Plausible Epigenetic Mechanisms of Ochratoxin A Carcinogenicity in Rat. Toxicological Sciences 89:1, pages 120-134.
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