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Research Article

Controlled delivery of drugs from a novel injectable in situ formed biodegradable PLGA microsphere system

Pages 343-362 | Published online: 29 Sep 2008

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Chetan Janrao, Shivani Khopade, Akshay Bavaskar, Shyam Sudhakar Gomte, Tejas Girish Agnihotri & Aakanchha Jain. (2023) Recent advances of polymer based nanosystems in cancer management. Journal of Biomaterials Science, Polymer Edition 34:9, pages 1274-1335.
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Andrea Salis, Elena P. Porcu, Elisabetta Gavini, Giulia R. Fois, Antonia Icaro Cornaglia, Giovanna Rassu, Marco Diana, Marcello Maestri, Paolo Giunchedi & Ioannis Nikolakakis. (2017) In situ forming biodegradable poly(ε-caprolactone) microsphere systems: a challenge for transarterial embolization therapy. In vitro and preliminary ex vivo studies. Expert Opinion on Drug Delivery 14:4, pages 453-465.
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Soad Ali Yehia, Sally Adel Abdel-Halim & Mary Yosry Aziz. (2017) Formulation and evaluation of injectable in situ forming microparticles for sustained delivery of lornoxicam. Drug Development and Industrial Pharmacy 43:2, pages 319-328.
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Ludmila N. Turino, Rodolfo N. Mariano, Luciano N. Mengatto & Julio A. Luna. (2015) In vitro evaluation of suspoemulsions for in situ-forming polymeric microspheres and controlled release of progesterone. Journal of Microencapsulation 32:6, pages 538-546.
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Ravi Vaishya, Varun Khurana, Sulabh Patel & Ashim K Mitra. (2015) Long-term delivery of protein therapeutics. Expert Opinion on Drug Delivery 12:3, pages 415-440.
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Tarun Garg & Amit K Goyal. (2014) Biomaterial-based scaffolds – current status and future directions. Expert Opinion on Drug Delivery 11:5, pages 767-789.
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Soad A. Yehia, Ahmed H. Elshafeey & Ibrahim Elsayed. (2012) A novel injectable in situ forming poly-DL-lactide and DL-lactide/glycolide implant containing lipospheres for controlled drug delivery. Journal of Liposome Research 22:2, pages 128-138.
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Jianpeng Zou, Jianming Ruan, Zhongcheng Zhou & Zhihua Zhou. (2010) Preparation of Poly (L-lactic Acid) Microsphere. Journal of Macromolecular Science, Part B 50:2, pages 300-305.
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K. Vivek, L. Harivardhan Reddy & R.S.R. Murthy. (2007) Comparative Study of Some Biodegradable Polymers on the Entrapment Efficiency and Release Behavior of Etoposide from Microspheres. Pharmaceutical Development and Technology 12:1, pages 79-88.
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S. Lee, M. S. Kim, J. S. Kim, H. J. Park, J. S. Woo, B. C. Lee & S. J. Hwang. (2006) Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique. Journal of Microencapsulation 23:7, pages 741-749.
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Articles from other publishers (28)

Saeed Bazraee, Hamid Mobedi, Arezuo Mashak & Ahmad Jamshidi. (2022) Long-Lasting In Situ Forming Implant Loaded with Bupivacaine: Investigation on Polymeric and Non-Polymeric Carrier and Solvent Effect. Current Drug Delivery 19:1, pages 157-166.
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Mohamed Haider, Ibrahim Elsayed, Iman S. Ahmed & Ahmed R. Fares. (2021) In Situ-Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In Vivo Evaluation. Pharmaceuticals 14:1, pages 66.
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Ivana Clark & David Taylor. (2020) Newer Formulations of Risperidone: Role in the Management of Psychotic Disorders. CNS Drugs 34:8, pages 841-852.
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Abeer Khattab, Dalia M.N. Abouhussein & Ebtehal Mohammad F. (2019) Development of injectable tenoxicam in situ forming microparticles based on sesame oil and poly-DL-lactide: Characterization, efficacy and acute toxicity. Journal of Drug Delivery Science and Technology 51, pages 682-694.
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Atul Chaudhari, Komal Vig, Dieudonné Baganizi, Rajnish Sahu, Saurabh Dixit, Vida Dennis, Shree Singh & Shreekumar Pillai. (2016) Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review. International Journal of Molecular Sciences 17:12, pages 1974.
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Sah Hongkee & Bhattacharjee Himanshu. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 4738 4755 .
Gholam Hossein Zohuri, Reza Sandaroos, Saeid Ahmadjo, Saman Damavandi, Ahmad Rabiee & Mohammad Amin Shamekhi. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 7901 7932 .
Wei Gao, Yuanyi Zheng, Ronghui Wang, Hangrong Chen, Xiaojun Cai, Guangming Lu, Lei Chu, Chunyan Xu, Nan Zhang, Zhigang Wang, Haitao Ran, Pan Li, Chunjiang Yang, Zhechuan Mei & Jinlin Song. (2016) A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication. Acta Biomaterialia 29, pages 298-306.
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Cheon Jung Lee, Su Young Kim, Hyun Gu Lee, Jaewon Yang, Jin Young Park, Seon Ui Lee, Dongwon Lee & Gilson Khang. (2015) IN VITRO CHARACTERIZATION OF TRAMADOL-HCL-LOADED POLYOXALATE MICROSPHERES DESIGNED FOR CONTROLLED DRUG RELEASE . Biomedical Engineering: Applications, Basis and Communications 27:03, pages 1550022.
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Ozlem Aydin, Baran Aydin, Aysen Tezcaner & Dilek Keskin. (2015) Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres . Journal of Applied Polymer Science 132:14, pages n/a-n/a.
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Adam A Walters, Christos Krastev, Adrian V S Hill & Anita Milicic. (2015) Next generation vaccines: single-dose encapsulated vaccines for improved global immunisation coverage and efficacy. Journal of Pharmacy and Pharmacology 67:3, pages 400-408.
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L. N. Turino, R. N. Mariano, S. Boimvaser & J. A. Luna. (2014) In Situ-Formed Microparticles of PLGA from O/W Emulsions Stabilized with PVA: Encapsulation and Controlled Release of Progesterone. Journal of Pharmaceutical Innovation 9:2, pages 132-140.
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Benjamin Teong, Shwu Jen Chang, Chin Wen Chuang, Shyh Ming Kuo & Ioannis Manousakas. (2013) The production of volvox spheres and their potential application in multi-drugs encapsulation and release. Materials Science and Engineering: C 33:8, pages 4859-4866.
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Priyanka Agarwal & Ilva D. Rupenthal. (2013) Injectable implants for the sustained release of protein and peptide drugs. Drug Discovery Today 18:7-8, pages 337-349.
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Liliana Bernardino, Maria Francisca Eiriz, Tiago Santos, Sara Xapelli, Sofia Grade, Alexandra Isabel Rosa, Luísa Cortes, Raquel Ferreira, José Bragança, Fabienne Agasse, Lino Ferreira & João O. Malva. (2012) Histamine Stimulates Neurogenesis in the Rodent Subventricular Zone. Stem Cells 30:4, pages 773-784.
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C. Wischke & S. P. Schwendeman. 2012. Fundamentals and Applications of Controlled Release Drug Delivery. Fundamentals and Applications of Controlled Release Drug Delivery 171 228 .
Brahatheeswaran Dhandayuthapani, Yasuhiko Yoshida, Toru Maekawa & D. Sakthi Kumar. (2011) Polymeric Scaffolds in Tissue Engineering Application: A Review. International Journal of Polymer Science 2011, pages 1-19.
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Christian Wischke & Steven P. Schwendeman. (2008) Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. International Journal of Pharmaceutics 364:2, pages 298-327.
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Carmen Garnacho, Rajwinder Dhami, Eric Simone, Thomas Dziubla, John Leferovich, Edward H. Schuchman, Vladimir Muzykantov & Silvia Muro. (2008) Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers. Journal of Pharmacology and Experimental Therapeutics 325:2, pages 400-408.
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Wandee Rungseevijitprapa, Gayle A. Brazeau, James W. Simkins & Roland Bodmeier. (2008) Myotoxicity studies of O/W-in situ forming microparticle systems. European Journal of Pharmaceutics and Biopharmaceutics 69:1, pages 126-133.
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R. Astaneh, M. Erfan, J. Barzin, H. Mobedi & HR. Moghimi. (2008) Effects of ethyl benzoate on performance, morphology, and erosion of PLGA implants formed in situ. Advances in Polymer Technology 27:1, pages 17-26.
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Mohammad Rafienia, Hamid MirzadehHamid Mirzadeh, Hamid Mobedi & Ahmad Jamshidi. (2016) In Vitro Evaluation of Drug Solubility and Gamma Irradiation on the Release of Betamethasone under Simulated In Vivo Conditions. Journal of Bioactive and Compatible Polymers 22:4, pages 443-459.
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W.Y. Dong, M. Körber, V. López Esguerra & R. Bodmeier. (2006) Stability of poly(d,l-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems. Journal of Controlled Release 115:2, pages 158-167.
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Chien-Chi Lin, Carlos C. Co & Chia-Chi Ho. (2005) Micropatterning proteins and cells on polylactic acid and poly(lactide-co-glycolide). Biomaterials 26:17, pages 3655-3662.
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C.B Packhaeuser, J Schnieders, C.G Oster & T Kissel. (2004) In situ forming parenteral drug delivery systems: an overview. European Journal of Pharmaceutics and Biopharmaceutics 58:2, pages 445-455.
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Guobao Wei, Glenda J. Pettway, Laurie K. McCauley & Peter X. Ma. (2004) The release profiles and bioactivity of parathyroid hormone from poly(lactic-co-glycolic acid) microspheres. Biomaterials 25:2, pages 345-352.
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P.B Malafaya, G.A Silva, E.T Baran & R.L Reis. (2002) Drug delivery therapies II.. Current Opinion in Solid State and Materials Science 6:4, pages 297-312.
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Derek O'Hagan, Manmohan Singh, Mildred Ugozzoli, Carl Wild, Susan Barnett, Minchao Chen, Mary Schaefer, Barbara Doe, Gillis R. Otten & Jeffrey B. Ulmer. (2001) Induction of Potent Immune Responses by Cationic Microparticles with Adsorbed Human Immunodeficiency Virus DNA Vaccines. Journal of Virology 75:19, pages 9037-9043.
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